Amino acid dipepetide frequency for Uliginosibacterium sp. TH139

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.671AlaAla: 16.671 ± 0.186	1.544AlaCys: 1.544 ± 0.037	6.032AlaAsp: 6.032 ± 0.083	7.62AlaGlu: 7.62 ± 0.098	3.931AlaPhe: 3.931 ± 0.063	10.342AlaGly: 10.342 ± 0.105	2.53AlaHis: 2.53 ± 0.049	5.418AlaIle: 5.418 ± 0.078	3.914AlaLys: 3.914 ± 0.089	14.788AlaLeu: 14.788 ± 0.163	3.138AlaMet: 3.138 ± 0.063	3.114AlaAsn: 3.114 ± 0.062	5.277AlaPro: 5.277 ± 0.082	5.272AlaGln: 5.272 ± 0.089	8.752AlaArg: 8.752 ± 0.104	7.84AlaSer: 7.84 ± 0.112	5.48AlaThr: 5.48 ± 0.086	7.804AlaVal: 7.804 ± 0.087	1.782AlaTrp: 1.782 ± 0.041	2.478AlaTyr: 2.478 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	1.295CysAla: 1.295 ± 0.034	0.175CysCys: 0.175 ± 0.015	0.513CysAsp: 0.513 ± 0.019	0.582CysGlu: 0.582 ± 0.024	0.409CysPhe: 0.409 ± 0.018	1.09CysGly: 1.09 ± 0.037	0.277CysHis: 0.277 ± 0.019	0.449CysIle: 0.449 ± 0.02	0.292CysLys: 0.292 ± 0.016	1.072CysLeu: 1.072 ± 0.03	0.202CysMet: 0.202 ± 0.013	0.265CysAsn: 0.265 ± 0.014	0.555CysPro: 0.555 ± 0.022	0.302CysGln: 0.302 ± 0.016	0.656CysArg: 0.656 ± 0.028	0.745CysSer: 0.745 ± 0.028	0.491CysThr: 0.491 ± 0.02	0.824CysVal: 0.824 ± 0.026	0.164CysTrp: 0.164 ± 0.01	0.251CysTyr: 0.251 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.338AspAla: 6.338 ± 0.095	0.526AspCys: 0.526 ± 0.022	2.381AspAsp: 2.381 ± 0.05	3.376AspGlu: 3.376 ± 0.06	2.17AspPhe: 2.17 ± 0.042	4.104AspGly: 4.104 ± 0.082	0.995AspHis: 0.995 ± 0.03	2.494AspIle: 2.494 ± 0.049	1.937AspLys: 1.937 ± 0.047	5.131AspLeu: 5.131 ± 0.063	1.149AspMet: 1.149 ± 0.034	1.216AspAsn: 1.216 ± 0.031	2.665AspPro: 2.665 ± 0.049	1.628AspGln: 1.628 ± 0.04	2.732AspArg: 2.732 ± 0.051	2.633AspSer: 2.633 ± 0.057	2.387AspThr: 2.387 ± 0.046	3.475AspVal: 3.475 ± 0.062	0.992AspTrp: 0.992 ± 0.029	1.548AspTyr: 1.548 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	8.158GluAla: 8.158 ± 0.102	0.476GluCys: 0.476 ± 0.021	2.577GluAsp: 2.577 ± 0.05	3.243GluGlu: 3.243 ± 0.073	1.983GluPhe: 1.983 ± 0.048	4.097GluGly: 4.097 ± 0.059	1.497GluHis: 1.497 ± 0.037	3.301GluIle: 3.301 ± 0.058	2.259GluLys: 2.259 ± 0.05	6.832GluLeu: 6.832 ± 0.09	1.461GluMet: 1.461 ± 0.035	1.587GluAsn: 1.587 ± 0.036	2.327GluPro: 2.327 ± 0.05	2.819GluGln: 2.819 ± 0.059	4.955GluArg: 4.955 ± 0.082	2.939GluSer: 2.939 ± 0.05	2.709GluThr: 2.709 ± 0.051	4.235GluVal: 4.235 ± 0.068	0.801GluTrp: 0.801 ± 0.029	1.204GluTyr: 1.204 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.364PheAla: 4.364 ± 0.061	0.446PheCys: 0.446 ± 0.02	2.41PheAsp: 2.41 ± 0.053	2.266PheGlu: 2.266 ± 0.048	1.543PhePhe: 1.543 ± 0.042	3.307PheGly: 3.307 ± 0.054	0.74PheHis: 0.74 ± 0.023	1.661PheIle: 1.661 ± 0.041	1.233PheLys: 1.233 ± 0.038	3.217PheLeu: 3.217 ± 0.051	0.815PheMet: 0.815 ± 0.028	1.148PheAsn: 1.148 ± 0.03	1.424PhePro: 1.424 ± 0.035	1.017PheGln: 1.017 ± 0.033	2.097PheArg: 2.097 ± 0.042	2.502PheSer: 2.502 ± 0.048	1.861PheThr: 1.861 ± 0.042	2.765PheVal: 2.765 ± 0.053	0.508PheTrp: 0.508 ± 0.021	0.879PheTyr: 0.879 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	8.005GlyAla: 8.005 ± 0.091	1.005GlyCys: 1.005 ± 0.027	3.641GlyAsp: 3.641 ± 0.06	5.101GlyGlu: 5.101 ± 0.069	3.476GlyPhe: 3.476 ± 0.058	6.259GlyGly: 6.259 ± 0.099	1.734GlyHis: 1.734 ± 0.034	4.03GlyIle: 4.03 ± 0.074	3.579GlyLys: 3.579 ± 0.056	9.088GlyLeu: 9.088 ± 0.106	2.279GlyMet: 2.279 ± 0.041	2.212GlyAsn: 2.212 ± 0.049	2.465GlyPro: 2.465 ± 0.046	3.2GlyGln: 3.2 ± 0.05	5.104GlyArg: 5.104 ± 0.07	5.073GlySer: 5.073 ± 0.097	3.564GlyThr: 3.564 ± 0.075	6.078GlyVal: 6.078 ± 0.081	1.371GlyTrp: 1.371 ± 0.04	2.078GlyTyr: 2.078 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	2.698HisAla: 2.698 ± 0.045	0.304HisCys: 0.304 ± 0.016	1.087HisAsp: 1.087 ± 0.032	1.233HisGlu: 1.233 ± 0.032	1.007HisPhe: 1.007 ± 0.028	1.846HisGly: 1.846 ± 0.04	0.608HisHis: 0.608 ± 0.022	0.995HisIle: 0.995 ± 0.025	0.639HisLys: 0.639 ± 0.025	2.298HisLeu: 2.298 ± 0.043	0.472HisMet: 0.472 ± 0.021	0.587HisAsn: 0.587 ± 0.023	1.39HisPro: 1.39 ± 0.035	0.738HisGln: 0.738 ± 0.023	1.303HisArg: 1.303 ± 0.032	1.176HisSer: 1.176 ± 0.03	1.048HisThr: 1.048 ± 0.027	1.333HisVal: 1.333 ± 0.031	0.372HisTrp: 0.372 ± 0.015	0.686HisTyr: 0.686 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.247IleAla: 6.247 ± 0.085	0.499IleCys: 0.499 ± 0.018	3.028IleAsp: 3.028 ± 0.053	3.687IleGlu: 3.687 ± 0.063	1.519IlePhe: 1.519 ± 0.035	4.27IleGly: 4.27 ± 0.074	0.989IleHis: 0.989 ± 0.026	1.912IleIle: 1.912 ± 0.044	1.694IleLys: 1.694 ± 0.04	4.229IleLeu: 4.229 ± 0.06	0.839IleMet: 0.839 ± 0.032	1.601IleAsn: 1.601 ± 0.045	2.259IlePro: 2.259 ± 0.049	1.53IleGln: 1.53 ± 0.042	2.991IleArg: 2.991 ± 0.046	3.1IleSer: 3.1 ± 0.056	2.74IleThr: 2.74 ± 0.068	3.517IleVal: 3.517 ± 0.057	0.485IleTrp: 0.485 ± 0.019	1.049IleTyr: 1.049 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	4.001LysAla: 4.001 ± 0.071	0.231LysCys: 0.231 ± 0.016	1.717LysAsp: 1.717 ± 0.042	1.655LysGlu: 1.655 ± 0.04	1.021LysPhe: 1.021 ± 0.033	2.498LysGly: 2.498 ± 0.055	0.715LysHis: 0.715 ± 0.025	1.866LysIle: 1.866 ± 0.046	1.526LysLys: 1.526 ± 0.045	4.136LysLeu: 4.136 ± 0.065	0.868LysMet: 0.868 ± 0.029	1.049LysAsn: 1.049 ± 0.033	2.1LysPro: 2.1 ± 0.058	1.353LysGln: 1.353 ± 0.033	2.228LysArg: 2.228 ± 0.039	1.945LysSer: 1.945 ± 0.043	1.842LysThr: 1.842 ± 0.042	2.466LysVal: 2.466 ± 0.058	0.386LysTrp: 0.386 ± 0.022	0.762LysTyr: 0.762 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	15.459LeuAla: 15.459 ± 0.136	1.309LeuCys: 1.309 ± 0.044	5.969LeuAsp: 5.969 ± 0.067	6.167LeuGlu: 6.167 ± 0.085	3.633LeuPhe: 3.633 ± 0.055	8.838LeuGly: 8.838 ± 0.105	2.397LeuHis: 2.397 ± 0.054	5.432LeuIle: 5.432 ± 0.07	3.774LeuLys: 3.774 ± 0.055	12.992LeuLeu: 12.992 ± 0.155	2.483LeuMet: 2.483 ± 0.045	3.079LeuAsn: 3.079 ± 0.05	6.41LeuPro: 6.41 ± 0.088	4.376LeuGln: 4.376 ± 0.068	8.236LeuArg: 8.236 ± 0.106	7.023LeuSer: 7.023 ± 0.105	5.457LeuThr: 5.457 ± 0.09	7.216LeuVal: 7.216 ± 0.1	1.364LeuTrp: 1.364 ± 0.039	2.143LeuTyr: 2.143 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	2.755MetAla: 2.755 ± 0.053	0.162MetCys: 0.162 ± 0.011	1.029MetAsp: 1.029 ± 0.031	1.081MetGlu: 1.081 ± 0.026	0.72MetPhe: 0.72 ± 0.023	1.63MetGly: 1.63 ± 0.038	0.506MetHis: 0.506 ± 0.019	1.073MetIle: 1.073 ± 0.033	0.998MetLys: 0.998 ± 0.03	2.81MetLeu: 2.81 ± 0.051	0.555MetMet: 0.555 ± 0.023	0.89MetAsn: 0.89 ± 0.025	1.432MetPro: 1.432 ± 0.034	1.105MetGln: 1.105 ± 0.029	1.676MetArg: 1.676 ± 0.039	1.701MetSer: 1.701 ± 0.03	1.159MetThr: 1.159 ± 0.034	1.47MetVal: 1.47 ± 0.035	0.207MetTrp: 0.207 ± 0.013	0.367MetTyr: 0.367 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.312AsnAla: 3.312 ± 0.054	0.297AsnCys: 0.297 ± 0.019	1.36AsnAsp: 1.36 ± 0.043	1.464AsnGlu: 1.464 ± 0.036	1.049AsnPhe: 1.049 ± 0.028	2.241AsnGly: 2.241 ± 0.059	0.562AsnHis: 0.562 ± 0.023	1.4AsnIle: 1.4 ± 0.033	0.909AsnLys: 0.909 ± 0.033	2.995AsnLeu: 2.995 ± 0.056	0.582AsnMet: 0.582 ± 0.02	0.87AsnAsn: 0.87 ± 0.031	1.828AsnPro: 1.828 ± 0.036	0.95AsnGln: 0.95 ± 0.03	1.71AsnArg: 1.71 ± 0.04	1.59AsnSer: 1.59 ± 0.043	1.55AsnThr: 1.55 ± 0.041	1.863AsnVal: 1.863 ± 0.042	0.433AsnTrp: 0.433 ± 0.021	0.735AsnTyr: 0.735 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	6.918ProAla: 6.918 ± 0.106	0.398ProCys: 0.398 ± 0.02	2.903ProAsp: 2.903 ± 0.053	3.595ProGlu: 3.595 ± 0.064	1.607ProPhe: 1.607 ± 0.033	4.033ProGly: 4.033 ± 0.057	1.006ProHis: 1.006 ± 0.03	1.936ProIle: 1.936 ± 0.041	1.393ProLys: 1.393 ± 0.037	5.331ProLeu: 5.331 ± 0.066	1.078ProMet: 1.078 ± 0.033	1.194ProAsn: 1.194 ± 0.031	2.298ProPro: 2.298 ± 0.059	1.944ProGln: 1.944 ± 0.039	2.752ProArg: 2.752 ± 0.051	2.378ProSer: 2.378 ± 0.049	2.056ProThr: 2.056 ± 0.048	3.94ProVal: 3.94 ± 0.06	0.726ProTrp: 0.726 ± 0.027	1.093ProTyr: 1.093 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	5.347GlnAla: 5.347 ± 0.08	0.3GlnCys: 0.3 ± 0.017	1.638GlnAsp: 1.638 ± 0.035	1.872GlnGlu: 1.872 ± 0.044	1.157GlnPhe: 1.157 ± 0.034	2.901GlnGly: 2.901 ± 0.053	1.034GlnHis: 1.034 ± 0.034	2.195GlnIle: 2.195 ± 0.085	1.212GlnLys: 1.212 ± 0.036	4.539GlnLeu: 4.539 ± 0.074	0.951GlnMet: 0.951 ± 0.032	0.976GlnAsn: 0.976 ± 0.029	2.137GlnPro: 2.137 ± 0.04	1.952GlnGln: 1.952 ± 0.053	3.234GlnArg: 3.234 ± 0.058	2.123GlnSer: 2.123 ± 0.045	1.927GlnThr: 1.927 ± 0.044	2.746GlnVal: 2.746 ± 0.069	0.531GlnTrp: 0.531 ± 0.022	0.79GlnTyr: 0.79 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	7.271ArgAla: 7.271 ± 0.081	0.659ArgCys: 0.659 ± 0.023	3.258ArgAsp: 3.258 ± 0.06	4.809ArgGlu: 4.809 ± 0.071	2.832ArgPhe: 2.832 ± 0.051	4.316ArgGly: 4.316 ± 0.057	1.717ArgHis: 1.717 ± 0.039	3.78ArgIle: 3.78 ± 0.06	2.235ArgLys: 2.235 ± 0.042	8.058ArgLeu: 8.058 ± 0.101	1.72ArgMet: 1.72 ± 0.04	2.038ArgAsn: 2.038 ± 0.036	2.943ArgPro: 2.943 ± 0.055	3.017ArgGln: 3.017 ± 0.054	4.642ArgArg: 4.642 ± 0.084	3.958ArgSer: 3.958 ± 0.061	2.777ArgThr: 2.777 ± 0.048	4.692ArgVal: 4.692 ± 0.064	1.029ArgTrp: 1.029 ± 0.032	1.817ArgTyr: 1.817 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	7.153SerAla: 7.153 ± 0.102	0.594SerCys: 0.594 ± 0.026	2.698SerAsp: 2.698 ± 0.068	3.26SerGlu: 3.26 ± 0.056	2.461SerPhe: 2.461 ± 0.046	5.734SerGly: 5.734 ± 0.085	1.292SerHis: 1.292 ± 0.029	2.845SerIle: 2.845 ± 0.058	1.867SerLys: 1.867 ± 0.044	7.139SerLeu: 7.139 ± 0.097	1.326SerMet: 1.326 ± 0.032	1.67SerAsn: 1.67 ± 0.055	2.804SerPro: 2.804 ± 0.045	2.191SerGln: 2.191 ± 0.048	3.711SerArg: 3.711 ± 0.052	4.435SerSer: 4.435 ± 0.11	3.121SerThr: 3.121 ± 0.078	4.27SerVal: 4.27 ± 0.069	0.854SerTrp: 0.854 ± 0.027	1.394SerTyr: 1.394 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	5.463ThrAla: 5.463 ± 0.089	0.455ThrCys: 0.455 ± 0.019	2.364ThrAsp: 2.364 ± 0.055	2.525ThrGlu: 2.525 ± 0.046	1.431ThrPhe: 1.431 ± 0.036	4.17ThrGly: 4.17 ± 0.071	1.148ThrHis: 1.148 ± 0.032	2.11ThrIle: 2.11 ± 0.059	1.256ThrLys: 1.256 ± 0.035	6.11ThrLeu: 6.11 ± 0.084	0.83ThrMet: 0.83 ± 0.025	1.267ThrAsn: 1.267 ± 0.035	3.239ThrPro: 3.239 ± 0.054	1.832ThrGln: 1.832 ± 0.055	3.29ThrArg: 3.29 ± 0.055	2.772ThrSer: 2.772 ± 0.077	2.655ThrThr: 2.655 ± 0.078	3.539ThrVal: 3.539 ± 0.066	0.562ThrTrp: 0.562 ± 0.021	1.079ThrTyr: 1.079 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	8.435ValAla: 8.435 ± 0.101	0.795ValCys: 0.795 ± 0.025	3.56ValAsp: 3.56 ± 0.059	4.2ValGlu: 4.2 ± 0.069	2.739ValPhe: 2.739 ± 0.049	4.891ValGly: 4.891 ± 0.078	1.257ValHis: 1.257 ± 0.03	3.695ValIle: 3.695 ± 0.059	2.43ValLys: 2.43 ± 0.049	8.206ValLeu: 8.206 ± 0.105	1.809ValMet: 1.809 ± 0.042	1.854ValAsn: 1.854 ± 0.05	3.183ValPro: 3.183 ± 0.056	2.568ValGln: 2.568 ± 0.048	4.607ValArg: 4.607 ± 0.07	4.686ValSer: 4.686 ± 0.074	3.568ValThr: 3.568 ± 0.07	5.406ValVal: 5.406 ± 0.087	0.908ValTrp: 0.908 ± 0.027	1.411ValTyr: 1.411 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.215TrpAla: 1.215 ± 0.036	0.153TrpCys: 0.153 ± 0.01	0.553TrpAsp: 0.553 ± 0.022	0.582TrpGlu: 0.582 ± 0.022	0.539TrpPhe: 0.539 ± 0.024	0.901TrpGly: 0.901 ± 0.031	0.367TrpHis: 0.367 ± 0.019	0.657TrpIle: 0.657 ± 0.022	0.46TrpLys: 0.46 ± 0.017	2.249TrpLeu: 2.249 ± 0.049	0.322TrpMet: 0.322 ± 0.017	0.451TrpAsn: 0.451 ± 0.02	0.671TrpPro: 0.671 ± 0.025	0.919TrpGln: 0.919 ± 0.034	1.19TrpArg: 1.19 ± 0.031	0.834TrpSer: 0.834 ± 0.027	0.515TrpThr: 0.515 ± 0.019	0.95TrpVal: 0.95 ± 0.026	0.237TrpTrp: 0.237 ± 0.013	0.319TrpTyr: 0.319 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.624TyrAla: 2.624 ± 0.051	0.281TyrCys: 0.281 ± 0.013	1.157TyrAsp: 1.157 ± 0.028	1.146TyrGlu: 1.146 ± 0.036	0.977TyrPhe: 0.977 ± 0.029	1.871TyrGly: 1.871 ± 0.039	0.451TyrHis: 0.451 ± 0.02	0.935TyrIle: 0.935 ± 0.025	0.76TyrLys: 0.76 ± 0.028	2.536TyrLeu: 2.536 ± 0.049	0.448TyrMet: 0.448 ± 0.018	0.632TyrAsn: 0.632 ± 0.024	1.17TyrPro: 1.17 ± 0.031	0.849TyrGln: 0.849 ± 0.028	1.702TyrArg: 1.702 ± 0.039	1.367TyrSer: 1.367 ± 0.043	1.187TyrThr: 1.187 ± 0.034	1.619TyrVal: 1.619 ± 0.035	0.371TyrTrp: 0.371 ± 0.017	0.632TyrTyr: 0.632 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3798 proteins (1251255 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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