Amino acid dipepetide frequency for Echinococcus multilocularis (Fox tapeworm)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.507AlaAla: 7.507 ± 0.085	1.518AlaCys: 1.518 ± 0.021	3.535AlaAsp: 3.535 ± 0.033	4.658AlaGlu: 4.658 ± 0.069	3.094AlaPhe: 3.094 ± 0.025	3.935AlaGly: 3.935 ± 0.035	1.592AlaHis: 1.592 ± 0.019	3.607AlaIle: 3.607 ± 0.028	3.541AlaLys: 3.541 ± 0.03	7.075AlaLeu: 7.075 ± 0.053	1.609AlaMet: 1.609 ± 0.019	2.966AlaAsn: 2.966 ± 0.024	3.806AlaPro: 3.806 ± 0.04	2.554AlaGln: 2.554 ± 0.026	3.816AlaArg: 3.816 ± 0.032	7.202AlaSer: 7.202 ± 0.051	4.844AlaThr: 4.844 ± 0.043	5.223AlaVal: 5.223 ± 0.039	0.764AlaTrp: 0.764 ± 0.013	1.948AlaTyr: 1.948 ± 0.02	0.001AlaXaa: 0.001 ± 0.0
Cys	1.371CysAla: 1.371 ± 0.019	0.621CysCys: 0.621 ± 0.014	1.064CysAsp: 1.064 ± 0.017	1.196CysGlu: 1.196 ± 0.022	0.913CysPhe: 0.913 ± 0.014	1.414CysGly: 1.414 ± 0.023	0.599CysHis: 0.599 ± 0.011	1.126CysIle: 1.126 ± 0.018	0.9CysLys: 0.9 ± 0.017	2.505CysLeu: 2.505 ± 0.03	0.401CysMet: 0.401 ± 0.011	0.794CysAsn: 0.794 ± 0.013	1.219CysPro: 1.219 ± 0.024	0.877CysGln: 0.877 ± 0.017	1.406CysArg: 1.406 ± 0.02	1.829CysSer: 1.829 ± 0.022	1.106CysThr: 1.106 ± 0.016	1.405CysVal: 1.405 ± 0.02	0.237CysTrp: 0.237 ± 0.008	0.558CysTyr: 0.558 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	3.748AspAla: 3.748 ± 0.028	1.04AspCys: 1.04 ± 0.016	3.132AspAsp: 3.132 ± 0.041	3.773AspGlu: 3.773 ± 0.036	2.298AspPhe: 2.298 ± 0.023	3.241AspGly: 3.241 ± 0.044	1.041AspHis: 1.041 ± 0.015	2.527AspIle: 2.527 ± 0.023	2.061AspLys: 2.061 ± 0.023	5.039AspLeu: 5.039 ± 0.039	1.02AspMet: 1.02 ± 0.012	1.768AspAsn: 1.768 ± 0.018	2.595AspPro: 2.595 ± 0.025	1.575AspGln: 1.575 ± 0.018	2.705AspArg: 2.705 ± 0.025	4.169AspSer: 4.169 ± 0.032	2.406AspThr: 2.406 ± 0.023	3.428AspVal: 3.428 ± 0.028	0.619AspTrp: 0.619 ± 0.011	1.493AspTyr: 1.493 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	5.339GluAla: 5.339 ± 0.066	1.157GluCys: 1.157 ± 0.019	3.544GluAsp: 3.544 ± 0.038	6.032GluGlu: 6.032 ± 0.073	2.077GluPhe: 2.077 ± 0.022	3.546GluGly: 3.546 ± 0.043	1.274GluHis: 1.274 ± 0.014	3.055GluIle: 3.055 ± 0.029	3.566GluLys: 3.566 ± 0.037	5.419GluLeu: 5.419 ± 0.04	1.598GluMet: 1.598 ± 0.02	2.628GluAsn: 2.628 ± 0.027	2.403GluPro: 2.403 ± 0.025	2.22GluGln: 2.22 ± 0.026	3.764GluArg: 3.764 ± 0.032	4.544GluSer: 4.544 ± 0.038	3.31GluThr: 3.31 ± 0.032	4.423GluVal: 4.423 ± 0.042	0.657GluTrp: 0.657 ± 0.012	1.48GluTyr: 1.48 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	2.786PheAla: 2.786 ± 0.024	1.026PheCys: 1.026 ± 0.02	2.189PheAsp: 2.189 ± 0.023	2.186PheGlu: 2.186 ± 0.022	1.794PhePhe: 1.794 ± 0.022	2.407PheGly: 2.407 ± 0.026	1.064PheHis: 1.064 ± 0.014	2.056PheIle: 2.056 ± 0.021	1.682PheLys: 1.682 ± 0.022	3.999PheLeu: 3.999 ± 0.034	0.779PheMet: 0.779 ± 0.013	1.611PheAsn: 1.611 ± 0.018	1.975PhePro: 1.975 ± 0.021	1.438PheGln: 1.438 ± 0.019	2.215PheArg: 2.215 ± 0.025	3.531PheSer: 3.531 ± 0.028	2.352PheThr: 2.352 ± 0.023	2.661PheVal: 2.661 ± 0.026	0.466PheTrp: 0.466 ± 0.011	1.305PheTyr: 1.305 ± 0.018	0.001PheXaa: 0.001 ± 0.0
Gly	3.901GlyAla: 3.901 ± 0.04	1.236GlyCys: 1.236 ± 0.017	3.199GlyAsp: 3.199 ± 0.037	3.607GlyGlu: 3.607 ± 0.051	2.278GlyPhe: 2.278 ± 0.026	5.403GlyGly: 5.403 ± 0.064	1.361GlyHis: 1.361 ± 0.018	2.773GlyIle: 2.773 ± 0.028	2.764GlyLys: 2.764 ± 0.028	5.098GlyLeu: 5.098 ± 0.043	1.174GlyMet: 1.174 ± 0.017	2.268GlyAsn: 2.268 ± 0.022	2.593GlyPro: 2.593 ± 0.101	2.039GlyGln: 2.039 ± 0.023	3.628GlyArg: 3.628 ± 0.034	5.252GlySer: 5.252 ± 0.046	3.118GlyThr: 3.118 ± 0.03	3.972GlyVal: 3.972 ± 0.033	0.668GlyTrp: 0.668 ± 0.02	1.567GlyTyr: 1.567 ± 0.023	0.001GlyXaa: 0.001 ± 0.001
His	1.468HisAla: 1.468 ± 0.017	0.637HisCys: 0.637 ± 0.011	0.961HisAsp: 0.961 ± 0.013	1.23HisGlu: 1.23 ± 0.015	1.204HisPhe: 1.204 ± 0.016	1.289HisGly: 1.289 ± 0.017	1.098HisHis: 1.098 ± 0.023	1.222HisIle: 1.222 ± 0.017	0.955HisLys: 0.955 ± 0.013	3.036HisLeu: 3.036 ± 0.028	0.505HisMet: 0.505 ± 0.01	0.899HisAsn: 0.899 ± 0.015	1.666HisPro: 1.666 ± 0.022	1.258HisGln: 1.258 ± 0.021	1.822HisArg: 1.822 ± 0.023	2.277HisSer: 2.277 ± 0.024	1.24HisThr: 1.24 ± 0.016	1.395HisVal: 1.395 ± 0.018	0.332HisTrp: 0.332 ± 0.008	0.77HisTyr: 0.77 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	3.57IleAla: 3.57 ± 0.03	1.274IleCys: 1.274 ± 0.019	2.61IleAsp: 2.61 ± 0.022	2.769IleGlu: 2.769 ± 0.026	2.207IlePhe: 2.207 ± 0.023	2.666IleGly: 2.666 ± 0.025	1.259IleHis: 1.259 ± 0.017	2.459IleIle: 2.459 ± 0.027	2.214IleLys: 2.214 ± 0.023	4.662IleLeu: 4.662 ± 0.038	0.912IleMet: 0.912 ± 0.014	2.038IleAsn: 2.038 ± 0.025	2.769IlePro: 2.769 ± 0.033	1.841IleGln: 1.841 ± 0.023	2.917IleArg: 2.917 ± 0.03	4.395IleSer: 4.395 ± 0.031	2.88IleThr: 2.88 ± 0.026	3.032IleVal: 3.032 ± 0.028	0.539IleTrp: 0.539 ± 0.011	1.508IleTyr: 1.508 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	3.559LysAla: 3.559 ± 0.034	0.963LysCys: 0.963 ± 0.019	2.18LysAsp: 2.18 ± 0.025	3.246LysGlu: 3.246 ± 0.034	1.64LysPhe: 1.64 ± 0.021	2.309LysGly: 2.309 ± 0.041	1.172LysHis: 1.172 ± 0.015	2.318LysIle: 2.318 ± 0.024	3.07LysLys: 3.07 ± 0.037	4.388LysLeu: 4.388 ± 0.036	1.208LysMet: 1.208 ± 0.015	1.914LysAsn: 1.914 ± 0.023	2.559LysPro: 2.559 ± 0.03	1.912LysGln: 1.912 ± 0.022	3.59LysArg: 3.59 ± 0.039	4.065LysSer: 4.065 ± 0.035	2.7LysThr: 2.7 ± 0.027	2.978LysVal: 2.978 ± 0.03	0.531LysTrp: 0.531 ± 0.011	1.271LysTyr: 1.271 ± 0.016	0.001LysXaa: 0.001 ± 0.001
Leu	7.229LeuAla: 7.229 ± 0.052	2.092LeuCys: 2.092 ± 0.023	4.719LeuAsp: 4.719 ± 0.029	5.899LeuGlu: 5.899 ± 0.051	3.843LeuPhe: 3.843 ± 0.032	4.716LeuGly: 4.716 ± 0.038	2.725LeuHis: 2.725 ± 0.029	4.754LeuIle: 4.754 ± 0.043	4.837LeuLys: 4.837 ± 0.034	10.539LeuLeu: 10.539 ± 0.079	2.032LeuMet: 2.032 ± 0.02	3.914LeuAsn: 3.914 ± 0.029	6.301LeuPro: 6.301 ± 0.049	4.408LeuGln: 4.408 ± 0.039	6.706LeuArg: 6.706 ± 0.044	8.601LeuSer: 8.601 ± 0.049	5.697LeuThr: 5.697 ± 0.041	5.871LeuVal: 5.871 ± 0.043	1.015LeuTrp: 1.015 ± 0.017	2.367LeuTyr: 2.367 ± 0.027	0.001LeuXaa: 0.001 ± 0.001
Met	1.783MetAla: 1.783 ± 0.021	0.387MetCys: 0.387 ± 0.009	1.218MetAsp: 1.218 ± 0.015	1.589MetGlu: 1.589 ± 0.017	0.64MetPhe: 0.64 ± 0.011	1.198MetGly: 1.198 ± 0.02	0.555MetHis: 0.555 ± 0.01	0.87MetIle: 0.87 ± 0.012	1.102MetLys: 1.102 ± 0.017	1.969MetLeu: 1.969 ± 0.018	0.5MetMet: 0.5 ± 0.012	0.902MetAsn: 0.902 ± 0.015	1.224MetPro: 1.224 ± 0.016	0.909MetGln: 0.909 ± 0.013	1.411MetArg: 1.411 ± 0.018	1.715MetSer: 1.715 ± 0.02	1.189MetThr: 1.189 ± 0.015	1.314MetVal: 1.314 ± 0.017	0.227MetTrp: 0.227 ± 0.008	0.471MetTyr: 0.471 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.078AsnAla: 3.078 ± 0.025	0.885AsnCys: 0.885 ± 0.014	1.972AsnAsp: 1.972 ± 0.023	2.415AsnGlu: 2.415 ± 0.023	1.739AsnPhe: 1.739 ± 0.02	2.61AsnGly: 2.61 ± 0.03	0.981AsnHis: 0.981 ± 0.016	1.979AsnIle: 1.979 ± 0.022	1.657AsnLys: 1.657 ± 0.021	4.039AsnLeu: 4.039 ± 0.035	0.791AsnMet: 0.791 ± 0.015	1.603AsnAsn: 1.603 ± 0.024	2.241AsnPro: 2.241 ± 0.021	1.564AsnGln: 1.564 ± 0.019	2.414AsnArg: 2.414 ± 0.023	3.551AsnSer: 3.551 ± 0.032	2.229AsnThr: 2.229 ± 0.024	2.497AsnVal: 2.497 ± 0.023	0.473AsnTrp: 0.473 ± 0.01	1.178AsnTyr: 1.178 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	3.618ProAla: 3.618 ± 0.035	0.992ProCys: 0.992 ± 0.019	2.525ProAsp: 2.525 ± 0.031	3.094ProGlu: 3.094 ± 0.029	2.101ProPhe: 2.101 ± 0.025	2.937ProGly: 2.937 ± 0.081	1.45ProHis: 1.45 ± 0.019	2.729ProIle: 2.729 ± 0.027	2.545ProLys: 2.545 ± 0.029	5.577ProLeu: 5.577 ± 0.037	1.104ProMet: 1.104 ± 0.017	2.277ProAsn: 2.277 ± 0.022	6.278ProPro: 6.278 ± 0.079	2.429ProGln: 2.429 ± 0.032	3.17ProArg: 3.17 ± 0.032	6.343ProSer: 6.343 ± 0.055	4.023ProThr: 4.023 ± 0.042	3.395ProVal: 3.395 ± 0.033	0.546ProTrp: 0.546 ± 0.011	1.361ProTyr: 1.361 ± 0.017	0.001ProXaa: 0.001 ± 0.0
Gln	2.688GlnAla: 2.688 ± 0.026	0.814GlnCys: 0.814 ± 0.014	1.409GlnAsp: 1.409 ± 0.017	2.202GlnGlu: 2.202 ± 0.022	1.387GlnPhe: 1.387 ± 0.018	1.691GlnGly: 1.691 ± 0.03	1.201GlnHis: 1.201 ± 0.017	1.982GlnIle: 1.982 ± 0.021	2.02GlnLys: 2.02 ± 0.02	4.269GlnLeu: 4.269 ± 0.036	1.073GlnMet: 1.073 ± 0.014	1.618GlnAsn: 1.618 ± 0.018	2.526GlnPro: 2.526 ± 0.027	2.961GlnGln: 2.961 ± 0.058	2.922GlnArg: 2.922 ± 0.027	3.358GlnSer: 3.358 ± 0.031	2.301GlnThr: 2.301 ± 0.029	2.215GlnVal: 2.215 ± 0.026	0.475GlnTrp: 0.475 ± 0.008	0.945GlnTyr: 0.945 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	3.864ArgAla: 3.864 ± 0.029	1.444ArgCys: 1.444 ± 0.022	2.705ArgAsp: 2.705 ± 0.028	3.515ArgGlu: 3.515 ± 0.03	2.497ArgPhe: 2.497 ± 0.02	3.473ArgGly: 3.473 ± 0.045	1.844ArgHis: 1.844 ± 0.023	3.2ArgIle: 3.2 ± 0.024	3.34ArgLys: 3.34 ± 0.034	7.013ArgLeu: 7.013 ± 0.043	1.347ArgMet: 1.347 ± 0.015	2.484ArgAsn: 2.484 ± 0.021	3.225ArgPro: 3.225 ± 0.028	2.817ArgGln: 2.817 ± 0.024	5.717ArgArg: 5.717 ± 0.053	5.257ArgSer: 5.257 ± 0.045	3.027ArgThr: 3.027 ± 0.026	3.658ArgVal: 3.658 ± 0.031	0.761ArgTrp: 0.761 ± 0.012	1.671ArgTyr: 1.671 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	6.828SerAla: 6.828 ± 0.047	1.765SerCys: 1.765 ± 0.022	4.303SerAsp: 4.303 ± 0.037	4.809SerGlu: 4.809 ± 0.037	3.2SerPhe: 3.2 ± 0.028	5.783SerGly: 5.783 ± 0.044	2.167SerHis: 2.167 ± 0.023	4.096SerIle: 4.096 ± 0.031	4.008SerLys: 4.008 ± 0.036	8.588SerLeu: 8.588 ± 0.055	1.789SerMet: 1.789 ± 0.019	3.585SerAsn: 3.585 ± 0.035	5.822SerPro: 5.822 ± 0.049	3.433SerGln: 3.433 ± 0.034	5.406SerArg: 5.406 ± 0.043	11.04SerSer: 11.04 ± 0.102	6.566SerThr: 6.566 ± 0.054	5.675SerVal: 5.675 ± 0.041	0.867SerTrp: 0.867 ± 0.017	1.958SerTyr: 1.958 ± 0.022	0.001SerXaa: 0.001 ± 0.0
Thr	4.951ThrAla: 4.951 ± 0.038	1.238ThrCys: 1.238 ± 0.02	2.803ThrAsp: 2.803 ± 0.023	3.317ThrGlu: 3.317 ± 0.03	2.27ThrPhe: 2.27 ± 0.022	3.467ThrGly: 3.467 ± 0.034	1.313ThrHis: 1.313 ± 0.016	2.683ThrIle: 2.683 ± 0.023	2.538ThrLys: 2.538 ± 0.03	5.389ThrLeu: 5.389 ± 0.034	1.184ThrMet: 1.184 ± 0.017	2.388ThrAsn: 2.388 ± 0.024	3.981ThrPro: 3.981 ± 0.042	2.009ThrGln: 2.009 ± 0.026	3.051ThrArg: 3.051 ± 0.025	6.295ThrSer: 6.295 ± 0.051	4.779ThrThr: 4.779 ± 0.101	3.907ThrVal: 3.907 ± 0.034	0.611ThrTrp: 0.611 ± 0.012	1.469ThrTyr: 1.469 ± 0.018	0.001ThrXaa: 0.001 ± 0.0
Val	5.022ValAla: 5.022 ± 0.035	1.526ValCys: 1.526 ± 0.019	3.75ValAsp: 3.75 ± 0.03	4.413ValGlu: 4.413 ± 0.048	2.62ValPhe: 2.62 ± 0.022	3.764ValGly: 3.764 ± 0.035	1.538ValHis: 1.538 ± 0.018	3.158ValIle: 3.158 ± 0.027	3.072ValLys: 3.072 ± 0.032	5.612ValLeu: 5.612 ± 0.037	1.289ValMet: 1.289 ± 0.017	2.692ValAsn: 2.692 ± 0.025	3.396ValPro: 3.396 ± 0.034	2.304ValGln: 2.304 ± 0.023	3.524ValArg: 3.524 ± 0.026	5.27ValSer: 5.27 ± 0.037	3.816ValThr: 3.816 ± 0.033	4.557ValVal: 4.557 ± 0.036	0.691ValTrp: 0.691 ± 0.013	1.794ValTyr: 1.794 ± 0.023	0.0ValXaa: 0.0 ± 0.0
Trp	0.616TrpAla: 0.616 ± 0.011	0.262TrpCys: 0.262 ± 0.006	0.544TrpAsp: 0.544 ± 0.014	0.558TrpGlu: 0.558 ± 0.011	0.458TrpPhe: 0.458 ± 0.01	0.48TrpGly: 0.48 ± 0.01	0.299TrpHis: 0.299 ± 0.009	0.637TrpIle: 0.637 ± 0.011	0.596TrpLys: 0.596 ± 0.012	1.223TrpLeu: 1.223 ± 0.023	0.302TrpMet: 0.302 ± 0.009	0.516TrpAsn: 0.516 ± 0.011	0.549TrpPro: 0.549 ± 0.011	0.458TrpGln: 0.458 ± 0.011	0.877TrpArg: 0.877 ± 0.015	0.933TrpSer: 0.933 ± 0.016	0.622TrpThr: 0.622 ± 0.012	0.597TrpVal: 0.597 ± 0.011	0.173TrpTrp: 0.173 ± 0.006	0.288TrpTyr: 0.288 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.867TyrAla: 1.867 ± 0.022	0.662TyrCys: 0.662 ± 0.015	1.318TyrAsp: 1.318 ± 0.017	1.529TyrGlu: 1.529 ± 0.019	1.263TyrPhe: 1.263 ± 0.018	1.569TyrGly: 1.569 ± 0.024	0.732TyrHis: 0.732 ± 0.011	1.291TyrIle: 1.291 ± 0.016	1.106TyrLys: 1.106 ± 0.015	2.827TyrLeu: 2.827 ± 0.026	0.556TyrMet: 0.556 ± 0.012	1.031TyrAsn: 1.031 ± 0.017	1.364TyrPro: 1.364 ± 0.018	1.05TyrGln: 1.05 ± 0.014	1.797TyrArg: 1.797 ± 0.022	2.058TyrSer: 2.058 ± 0.019	1.437TyrThr: 1.437 ± 0.016	1.607TyrVal: 1.607 ± 0.022	0.336TyrTrp: 0.336 ± 0.007	0.88TyrTyr: 0.88 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.0	0.001XaaArg: 0.001 ± 0.0	0.001XaaSer: 0.001 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 10472 proteins (5200134 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---