Amino acid dipepetide frequency for Salmonella phage SAP012

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.665AlaAla: 11.665 ± 1.53
0.654AlaCys: 0.654 ± 0.199
6.432AlaAsp: 6.432 ± 0.552
6.595AlaGlu: 6.595 ± 0.711
2.725AlaPhe: 2.725 ± 0.392
7.958AlaGly: 7.958 ± 0.71
1.526AlaHis: 1.526 ± 0.271
4.797AlaIle: 4.797 ± 0.598
5.723AlaLys: 5.723 ± 0.681
8.013AlaLeu: 8.013 ± 0.642
3.161AlaMet: 3.161 ± 0.505
2.889AlaAsn: 2.889 ± 0.483
3.598AlaPro: 3.598 ± 0.423
4.088AlaGln: 4.088 ± 0.74
4.306AlaArg: 4.306 ± 0.64
4.906AlaSer: 4.906 ± 0.661
5.287AlaThr: 5.287 ± 0.751
6.759AlaVal: 6.759 ± 0.818
1.744AlaTrp: 1.744 ± 0.289
2.998AlaTyr: 2.998 ± 0.378
0.0AlaXaa: 0.0 ± 0.0
Cys
0.872CysAla: 0.872 ± 0.222
0.218CysCys: 0.218 ± 0.154
0.927CysAsp: 0.927 ± 0.267
1.036CysGlu: 1.036 ± 0.247
0.218CysPhe: 0.218 ± 0.097
0.709CysGly: 0.709 ± 0.201
0.109CysHis: 0.109 ± 0.068
0.436CysIle: 0.436 ± 0.156
0.218CysLys: 0.218 ± 0.099
0.763CysLeu: 0.763 ± 0.218
0.164CysMet: 0.164 ± 0.087
0.382CysAsn: 0.382 ± 0.151
0.818CysPro: 0.818 ± 0.286
0.218CysGln: 0.218 ± 0.099
1.036CysArg: 1.036 ± 0.257
0.382CysSer: 0.382 ± 0.153
0.327CysThr: 0.327 ± 0.145
0.273CysVal: 0.273 ± 0.116
0.109CysTrp: 0.109 ± 0.074
0.6CysTyr: 0.6 ± 0.203
0.0CysXaa: 0.0 ± 0.0
Asp
5.56AspAla: 5.56 ± 0.499
0.654AspCys: 0.654 ± 0.195
4.96AspAsp: 4.96 ± 0.443
4.361AspGlu: 4.361 ± 0.69
2.507AspPhe: 2.507 ± 0.332
5.342AspGly: 5.342 ± 0.601
0.818AspHis: 0.818 ± 0.227
4.306AspIle: 4.306 ± 0.606
2.998AspLys: 2.998 ± 0.465
4.579AspLeu: 4.579 ± 0.634
2.344AspMet: 2.344 ± 0.341
2.943AspAsn: 2.943 ± 0.42
3.652AspPro: 3.652 ± 0.504
2.289AspGln: 2.289 ± 0.312
3.379AspArg: 3.379 ± 0.54
2.616AspSer: 2.616 ± 0.353
4.034AspThr: 4.034 ± 0.505
5.069AspVal: 5.069 ± 0.447
1.417AspTrp: 1.417 ± 0.276
2.453AspTyr: 2.453 ± 0.401
0.0AspXaa: 0.0 ± 0.0
Glu
5.069GluAla: 5.069 ± 0.609
0.763GluCys: 0.763 ± 0.211
4.088GluAsp: 4.088 ± 0.507
5.015GluGlu: 5.015 ± 0.634
1.962GluPhe: 1.962 ± 0.384
3.27GluGly: 3.27 ± 0.44
1.308GluHis: 1.308 ± 0.403
3.707GluIle: 3.707 ± 0.551
2.834GluLys: 2.834 ± 0.453
4.034GluLeu: 4.034 ± 0.531
2.616GluMet: 2.616 ± 0.363
3.379GluAsn: 3.379 ± 0.413
2.126GluPro: 2.126 ± 0.354
1.853GluGln: 1.853 ± 0.305
3.107GluArg: 3.107 ± 0.486
3.543GluSer: 3.543 ± 0.357
3.488GluThr: 3.488 ± 0.454
5.178GluVal: 5.178 ± 0.494
1.962GluTrp: 1.962 ± 0.33
2.344GluTyr: 2.344 ± 0.473
0.0GluXaa: 0.0 ± 0.0
Phe
3.652PheAla: 3.652 ± 0.482
0.545PheCys: 0.545 ± 0.174
3.161PheAsp: 3.161 ± 0.404
1.962PheGlu: 1.962 ± 0.322
0.981PhePhe: 0.981 ± 0.293
2.834PheGly: 2.834 ± 0.358
0.709PheHis: 0.709 ± 0.195
1.635PheIle: 1.635 ± 0.326
2.289PheLys: 2.289 ± 0.337
1.526PheLeu: 1.526 ± 0.25
1.417PheMet: 1.417 ± 0.276
1.417PheAsn: 1.417 ± 0.248
1.363PhePro: 1.363 ± 0.272
0.654PheGln: 0.654 ± 0.169
2.126PheArg: 2.126 ± 0.38
2.289PheSer: 2.289 ± 0.359
2.398PheThr: 2.398 ± 0.424
1.908PheVal: 1.908 ± 0.39
0.382PheTrp: 0.382 ± 0.155
0.818PheTyr: 0.818 ± 0.198
0.0PheXaa: 0.0 ± 0.0
Gly
6.323GlyAla: 6.323 ± 0.471
1.09GlyCys: 1.09 ± 0.333
4.252GlyAsp: 4.252 ± 0.476
4.034GlyGlu: 4.034 ± 0.444
2.943GlyPhe: 2.943 ± 0.354
5.996GlyGly: 5.996 ± 0.899
0.927GlyHis: 0.927 ± 0.23
4.088GlyIle: 4.088 ± 0.52
5.451GlyLys: 5.451 ± 0.591
5.069GlyLeu: 5.069 ± 0.493
2.126GlyMet: 2.126 ± 0.368
2.78GlyAsn: 2.78 ± 0.386
1.09GlyPro: 1.09 ± 0.272
3.325GlyGln: 3.325 ± 0.362
4.252GlyArg: 4.252 ± 0.454
4.088GlySer: 4.088 ± 0.493
5.015GlyThr: 5.015 ± 0.659
5.233GlyVal: 5.233 ± 0.483
1.635GlyTrp: 1.635 ± 0.309
3.925GlyTyr: 3.925 ± 0.64
0.0GlyXaa: 0.0 ± 0.0
His
1.254HisAla: 1.254 ± 0.273
0.436HisCys: 0.436 ± 0.173
0.981HisAsp: 0.981 ± 0.255
0.763HisGlu: 0.763 ± 0.212
1.036HisPhe: 1.036 ± 0.268
1.526HisGly: 1.526 ± 0.314
0.218HisHis: 0.218 ± 0.121
1.417HisIle: 1.417 ± 0.261
0.872HisLys: 0.872 ± 0.19
1.69HisLeu: 1.69 ± 0.241
0.382HisMet: 0.382 ± 0.136
1.036HisAsn: 1.036 ± 0.23
0.654HisPro: 0.654 ± 0.222
0.545HisGln: 0.545 ± 0.215
1.036HisArg: 1.036 ± 0.221
0.927HisSer: 0.927 ± 0.222
0.818HisThr: 0.818 ± 0.214
0.981HisVal: 0.981 ± 0.313
0.164HisTrp: 0.164 ± 0.093
0.818HisTyr: 0.818 ± 0.205
0.0HisXaa: 0.0 ± 0.0
Ile
6.323IleAla: 6.323 ± 0.699
0.218IleCys: 0.218 ± 0.123
4.143IleAsp: 4.143 ± 0.562
3.652IleGlu: 3.652 ± 0.469
1.635IlePhe: 1.635 ± 0.297
3.434IleGly: 3.434 ± 0.355
0.927IleHis: 0.927 ± 0.256
3.325IleIle: 3.325 ± 0.436
3.434IleLys: 3.434 ± 0.42
3.379IleLeu: 3.379 ± 0.356
1.417IleMet: 1.417 ± 0.317
3.052IleAsn: 3.052 ± 0.397
2.18IlePro: 2.18 ± 0.377
1.145IleGln: 1.145 ± 0.266
3.707IleArg: 3.707 ± 0.522
3.488IleSer: 3.488 ± 0.511
3.87IleThr: 3.87 ± 0.395
3.925IleVal: 3.925 ± 0.517
0.491IleTrp: 0.491 ± 0.158
1.853IleTyr: 1.853 ± 0.281
0.0IleXaa: 0.0 ± 0.0
Lys
5.614LysAla: 5.614 ± 0.646
0.382LysCys: 0.382 ± 0.159
3.161LysAsp: 3.161 ± 0.351
3.652LysGlu: 3.652 ± 0.637
1.417LysPhe: 1.417 ± 0.34
3.652LysGly: 3.652 ± 0.518
1.254LysHis: 1.254 ± 0.32
2.998LysIle: 2.998 ± 0.408
3.652LysLys: 3.652 ± 0.585
4.361LysLeu: 4.361 ± 0.481
1.472LysMet: 1.472 ± 0.274
2.453LysAsn: 2.453 ± 0.378
3.27LysPro: 3.27 ± 0.452
2.126LysGln: 2.126 ± 0.355
3.325LysArg: 3.325 ± 0.485
3.107LysSer: 3.107 ± 0.46
2.616LysThr: 2.616 ± 0.368
3.379LysVal: 3.379 ± 0.399
1.036LysTrp: 1.036 ± 0.315
2.289LysTyr: 2.289 ± 0.317
0.0LysXaa: 0.0 ± 0.0
Leu
7.359LeuAla: 7.359 ± 0.871
0.927LeuCys: 0.927 ± 0.232
4.361LeuAsp: 4.361 ± 0.565
4.143LeuGlu: 4.143 ± 0.469
2.507LeuPhe: 2.507 ± 0.383
5.287LeuGly: 5.287 ± 0.578
1.254LeuHis: 1.254 ± 0.275
3.434LeuIle: 3.434 ± 0.497
4.688LeuLys: 4.688 ± 0.51
4.361LeuLeu: 4.361 ± 0.51
1.962LeuMet: 1.962 ± 0.404
3.816LeuAsn: 3.816 ± 0.501
4.306LeuPro: 4.306 ± 0.637
2.834LeuGln: 2.834 ± 0.463
4.252LeuArg: 4.252 ± 0.457
5.233LeuSer: 5.233 ± 0.609
4.96LeuThr: 4.96 ± 0.572
4.47LeuVal: 4.47 ± 0.476
0.981LeuTrp: 0.981 ± 0.211
1.908LeuTyr: 1.908 ± 0.311
0.0LeuXaa: 0.0 ± 0.0
Met
3.325MetAla: 3.325 ± 0.392
0.109MetCys: 0.109 ± 0.08
1.744MetAsp: 1.744 ± 0.304
1.581MetGlu: 1.581 ± 0.33
1.145MetPhe: 1.145 ± 0.244
1.69MetGly: 1.69 ± 0.282
0.927MetHis: 0.927 ± 0.171
1.908MetIle: 1.908 ± 0.261
1.908MetLys: 1.908 ± 0.29
2.671MetLeu: 2.671 ± 0.405
0.927MetMet: 0.927 ± 0.258
1.363MetAsn: 1.363 ± 0.263
1.635MetPro: 1.635 ± 0.306
0.981MetGln: 0.981 ± 0.249
2.126MetArg: 2.126 ± 0.404
2.126MetSer: 2.126 ± 0.343
2.344MetThr: 2.344 ± 0.408
1.908MetVal: 1.908 ± 0.3
0.327MetTrp: 0.327 ± 0.164
1.036MetTyr: 1.036 ± 0.194
0.0MetXaa: 0.0 ± 0.0
Asn
4.306AsnAla: 4.306 ± 0.678
0.327AsnCys: 0.327 ± 0.126
2.889AsnAsp: 2.889 ± 0.394
2.017AsnGlu: 2.017 ± 0.323
1.199AsnPhe: 1.199 ± 0.212
5.069AsnGly: 5.069 ± 0.613
0.927AsnHis: 0.927 ± 0.228
2.507AsnIle: 2.507 ± 0.292
2.398AsnLys: 2.398 ± 0.441
3.27AsnLeu: 3.27 ± 0.456
1.254AsnMet: 1.254 ± 0.223
2.18AsnAsn: 2.18 ± 0.389
2.889AsnPro: 2.889 ± 0.547
1.69AsnGln: 1.69 ± 0.311
2.671AsnArg: 2.671 ± 0.373
2.017AsnSer: 2.017 ± 0.359
2.289AsnThr: 2.289 ± 0.322
2.562AsnVal: 2.562 ± 0.467
0.491AsnTrp: 0.491 ± 0.156
1.09AsnTyr: 1.09 ± 0.301
0.0AsnXaa: 0.0 ± 0.0
Pro
4.088ProAla: 4.088 ± 0.46
0.382ProCys: 0.382 ± 0.164
4.306ProAsp: 4.306 ± 0.661
3.052ProGlu: 3.052 ± 0.423
1.472ProPhe: 1.472 ± 0.306
3.434ProGly: 3.434 ± 0.459
0.981ProHis: 0.981 ± 0.225
2.18ProIle: 2.18 ± 0.306
2.289ProLys: 2.289 ± 0.332
2.071ProLeu: 2.071 ± 0.383
1.254ProMet: 1.254 ± 0.324
2.18ProAsn: 2.18 ± 0.327
2.126ProPro: 2.126 ± 0.423
1.581ProGln: 1.581 ± 0.306
1.853ProArg: 1.853 ± 0.373
2.616ProSer: 2.616 ± 0.448
2.889ProThr: 2.889 ± 0.415
4.252ProVal: 4.252 ± 0.698
0.981ProTrp: 0.981 ± 0.282
1.799ProTyr: 1.799 ± 0.328
0.0ProXaa: 0.0 ± 0.0
Gln
3.761GlnAla: 3.761 ± 0.646
0.218GlnCys: 0.218 ± 0.102
1.853GlnAsp: 1.853 ± 0.332
1.908GlnGlu: 1.908 ± 0.309
1.308GlnPhe: 1.308 ± 0.278
2.071GlnGly: 2.071 ± 0.312
0.436GlnHis: 0.436 ± 0.142
2.344GlnIle: 2.344 ± 0.342
1.744GlnLys: 1.744 ± 0.328
3.216GlnLeu: 3.216 ± 0.439
1.635GlnMet: 1.635 ± 0.39
1.199GlnAsn: 1.199 ± 0.283
1.853GlnPro: 1.853 ± 0.399
1.472GlnGln: 1.472 ± 0.495
2.235GlnArg: 2.235 ± 0.405
2.289GlnSer: 2.289 ± 0.536
2.126GlnThr: 2.126 ± 0.4
3.216GlnVal: 3.216 ± 0.709
0.436GlnTrp: 0.436 ± 0.141
1.199GlnTyr: 1.199 ± 0.255
0.0GlnXaa: 0.0 ± 0.0
Arg
4.47ArgAla: 4.47 ± 0.529
0.872ArgCys: 0.872 ± 0.214
3.816ArgAsp: 3.816 ± 0.431
2.998ArgGlu: 2.998 ± 0.442
2.78ArgPhe: 2.78 ± 0.256
3.107ArgGly: 3.107 ± 0.415
0.763ArgHis: 0.763 ± 0.276
3.27ArgIle: 3.27 ± 0.39
2.998ArgLys: 2.998 ± 0.389
5.233ArgLeu: 5.233 ± 0.588
1.799ArgMet: 1.799 ± 0.337
2.289ArgAsn: 2.289 ± 0.474
2.18ArgPro: 2.18 ± 0.376
2.017ArgGln: 2.017 ± 0.429
3.761ArgArg: 3.761 ± 0.478
3.161ArgSer: 3.161 ± 0.452
3.434ArgThr: 3.434 ± 0.395
4.688ArgVal: 4.688 ± 0.405
1.145ArgTrp: 1.145 ± 0.23
1.853ArgTyr: 1.853 ± 0.308
0.0ArgXaa: 0.0 ± 0.0
Ser
5.451SerAla: 5.451 ± 0.581
0.491SerCys: 0.491 ± 0.165
4.143SerAsp: 4.143 ± 0.463
3.052SerGlu: 3.052 ± 0.352
2.126SerPhe: 2.126 ± 0.391
4.361SerGly: 4.361 ± 0.46
0.927SerHis: 0.927 ± 0.231
3.434SerIle: 3.434 ± 0.432
2.78SerLys: 2.78 ± 0.397
4.96SerLeu: 4.96 ± 0.52
1.472SerMet: 1.472 ± 0.314
2.453SerAsn: 2.453 ± 0.362
2.289SerPro: 2.289 ± 0.327
2.289SerGln: 2.289 ± 0.395
3.216SerArg: 3.216 ± 0.415
2.889SerSer: 2.889 ± 0.362
3.925SerThr: 3.925 ± 0.487
4.088SerVal: 4.088 ± 0.606
0.927SerTrp: 0.927 ± 0.206
1.744SerTyr: 1.744 ± 0.382
0.0SerXaa: 0.0 ± 0.0
Thr
5.669ThrAla: 5.669 ± 0.621
0.327ThrCys: 0.327 ± 0.124
3.434ThrAsp: 3.434 ± 0.49
3.598ThrGlu: 3.598 ± 0.466
2.017ThrPhe: 2.017 ± 0.319
5.614ThrGly: 5.614 ± 0.621
0.872ThrHis: 0.872 ± 0.205
3.107ThrIle: 3.107 ± 0.481
3.052ThrLys: 3.052 ± 0.479
5.287ThrLeu: 5.287 ± 0.435
2.562ThrMet: 2.562 ± 0.356
2.453ThrAsn: 2.453 ± 0.31
3.816ThrPro: 3.816 ± 0.489
2.235ThrGln: 2.235 ± 0.354
2.943ThrArg: 2.943 ± 0.355
3.434ThrSer: 3.434 ± 0.43
3.434ThrThr: 3.434 ± 0.626
5.941ThrVal: 5.941 ± 0.779
0.927ThrTrp: 0.927 ± 0.259
1.199ThrTyr: 1.199 ± 0.273
0.0ThrXaa: 0.0 ± 0.0
Val
6.704ValAla: 6.704 ± 0.795
0.763ValCys: 0.763 ± 0.232
4.088ValAsp: 4.088 ± 0.419
4.96ValGlu: 4.96 ± 0.468
2.562ValPhe: 2.562 ± 0.324
4.851ValGly: 4.851 ± 0.482
1.254ValHis: 1.254 ± 0.273
4.143ValIle: 4.143 ± 0.501
3.761ValLys: 3.761 ± 0.357
4.797ValLeu: 4.797 ± 0.591
2.235ValMet: 2.235 ± 0.39
3.434ValAsn: 3.434 ± 0.386
3.216ValPro: 3.216 ± 0.485
2.834ValGln: 2.834 ± 0.37
4.252ValArg: 4.252 ± 0.402
5.124ValSer: 5.124 ± 0.602
5.342ValThr: 5.342 ± 0.641
4.415ValVal: 4.415 ± 0.505
1.363ValTrp: 1.363 ± 0.284
2.235ValTyr: 2.235 ± 0.462
0.0ValXaa: 0.0 ± 0.0
Trp
1.69TrpAla: 1.69 ± 0.328
0.109TrpCys: 0.109 ± 0.074
1.526TrpAsp: 1.526 ± 0.332
1.308TrpGlu: 1.308 ± 0.225
0.6TrpPhe: 0.6 ± 0.144
1.308TrpGly: 1.308 ± 0.227
0.436TrpHis: 0.436 ± 0.161
0.709TrpIle: 0.709 ± 0.215
0.927TrpLys: 0.927 ± 0.235
1.799TrpLeu: 1.799 ± 0.32
0.327TrpMet: 0.327 ± 0.142
0.545TrpAsn: 0.545 ± 0.158
0.6TrpPro: 0.6 ± 0.208
0.927TrpGln: 0.927 ± 0.193
0.927TrpArg: 0.927 ± 0.248
0.763TrpSer: 0.763 ± 0.211
0.927TrpThr: 0.927 ± 0.277
0.927TrpVal: 0.927 ± 0.255
0.327TrpTrp: 0.327 ± 0.152
0.6TrpTyr: 0.6 ± 0.18
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.671TyrAla: 2.671 ± 0.489
0.327TyrCys: 0.327 ± 0.176
2.017TyrAsp: 2.017 ± 0.346
2.017TyrGlu: 2.017 ± 0.268
0.927TyrPhe: 0.927 ± 0.257
2.126TyrGly: 2.126 ± 0.338
0.981TyrHis: 0.981 ± 0.234
1.853TyrIle: 1.853 ± 0.283
1.199TyrLys: 1.199 ± 0.219
1.962TyrLeu: 1.962 ± 0.424
1.199TyrMet: 1.199 ± 0.212
1.799TyrAsn: 1.799 ± 0.37
2.126TyrPro: 2.126 ± 0.506
1.417TyrGln: 1.417 ± 0.274
2.126TyrArg: 2.126 ± 0.337
2.017TyrSer: 2.017 ± 0.276
2.398TyrThr: 2.398 ± 0.411
3.161TyrVal: 3.161 ± 0.444
0.436TyrTrp: 0.436 ± 0.177
1.254TyrTyr: 1.254 ± 0.273
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 72 proteins (18347 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski