Amino acid dipepetide frequency for Paenibacillus psychroresistens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.049AlaAla: 7.049 ± 0.087	0.63AlaCys: 0.63 ± 0.018	3.908AlaAsp: 3.908 ± 0.052	4.776AlaGlu: 4.776 ± 0.055	3.355AlaPhe: 3.355 ± 0.046	5.412AlaGly: 5.412 ± 0.07	1.27AlaHis: 1.27 ± 0.02	5.904AlaIle: 5.904 ± 0.068	4.447AlaLys: 4.447 ± 0.04	7.358AlaLeu: 7.358 ± 0.071	1.933AlaMet: 1.933 ± 0.028	3.287AlaAsn: 3.287 ± 0.047	2.464AlaPro: 2.464 ± 0.043	2.601AlaGln: 2.601 ± 0.037	2.58AlaArg: 2.58 ± 0.033	4.84AlaSer: 4.84 ± 0.051	4.303AlaThr: 4.303 ± 0.112	5.284AlaVal: 5.284 ± 0.063	0.943AlaTrp: 0.943 ± 0.02	2.669AlaTyr: 2.669 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	0.464CysAla: 0.464 ± 0.015	0.109CysCys: 0.109 ± 0.007	0.377CysAsp: 0.377 ± 0.01	0.464CysGlu: 0.464 ± 0.015	0.349CysPhe: 0.349 ± 0.013	0.651CysGly: 0.651 ± 0.02	0.192CysHis: 0.192 ± 0.01	0.551CysIle: 0.551 ± 0.017	0.363CysLys: 0.363 ± 0.012	0.799CysLeu: 0.799 ± 0.022	0.198CysMet: 0.198 ± 0.011	0.295CysAsn: 0.295 ± 0.012	0.299CysPro: 0.299 ± 0.013	0.199CysGln: 0.199 ± 0.008	0.317CysArg: 0.317 ± 0.012	0.571CysSer: 0.571 ± 0.015	0.382CysThr: 0.382 ± 0.014	0.416CysVal: 0.416 ± 0.014	0.104CysTrp: 0.104 ± 0.006	0.283CysTyr: 0.283 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	3.479AspAla: 3.479 ± 0.037	0.381AspCys: 0.381 ± 0.012	2.353AspAsp: 2.353 ± 0.037	3.58AspGlu: 3.58 ± 0.039	2.377AspPhe: 2.377 ± 0.034	3.723AspGly: 3.723 ± 0.05	1.121AspHis: 1.121 ± 0.021	3.957AspIle: 3.957 ± 0.043	3.052AspLys: 3.052 ± 0.042	5.058AspLeu: 5.058 ± 0.052	1.206AspMet: 1.206 ± 0.022	2.291AspAsn: 2.291 ± 0.034	2.186AspPro: 2.186 ± 0.033	2.069AspGln: 2.069 ± 0.031	2.092AspArg: 2.092 ± 0.028	3.261AspSer: 3.261 ± 0.047	2.548AspThr: 2.548 ± 0.038	3.211AspVal: 3.211 ± 0.05	0.894AspTrp: 0.894 ± 0.024	2.257AspTyr: 2.257 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	5.233GluAla: 5.233 ± 0.053	0.364GluCys: 0.364 ± 0.012	2.861GluAsp: 2.861 ± 0.042	4.19GluGlu: 4.19 ± 0.055	2.393GluPhe: 2.393 ± 0.031	3.616GluGly: 3.616 ± 0.041	1.393GluHis: 1.393 ± 0.025	4.969GluIle: 4.969 ± 0.052	4.008GluLys: 4.008 ± 0.043	6.803GluLeu: 6.803 ± 0.068	1.949GluMet: 1.949 ± 0.035	2.771GluAsn: 2.771 ± 0.038	1.931GluPro: 1.931 ± 0.029	3.246GluGln: 3.246 ± 0.043	2.831GluArg: 2.831 ± 0.036	3.532GluSer: 3.532 ± 0.039	3.233GluThr: 3.233 ± 0.046	4.224GluVal: 4.224 ± 0.05	0.892GluTrp: 0.892 ± 0.021	2.039GluTyr: 2.039 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	3.162PheAla: 3.162 ± 0.04	0.399PheCys: 0.399 ± 0.014	2.408PheAsp: 2.408 ± 0.03	2.602PheGlu: 2.602 ± 0.038	2.052PhePhe: 2.052 ± 0.038	3.045PheGly: 3.045 ± 0.04	0.996PheHis: 0.996 ± 0.022	3.666PheIle: 3.666 ± 0.05	2.558PheLys: 2.558 ± 0.036	4.092PheLeu: 4.092 ± 0.059	1.17PheMet: 1.17 ± 0.024	2.212PheAsn: 2.212 ± 0.036	1.649PhePro: 1.649 ± 0.028	1.602PheGln: 1.602 ± 0.026	1.782PheArg: 1.782 ± 0.027	3.275PheSer: 3.275 ± 0.038	2.853PheThr: 2.853 ± 0.041	2.85PheVal: 2.85 ± 0.036	0.576PheTrp: 0.576 ± 0.016	1.763PheTyr: 1.763 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	4.927GlyAla: 4.927 ± 0.111	0.665GlyCys: 0.665 ± 0.019	3.314GlyAsp: 3.314 ± 0.046	3.802GlyGlu: 3.802 ± 0.052	3.344GlyPhe: 3.344 ± 0.04	4.666GlyGly: 4.666 ± 0.065	1.317GlyHis: 1.317 ± 0.023	5.791GlyIle: 5.791 ± 0.056	4.432GlyLys: 4.432 ± 0.054	6.551GlyLeu: 6.551 ± 0.066	1.983GlyMet: 1.983 ± 0.029	3.033GlyAsn: 3.033 ± 0.042	1.654GlyPro: 1.654 ± 0.03	2.287GlyGln: 2.287 ± 0.035	2.478GlyArg: 2.478 ± 0.036	4.539GlySer: 4.539 ± 0.055	4.3GlyThr: 4.3 ± 0.067	4.705GlyVal: 4.705 ± 0.069	1.018GlyTrp: 1.018 ± 0.022	2.867GlyTyr: 2.867 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	1.374HisAla: 1.374 ± 0.027	0.186HisCys: 0.186 ± 0.009	0.948HisAsp: 0.948 ± 0.02	1.222HisGlu: 1.222 ± 0.024	1.141HisPhe: 1.141 ± 0.024	1.312HisGly: 1.312 ± 0.023	0.546HisHis: 0.546 ± 0.015	1.539HisIle: 1.539 ± 0.035	0.996HisLys: 0.996 ± 0.021	2.184HisLeu: 2.184 ± 0.034	0.52HisMet: 0.52 ± 0.014	0.857HisAsn: 0.857 ± 0.019	1.089HisPro: 1.089 ± 0.023	0.769HisGln: 0.769 ± 0.018	0.843HisArg: 0.843 ± 0.019	1.307HisSer: 1.307 ± 0.024	1.068HisThr: 1.068 ± 0.023	1.26HisVal: 1.26 ± 0.023	0.329HisTrp: 0.329 ± 0.012	0.922HisTyr: 0.922 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.093IleAla: 6.093 ± 0.056	0.669IleCys: 0.669 ± 0.016	4.186IleAsp: 4.186 ± 0.044	4.906IleGlu: 4.906 ± 0.055	3.139IlePhe: 3.139 ± 0.046	5.296IleGly: 5.296 ± 0.05	1.713IleHis: 1.713 ± 0.026	5.871IleIle: 5.871 ± 0.069	4.382IleLys: 4.382 ± 0.053	7.01IleLeu: 7.01 ± 0.073	1.894IleMet: 1.894 ± 0.029	3.584IleAsn: 3.584 ± 0.046	3.508IlePro: 3.508 ± 0.04	3.195IleGln: 3.195 ± 0.046	3.437IleArg: 3.437 ± 0.042	5.565IleSer: 5.565 ± 0.056	4.835IleThr: 4.835 ± 0.052	5.32IleVal: 5.32 ± 0.051	0.897IleTrp: 0.897 ± 0.019	2.698IleTyr: 2.698 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.693LysAla: 4.693 ± 0.047	0.283LysCys: 0.283 ± 0.012	3.303LysAsp: 3.303 ± 0.043	4.204LysGlu: 4.204 ± 0.053	1.949LysPhe: 1.949 ± 0.031	3.656LysGly: 3.656 ± 0.046	1.259LysHis: 1.259 ± 0.028	4.172LysIle: 4.172 ± 0.05	3.907LysLys: 3.907 ± 0.056	6.452LysLeu: 6.452 ± 0.06	1.747LysMet: 1.747 ± 0.027	2.691LysAsn: 2.691 ± 0.038	2.334LysPro: 2.334 ± 0.036	2.905LysGln: 2.905 ± 0.038	2.558LysArg: 2.558 ± 0.039	3.617LysSer: 3.617 ± 0.044	3.321LysThr: 3.321 ± 0.042	3.983LysVal: 3.983 ± 0.045	0.798LysTrp: 0.798 ± 0.019	2.046LysTyr: 2.046 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	7.591LeuAla: 7.591 ± 0.069	0.762LeuCys: 0.762 ± 0.019	5.102LeuAsp: 5.102 ± 0.05	6.069LeuGlu: 6.069 ± 0.06	4.779LeuPhe: 4.779 ± 0.061	6.268LeuGly: 6.268 ± 0.061	2.059LeuHis: 2.059 ± 0.032	7.737LeuIle: 7.737 ± 0.08	6.225LeuLys: 6.225 ± 0.063	10.658LeuLeu: 10.658 ± 0.093	2.507LeuMet: 2.507 ± 0.035	4.812LeuAsn: 4.812 ± 0.048	4.224LeuPro: 4.224 ± 0.05	4.419LeuGln: 4.419 ± 0.049	3.985LeuArg: 3.985 ± 0.046	7.137LeuSer: 7.137 ± 0.063	5.785LeuThr: 5.785 ± 0.061	6.153LeuVal: 6.153 ± 0.061	1.078LeuTrp: 1.078 ± 0.024	3.337LeuTyr: 3.337 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	1.909MetAla: 1.909 ± 0.032	0.154MetCys: 0.154 ± 0.008	1.599MetAsp: 1.599 ± 0.028	1.742MetGlu: 1.742 ± 0.03	1.057MetPhe: 1.057 ± 0.024	1.704MetGly: 1.704 ± 0.029	0.488MetHis: 0.488 ± 0.015	1.976MetIle: 1.976 ± 0.029	2.007MetLys: 2.007 ± 0.031	2.683MetLeu: 2.683 ± 0.038	0.747MetMet: 0.747 ± 0.021	1.545MetAsn: 1.545 ± 0.026	1.105MetPro: 1.105 ± 0.026	1.041MetGln: 1.041 ± 0.022	1.155MetArg: 1.155 ± 0.023	1.657MetSer: 1.657 ± 0.029	1.499MetThr: 1.499 ± 0.024	1.713MetVal: 1.713 ± 0.025	0.237MetTrp: 0.237 ± 0.011	0.731MetTyr: 0.731 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.174AsnAla: 3.174 ± 0.043	0.308AsnCys: 0.308 ± 0.011	2.332AsnAsp: 2.332 ± 0.033	3.055AsnGlu: 3.055 ± 0.041	1.67AsnPhe: 1.67 ± 0.027	3.692AsnGly: 3.692 ± 0.047	1.024AsnHis: 1.024 ± 0.024	3.221AsnIle: 3.221 ± 0.04	2.886AsnLys: 2.886 ± 0.039	4.328AsnLeu: 4.328 ± 0.047	1.142AsnMet: 1.142 ± 0.02	2.351AsnAsn: 2.351 ± 0.045	2.251AsnPro: 2.251 ± 0.032	2.102AsnGln: 2.102 ± 0.037	1.972AsnArg: 1.972 ± 0.03	3.052AsnSer: 3.052 ± 0.046	2.6AsnThr: 2.6 ± 0.043	2.977AsnVal: 2.977 ± 0.042	0.721AsnTrp: 0.721 ± 0.016	1.881AsnTyr: 1.881 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	2.84ProAla: 2.84 ± 0.042	0.221ProCys: 0.221 ± 0.009	2.194ProAsp: 2.194 ± 0.036	2.783ProGlu: 2.783 ± 0.036	1.9ProPhe: 1.9 ± 0.03	2.337ProGly: 2.337 ± 0.035	0.845ProHis: 0.845 ± 0.019	3.007ProIle: 3.007 ± 0.038	1.89ProLys: 1.89 ± 0.032	3.943ProLeu: 3.943 ± 0.042	0.913ProMet: 0.913 ± 0.022	1.846ProAsn: 1.846 ± 0.028	1.071ProPro: 1.071 ± 0.024	1.423ProGln: 1.423 ± 0.024	1.14ProArg: 1.14 ± 0.023	2.498ProSer: 2.498 ± 0.039	2.593ProThr: 2.593 ± 0.051	2.641ProVal: 2.641 ± 0.036	0.527ProTrp: 0.527 ± 0.016	1.481ProTyr: 1.481 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.235GlnAla: 3.235 ± 0.039	0.218GlnCys: 0.218 ± 0.01	1.762GlnAsp: 1.762 ± 0.025	2.384GlnGlu: 2.384 ± 0.039	1.775GlnPhe: 1.775 ± 0.028	2.432GlnGly: 2.432 ± 0.042	0.789GlnHis: 0.789 ± 0.021	3.168GlnIle: 3.168 ± 0.038	2.39GlnLys: 2.39 ± 0.036	4.472GlnLeu: 4.472 ± 0.05	1.243GlnMet: 1.243 ± 0.026	1.58GlnAsn: 1.58 ± 0.026	1.389GlnPro: 1.389 ± 0.024	1.987GlnGln: 1.987 ± 0.041	1.553GlnArg: 1.553 ± 0.028	2.484GlnSer: 2.484 ± 0.036	2.236GlnThr: 2.236 ± 0.036	2.59GlnVal: 2.59 ± 0.035	0.576GlnTrp: 0.576 ± 0.016	1.497GlnTyr: 1.497 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	2.474ArgAla: 2.474 ± 0.035	0.27ArgCys: 0.27 ± 0.011	1.914ArgAsp: 1.914 ± 0.029	2.616ArgGlu: 2.616 ± 0.035	1.98ArgPhe: 1.98 ± 0.034	2.256ArgGly: 2.256 ± 0.037	0.744ArgHis: 0.744 ± 0.017	3.535ArgIle: 3.535 ± 0.042	2.624ArgLys: 2.624 ± 0.035	4.267ArgLeu: 4.267 ± 0.051	1.35ArgMet: 1.35 ± 0.027	1.948ArgAsn: 1.948 ± 0.032	1.203ArgPro: 1.203 ± 0.025	1.468ArgGln: 1.468 ± 0.026	1.779ArgArg: 1.779 ± 0.034	2.571ArgSer: 2.571 ± 0.027	2.053ArgThr: 2.053 ± 0.028	2.573ArgVal: 2.573 ± 0.032	0.587ArgTrp: 0.587 ± 0.016	1.542ArgTyr: 1.542 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	4.563SerAla: 4.563 ± 0.054	0.446SerCys: 0.446 ± 0.016	3.237SerAsp: 3.237 ± 0.039	3.845SerGlu: 3.845 ± 0.04	3.38SerPhe: 3.38 ± 0.04	5.077SerGly: 5.077 ± 0.068	1.284SerHis: 1.284 ± 0.027	5.472SerIle: 5.472 ± 0.06	3.83SerLys: 3.83 ± 0.041	6.86SerLeu: 6.86 ± 0.055	1.733SerMet: 1.733 ± 0.026	3.145SerAsn: 3.145 ± 0.044	2.435SerPro: 2.435 ± 0.036	2.296SerGln: 2.296 ± 0.03	2.51SerArg: 2.51 ± 0.037	4.921SerSer: 4.921 ± 0.067	3.868SerThr: 3.868 ± 0.052	4.335SerVal: 4.335 ± 0.048	0.921SerTrp: 0.921 ± 0.023	2.52SerTyr: 2.52 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	4.646ThrAla: 4.646 ± 0.075	0.353ThrCys: 0.353 ± 0.014	3.074ThrAsp: 3.074 ± 0.045	3.226ThrGlu: 3.226 ± 0.042	2.624ThrPhe: 2.624 ± 0.041	4.734ThrGly: 4.734 ± 0.168	1.048ThrHis: 1.048 ± 0.02	4.769ThrIle: 4.769 ± 0.052	3.038ThrLys: 3.038 ± 0.037	5.741ThrLeu: 5.741 ± 0.064	1.345ThrMet: 1.345 ± 0.027	2.667ThrAsn: 2.667 ± 0.05	2.819ThrPro: 2.819 ± 0.054	1.877ThrGln: 1.877 ± 0.029	1.936ThrArg: 1.936 ± 0.029	3.782ThrSer: 3.782 ± 0.046	3.483ThrThr: 3.483 ± 0.061	4.214ThrVal: 4.214 ± 0.068	0.715ThrTrp: 0.715 ± 0.02	2.076ThrTyr: 2.076 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	4.766ValAla: 4.766 ± 0.059	0.528ValCys: 0.528 ± 0.018	3.551ValAsp: 3.551 ± 0.045	4.04ValGlu: 4.04 ± 0.04	3.004ValPhe: 3.004 ± 0.04	4.269ValGly: 4.269 ± 0.048	1.25ValHis: 1.25 ± 0.026	5.241ValIle: 5.241 ± 0.051	4.032ValLys: 4.032 ± 0.045	6.347ValLeu: 6.347 ± 0.053	1.754ValMet: 1.754 ± 0.029	3.188ValAsn: 3.188 ± 0.044	2.536ValPro: 2.536 ± 0.039	2.353ValGln: 2.353 ± 0.034	2.556ValArg: 2.556 ± 0.037	4.639ValSer: 4.639 ± 0.044	4.387ValThr: 4.387 ± 0.08	4.472ValVal: 4.472 ± 0.053	0.805ValTrp: 0.805 ± 0.021	2.388ValTyr: 2.388 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	0.778TrpAla: 0.778 ± 0.018	0.109TrpCys: 0.109 ± 0.007	0.747TrpAsp: 0.747 ± 0.02	0.767TrpGlu: 0.767 ± 0.02	0.635TrpPhe: 0.635 ± 0.017	0.894TrpGly: 0.894 ± 0.024	0.293TrpHis: 0.293 ± 0.011	1.041TrpIle: 1.041 ± 0.022	0.806TrpLys: 0.806 ± 0.02	1.354TrpLeu: 1.354 ± 0.024	0.42TrpMet: 0.42 ± 0.013	0.831TrpAsn: 0.831 ± 0.02	0.369TrpPro: 0.369 ± 0.012	0.54TrpGln: 0.54 ± 0.016	0.551TrpArg: 0.551 ± 0.017	0.904TrpSer: 0.904 ± 0.02	0.753TrpThr: 0.753 ± 0.021	0.883TrpVal: 0.883 ± 0.021	0.193TrpTrp: 0.193 ± 0.009	0.469TrpTyr: 0.469 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.561TyrAla: 2.561 ± 0.039	0.329TyrCys: 0.329 ± 0.014	1.924TyrAsp: 1.924 ± 0.034	2.205TyrGlu: 2.205 ± 0.032	1.806TyrPhe: 1.806 ± 0.028	2.635TyrGly: 2.635 ± 0.041	0.781TyrHis: 0.781 ± 0.02	2.612TyrIle: 2.612 ± 0.042	2.004TyrLys: 2.004 ± 0.03	3.728TyrLeu: 3.728 ± 0.048	0.995TyrMet: 0.995 ± 0.019	1.805TyrAsn: 1.805 ± 0.03	1.578TyrPro: 1.578 ± 0.03	1.381TyrGln: 1.381 ± 0.024	1.696TyrArg: 1.696 ± 0.028	2.526TyrSer: 2.526 ± 0.038	2.067TyrThr: 2.067 ± 0.034	2.304TyrVal: 2.304 ± 0.034	0.527TyrTrp: 0.527 ± 0.016	1.621TyrTyr: 1.621 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6938 proteins (2366348 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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