Amino acid dipepetide frequency for Corynebacterium sp. ATCC 6931

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.586AlaAla: 15.586 ± 0.2
0.885AlaCys: 0.885 ± 0.037
7.751AlaAsp: 7.751 ± 0.118
8.365AlaGlu: 8.365 ± 0.119
3.433AlaPhe: 3.433 ± 0.075
10.017AlaGly: 10.017 ± 0.128
2.216AlaHis: 2.216 ± 0.066
5.689AlaIle: 5.689 ± 0.118
4.3AlaLys: 4.3 ± 0.098
10.97AlaLeu: 10.97 ± 0.14
2.678AlaMet: 2.678 ± 0.064
3.064AlaAsn: 3.064 ± 0.069
5.192AlaPro: 5.192 ± 0.114
3.876AlaGln: 3.876 ± 0.081
6.68AlaArg: 6.68 ± 0.112
6.155AlaSer: 6.155 ± 0.12
6.943AlaThr: 6.943 ± 0.109
9.433AlaVal: 9.433 ± 0.161
1.427AlaTrp: 1.427 ± 0.042
2.175AlaTyr: 2.175 ± 0.055
0.0AlaXaa: 0.0 ± 0.0
Cys
0.828CysAla: 0.828 ± 0.033
0.099CysCys: 0.099 ± 0.014
0.429CysAsp: 0.429 ± 0.025
0.464CysGlu: 0.464 ± 0.026
0.245CysPhe: 0.245 ± 0.02
0.809CysGly: 0.809 ± 0.038
0.172CysHis: 0.172 ± 0.016
0.356CysIle: 0.356 ± 0.022
0.165CysLys: 0.165 ± 0.017
0.604CysLeu: 0.604 ± 0.032
0.119CysMet: 0.119 ± 0.013
0.179CysAsn: 0.179 ± 0.017
0.419CysPro: 0.419 ± 0.023
0.182CysGln: 0.182 ± 0.015
0.452CysArg: 0.452 ± 0.027
0.506CysSer: 0.506 ± 0.028
0.447CysThr: 0.447 ± 0.029
0.577CysVal: 0.577 ± 0.029
0.102CysTrp: 0.102 ± 0.012
0.159CysTyr: 0.159 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
7.11AspAla: 7.11 ± 0.126
0.482AspCys: 0.482 ± 0.029
4.047AspAsp: 4.047 ± 0.095
4.701AspGlu: 4.701 ± 0.096
2.132AspPhe: 2.132 ± 0.058
5.484AspGly: 5.484 ± 0.098
1.171AspHis: 1.171 ± 0.049
3.295AspIle: 3.295 ± 0.072
2.14AspLys: 2.14 ± 0.061
5.291AspLeu: 5.291 ± 0.079
1.331AspMet: 1.331 ± 0.047
1.834AspAsn: 1.834 ± 0.057
3.239AspPro: 3.239 ± 0.077
1.69AspGln: 1.69 ± 0.049
3.613AspArg: 3.613 ± 0.085
3.738AspSer: 3.738 ± 0.075
3.149AspThr: 3.149 ± 0.072
5.08AspVal: 5.08 ± 0.089
0.842AspTrp: 0.842 ± 0.037
1.522AspTyr: 1.522 ± 0.053
0.0AspXaa: 0.0 ± 0.0
Glu
7.062GluAla: 7.062 ± 0.127
0.39GluCys: 0.39 ± 0.025
3.62GluAsp: 3.62 ± 0.077
4.496GluGlu: 4.496 ± 0.104
2.213GluPhe: 2.213 ± 0.055
4.614GluGly: 4.614 ± 0.084
1.437GluHis: 1.437 ± 0.049
3.429GluIle: 3.429 ± 0.07
2.832GluLys: 2.832 ± 0.077
6.81GluLeu: 6.81 ± 0.1
1.452GluMet: 1.452 ± 0.046
2.16GluAsn: 2.16 ± 0.055
2.909GluPro: 2.909 ± 0.069
2.786GluGln: 2.786 ± 0.064
4.247GluArg: 4.247 ± 0.083
3.679GluSer: 3.679 ± 0.08
3.363GluThr: 3.363 ± 0.07
5.207GluVal: 5.207 ± 0.096
0.773GluTrp: 0.773 ± 0.039
1.434GluTyr: 1.434 ± 0.052
0.0GluXaa: 0.0 ± 0.0
Phe
3.776PheAla: 3.776 ± 0.077
0.271PheCys: 0.271 ± 0.02
2.306PheAsp: 2.306 ± 0.058
1.88PheGlu: 1.88 ± 0.061
1.223PhePhe: 1.223 ± 0.047
3.433PheGly: 3.433 ± 0.075
0.681PheHis: 0.681 ± 0.025
1.747PheIle: 1.747 ± 0.052
0.814PheLys: 0.814 ± 0.035
2.757PheLeu: 2.757 ± 0.069
0.65PheMet: 0.65 ± 0.031
0.985PheAsn: 0.985 ± 0.035
1.423PhePro: 1.423 ± 0.045
0.844PheGln: 0.844 ± 0.038
1.677PheArg: 1.677 ± 0.048
2.119PheSer: 2.119 ± 0.06
2.095PheThr: 2.095 ± 0.057
2.629PheVal: 2.629 ± 0.066
0.401PheTrp: 0.401 ± 0.024
0.784PheTyr: 0.784 ± 0.035
0.0PheXaa: 0.0 ± 0.0
Gly
9.167GlyAla: 9.167 ± 0.136
0.691GlyCys: 0.691 ± 0.037
4.677GlyAsp: 4.677 ± 0.087
5.204GlyGlu: 5.204 ± 0.087
3.142GlyPhe: 3.142 ± 0.075
6.933GlyGly: 6.933 ± 0.131
1.928GlyHis: 1.928 ± 0.057
4.89GlyIle: 4.89 ± 0.085
3.38GlyLys: 3.38 ± 0.071
7.855GlyLeu: 7.855 ± 0.13
2.161GlyMet: 2.161 ± 0.055
2.417GlyAsn: 2.417 ± 0.062
3.191GlyPro: 3.191 ± 0.074
2.861GlyGln: 2.861 ± 0.068
5.175GlyArg: 5.175 ± 0.087
5.175GlySer: 5.175 ± 0.11
5.066GlyThr: 5.066 ± 0.095
6.838GlyVal: 6.838 ± 0.112
1.35GlyTrp: 1.35 ± 0.042
2.162GlyTyr: 2.162 ± 0.053
0.0GlyXaa: 0.0 ± 0.0
His
2.038HisAla: 2.038 ± 0.057
0.2HisCys: 0.2 ± 0.019
1.338HisAsp: 1.338 ± 0.051
1.183HisGlu: 1.183 ± 0.041
0.643HisPhe: 0.643 ± 0.028
1.887HisGly: 1.887 ± 0.064
0.555HisHis: 0.555 ± 0.033
1.095HisIle: 1.095 ± 0.046
0.544HisLys: 0.544 ± 0.028
1.778HisLeu: 1.778 ± 0.051
0.412HisMet: 0.412 ± 0.027
0.642HisAsn: 0.642 ± 0.029
1.321HisPro: 1.321 ± 0.04
0.611HisGln: 0.611 ± 0.032
1.458HisArg: 1.458 ± 0.048
1.237HisSer: 1.237 ± 0.05
1.032HisThr: 1.032 ± 0.037
1.54HisVal: 1.54 ± 0.048
0.259HisTrp: 0.259 ± 0.021
0.502HisTyr: 0.502 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
6.988IleAla: 6.988 ± 0.104
0.393IleCys: 0.393 ± 0.027
3.906IleAsp: 3.906 ± 0.075
3.236IleGlu: 3.236 ± 0.07
1.599IlePhe: 1.599 ± 0.049
4.859IleGly: 4.859 ± 0.097
0.952IleHis: 0.952 ± 0.037
2.81IleIle: 2.81 ± 0.082
1.377IleLys: 1.377 ± 0.048
3.92IleLeu: 3.92 ± 0.074
0.938IleMet: 0.938 ± 0.039
1.615IleAsn: 1.615 ± 0.044
2.62IlePro: 2.62 ± 0.071
1.167IleGln: 1.167 ± 0.048
2.819IleArg: 2.819 ± 0.062
3.166IleSer: 3.166 ± 0.069
3.032IleThr: 3.032 ± 0.065
4.695IleVal: 4.695 ± 0.109
0.488IleTrp: 0.488 ± 0.023
1.008IleTyr: 1.008 ± 0.041
0.0IleXaa: 0.0 ± 0.0
Lys
3.725LysAla: 3.725 ± 0.077
0.171LysCys: 0.171 ± 0.015
1.95LysAsp: 1.95 ± 0.054
2.146LysGlu: 2.146 ± 0.064
0.992LysPhe: 0.992 ± 0.037
2.288LysGly: 2.288 ± 0.065
0.688LysHis: 0.688 ± 0.029
1.67LysIle: 1.67 ± 0.05
1.865LysLys: 1.865 ± 0.081
3.324LysLeu: 3.324 ± 0.066
0.942LysMet: 0.942 ± 0.033
1.183LysAsn: 1.183 ± 0.038
1.998LysPro: 1.998 ± 0.077
1.199LysGln: 1.199 ± 0.042
2.167LysArg: 2.167 ± 0.064
2.065LysSer: 2.065 ± 0.054
2.014LysThr: 2.014 ± 0.058
2.878LysVal: 2.878 ± 0.068
0.496LysTrp: 0.496 ± 0.025
0.794LysTyr: 0.794 ± 0.034
0.0LysXaa: 0.0 ± 0.0
Leu
11.717LeuAla: 11.717 ± 0.126
0.651LeuCys: 0.651 ± 0.027
5.805LeuAsp: 5.805 ± 0.09
5.125LeuGlu: 5.125 ± 0.098
2.771LeuPhe: 2.771 ± 0.088
8.0LeuGly: 8.0 ± 0.127
1.782LeuHis: 1.782 ± 0.05
4.722LeuIle: 4.722 ± 0.089
2.782LeuLys: 2.782 ± 0.077
8.623LeuLeu: 8.623 ± 0.155
1.965LeuMet: 1.965 ± 0.05
2.566LeuAsn: 2.566 ± 0.07
5.169LeuPro: 5.169 ± 0.092
2.551LeuGln: 2.551 ± 0.059
6.212LeuArg: 6.212 ± 0.105
5.87LeuSer: 5.87 ± 0.094
5.671LeuThr: 5.671 ± 0.11
7.723LeuVal: 7.723 ± 0.126
1.09LeuTrp: 1.09 ± 0.041
1.7LeuTyr: 1.7 ± 0.051
0.0LeuXaa: 0.0 ± 0.0
Met
2.657MetAla: 2.657 ± 0.064
0.176MetCys: 0.176 ± 0.017
1.12MetAsp: 1.12 ± 0.039
1.177MetGlu: 1.177 ± 0.048
0.721MetPhe: 0.721 ± 0.034
1.8MetGly: 1.8 ± 0.053
0.417MetHis: 0.417 ± 0.026
1.176MetIle: 1.176 ± 0.049
0.751MetLys: 0.751 ± 0.035
2.199MetLeu: 2.199 ± 0.052
0.544MetMet: 0.544 ± 0.028
0.681MetAsn: 0.681 ± 0.033
1.32MetPro: 1.32 ± 0.049
0.7MetGln: 0.7 ± 0.032
1.398MetArg: 1.398 ± 0.041
1.756MetSer: 1.756 ± 0.049
1.711MetThr: 1.711 ± 0.048
1.754MetVal: 1.754 ± 0.048
0.287MetTrp: 0.287 ± 0.02
0.352MetTyr: 0.352 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
3.138AsnAla: 3.138 ± 0.066
0.21AsnCys: 0.21 ± 0.016
1.714AsnAsp: 1.714 ± 0.05
1.704AsnGlu: 1.704 ± 0.047
0.953AsnPhe: 0.953 ± 0.039
2.361AsnGly: 2.361 ± 0.066
0.65AsnHis: 0.65 ± 0.031
1.458AsnIle: 1.458 ± 0.044
0.999AsnLys: 0.999 ± 0.037
2.783AsnLeu: 2.783 ± 0.066
0.658AsnMet: 0.658 ± 0.033
0.969AsnAsn: 0.969 ± 0.043
2.256AsnPro: 2.256 ± 0.065
0.992AsnGln: 0.992 ± 0.041
1.958AsnArg: 1.958 ± 0.055
1.937AsnSer: 1.937 ± 0.065
1.563AsnThr: 1.563 ± 0.047
2.151AsnVal: 2.151 ± 0.059
0.463AsnTrp: 0.463 ± 0.026
0.746AsnTyr: 0.746 ± 0.032
0.0AsnXaa: 0.0 ± 0.0
Pro
5.646ProAla: 5.646 ± 0.122
0.288ProCys: 0.288 ± 0.018
3.124ProAsp: 3.124 ± 0.067
4.613ProGlu: 4.613 ± 0.1
1.522ProPhe: 1.522 ± 0.043
4.414ProGly: 4.414 ± 0.096
1.054ProHis: 1.054 ± 0.038
2.149ProIle: 2.149 ± 0.052
1.837ProLys: 1.837 ± 0.051
4.254ProLeu: 4.254 ± 0.084
1.085ProMet: 1.085 ± 0.037
1.58ProAsn: 1.58 ± 0.054
1.778ProPro: 1.778 ± 0.072
1.77ProGln: 1.77 ± 0.057
2.762ProArg: 2.762 ± 0.065
2.906ProSer: 2.906 ± 0.08
3.176ProThr: 3.176 ± 0.073
4.154ProVal: 4.154 ± 0.078
0.804ProTrp: 0.804 ± 0.036
1.06ProTyr: 1.06 ± 0.04
0.0ProXaa: 0.0 ± 0.0
Gln
3.612GlnAla: 3.612 ± 0.075
0.201GlnCys: 0.201 ± 0.019
1.528GlnAsp: 1.528 ± 0.047
1.855GlnGlu: 1.855 ± 0.056
1.037GlnPhe: 1.037 ± 0.038
2.132GlnGly: 2.132 ± 0.057
0.675GlnHis: 0.675 ± 0.037
1.589GlnIle: 1.589 ± 0.054
1.111GlnLys: 1.111 ± 0.04
3.523GlnLeu: 3.523 ± 0.077
0.872GlnMet: 0.872 ± 0.032
0.914GlnAsn: 0.914 ± 0.044
1.714GlnPro: 1.714 ± 0.074
1.436GlnGln: 1.436 ± 0.047
2.432GlnArg: 2.432 ± 0.06
1.771GlnSer: 1.771 ± 0.064
1.662GlnThr: 1.662 ± 0.052
2.565GlnVal: 2.565 ± 0.066
0.588GlnTrp: 0.588 ± 0.033
0.671GlnTyr: 0.671 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
6.584ArgAla: 6.584 ± 0.095
0.382ArgCys: 0.382 ± 0.021
3.763ArgAsp: 3.763 ± 0.073
4.342ArgGlu: 4.342 ± 0.077
2.039ArgPhe: 2.039 ± 0.053
4.746ArgGly: 4.746 ± 0.094
1.311ArgHis: 1.311 ± 0.044
3.454ArgIle: 3.454 ± 0.073
2.344ArgLys: 2.344 ± 0.06
5.47ArgLeu: 5.47 ± 0.089
1.71ArgMet: 1.71 ± 0.048
1.999ArgAsn: 1.999 ± 0.061
2.927ArgPro: 2.927 ± 0.075
2.195ArgGln: 2.195 ± 0.057
5.196ArgArg: 5.196 ± 0.123
3.402ArgSer: 3.402 ± 0.08
3.479ArgThr: 3.479 ± 0.068
4.653ArgVal: 4.653 ± 0.08
0.874ArgTrp: 0.874 ± 0.037
1.507ArgTyr: 1.507 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
7.012SerAla: 7.012 ± 0.113
0.368SerCys: 0.368 ± 0.024
3.755SerAsp: 3.755 ± 0.072
3.696SerGlu: 3.696 ± 0.083
1.964SerPhe: 1.964 ± 0.053
5.807SerGly: 5.807 ± 0.101
1.167SerHis: 1.167 ± 0.043
2.817SerIle: 2.817 ± 0.06
2.037SerLys: 2.037 ± 0.06
5.343SerLeu: 5.343 ± 0.086
1.512SerMet: 1.512 ± 0.043
1.813SerAsn: 1.813 ± 0.052
2.987SerPro: 2.987 ± 0.071
2.002SerGln: 2.002 ± 0.053
3.692SerArg: 3.692 ± 0.075
4.458SerSer: 4.458 ± 0.112
3.85SerThr: 3.85 ± 0.087
4.519SerVal: 4.519 ± 0.089
0.921SerTrp: 0.921 ± 0.038
1.304SerTyr: 1.304 ± 0.04
0.0SerXaa: 0.0 ± 0.0
Thr
6.764ThrAla: 6.764 ± 0.107
0.499ThrCys: 0.499 ± 0.027
3.528ThrAsp: 3.528 ± 0.074
3.528ThrGlu: 3.528 ± 0.069
1.859ThrPhe: 1.859 ± 0.052
5.34ThrGly: 5.34 ± 0.099
1.104ThrHis: 1.104 ± 0.045
3.008ThrIle: 3.008 ± 0.07
1.901ThrLys: 1.901 ± 0.05
5.379ThrLeu: 5.379 ± 0.094
1.248ThrMet: 1.248 ± 0.044
1.746ThrAsn: 1.746 ± 0.048
3.619ThrPro: 3.619 ± 0.088
1.698ThrGln: 1.698 ± 0.051
3.131ThrArg: 3.131 ± 0.074
3.815ThrSer: 3.815 ± 0.077
3.79ThrThr: 3.79 ± 0.094
5.201ThrVal: 5.201 ± 0.083
0.826ThrTrp: 0.826 ± 0.033
1.211ThrTyr: 1.211 ± 0.043
0.0ThrXaa: 0.0 ± 0.0
Val
9.939ValAla: 9.939 ± 0.147
0.685ValCys: 0.685 ± 0.033
5.475ValAsp: 5.475 ± 0.086
5.175ValGlu: 5.175 ± 0.096
2.603ValPhe: 2.603 ± 0.058
6.425ValGly: 6.425 ± 0.101
1.589ValHis: 1.589 ± 0.046
4.578ValIle: 4.578 ± 0.09
2.376ValLys: 2.376 ± 0.06
7.772ValLeu: 7.772 ± 0.114
1.732ValMet: 1.732 ± 0.054
2.209ValAsn: 2.209 ± 0.055
4.142ValPro: 4.142 ± 0.073
2.038ValGln: 2.038 ± 0.055
4.8ValArg: 4.8 ± 0.088
4.983ValSer: 4.983 ± 0.083
5.27ValThr: 5.27 ± 0.096
7.473ValVal: 7.473 ± 0.132
0.925ValTrp: 0.925 ± 0.037
1.451ValTyr: 1.451 ± 0.052
0.0ValXaa: 0.0 ± 0.0
Trp
1.345TrpAla: 1.345 ± 0.04
0.105TrpCys: 0.105 ± 0.013
0.677TrpAsp: 0.677 ± 0.032
0.767TrpGlu: 0.767 ± 0.032
0.538TrpPhe: 0.538 ± 0.03
0.953TrpGly: 0.953 ± 0.036
0.324TrpHis: 0.324 ± 0.022
0.7TrpIle: 0.7 ± 0.034
0.445TrpLys: 0.445 ± 0.026
1.623TrpLeu: 1.623 ± 0.046
0.308TrpMet: 0.308 ± 0.021
0.47TrpAsn: 0.47 ± 0.025
0.609TrpPro: 0.609 ± 0.028
0.569TrpGln: 0.569 ± 0.026
0.938TrpArg: 0.938 ± 0.04
0.837TrpSer: 0.837 ± 0.036
0.765TrpThr: 0.765 ± 0.03
0.983TrpVal: 0.983 ± 0.035
0.337TrpTrp: 0.337 ± 0.026
0.291TrpTyr: 0.291 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.144TyrAla: 2.144 ± 0.053
0.168TyrCys: 0.168 ± 0.017
1.377TyrAsp: 1.377 ± 0.04
1.258TyrGlu: 1.258 ± 0.041
0.867TyrPhe: 0.867 ± 0.03
1.961TyrGly: 1.961 ± 0.059
0.4TyrHis: 0.4 ± 0.023
0.955TyrIle: 0.955 ± 0.042
0.556TyrLys: 0.556 ± 0.03
2.22TyrLeu: 2.22 ± 0.054
0.376TyrMet: 0.376 ± 0.02
0.642TyrAsn: 0.642 ± 0.032
1.142TyrPro: 1.142 ± 0.041
0.721TyrGln: 0.721 ± 0.034
1.568TyrArg: 1.568 ± 0.048
1.447TyrSer: 1.447 ± 0.049
1.118TyrThr: 1.118 ± 0.037
1.584TyrVal: 1.584 ± 0.049
0.33TyrTrp: 0.33 ± 0.021
0.495TyrTyr: 0.495 ± 0.028
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2105 proteins (715380 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski