Amino acid dipepetide frequency for Sinomicrobium oceani

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.142AlaAla: 5.142 ± 0.07
0.619AlaCys: 0.619 ± 0.022
3.846AlaAsp: 3.846 ± 0.056
4.56AlaGlu: 4.56 ± 0.063
3.422AlaPhe: 3.422 ± 0.049
5.487AlaGly: 5.487 ± 0.071
1.267AlaHis: 1.267 ± 0.032
4.877AlaIle: 4.877 ± 0.058
3.59AlaLys: 3.59 ± 0.061
6.855AlaLeu: 6.855 ± 0.075
1.749AlaMet: 1.749 ± 0.035
2.839AlaAsn: 2.839 ± 0.049
2.365AlaPro: 2.365 ± 0.039
2.357AlaGln: 2.357 ± 0.038
3.195AlaArg: 3.195 ± 0.053
4.317AlaSer: 4.317 ± 0.061
3.746AlaThr: 3.746 ± 0.056
4.911AlaVal: 4.911 ± 0.074
0.858AlaTrp: 0.858 ± 0.023
3.012AlaTyr: 3.012 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
0.447CysAla: 0.447 ± 0.018
0.138CysCys: 0.138 ± 0.012
0.397CysAsp: 0.397 ± 0.017
0.404CysGlu: 0.404 ± 0.021
0.411CysPhe: 0.411 ± 0.017
0.626CysGly: 0.626 ± 0.025
0.193CysHis: 0.193 ± 0.012
0.56CysIle: 0.56 ± 0.021
0.42CysLys: 0.42 ± 0.018
0.679CysLeu: 0.679 ± 0.024
0.199CysMet: 0.199 ± 0.011
0.364CysAsn: 0.364 ± 0.018
0.339CysPro: 0.339 ± 0.018
0.196CysGln: 0.196 ± 0.012
0.326CysArg: 0.326 ± 0.014
0.528CysSer: 0.528 ± 0.021
0.451CysThr: 0.451 ± 0.018
0.414CysVal: 0.414 ± 0.017
0.065CysTrp: 0.065 ± 0.007
0.302CysTyr: 0.302 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
3.752AspAla: 3.752 ± 0.059
0.365AspCys: 0.365 ± 0.019
2.922AspAsp: 2.922 ± 0.056
3.635AspGlu: 3.635 ± 0.044
3.419AspPhe: 3.419 ± 0.049
4.005AspGly: 4.005 ± 0.071
1.287AspHis: 1.287 ± 0.03
4.748AspIle: 4.748 ± 0.061
3.762AspLys: 3.762 ± 0.052
4.84AspLeu: 4.84 ± 0.065
1.391AspMet: 1.391 ± 0.032
2.964AspAsn: 2.964 ± 0.042
2.29AspPro: 2.29 ± 0.042
1.621AspGln: 1.621 ± 0.035
2.845AspArg: 2.845 ± 0.048
2.901AspSer: 2.901 ± 0.054
3.227AspThr: 3.227 ± 0.05
3.469AspVal: 3.469 ± 0.055
0.8AspTrp: 0.8 ± 0.024
2.796AspTyr: 2.796 ± 0.043
0.0AspXaa: 0.0 ± 0.0
Glu
4.967GluAla: 4.967 ± 0.062
0.333GluCys: 0.333 ± 0.016
3.895GluAsp: 3.895 ± 0.058
5.613GluGlu: 5.613 ± 0.066
2.508GluPhe: 2.508 ± 0.044
4.374GluGly: 4.374 ± 0.06
1.409GluHis: 1.409 ± 0.035
4.967GluIle: 4.967 ± 0.059
5.886GluLys: 5.886 ± 0.079
5.999GluLeu: 5.999 ± 0.075
1.605GluMet: 1.605 ± 0.04
4.103GluAsn: 4.103 ± 0.05
1.741GluPro: 1.741 ± 0.036
2.444GluGln: 2.444 ± 0.043
2.895GluArg: 2.895 ± 0.048
3.117GluSer: 3.117 ± 0.05
3.734GluThr: 3.734 ± 0.048
4.582GluVal: 4.582 ± 0.051
0.671GluTrp: 0.671 ± 0.021
2.505GluTyr: 2.505 ± 0.045
0.0GluXaa: 0.0 ± 0.0
Phe
3.024PheAla: 3.024 ± 0.041
0.432PheCys: 0.432 ± 0.018
3.014PheAsp: 3.014 ± 0.049
2.935PheGlu: 2.935 ± 0.048
2.523PhePhe: 2.523 ± 0.049
3.712PheGly: 3.712 ± 0.058
0.893PheHis: 0.893 ± 0.023
3.26PheIle: 3.26 ± 0.053
2.489PheLys: 2.489 ± 0.048
4.433PheLeu: 4.433 ± 0.069
1.159PheMet: 1.159 ± 0.029
2.371PheAsn: 2.371 ± 0.04
1.87PhePro: 1.87 ± 0.038
1.284PheGln: 1.284 ± 0.026
2.669PheArg: 2.669 ± 0.049
3.66PheSer: 3.66 ± 0.055
3.039PheThr: 3.039 ± 0.046
2.849PheVal: 2.849 ± 0.048
0.564PheTrp: 0.564 ± 0.021
2.16PheTyr: 2.16 ± 0.039
0.0PheXaa: 0.0 ± 0.0
Gly
4.677GlyAla: 4.677 ± 0.066
0.611GlyCys: 0.611 ± 0.024
3.821GlyAsp: 3.821 ± 0.052
4.414GlyGlu: 4.414 ± 0.053
3.665GlyPhe: 3.665 ± 0.053
5.223GlyGly: 5.223 ± 0.09
1.391GlyHis: 1.391 ± 0.031
5.647GlyIle: 5.647 ± 0.072
5.482GlyLys: 5.482 ± 0.078
6.156GlyLeu: 6.156 ± 0.07
2.025GlyMet: 2.025 ± 0.034
3.951GlyAsn: 3.951 ± 0.063
1.537GlyPro: 1.537 ± 0.035
2.264GlyGln: 2.264 ± 0.041
2.857GlyArg: 2.857 ± 0.042
4.331GlySer: 4.331 ± 0.063
4.428GlyThr: 4.428 ± 0.07
4.718GlyVal: 4.718 ± 0.068
0.994GlyTrp: 0.994 ± 0.03
3.427GlyTyr: 3.427 ± 0.056
0.0GlyXaa: 0.0 ± 0.0
His
1.19HisAla: 1.19 ± 0.028
0.197HisCys: 0.197 ± 0.012
0.938HisAsp: 0.938 ± 0.027
1.057HisGlu: 1.057 ± 0.03
1.161HisPhe: 1.161 ± 0.031
1.237HisGly: 1.237 ± 0.032
0.637HisHis: 0.637 ± 0.024
1.689HisIle: 1.689 ± 0.036
1.144HisLys: 1.144 ± 0.027
1.912HisLeu: 1.912 ± 0.04
0.389HisMet: 0.389 ± 0.016
0.941HisAsn: 0.941 ± 0.027
1.131HisPro: 1.131 ± 0.028
0.684HisGln: 0.684 ± 0.021
1.082HisArg: 1.082 ± 0.026
1.105HisSer: 1.105 ± 0.03
1.315HisThr: 1.315 ± 0.035
1.085HisVal: 1.085 ± 0.027
0.279HisTrp: 0.279 ± 0.014
1.036HisTyr: 1.036 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
5.691IleAla: 5.691 ± 0.078
0.571IleCys: 0.571 ± 0.018
4.039IleAsp: 4.039 ± 0.051
4.202IleGlu: 4.202 ± 0.058
3.034IlePhe: 3.034 ± 0.051
4.698IleGly: 4.698 ± 0.058
1.385IleHis: 1.385 ± 0.032
4.583IleIle: 4.583 ± 0.075
3.992IleLys: 3.992 ± 0.061
6.179IleLeu: 6.179 ± 0.075
1.31IleMet: 1.31 ± 0.03
3.454IleAsn: 3.454 ± 0.048
3.47IlePro: 3.47 ± 0.051
2.087IleGln: 2.087 ± 0.041
4.057IleArg: 4.057 ± 0.052
4.991IleSer: 4.991 ± 0.064
4.62IleThr: 4.62 ± 0.058
4.138IleVal: 4.138 ± 0.064
0.681IleTrp: 0.681 ± 0.02
2.544IleTyr: 2.544 ± 0.043
0.0IleXaa: 0.0 ± 0.0
Lys
4.683LysAla: 4.683 ± 0.076
0.265LysCys: 0.265 ± 0.015
3.962LysAsp: 3.962 ± 0.055
5.234LysGlu: 5.234 ± 0.076
2.139LysPhe: 2.139 ± 0.042
4.263LysGly: 4.263 ± 0.069
1.249LysHis: 1.249 ± 0.033
4.729LysIle: 4.729 ± 0.063
5.611LysLys: 5.611 ± 0.075
5.428LysLeu: 5.428 ± 0.076
1.648LysMet: 1.648 ± 0.037
3.938LysAsn: 3.938 ± 0.054
2.181LysPro: 2.181 ± 0.038
2.309LysGln: 2.309 ± 0.044
2.836LysArg: 2.836 ± 0.052
3.392LysSer: 3.392 ± 0.053
4.045LysThr: 4.045 ± 0.05
4.082LysVal: 4.082 ± 0.058
0.701LysTrp: 0.701 ± 0.021
2.61LysTyr: 2.61 ± 0.047
0.0LysXaa: 0.0 ± 0.0
Leu
5.793LeuAla: 5.793 ± 0.065
0.775LeuCys: 0.775 ± 0.024
5.006LeuAsp: 5.006 ± 0.057
5.933LeuGlu: 5.933 ± 0.076
4.597LeuPhe: 4.597 ± 0.066
5.987LeuGly: 5.987 ± 0.064
2.052LeuHis: 2.052 ± 0.042
5.684LeuIle: 5.684 ± 0.074
6.427LeuLys: 6.427 ± 0.076
8.929LeuLeu: 8.929 ± 0.104
2.146LeuMet: 2.146 ± 0.04
4.437LeuAsn: 4.437 ± 0.056
3.994LeuPro: 3.994 ± 0.05
3.497LeuGln: 3.497 ± 0.047
4.494LeuArg: 4.494 ± 0.066
6.642LeuSer: 6.642 ± 0.077
5.049LeuThr: 5.049 ± 0.065
5.259LeuVal: 5.259 ± 0.066
1.045LeuTrp: 1.045 ± 0.026
3.529LeuTyr: 3.529 ± 0.058
0.0LeuXaa: 0.0 ± 0.0
Met
1.906MetAla: 1.906 ± 0.034
0.154MetCys: 0.154 ± 0.01
1.31MetAsp: 1.31 ± 0.028
1.713MetGlu: 1.713 ± 0.033
0.848MetPhe: 0.848 ± 0.023
1.566MetGly: 1.566 ± 0.036
0.503MetHis: 0.503 ± 0.018
1.451MetIle: 1.451 ± 0.031
2.053MetLys: 2.053 ± 0.034
2.157MetLeu: 2.157 ± 0.037
0.575MetMet: 0.575 ± 0.02
1.214MetAsn: 1.214 ± 0.025
0.963MetPro: 0.963 ± 0.024
0.917MetGln: 0.917 ± 0.03
1.048MetArg: 1.048 ± 0.027
1.384MetSer: 1.384 ± 0.029
1.272MetThr: 1.272 ± 0.029
1.478MetVal: 1.478 ± 0.034
0.187MetTrp: 0.187 ± 0.011
0.848MetTyr: 0.848 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
3.49AsnAla: 3.49 ± 0.053
0.314AsnCys: 0.314 ± 0.015
2.625AsnAsp: 2.625 ± 0.044
2.848AsnGlu: 2.848 ± 0.043
2.446AsnPhe: 2.446 ± 0.05
3.773AsnGly: 3.773 ± 0.056
0.992AsnHis: 0.992 ± 0.025
3.891AsnIle: 3.891 ± 0.054
2.942AsnLys: 2.942 ± 0.048
4.272AsnLeu: 4.272 ± 0.054
1.136AsnMet: 1.136 ± 0.028
2.747AsnAsn: 2.747 ± 0.056
2.607AsnPro: 2.607 ± 0.039
1.541AsnGln: 1.541 ± 0.032
2.653AsnArg: 2.653 ± 0.047
2.931AsnSer: 2.931 ± 0.043
3.541AsnThr: 3.541 ± 0.052
2.92AsnVal: 2.92 ± 0.056
0.679AsnTrp: 0.679 ± 0.023
2.417AsnTyr: 2.417 ± 0.047
0.0AsnXaa: 0.0 ± 0.0
Pro
2.645ProAla: 2.645 ± 0.045
0.22ProCys: 0.22 ± 0.013
2.98ProAsp: 2.98 ± 0.044
4.049ProGlu: 4.049 ± 0.057
1.862ProPhe: 1.862 ± 0.035
3.225ProGly: 3.225 ± 0.056
0.681ProHis: 0.681 ± 0.021
1.906ProIle: 1.906 ± 0.035
1.891ProLys: 1.891 ± 0.04
3.332ProLeu: 3.332 ± 0.05
0.864ProMet: 0.864 ± 0.028
1.493ProAsn: 1.493 ± 0.034
1.134ProPro: 1.134 ± 0.03
1.29ProGln: 1.29 ± 0.029
1.268ProArg: 1.268 ± 0.032
2.225ProSer: 2.225 ± 0.04
1.656ProThr: 1.656 ± 0.036
3.556ProVal: 3.556 ± 0.056
0.456ProTrp: 0.456 ± 0.018
1.712ProTyr: 1.712 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
2.201GlnAla: 2.201 ± 0.04
0.199GlnCys: 0.199 ± 0.013
1.718GlnAsp: 1.718 ± 0.03
2.381GlnGlu: 2.381 ± 0.042
1.388GlnPhe: 1.388 ± 0.036
2.118GlnGly: 2.118 ± 0.038
0.738GlnHis: 0.738 ± 0.02
2.061GlnIle: 2.061 ± 0.035
2.4GlnLys: 2.4 ± 0.044
3.248GlnLeu: 3.248 ± 0.05
0.808GlnMet: 0.808 ± 0.025
1.765GlnAsn: 1.765 ± 0.041
1.194GlnPro: 1.194 ± 0.029
1.647GlnGln: 1.647 ± 0.039
1.516GlnArg: 1.516 ± 0.033
1.769GlnSer: 1.769 ± 0.04
1.8GlnThr: 1.8 ± 0.04
2.144GlnVal: 2.144 ± 0.037
0.481GlnTrp: 0.481 ± 0.018
1.421GlnTyr: 1.421 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
2.928ArgAla: 2.928 ± 0.046
0.254ArgCys: 0.254 ± 0.013
2.533ArgAsp: 2.533 ± 0.044
3.59ArgGlu: 3.59 ± 0.053
2.462ArgPhe: 2.462 ± 0.042
2.622ArgGly: 2.622 ± 0.047
0.94ArgHis: 0.94 ± 0.026
3.613ArgIle: 3.613 ± 0.055
3.841ArgLys: 3.841 ± 0.059
4.213ArgLeu: 4.213 ± 0.054
1.286ArgMet: 1.286 ± 0.029
2.755ArgAsn: 2.755 ± 0.051
1.522ArgPro: 1.522 ± 0.03
1.677ArgGln: 1.677 ± 0.034
1.971ArgArg: 1.971 ± 0.046
2.614ArgSer: 2.614 ± 0.047
2.526ArgThr: 2.526 ± 0.041
2.881ArgVal: 2.881 ± 0.049
0.624ArgTrp: 0.624 ± 0.022
2.339ArgTyr: 2.339 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
4.116SerAla: 4.116 ± 0.058
0.65SerCys: 0.65 ± 0.022
3.535SerAsp: 3.535 ± 0.046
3.988SerGlu: 3.988 ± 0.05
3.35SerPhe: 3.35 ± 0.048
5.823SerGly: 5.823 ± 0.083
1.08SerHis: 1.08 ± 0.028
3.816SerIle: 3.816 ± 0.054
3.137SerLys: 3.137 ± 0.054
5.703SerLeu: 5.703 ± 0.064
1.33SerMet: 1.33 ± 0.031
2.612SerAsn: 2.612 ± 0.047
2.417SerPro: 2.417 ± 0.037
1.684SerGln: 1.684 ± 0.035
3.061SerArg: 3.061 ± 0.048
3.819SerSer: 3.819 ± 0.067
3.012SerThr: 3.012 ± 0.052
4.385SerVal: 4.385 ± 0.053
0.815SerTrp: 0.815 ± 0.021
2.864SerTyr: 2.864 ± 0.051
0.001SerXaa: 0.001 ± 0.001
Thr
4.316ThrAla: 4.316 ± 0.067
0.375ThrCys: 0.375 ± 0.014
3.785ThrAsp: 3.785 ± 0.053
3.709ThrGlu: 3.709 ± 0.053
2.78ThrPhe: 2.78 ± 0.046
5.295ThrGly: 5.295 ± 0.065
1.042ThrHis: 1.042 ± 0.03
4.018ThrIle: 4.018 ± 0.059
2.59ThrLys: 2.59 ± 0.046
5.464ThrLeu: 5.464 ± 0.061
1.123ThrMet: 1.123 ± 0.031
2.438ThrAsn: 2.438 ± 0.047
2.793ThrPro: 2.793 ± 0.049
1.624ThrGln: 1.624 ± 0.031
2.574ThrArg: 2.574 ± 0.051
3.592ThrSer: 3.592 ± 0.055
3.405ThrThr: 3.405 ± 0.064
4.312ThrVal: 4.312 ± 0.062
0.649ThrTrp: 0.649 ± 0.022
2.58ThrTyr: 2.58 ± 0.054
0.0ThrXaa: 0.0 ± 0.0
Val
4.414ValAla: 4.414 ± 0.074
0.555ValCys: 0.555 ± 0.02
3.298ValAsp: 3.298 ± 0.044
3.757ValGlu: 3.757 ± 0.053
3.454ValPhe: 3.454 ± 0.055
3.613ValGly: 3.613 ± 0.05
1.257ValHis: 1.257 ± 0.03
4.601ValIle: 4.601 ± 0.054
4.2ValLys: 4.2 ± 0.055
6.581ValLeu: 6.581 ± 0.079
1.526ValMet: 1.526 ± 0.034
3.262ValAsn: 3.262 ± 0.053
2.681ValPro: 2.681 ± 0.039
1.923ValGln: 1.923 ± 0.04
2.908ValArg: 2.908 ± 0.042
4.692ValSer: 4.692 ± 0.061
4.027ValThr: 4.027 ± 0.074
4.471ValVal: 4.471 ± 0.065
0.704ValTrp: 0.704 ± 0.022
2.694ValTyr: 2.694 ± 0.044
0.0ValXaa: 0.0 ± 0.0
Trp
0.69TrpAla: 0.69 ± 0.02
0.122TrpCys: 0.122 ± 0.009
0.694TrpAsp: 0.694 ± 0.024
0.831TrpGlu: 0.831 ± 0.024
0.573TrpPhe: 0.573 ± 0.019
0.839TrpGly: 0.839 ± 0.025
0.266TrpHis: 0.266 ± 0.013
0.795TrpIle: 0.795 ± 0.025
0.929TrpLys: 0.929 ± 0.027
1.086TrpLeu: 1.086 ± 0.028
0.37TrpMet: 0.37 ± 0.016
0.698TrpAsn: 0.698 ± 0.022
0.334TrpPro: 0.334 ± 0.016
0.492TrpGln: 0.492 ± 0.019
0.495TrpArg: 0.495 ± 0.019
0.696TrpSer: 0.696 ± 0.021
0.664TrpThr: 0.664 ± 0.021
0.665TrpVal: 0.665 ± 0.022
0.211TrpTrp: 0.211 ± 0.012
0.562TrpTyr: 0.562 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.939TyrAla: 2.939 ± 0.041
0.31TyrCys: 0.31 ± 0.013
2.718TyrAsp: 2.718 ± 0.05
2.494TyrGlu: 2.494 ± 0.04
2.297TyrPhe: 2.297 ± 0.045
3.135TyrGly: 3.135 ± 0.053
0.946TyrHis: 0.946 ± 0.026
2.833TyrIle: 2.833 ± 0.047
2.522TyrLys: 2.522 ± 0.043
3.808TyrLeu: 3.808 ± 0.048
0.908TyrMet: 0.908 ± 0.024
2.418TyrAsn: 2.418 ± 0.044
1.88TyrPro: 1.88 ± 0.033
1.459TyrGln: 1.459 ± 0.034
2.44TyrArg: 2.44 ± 0.045
2.493TyrSer: 2.493 ± 0.046
2.906TyrThr: 2.906 ± 0.055
2.3TyrVal: 2.3 ± 0.043
0.55TyrTrp: 0.55 ± 0.02
2.077TyrTyr: 2.077 ± 0.042
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.001XaaPro: 0.001 ± 0.001
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.002XaaXaa: 0.002 ± 0.002
Statistics based on 4212 proteins (1479298 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski