Amino acid dipepetide frequency for Frog adenovirus 1 (strain ATCC VR-896) (FrAdV-1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.677AlaAla: 4.677 ± 0.805
0.615AlaCys: 0.615 ± 0.24
2.708AlaAsp: 2.708 ± 0.46
3.2AlaGlu: 3.2 ± 0.553
3.077AlaPhe: 3.077 ± 0.564
3.2AlaGly: 3.2 ± 0.626
0.985AlaHis: 0.985 ± 0.273
4.062AlaIle: 4.062 ± 0.675
3.57AlaLys: 3.57 ± 0.95
5.047AlaLeu: 5.047 ± 0.977
1.6AlaMet: 1.6 ± 0.47
2.339AlaAsn: 2.339 ± 0.473
3.323AlaPro: 3.323 ± 0.609
1.477AlaGln: 1.477 ± 0.648
2.216AlaArg: 2.216 ± 0.555
3.816AlaSer: 3.816 ± 0.78
3.2AlaThr: 3.2 ± 0.913
5.908AlaVal: 5.908 ± 0.899
0.862AlaTrp: 0.862 ± 0.369
1.969AlaTyr: 1.969 ± 0.541
0.0AlaXaa: 0.0 ± 0.0
Cys
1.231CysAla: 1.231 ± 0.513
0.862CysCys: 0.862 ± 0.274
0.739CysAsp: 0.739 ± 0.271
0.492CysGlu: 0.492 ± 0.204
1.477CysPhe: 1.477 ± 0.392
1.231CysGly: 1.231 ± 0.43
0.492CysHis: 0.492 ± 0.239
0.862CysIle: 0.862 ± 0.361
1.231CysLys: 1.231 ± 0.522
0.862CysLeu: 0.862 ± 0.288
0.739CysMet: 0.739 ± 0.276
1.477CysAsn: 1.477 ± 0.472
1.477CysPro: 1.477 ± 0.528
0.985CysGln: 0.985 ± 0.378
0.369CysArg: 0.369 ± 0.296
1.969CysSer: 1.969 ± 0.521
0.739CysThr: 0.739 ± 0.26
0.985CysVal: 0.985 ± 0.305
0.246CysTrp: 0.246 ± 0.208
0.615CysTyr: 0.615 ± 0.259
0.0CysXaa: 0.0 ± 0.0
Asp
2.093AspAla: 2.093 ± 0.387
0.492AspCys: 0.492 ± 0.264
2.216AspAsp: 2.216 ± 0.631
2.708AspGlu: 2.708 ± 0.497
3.323AspPhe: 3.323 ± 0.784
3.323AspGly: 3.323 ± 0.676
0.862AspHis: 0.862 ± 0.342
3.939AspIle: 3.939 ± 0.82
2.339AspLys: 2.339 ± 0.506
5.293AspLeu: 5.293 ± 0.824
0.985AspMet: 0.985 ± 0.278
3.077AspAsn: 3.077 ± 0.425
2.216AspPro: 2.216 ± 0.374
1.723AspGln: 1.723 ± 0.35
0.862AspArg: 0.862 ± 0.339
4.185AspSer: 4.185 ± 0.788
3.2AspThr: 3.2 ± 0.611
2.831AspVal: 2.831 ± 0.691
0.615AspTrp: 0.615 ± 0.213
1.846AspTyr: 1.846 ± 0.423
0.0AspXaa: 0.0 ± 0.0
Glu
3.447GluAla: 3.447 ± 0.493
0.985GluCys: 0.985 ± 0.402
3.2GluAsp: 3.2 ± 0.688
5.662GluGlu: 5.662 ± 1.342
1.969GluPhe: 1.969 ± 0.529
2.339GluGly: 2.339 ± 0.514
0.862GluHis: 0.862 ± 0.425
4.924GluIle: 4.924 ± 0.824
3.323GluLys: 3.323 ± 0.904
5.908GluLeu: 5.908 ± 0.786
1.6GluMet: 1.6 ± 0.417
4.801GluAsn: 4.801 ± 1.018
2.831GluPro: 2.831 ± 0.472
1.969GluGln: 1.969 ± 0.512
2.093GluArg: 2.093 ± 0.735
2.954GluSer: 2.954 ± 0.667
3.939GluThr: 3.939 ± 0.717
2.831GluVal: 2.831 ± 0.765
0.862GluTrp: 0.862 ± 0.219
2.093GluTyr: 2.093 ± 0.439
0.0GluXaa: 0.0 ± 0.0
Phe
2.954PheAla: 2.954 ± 0.732
0.985PheCys: 0.985 ± 0.574
2.708PheAsp: 2.708 ± 0.45
2.585PheGlu: 2.585 ± 0.556
2.462PhePhe: 2.462 ± 0.482
1.969PheGly: 1.969 ± 0.634
0.985PheHis: 0.985 ± 0.301
2.954PheIle: 2.954 ± 0.677
2.831PheLys: 2.831 ± 0.533
5.293PheLeu: 5.293 ± 0.681
1.354PheMet: 1.354 ± 0.547
2.216PheAsn: 2.216 ± 0.485
2.831PhePro: 2.831 ± 0.634
2.093PheGln: 2.093 ± 0.548
2.585PheArg: 2.585 ± 0.578
4.308PheSer: 4.308 ± 0.702
2.339PheThr: 2.339 ± 0.468
3.693PheVal: 3.693 ± 0.858
0.492PheTrp: 0.492 ± 0.238
2.216PheTyr: 2.216 ± 0.419
0.0PheXaa: 0.0 ± 0.0
Gly
3.323GlyAla: 3.323 ± 0.941
0.862GlyCys: 0.862 ± 0.411
3.077GlyAsp: 3.077 ± 0.625
3.693GlyGlu: 3.693 ± 0.574
1.846GlyPhe: 1.846 ± 0.45
3.816GlyGly: 3.816 ± 1.037
1.231GlyHis: 1.231 ± 0.391
3.077GlyIle: 3.077 ± 0.597
2.708GlyLys: 2.708 ± 0.596
4.431GlyLeu: 4.431 ± 1.318
1.231GlyMet: 1.231 ± 0.357
3.447GlyAsn: 3.447 ± 0.974
2.339GlyPro: 2.339 ± 0.852
1.723GlyGln: 1.723 ± 0.436
3.323GlyArg: 3.323 ± 0.536
4.062GlySer: 4.062 ± 0.934
3.816GlyThr: 3.816 ± 0.908
3.447GlyVal: 3.447 ± 0.814
0.739GlyTrp: 0.739 ± 0.244
1.354GlyTyr: 1.354 ± 0.413
0.0GlyXaa: 0.0 ± 0.0
His
1.231HisAla: 1.231 ± 0.287
0.369HisCys: 0.369 ± 0.202
0.492HisAsp: 0.492 ± 0.234
0.862HisGlu: 0.862 ± 0.27
0.985HisPhe: 0.985 ± 0.281
1.108HisGly: 1.108 ± 0.309
0.739HisHis: 0.739 ± 0.328
1.6HisIle: 1.6 ± 0.399
0.985HisLys: 0.985 ± 0.393
1.231HisLeu: 1.231 ± 0.292
0.615HisMet: 0.615 ± 0.225
1.354HisAsn: 1.354 ± 0.362
0.739HisPro: 0.739 ± 0.292
0.739HisGln: 0.739 ± 0.289
1.231HisArg: 1.231 ± 0.358
1.354HisSer: 1.354 ± 0.45
0.985HisThr: 0.985 ± 0.374
1.477HisVal: 1.477 ± 0.443
0.123HisTrp: 0.123 ± 0.12
0.615HisTyr: 0.615 ± 0.297
0.0HisXaa: 0.0 ± 0.0
Ile
3.2IleAla: 3.2 ± 0.608
1.354IleCys: 1.354 ± 0.404
3.816IleAsp: 3.816 ± 0.889
3.077IleGlu: 3.077 ± 0.545
2.093IlePhe: 2.093 ± 0.528
3.2IleGly: 3.2 ± 0.683
1.231IleHis: 1.231 ± 0.34
2.954IleIle: 2.954 ± 0.437
3.57IleLys: 3.57 ± 0.754
6.77IleLeu: 6.77 ± 1.227
1.354IleMet: 1.354 ± 0.311
3.447IleAsn: 3.447 ± 0.744
3.816IlePro: 3.816 ± 0.602
3.077IleGln: 3.077 ± 0.604
2.216IleArg: 2.216 ± 0.459
5.047IleSer: 5.047 ± 0.981
2.585IleThr: 2.585 ± 0.481
4.308IleVal: 4.308 ± 0.612
0.615IleTrp: 0.615 ± 0.318
1.969IleTyr: 1.969 ± 0.415
0.0IleXaa: 0.0 ± 0.0
Lys
3.2LysAla: 3.2 ± 0.668
0.492LysCys: 0.492 ± 0.263
2.462LysAsp: 2.462 ± 0.503
4.185LysGlu: 4.185 ± 1.308
4.185LysPhe: 4.185 ± 0.548
2.708LysGly: 2.708 ± 0.593
1.108LysHis: 1.108 ± 0.439
3.693LysIle: 3.693 ± 0.804
4.062LysLys: 4.062 ± 0.72
7.755LysLeu: 7.755 ± 1.318
1.354LysMet: 1.354 ± 0.495
4.554LysAsn: 4.554 ± 0.699
2.093LysPro: 2.093 ± 0.325
1.231LysGln: 1.231 ± 0.474
4.062LysArg: 4.062 ± 0.8
4.431LysSer: 4.431 ± 0.699
3.447LysThr: 3.447 ± 0.767
2.339LysVal: 2.339 ± 0.555
0.369LysTrp: 0.369 ± 0.181
1.6LysTyr: 1.6 ± 0.412
0.0LysXaa: 0.0 ± 0.0
Leu
5.908LeuAla: 5.908 ± 0.924
2.093LeuCys: 2.093 ± 0.622
3.816LeuAsp: 3.816 ± 0.816
5.293LeuGlu: 5.293 ± 0.751
4.308LeuPhe: 4.308 ± 0.624
4.431LeuGly: 4.431 ± 0.855
2.216LeuHis: 2.216 ± 0.502
5.416LeuIle: 5.416 ± 0.884
6.647LeuLys: 6.647 ± 1.424
8.863LeuLeu: 8.863 ± 1.112
2.216LeuMet: 2.216 ± 0.583
6.893LeuAsn: 6.893 ± 0.997
4.677LeuPro: 4.677 ± 0.895
5.047LeuGln: 5.047 ± 0.691
5.17LeuArg: 5.17 ± 0.765
7.262LeuSer: 7.262 ± 0.908
7.139LeuThr: 7.139 ± 1.266
4.801LeuVal: 4.801 ± 0.685
1.477LeuTrp: 1.477 ± 0.315
4.062LeuTyr: 4.062 ± 0.706
0.0LeuXaa: 0.0 ± 0.0
Met
0.862MetAla: 0.862 ± 0.303
0.492MetCys: 0.492 ± 0.28
2.216MetAsp: 2.216 ± 0.534
0.739MetGlu: 0.739 ± 0.298
0.985MetPhe: 0.985 ± 0.453
1.231MetGly: 1.231 ± 0.503
0.123MetHis: 0.123 ± 0.115
1.6MetIle: 1.6 ± 0.535
1.354MetLys: 1.354 ± 0.494
2.339MetLeu: 2.339 ± 0.498
0.739MetMet: 0.739 ± 0.388
1.723MetAsn: 1.723 ± 0.603
1.108MetPro: 1.108 ± 0.369
0.985MetGln: 0.985 ± 0.381
1.108MetArg: 1.108 ± 0.374
2.339MetSer: 2.339 ± 0.466
1.354MetThr: 1.354 ± 0.492
0.862MetVal: 0.862 ± 0.244
0.123MetTrp: 0.123 ± 0.109
1.354MetTyr: 1.354 ± 0.24
0.0MetXaa: 0.0 ± 0.0
Asn
2.831AsnAla: 2.831 ± 0.443
1.846AsnCys: 1.846 ± 0.68
2.831AsnAsp: 2.831 ± 0.543
4.062AsnGlu: 4.062 ± 0.801
3.2AsnPhe: 3.2 ± 0.784
3.077AsnGly: 3.077 ± 0.733
1.354AsnHis: 1.354 ± 0.274
4.431AsnIle: 4.431 ± 0.602
3.693AsnLys: 3.693 ± 0.586
6.524AsnLeu: 6.524 ± 0.744
1.231AsnMet: 1.231 ± 0.382
3.939AsnAsn: 3.939 ± 0.89
2.339AsnPro: 2.339 ± 0.489
2.954AsnGln: 2.954 ± 0.67
3.323AsnArg: 3.323 ± 0.453
4.308AsnSer: 4.308 ± 0.707
3.816AsnThr: 3.816 ± 0.797
4.308AsnVal: 4.308 ± 0.694
1.354AsnTrp: 1.354 ± 0.295
3.447AsnTyr: 3.447 ± 0.633
0.0AsnXaa: 0.0 ± 0.0
Pro
3.077ProAla: 3.077 ± 0.82
0.985ProCys: 0.985 ± 0.338
2.954ProAsp: 2.954 ± 0.5
2.831ProGlu: 2.831 ± 0.586
3.693ProPhe: 3.693 ± 0.664
3.2ProGly: 3.2 ± 0.726
0.492ProHis: 0.492 ± 0.193
1.6ProIle: 1.6 ± 0.514
2.831ProLys: 2.831 ± 0.639
4.801ProLeu: 4.801 ± 0.889
1.354ProMet: 1.354 ± 0.418
2.831ProAsn: 2.831 ± 0.655
4.924ProPro: 4.924 ± 1.33
1.723ProGln: 1.723 ± 0.486
1.723ProArg: 1.723 ± 0.476
4.677ProSer: 4.677 ± 0.837
3.2ProThr: 3.2 ± 0.577
4.185ProVal: 4.185 ± 0.898
0.492ProTrp: 0.492 ± 0.195
1.846ProTyr: 1.846 ± 0.475
0.0ProXaa: 0.0 ± 0.0
Gln
2.462GlnAla: 2.462 ± 0.432
0.615GlnCys: 0.615 ± 0.204
1.969GlnAsp: 1.969 ± 0.467
1.969GlnGlu: 1.969 ± 0.513
1.477GlnPhe: 1.477 ± 0.456
1.723GlnGly: 1.723 ± 0.439
1.108GlnHis: 1.108 ± 0.293
2.585GlnIle: 2.585 ± 0.509
2.954GlnLys: 2.954 ± 0.47
4.062GlnLeu: 4.062 ± 0.684
1.354GlnMet: 1.354 ± 0.441
2.831GlnAsn: 2.831 ± 0.543
1.723GlnPro: 1.723 ± 0.41
1.969GlnGln: 1.969 ± 0.5
2.216GlnArg: 2.216 ± 0.581
3.693GlnSer: 3.693 ± 1.027
2.831GlnThr: 2.831 ± 0.78
1.969GlnVal: 1.969 ± 0.549
0.123GlnTrp: 0.123 ± 0.104
1.231GlnTyr: 1.231 ± 0.405
0.0GlnXaa: 0.0 ± 0.0
Arg
2.585ArgAla: 2.585 ± 0.862
1.231ArgCys: 1.231 ± 0.444
1.723ArgAsp: 1.723 ± 0.375
1.969ArgGlu: 1.969 ± 0.354
2.216ArgPhe: 2.216 ± 0.599
2.585ArgGly: 2.585 ± 0.747
0.862ArgHis: 0.862 ± 0.339
2.093ArgIle: 2.093 ± 0.466
2.708ArgLys: 2.708 ± 0.749
5.17ArgLeu: 5.17 ± 0.644
1.108ArgMet: 1.108 ± 0.257
3.447ArgAsn: 3.447 ± 0.884
2.585ArgPro: 2.585 ± 0.542
1.477ArgGln: 1.477 ± 0.41
2.954ArgArg: 2.954 ± 1.061
2.708ArgSer: 2.708 ± 0.64
3.077ArgThr: 3.077 ± 0.542
2.585ArgVal: 2.585 ± 0.579
0.492ArgTrp: 0.492 ± 0.255
1.6ArgTyr: 1.6 ± 0.379
0.0ArgXaa: 0.0 ± 0.0
Ser
5.047SerAla: 5.047 ± 0.737
1.477SerCys: 1.477 ± 0.582
3.447SerAsp: 3.447 ± 0.91
4.308SerGlu: 4.308 ± 0.882
4.185SerPhe: 4.185 ± 0.703
4.924SerGly: 4.924 ± 0.864
0.492SerHis: 0.492 ± 0.274
5.047SerIle: 5.047 ± 0.688
3.939SerLys: 3.939 ± 0.563
6.893SerLeu: 6.893 ± 0.923
1.231SerMet: 1.231 ± 0.461
4.062SerAsn: 4.062 ± 0.9
4.185SerPro: 4.185 ± 1.157
3.077SerGln: 3.077 ± 0.566
2.585SerArg: 2.585 ± 0.514
6.647SerSer: 6.647 ± 1.118
5.17SerThr: 5.17 ± 0.822
4.431SerVal: 4.431 ± 0.93
1.477SerTrp: 1.477 ± 0.591
3.077SerTyr: 3.077 ± 0.421
0.0SerXaa: 0.0 ± 0.0
Thr
3.447ThrAla: 3.447 ± 1.111
1.477ThrCys: 1.477 ± 0.35
2.585ThrAsp: 2.585 ± 0.498
3.816ThrGlu: 3.816 ± 0.749
2.093ThrPhe: 2.093 ± 0.59
4.308ThrGly: 4.308 ± 1.045
1.108ThrHis: 1.108 ± 0.321
3.939ThrIle: 3.939 ± 1.018
4.554ThrLys: 4.554 ± 0.968
6.524ThrLeu: 6.524 ± 1.093
0.739ThrMet: 0.739 ± 0.297
3.693ThrAsn: 3.693 ± 0.596
2.954ThrPro: 2.954 ± 0.743
3.323ThrGln: 3.323 ± 0.492
2.585ThrArg: 2.585 ± 0.577
3.816ThrSer: 3.816 ± 0.842
3.447ThrThr: 3.447 ± 0.571
4.062ThrVal: 4.062 ± 0.773
0.862ThrTrp: 0.862 ± 0.24
2.462ThrTyr: 2.462 ± 0.852
0.0ThrXaa: 0.0 ± 0.0
Val
3.939ValAla: 3.939 ± 1.119
1.231ValCys: 1.231 ± 0.401
2.585ValAsp: 2.585 ± 0.48
3.816ValGlu: 3.816 ± 0.535
3.816ValPhe: 3.816 ± 0.817
2.585ValGly: 2.585 ± 0.69
0.862ValHis: 0.862 ± 0.369
2.462ValIle: 2.462 ± 0.753
3.323ValLys: 3.323 ± 0.6
4.801ValLeu: 4.801 ± 0.795
1.108ValMet: 1.108 ± 0.554
5.293ValAsn: 5.293 ± 0.651
4.185ValPro: 4.185 ± 0.894
3.077ValGln: 3.077 ± 0.655
2.339ValArg: 2.339 ± 0.536
4.554ValSer: 4.554 ± 0.911
4.677ValThr: 4.677 ± 0.707
3.939ValVal: 3.939 ± 0.914
0.369ValTrp: 0.369 ± 0.181
2.585ValTyr: 2.585 ± 0.524
0.0ValXaa: 0.0 ± 0.0
Trp
0.862TrpAla: 0.862 ± 0.365
0.246TrpCys: 0.246 ± 0.177
0.492TrpAsp: 0.492 ± 0.233
0.492TrpGlu: 0.492 ± 0.208
0.615TrpPhe: 0.615 ± 0.232
0.739TrpGly: 0.739 ± 0.345
0.246TrpHis: 0.246 ± 0.157
0.492TrpIle: 0.492 ± 0.223
0.985TrpLys: 0.985 ± 0.351
1.231TrpLeu: 1.231 ± 0.389
0.0TrpMet: 0.0 ± 0.0
0.739TrpAsn: 0.739 ± 0.255
0.615TrpPro: 0.615 ± 0.26
1.108TrpGln: 1.108 ± 0.381
0.369TrpArg: 0.369 ± 0.23
1.108TrpSer: 1.108 ± 0.367
1.354TrpThr: 1.354 ± 0.597
0.246TrpVal: 0.246 ± 0.164
0.369TrpTrp: 0.369 ± 0.193
0.369TrpTyr: 0.369 ± 0.185
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.477TyrAla: 1.477 ± 0.542
0.369TyrCys: 0.369 ± 0.171
2.093TyrAsp: 2.093 ± 0.696
2.831TyrGlu: 2.831 ± 0.531
1.846TyrPhe: 1.846 ± 0.554
1.846TyrGly: 1.846 ± 0.416
1.477TyrHis: 1.477 ± 0.316
1.969TyrIle: 1.969 ± 0.528
1.723TyrLys: 1.723 ± 0.535
3.939TyrLeu: 3.939 ± 0.658
1.6TyrMet: 1.6 ± 0.47
2.708TyrAsn: 2.708 ± 0.436
2.462TyrPro: 2.462 ± 0.423
1.108TyrGln: 1.108 ± 0.327
1.846TyrArg: 1.846 ± 0.471
2.462TyrSer: 2.462 ± 0.466
1.477TyrThr: 1.477 ± 0.574
2.462TyrVal: 2.462 ± 0.54
0.615TyrTrp: 0.615 ± 0.27
1.354TyrTyr: 1.354 ± 0.442
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 23 proteins (8125 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski