Amino acid dipepetide frequency for Sulfolobus virus Ragged Hills

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.0AlaCys: 0.0 ± 0.0
0.745AlaAsp: 0.745 ± 0.367
3.91AlaGlu: 3.91 ± 0.947
3.724AlaPhe: 3.724 ± 1.001
1.862AlaGly: 1.862 ± 0.72
0.186AlaHis: 0.186 ± 0.219
5.027AlaIle: 5.027 ± 1.166
5.958AlaLys: 5.958 ± 1.534
6.703AlaLeu: 6.703 ± 0.935
1.303AlaMet: 1.303 ± 0.449
2.793AlaAsn: 2.793 ± 0.658
1.489AlaPro: 1.489 ± 0.542
1.862AlaGln: 1.862 ± 0.537
1.489AlaArg: 1.489 ± 0.514
3.538AlaSer: 3.538 ± 0.822
2.234AlaThr: 2.234 ± 0.607
2.793AlaVal: 2.793 ± 0.986
1.117AlaTrp: 1.117 ± 0.741
2.42AlaTyr: 2.42 ± 0.532
0.0AlaXaa: 0.0 ± 0.0
Cys
0.186CysAla: 0.186 ± 0.188
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.559CysGlu: 0.559 ± 0.452
0.186CysPhe: 0.186 ± 0.205
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.372CysIle: 0.372 ± 0.287
0.745CysLys: 0.745 ± 0.398
0.931CysLeu: 0.931 ± 0.402
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.931CysPro: 0.931 ± 0.537
0.745CysGln: 0.745 ± 0.492
0.0CysArg: 0.0 ± 0.0
0.186CysSer: 0.186 ± 0.185
0.186CysThr: 0.186 ± 0.219
0.745CysVal: 0.745 ± 0.339
0.186CysTrp: 0.186 ± 0.188
0.372CysTyr: 0.372 ± 0.285
0.0CysXaa: 0.0 ± 0.0
Asp
2.048AspAla: 2.048 ± 0.658
0.0AspCys: 0.0 ± 0.0
1.676AspAsp: 1.676 ± 0.68
2.793AspGlu: 2.793 ± 0.888
1.489AspPhe: 1.489 ± 0.651
2.607AspGly: 2.607 ± 0.576
0.745AspHis: 0.745 ± 0.46
3.165AspIle: 3.165 ± 0.827
2.979AspLys: 2.979 ± 1.018
3.538AspLeu: 3.538 ± 0.989
1.117AspMet: 1.117 ± 0.478
0.745AspAsn: 0.745 ± 0.317
0.559AspPro: 0.559 ± 0.337
1.117AspGln: 1.117 ± 0.508
0.372AspArg: 0.372 ± 0.221
1.862AspSer: 1.862 ± 0.526
1.303AspThr: 1.303 ± 0.487
2.979AspVal: 2.979 ± 0.727
0.372AspTrp: 0.372 ± 0.259
2.42AspTyr: 2.42 ± 0.737
0.0AspXaa: 0.0 ± 0.0
Glu
3.165GluAla: 3.165 ± 0.988
0.745GluCys: 0.745 ± 0.471
3.351GluAsp: 3.351 ± 1.062
8.565GluGlu: 8.565 ± 2.257
2.979GluPhe: 2.979 ± 0.668
2.607GluGly: 2.607 ± 0.788
1.303GluHis: 1.303 ± 0.54
5.213GluIle: 5.213 ± 0.888
6.144GluLys: 6.144 ± 1.465
7.261GluLeu: 7.261 ± 1.518
1.676GluMet: 1.676 ± 0.535
3.165GluAsn: 3.165 ± 1.07
1.862GluPro: 1.862 ± 0.649
0.931GluGln: 0.931 ± 0.495
2.42GluArg: 2.42 ± 0.868
2.979GluSer: 2.979 ± 0.747
2.607GluThr: 2.607 ± 0.955
4.096GluVal: 4.096 ± 1.21
1.117GluTrp: 1.117 ± 0.514
2.979GluTyr: 2.979 ± 0.99
0.0GluXaa: 0.0 ± 0.0
Phe
2.793PheAla: 2.793 ± 0.677
0.372PheCys: 0.372 ± 0.292
2.048PheAsp: 2.048 ± 0.56
2.048PheGlu: 2.048 ± 0.685
2.793PhePhe: 2.793 ± 0.682
2.793PheGly: 2.793 ± 0.645
0.372PheHis: 0.372 ± 0.227
3.538PheIle: 3.538 ± 0.868
2.42PheLys: 2.42 ± 0.583
4.096PheLeu: 4.096 ± 1.046
0.931PheMet: 0.931 ± 0.465
1.676PheAsn: 1.676 ± 0.573
1.117PhePro: 1.117 ± 0.368
2.793PheGln: 2.793 ± 0.613
1.862PheArg: 1.862 ± 0.797
4.655PheSer: 4.655 ± 1.155
2.793PheThr: 2.793 ± 0.762
3.724PheVal: 3.724 ± 0.91
0.372PheTrp: 0.372 ± 0.253
3.724PheTyr: 3.724 ± 0.752
0.0PheXaa: 0.0 ± 0.0
Gly
3.724GlyAla: 3.724 ± 0.879
0.0GlyCys: 0.0 ± 0.0
1.303GlyAsp: 1.303 ± 0.574
2.234GlyGlu: 2.234 ± 0.842
4.096GlyPhe: 4.096 ± 1.073
3.724GlyGly: 3.724 ± 1.211
0.372GlyHis: 0.372 ± 0.306
6.144GlyIle: 6.144 ± 1.01
3.91GlyLys: 3.91 ± 0.783
5.772GlyLeu: 5.772 ± 1.379
0.931GlyMet: 0.931 ± 0.437
3.351GlyAsn: 3.351 ± 0.716
1.303GlyPro: 1.303 ± 0.565
2.048GlyGln: 2.048 ± 0.998
2.607GlyArg: 2.607 ± 0.771
3.538GlySer: 3.538 ± 1.081
3.538GlyThr: 3.538 ± 0.826
4.655GlyVal: 4.655 ± 1.036
0.745GlyTrp: 0.745 ± 0.393
3.165GlyTyr: 3.165 ± 0.915
0.0GlyXaa: 0.0 ± 0.0
His
0.559HisAla: 0.559 ± 0.327
0.0HisCys: 0.0 ± 0.0
0.372HisAsp: 0.372 ± 0.267
0.931HisGlu: 0.931 ± 0.425
0.372HisPhe: 0.372 ± 0.25
0.559HisGly: 0.559 ± 0.312
0.0HisHis: 0.0 ± 0.0
0.931HisIle: 0.931 ± 0.413
0.559HisLys: 0.559 ± 0.365
1.862HisLeu: 1.862 ± 0.712
0.186HisMet: 0.186 ± 0.188
0.931HisAsn: 0.931 ± 0.439
0.372HisPro: 0.372 ± 0.22
0.0HisGln: 0.0 ± 0.0
0.559HisArg: 0.559 ± 0.345
0.372HisSer: 0.372 ± 0.256
1.117HisThr: 1.117 ± 0.481
1.303HisVal: 1.303 ± 0.686
0.0HisTrp: 0.0 ± 0.0
1.489HisTyr: 1.489 ± 0.517
0.0HisXaa: 0.0 ± 0.0
Ile
4.841IleAla: 4.841 ± 0.833
0.559IleCys: 0.559 ± 0.426
2.793IleAsp: 2.793 ± 0.74
4.282IleGlu: 4.282 ± 0.958
4.468IlePhe: 4.468 ± 1.161
4.841IleGly: 4.841 ± 1.093
0.745IleHis: 0.745 ± 0.366
5.772IleIle: 5.772 ± 1.2
4.096IleLys: 4.096 ± 0.938
8.937IleLeu: 8.937 ± 1.273
1.117IleMet: 1.117 ± 0.487
3.351IleAsn: 3.351 ± 0.933
5.027IlePro: 5.027 ± 1.068
2.793IleGln: 2.793 ± 0.719
4.468IleArg: 4.468 ± 1.349
5.027IleSer: 5.027 ± 1.067
5.213IleThr: 5.213 ± 1.091
6.144IleVal: 6.144 ± 0.955
0.745IleTrp: 0.745 ± 0.358
4.655IleTyr: 4.655 ± 0.831
0.0IleXaa: 0.0 ± 0.0
Lys
3.724LysAla: 3.724 ± 1.328
0.745LysCys: 0.745 ± 0.442
3.91LysAsp: 3.91 ± 1.051
5.958LysGlu: 5.958 ± 1.356
3.351LysPhe: 3.351 ± 0.869
3.724LysGly: 3.724 ± 0.704
1.303LysHis: 1.303 ± 0.382
5.213LysIle: 5.213 ± 1.132
8.937LysLys: 8.937 ± 2.011
9.123LysLeu: 9.123 ± 1.784
2.048LysMet: 2.048 ± 0.651
3.165LysAsn: 3.165 ± 0.858
1.489LysPro: 1.489 ± 0.762
2.607LysGln: 2.607 ± 0.663
3.724LysArg: 3.724 ± 1.04
4.282LysSer: 4.282 ± 1.073
4.096LysThr: 4.096 ± 0.568
6.144LysVal: 6.144 ± 0.925
1.117LysTrp: 1.117 ± 0.406
4.282LysTyr: 4.282 ± 0.907
0.0LysXaa: 0.0 ± 0.0
Leu
5.399LeuAla: 5.399 ± 1.156
0.559LeuCys: 0.559 ± 0.356
4.282LeuAsp: 4.282 ± 1.119
5.027LeuGlu: 5.027 ± 1.045
5.213LeuPhe: 5.213 ± 1.368
7.261LeuGly: 7.261 ± 1.626
1.676LeuHis: 1.676 ± 0.631
9.309LeuIle: 9.309 ± 1.381
8.378LeuLys: 8.378 ± 1.474
14.15LeuLeu: 14.15 ± 1.598
2.793LeuMet: 2.793 ± 0.775
8.565LeuAsn: 8.565 ± 1.826
4.841LeuPro: 4.841 ± 0.769
3.165LeuGln: 3.165 ± 0.607
5.399LeuArg: 5.399 ± 1.427
7.82LeuSer: 7.82 ± 0.978
10.054LeuThr: 10.054 ± 1.331
5.213LeuVal: 5.213 ± 0.942
1.117LeuTrp: 1.117 ± 0.613
5.958LeuTyr: 5.958 ± 1.088
0.0LeuXaa: 0.0 ± 0.0
Met
0.372MetAla: 0.372 ± 0.251
0.0MetCys: 0.0 ± 0.0
0.931MetAsp: 0.931 ± 0.41
1.676MetGlu: 1.676 ± 0.654
0.372MetPhe: 0.372 ± 0.311
1.676MetGly: 1.676 ± 0.592
0.559MetHis: 0.559 ± 0.279
0.931MetIle: 0.931 ± 0.458
1.862MetLys: 1.862 ± 0.53
2.42MetLeu: 2.42 ± 0.758
0.931MetMet: 0.931 ± 0.491
0.372MetAsn: 0.372 ± 0.282
0.372MetPro: 0.372 ± 0.281
0.559MetGln: 0.559 ± 0.317
2.048MetArg: 2.048 ± 0.741
2.234MetSer: 2.234 ± 0.527
0.931MetThr: 0.931 ± 0.447
1.862MetVal: 1.862 ± 0.615
0.186MetTrp: 0.186 ± 0.161
1.303MetTyr: 1.303 ± 0.743
0.0MetXaa: 0.0 ± 0.0
Asn
3.351AsnAla: 3.351 ± 0.8
0.372AsnCys: 0.372 ± 0.292
1.676AsnAsp: 1.676 ± 0.466
4.468AsnGlu: 4.468 ± 1.161
2.607AsnPhe: 2.607 ± 0.796
3.538AsnGly: 3.538 ± 1.046
1.117AsnHis: 1.117 ± 0.486
3.538AsnIle: 3.538 ± 0.935
2.793AsnLys: 2.793 ± 0.978
3.165AsnLeu: 3.165 ± 1.005
0.186AsnMet: 0.186 ± 0.166
3.91AsnAsn: 3.91 ± 1.011
2.793AsnPro: 2.793 ± 0.906
1.862AsnGln: 1.862 ± 0.61
0.931AsnArg: 0.931 ± 0.4
3.538AsnSer: 3.538 ± 1.033
2.979AsnThr: 2.979 ± 1.232
4.282AsnVal: 4.282 ± 1.412
0.372AsnTrp: 0.372 ± 0.26
4.096AsnTyr: 4.096 ± 1.104
0.0AsnXaa: 0.0 ± 0.0
Pro
2.048ProAla: 2.048 ± 0.686
0.0ProCys: 0.0 ± 0.0
1.303ProAsp: 1.303 ± 0.516
1.676ProGlu: 1.676 ± 0.627
2.793ProPhe: 2.793 ± 0.674
1.489ProGly: 1.489 ± 0.595
0.186ProHis: 0.186 ± 0.148
2.793ProIle: 2.793 ± 0.978
2.607ProLys: 2.607 ± 0.811
3.165ProLeu: 3.165 ± 0.648
0.559ProMet: 0.559 ± 0.297
1.303ProAsn: 1.303 ± 0.421
2.42ProPro: 2.42 ± 0.875
2.048ProGln: 2.048 ± 0.722
0.372ProArg: 0.372 ± 0.286
2.979ProSer: 2.979 ± 0.878
2.42ProThr: 2.42 ± 1.142
2.793ProVal: 2.793 ± 0.873
0.745ProTrp: 0.745 ± 0.452
2.234ProTyr: 2.234 ± 0.632
0.0ProXaa: 0.0 ± 0.0
Gln
0.931GlnAla: 0.931 ± 0.369
0.0GlnCys: 0.0 ± 0.0
0.372GlnAsp: 0.372 ± 0.285
1.117GlnGlu: 1.117 ± 0.496
2.42GlnPhe: 2.42 ± 0.652
1.489GlnGly: 1.489 ± 0.372
0.745GlnHis: 0.745 ± 0.499
3.165GlnIle: 3.165 ± 0.845
2.979GlnLys: 2.979 ± 0.759
3.91GlnLeu: 3.91 ± 0.723
1.489GlnMet: 1.489 ± 0.639
2.42GlnAsn: 2.42 ± 0.635
0.745GlnPro: 0.745 ± 0.341
0.745GlnGln: 0.745 ± 0.329
0.745GlnArg: 0.745 ± 0.378
2.048GlnSer: 2.048 ± 0.609
2.42GlnThr: 2.42 ± 0.63
1.303GlnVal: 1.303 ± 0.61
0.186GlnTrp: 0.186 ± 0.148
1.489GlnTyr: 1.489 ± 0.7
0.0GlnXaa: 0.0 ± 0.0
Arg
1.862ArgAla: 1.862 ± 0.746
0.186ArgCys: 0.186 ± 0.188
1.489ArgAsp: 1.489 ± 0.614
2.979ArgGlu: 2.979 ± 0.871
0.931ArgPhe: 0.931 ± 0.386
1.676ArgGly: 1.676 ± 0.639
0.559ArgHis: 0.559 ± 0.339
3.165ArgIle: 3.165 ± 0.904
5.958ArgLys: 5.958 ± 1.539
4.655ArgLeu: 4.655 ± 1.078
1.676ArgMet: 1.676 ± 0.633
0.559ArgAsn: 0.559 ± 0.372
1.117ArgPro: 1.117 ± 0.554
0.931ArgGln: 0.931 ± 0.389
2.234ArgArg: 2.234 ± 0.715
1.862ArgSer: 1.862 ± 0.672
0.931ArgThr: 0.931 ± 0.396
2.607ArgVal: 2.607 ± 0.79
0.559ArgTrp: 0.559 ± 0.35
1.862ArgTyr: 1.862 ± 0.983
0.0ArgXaa: 0.0 ± 0.0
Ser
3.165SerAla: 3.165 ± 0.839
0.0SerCys: 0.0 ± 0.0
0.745SerAsp: 0.745 ± 0.32
3.351SerGlu: 3.351 ± 0.812
2.793SerPhe: 2.793 ± 0.612
4.468SerGly: 4.468 ± 0.992
0.372SerHis: 0.372 ± 0.253
5.213SerIle: 5.213 ± 1.285
5.027SerLys: 5.027 ± 1.114
8.937SerLeu: 8.937 ± 1.141
0.745SerMet: 0.745 ± 0.465
3.538SerAsn: 3.538 ± 1.164
2.793SerPro: 2.793 ± 0.794
3.351SerGln: 3.351 ± 0.724
1.862SerArg: 1.862 ± 0.7
6.33SerSer: 6.33 ± 1.766
4.282SerThr: 4.282 ± 1.162
5.958SerVal: 5.958 ± 1.485
0.745SerTrp: 0.745 ± 0.312
4.282SerTyr: 4.282 ± 0.958
0.0SerXaa: 0.0 ± 0.0
Thr
3.91ThrAla: 3.91 ± 0.829
0.186ThrCys: 0.186 ± 0.176
1.676ThrAsp: 1.676 ± 0.508
3.538ThrGlu: 3.538 ± 1.274
2.42ThrPhe: 2.42 ± 0.786
3.91ThrGly: 3.91 ± 1.021
0.931ThrHis: 0.931 ± 0.475
4.841ThrIle: 4.841 ± 1.419
4.468ThrLys: 4.468 ± 1.012
10.24ThrLeu: 10.24 ± 1.741
1.303ThrMet: 1.303 ± 0.466
3.724ThrAsn: 3.724 ± 1.148
2.42ThrPro: 2.42 ± 0.829
1.117ThrGln: 1.117 ± 0.497
1.303ThrArg: 1.303 ± 0.563
4.282ThrSer: 4.282 ± 1.01
4.841ThrThr: 4.841 ± 1.463
4.282ThrVal: 4.282 ± 0.93
0.931ThrTrp: 0.931 ± 0.451
3.538ThrTyr: 3.538 ± 1.182
0.0ThrXaa: 0.0 ± 0.0
Val
2.793ValAla: 2.793 ± 0.984
1.489ValCys: 1.489 ± 0.742
2.234ValAsp: 2.234 ± 0.726
5.586ValGlu: 5.586 ± 1.519
1.862ValPhe: 1.862 ± 0.64
4.655ValGly: 4.655 ± 0.97
0.559ValHis: 0.559 ± 0.327
5.213ValIle: 5.213 ± 1.051
4.841ValLys: 4.841 ± 0.819
8.006ValLeu: 8.006 ± 1.215
1.862ValMet: 1.862 ± 0.584
3.538ValAsn: 3.538 ± 1.076
2.048ValPro: 2.048 ± 0.651
1.303ValGln: 1.303 ± 0.449
3.165ValArg: 3.165 ± 0.974
6.144ValSer: 6.144 ± 1.413
6.703ValThr: 6.703 ± 1.517
5.399ValVal: 5.399 ± 1.101
0.186ValTrp: 0.186 ± 0.163
4.468ValTyr: 4.468 ± 0.603
0.0ValXaa: 0.0 ± 0.0
Trp
0.559TrpAla: 0.559 ± 0.279
0.372TrpCys: 0.372 ± 0.248
0.372TrpAsp: 0.372 ± 0.282
0.745TrpGlu: 0.745 ± 0.381
0.559TrpPhe: 0.559 ± 0.27
1.117TrpGly: 1.117 ± 0.449
0.186TrpHis: 0.186 ± 0.175
1.303TrpIle: 1.303 ± 0.577
0.559TrpLys: 0.559 ± 0.317
1.676TrpLeu: 1.676 ± 0.622
0.186TrpMet: 0.186 ± 0.175
0.372TrpAsn: 0.372 ± 0.273
0.186TrpPro: 0.186 ± 0.163
0.186TrpGln: 0.186 ± 0.175
0.372TrpArg: 0.372 ± 0.313
0.559TrpSer: 0.559 ± 0.259
1.117TrpThr: 1.117 ± 0.399
0.745TrpVal: 0.745 ± 0.313
0.372TrpTrp: 0.372 ± 0.251
0.931TrpTyr: 0.931 ± 0.468
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.724TyrAla: 3.724 ± 0.622
0.745TyrCys: 0.745 ± 0.393
2.607TyrAsp: 2.607 ± 0.903
3.724TyrGlu: 3.724 ± 0.811
1.489TyrPhe: 1.489 ± 0.471
3.165TyrGly: 3.165 ± 0.875
0.559TyrHis: 0.559 ± 0.301
5.213TyrIle: 5.213 ± 0.885
3.724TyrLys: 3.724 ± 0.884
7.634TyrLeu: 7.634 ± 1.087
0.372TyrMet: 0.372 ± 0.283
4.096TyrAsn: 4.096 ± 0.954
2.048TyrPro: 2.048 ± 0.714
0.559TyrGln: 0.559 ± 0.359
1.862TyrArg: 1.862 ± 0.663
3.724TyrSer: 3.724 ± 1.195
4.096TyrThr: 4.096 ± 1.086
5.027TyrVal: 5.027 ± 0.811
1.303TyrTrp: 1.303 ± 0.582
4.282TyrTyr: 4.282 ± 0.993
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 37 proteins (5372 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski