Amino acid dipepetide frequency for Streptococcus satellite phage Javan293

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.052AlaAla: 1.052 ± 0.547
0.263AlaCys: 0.263 ± 0.216
5.783AlaAsp: 5.783 ± 1.581
4.469AlaGlu: 4.469 ± 0.883
4.206AlaPhe: 4.206 ± 0.928
4.206AlaGly: 4.206 ± 1.197
0.526AlaHis: 0.526 ± 0.328
6.835AlaIle: 6.835 ± 1.271
7.361AlaLys: 7.361 ± 1.021
4.732AlaLeu: 4.732 ± 1.181
2.366AlaMet: 2.366 ± 0.923
3.155AlaAsn: 3.155 ± 0.815
1.84AlaPro: 1.84 ± 0.561
2.629AlaGln: 2.629 ± 0.661
4.732AlaArg: 4.732 ± 1.231
3.417AlaSer: 3.417 ± 0.639
3.68AlaThr: 3.68 ± 0.756
4.995AlaVal: 4.995 ± 0.87
0.263AlaTrp: 0.263 ± 0.216
2.892AlaTyr: 2.892 ± 0.939
0.0AlaXaa: 0.0 ± 0.0
Cys
0.263CysAla: 0.263 ± 0.251
0.0CysCys: 0.0 ± 0.0
0.263CysAsp: 0.263 ± 0.228
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.526CysGly: 0.526 ± 0.268
0.526CysHis: 0.526 ± 0.293
0.263CysIle: 0.263 ± 0.299
0.526CysLys: 0.526 ± 0.456
0.263CysLeu: 0.263 ± 0.251
0.263CysMet: 0.263 ± 0.223
0.0CysAsn: 0.0 ± 0.0
0.526CysPro: 0.526 ± 0.268
0.0CysGln: 0.0 ± 0.0
0.263CysArg: 0.263 ± 0.229
0.263CysSer: 0.263 ± 0.227
0.0CysThr: 0.0 ± 0.0
0.263CysVal: 0.263 ± 0.216
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
1.84AspAla: 1.84 ± 0.673
0.526AspCys: 0.526 ± 0.339
3.417AspAsp: 3.417 ± 0.876
4.469AspGlu: 4.469 ± 1.258
3.943AspPhe: 3.943 ± 0.768
2.366AspGly: 2.366 ± 0.667
0.526AspHis: 0.526 ± 0.268
5.521AspIle: 5.521 ± 1.204
7.361AspLys: 7.361 ± 1.212
4.469AspLeu: 4.469 ± 1.301
2.103AspMet: 2.103 ± 0.688
3.417AspAsn: 3.417 ± 0.747
1.314AspPro: 1.314 ± 0.565
0.789AspGln: 0.789 ± 0.632
2.629AspArg: 2.629 ± 0.993
0.789AspSer: 0.789 ± 0.289
4.469AspThr: 4.469 ± 0.862
3.68AspVal: 3.68 ± 0.759
1.052AspTrp: 1.052 ± 0.461
3.68AspTyr: 3.68 ± 0.822
0.0AspXaa: 0.0 ± 0.0
Glu
6.046GluAla: 6.046 ± 1.589
0.263GluCys: 0.263 ± 0.228
3.417GluAsp: 3.417 ± 0.995
3.155GluGlu: 3.155 ± 1.165
2.366GluPhe: 2.366 ± 0.674
1.84GluGly: 1.84 ± 0.716
0.789GluHis: 0.789 ± 0.406
4.732GluIle: 4.732 ± 0.655
8.412GluLys: 8.412 ± 1.293
10.252GluLeu: 10.252 ± 0.863
1.84GluMet: 1.84 ± 0.641
4.732GluAsn: 4.732 ± 1.119
2.366GluPro: 2.366 ± 0.844
6.309GluGln: 6.309 ± 1.303
6.835GluArg: 6.835 ± 1.609
3.417GluSer: 3.417 ± 1.128
5.521GluThr: 5.521 ± 1.022
5.258GluVal: 5.258 ± 0.923
0.0GluTrp: 0.0 ± 0.0
2.103GluTyr: 2.103 ± 0.681
0.0GluXaa: 0.0 ± 0.0
Phe
1.577PheAla: 1.577 ± 0.498
0.0PheCys: 0.0 ± 0.0
2.892PheAsp: 2.892 ± 0.909
3.68PheGlu: 3.68 ± 0.898
1.052PhePhe: 1.052 ± 0.484
2.629PheGly: 2.629 ± 0.711
1.052PheHis: 1.052 ± 0.446
2.892PheIle: 2.892 ± 0.837
4.995PheLys: 4.995 ± 0.956
5.521PheLeu: 5.521 ± 1.08
0.0PheMet: 0.0 ± 0.287
1.314PheAsn: 1.314 ± 0.576
1.314PhePro: 1.314 ± 0.622
1.052PheGln: 1.052 ± 0.719
1.577PheArg: 1.577 ± 0.604
4.206PheSer: 4.206 ± 0.851
1.314PheThr: 1.314 ± 0.592
1.577PheVal: 1.577 ± 0.844
0.0PheTrp: 0.0 ± 0.0
1.84PheTyr: 1.84 ± 0.611
0.0PheXaa: 0.0 ± 0.0
Gly
2.892GlyAla: 2.892 ± 0.919
0.526GlyCys: 0.526 ± 0.293
1.577GlyAsp: 1.577 ± 0.599
2.103GlyGlu: 2.103 ± 0.732
2.629GlyPhe: 2.629 ± 0.728
2.103GlyGly: 2.103 ± 0.706
1.314GlyHis: 1.314 ± 0.515
4.206GlyIle: 4.206 ± 0.998
4.469GlyLys: 4.469 ± 0.843
4.995GlyLeu: 4.995 ± 1.091
0.789GlyMet: 0.789 ± 0.461
1.84GlyAsn: 1.84 ± 1.013
0.0GlyPro: 0.0 ± 0.0
2.366GlyGln: 2.366 ± 0.64
3.417GlyArg: 3.417 ± 0.946
2.629GlySer: 2.629 ± 0.824
2.366GlyThr: 2.366 ± 0.818
1.84GlyVal: 1.84 ± 0.737
0.789GlyTrp: 0.789 ± 0.494
3.417GlyTyr: 3.417 ± 0.768
0.0GlyXaa: 0.0 ± 0.0
His
1.314HisAla: 1.314 ± 0.77
0.263HisCys: 0.263 ± 0.216
0.526HisAsp: 0.526 ± 0.385
1.314HisGlu: 1.314 ± 0.404
1.577HisPhe: 1.577 ± 0.768
1.577HisGly: 1.577 ± 0.599
0.263HisHis: 0.263 ± 0.227
1.84HisIle: 1.84 ± 0.554
1.052HisLys: 1.052 ± 0.678
3.417HisLeu: 3.417 ± 0.909
0.0HisMet: 0.0 ± 0.0
0.526HisAsn: 0.526 ± 0.402
1.052HisPro: 1.052 ± 0.507
0.526HisGln: 0.526 ± 0.322
1.314HisArg: 1.314 ± 0.54
0.789HisSer: 0.789 ± 0.437
1.314HisThr: 1.314 ± 0.495
1.052HisVal: 1.052 ± 0.477
0.263HisTrp: 0.263 ± 0.256
2.103HisTyr: 2.103 ± 0.602
0.0HisXaa: 0.0 ± 0.0
Ile
6.046IleAla: 6.046 ± 1.646
0.0IleCys: 0.0 ± 0.0
3.68IleAsp: 3.68 ± 0.874
6.835IleGlu: 6.835 ± 1.018
2.629IlePhe: 2.629 ± 0.804
2.366IleGly: 2.366 ± 0.822
1.577IleHis: 1.577 ± 0.624
6.572IleIle: 6.572 ± 1.451
4.995IleLys: 4.995 ± 1.412
6.835IleLeu: 6.835 ± 1.181
1.84IleMet: 1.84 ± 0.581
3.68IleAsn: 3.68 ± 1.021
2.366IlePro: 2.366 ± 0.689
2.892IleGln: 2.892 ± 0.786
3.417IleArg: 3.417 ± 0.733
3.68IleSer: 3.68 ± 1.198
4.732IleThr: 4.732 ± 1.283
4.995IleVal: 4.995 ± 0.875
0.526IleTrp: 0.526 ± 0.388
2.366IleTyr: 2.366 ± 0.575
0.0IleXaa: 0.0 ± 0.0
Lys
6.572LysAla: 6.572 ± 0.985
0.526LysCys: 0.526 ± 0.456
4.995LysAsp: 4.995 ± 0.953
9.201LysGlu: 9.201 ± 2.063
0.789LysPhe: 0.789 ± 0.43
4.206LysGly: 4.206 ± 1.273
1.314LysHis: 1.314 ± 0.458
6.835LysIle: 6.835 ± 1.342
8.412LysLys: 8.412 ± 1.331
7.624LysLeu: 7.624 ± 1.668
1.314LysMet: 1.314 ± 0.567
4.206LysAsn: 4.206 ± 0.784
3.417LysPro: 3.417 ± 1.008
4.469LysGln: 4.469 ± 1.061
3.943LysArg: 3.943 ± 1.297
5.258LysSer: 5.258 ± 1.006
5.521LysThr: 5.521 ± 1.069
4.995LysVal: 4.995 ± 1.087
0.526LysTrp: 0.526 ± 0.342
2.629LysTyr: 2.629 ± 0.707
0.0LysXaa: 0.0 ± 0.0
Leu
9.727LeuAla: 9.727 ± 1.76
0.0LeuCys: 0.0 ± 0.0
6.572LeuAsp: 6.572 ± 1.241
12.618LeuGlu: 12.618 ± 2.075
3.417LeuPhe: 3.417 ± 1.145
6.835LeuGly: 6.835 ± 1.561
1.577LeuHis: 1.577 ± 0.585
4.206LeuIle: 4.206 ± 1.303
6.835LeuLys: 6.835 ± 1.167
8.412LeuLeu: 8.412 ± 2.041
2.629LeuMet: 2.629 ± 0.822
4.469LeuAsn: 4.469 ± 1.218
4.995LeuPro: 4.995 ± 1.21
4.995LeuGln: 4.995 ± 1.0
3.943LeuArg: 3.943 ± 0.999
4.206LeuSer: 4.206 ± 1.357
5.783LeuThr: 5.783 ± 1.096
4.995LeuVal: 4.995 ± 1.0
1.314LeuTrp: 1.314 ± 0.688
3.943LeuTyr: 3.943 ± 0.872
0.0LeuXaa: 0.0 ± 0.0
Met
1.314MetAla: 1.314 ± 0.626
0.0MetCys: 0.0 ± 0.0
1.052MetAsp: 1.052 ± 0.42
1.84MetGlu: 1.84 ± 0.543
1.314MetPhe: 1.314 ± 0.581
0.526MetGly: 0.526 ± 0.305
0.789MetHis: 0.789 ± 0.44
0.526MetIle: 0.526 ± 0.376
1.84MetLys: 1.84 ± 0.553
1.577MetLeu: 1.577 ± 0.669
0.263MetMet: 0.263 ± 0.284
1.84MetAsn: 1.84 ± 0.654
0.263MetPro: 0.263 ± 0.259
0.526MetGln: 0.526 ± 0.415
0.526MetArg: 0.526 ± 0.393
0.789MetSer: 0.789 ± 0.498
2.629MetThr: 2.629 ± 0.806
2.366MetVal: 2.366 ± 0.803
0.0MetTrp: 0.0 ± 0.0
0.263MetTyr: 0.263 ± 0.291
0.0MetXaa: 0.0 ± 0.0
Asn
4.469AsnAla: 4.469 ± 1.013
0.263AsnCys: 0.263 ± 0.251
3.68AsnAsp: 3.68 ± 0.993
2.103AsnGlu: 2.103 ± 0.627
2.892AsnPhe: 2.892 ± 0.695
3.155AsnGly: 3.155 ± 0.921
2.103AsnHis: 2.103 ± 0.646
4.206AsnIle: 4.206 ± 1.064
3.417AsnLys: 3.417 ± 1.536
4.995AsnLeu: 4.995 ± 1.294
0.789AsnMet: 0.789 ± 0.392
1.84AsnAsn: 1.84 ± 0.655
1.84AsnPro: 1.84 ± 0.442
2.366AsnGln: 2.366 ± 0.537
1.84AsnArg: 1.84 ± 0.617
2.103AsnSer: 2.103 ± 0.512
3.155AsnThr: 3.155 ± 1.023
2.103AsnVal: 2.103 ± 0.762
0.789AsnTrp: 0.789 ± 0.34
1.577AsnTyr: 1.577 ± 0.626
0.0AsnXaa: 0.0 ± 0.0
Pro
1.577ProAla: 1.577 ± 0.68
0.0ProCys: 0.0 ± 0.0
2.103ProAsp: 2.103 ± 0.785
3.155ProGlu: 3.155 ± 0.928
1.314ProPhe: 1.314 ± 0.633
1.052ProGly: 1.052 ± 0.459
1.314ProHis: 1.314 ± 0.412
3.155ProIle: 3.155 ± 0.759
1.84ProLys: 1.84 ± 0.679
2.629ProLeu: 2.629 ± 0.882
0.789ProMet: 0.789 ± 0.369
0.789ProAsn: 0.789 ± 0.419
1.84ProPro: 1.84 ± 0.698
0.789ProGln: 0.789 ± 0.533
1.84ProArg: 1.84 ± 0.623
1.577ProSer: 1.577 ± 0.44
1.577ProThr: 1.577 ± 0.591
2.103ProVal: 2.103 ± 0.912
0.789ProTrp: 0.789 ± 0.368
2.366ProTyr: 2.366 ± 0.634
0.0ProXaa: 0.0 ± 0.0
Gln
4.732GlnAla: 4.732 ± 1.468
0.263GlnCys: 0.263 ± 0.216
3.68GlnAsp: 3.68 ± 0.684
3.943GlnGlu: 3.943 ± 0.915
0.789GlnPhe: 0.789 ± 0.468
2.366GlnGly: 2.366 ± 0.827
1.314GlnHis: 1.314 ± 0.483
2.629GlnIle: 2.629 ± 0.676
2.629GlnLys: 2.629 ± 0.84
6.309GlnLeu: 6.309 ± 1.377
0.789GlnMet: 0.789 ± 0.388
2.629GlnAsn: 2.629 ± 0.849
1.314GlnPro: 1.314 ± 0.642
1.84GlnGln: 1.84 ± 0.681
2.366GlnArg: 2.366 ± 0.89
2.103GlnSer: 2.103 ± 0.761
1.84GlnThr: 1.84 ± 0.52
2.366GlnVal: 2.366 ± 0.802
0.263GlnTrp: 0.263 ± 0.291
2.103GlnTyr: 2.103 ± 0.752
0.0GlnXaa: 0.0 ± 0.0
Arg
3.68ArgAla: 3.68 ± 1.05
0.526ArgCys: 0.526 ± 0.361
2.103ArgAsp: 2.103 ± 0.705
2.892ArgGlu: 2.892 ± 0.964
2.892ArgPhe: 2.892 ± 0.759
0.789ArgGly: 0.789 ± 0.413
1.84ArgHis: 1.84 ± 0.553
3.155ArgIle: 3.155 ± 0.885
4.995ArgLys: 4.995 ± 1.202
8.149ArgLeu: 8.149 ± 1.191
0.789ArgMet: 0.789 ± 0.324
2.366ArgAsn: 2.366 ± 0.968
0.789ArgPro: 0.789 ± 0.376
3.943ArgGln: 3.943 ± 1.448
2.629ArgArg: 2.629 ± 0.803
1.314ArgSer: 1.314 ± 0.568
3.155ArgThr: 3.155 ± 0.785
1.84ArgVal: 1.84 ± 0.617
1.052ArgTrp: 1.052 ± 0.518
2.629ArgTyr: 2.629 ± 0.767
0.0ArgXaa: 0.0 ± 0.0
Ser
4.206SerAla: 4.206 ± 0.74
0.263SerCys: 0.263 ± 0.228
4.732SerAsp: 4.732 ± 1.309
2.629SerGlu: 2.629 ± 0.836
1.577SerPhe: 1.577 ± 0.726
1.84SerGly: 1.84 ± 0.924
1.577SerHis: 1.577 ± 0.564
4.469SerIle: 4.469 ± 1.315
4.469SerLys: 4.469 ± 1.025
4.206SerLeu: 4.206 ± 1.313
0.526SerMet: 0.526 ± 0.323
1.577SerAsn: 1.577 ± 0.514
1.577SerPro: 1.577 ± 0.52
2.103SerGln: 2.103 ± 0.915
2.103SerArg: 2.103 ± 0.794
2.103SerSer: 2.103 ± 0.538
2.366SerThr: 2.366 ± 0.626
3.155SerVal: 3.155 ± 0.949
0.526SerTrp: 0.526 ± 0.353
4.206SerTyr: 4.206 ± 1.121
0.0SerXaa: 0.0 ± 0.0
Thr
4.469ThrAla: 4.469 ± 1.025
0.0ThrCys: 0.0 ± 0.0
2.103ThrAsp: 2.103 ± 0.696
6.309ThrGlu: 6.309 ± 1.659
1.84ThrPhe: 1.84 ± 0.588
3.943ThrGly: 3.943 ± 1.212
1.577ThrHis: 1.577 ± 0.454
3.943ThrIle: 3.943 ± 0.937
3.417ThrLys: 3.417 ± 0.843
4.732ThrLeu: 4.732 ± 1.697
0.526ThrMet: 0.526 ± 0.321
4.995ThrAsn: 4.995 ± 1.478
2.103ThrPro: 2.103 ± 0.618
2.892ThrGln: 2.892 ± 0.673
1.84ThrArg: 1.84 ± 0.679
4.206ThrSer: 4.206 ± 0.745
3.417ThrThr: 3.417 ± 0.91
4.206ThrVal: 4.206 ± 0.957
0.0ThrTrp: 0.0 ± 0.0
2.366ThrTyr: 2.366 ± 0.755
0.0ThrXaa: 0.0 ± 0.0
Val
4.995ValAla: 4.995 ± 1.185
0.263ValCys: 0.263 ± 0.251
2.892ValAsp: 2.892 ± 0.82
4.206ValGlu: 4.206 ± 1.253
1.84ValPhe: 1.84 ± 0.75
1.052ValGly: 1.052 ± 0.494
0.526ValHis: 0.526 ± 0.37
3.68ValIle: 3.68 ± 0.757
3.943ValLys: 3.943 ± 0.904
6.309ValLeu: 6.309 ± 1.072
1.84ValMet: 1.84 ± 0.686
3.68ValAsn: 3.68 ± 0.867
1.314ValPro: 1.314 ± 0.511
3.155ValGln: 3.155 ± 0.912
2.892ValArg: 2.892 ± 0.869
3.943ValSer: 3.943 ± 0.899
3.155ValThr: 3.155 ± 0.915
1.84ValVal: 1.84 ± 0.737
0.0ValTrp: 0.0 ± 0.0
3.155ValTyr: 3.155 ± 1.012
0.0ValXaa: 0.0 ± 0.0
Trp
0.526TrpAla: 0.526 ± 0.39
0.0TrpCys: 0.0 ± 0.0
1.052TrpAsp: 1.052 ± 0.464
1.052TrpGlu: 1.052 ± 0.447
0.263TrpPhe: 0.263 ± 0.239
0.263TrpGly: 0.263 ± 0.216
0.0TrpHis: 0.0 ± 0.0
0.263TrpIle: 0.263 ± 0.256
1.052TrpLys: 1.052 ± 0.435
1.314TrpLeu: 1.314 ± 0.462
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.526TrpGln: 0.526 ± 0.354
0.526TrpArg: 0.526 ± 0.389
0.526TrpSer: 0.526 ± 0.293
0.263TrpThr: 0.263 ± 0.259
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.789TrpTyr: 0.789 ± 0.485
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.103TyrAla: 2.103 ± 0.58
0.263TyrCys: 0.263 ± 0.229
1.84TyrAsp: 1.84 ± 0.71
3.68TyrGlu: 3.68 ± 0.913
3.417TyrPhe: 3.417 ± 1.185
2.629TyrGly: 2.629 ± 0.912
1.577TyrHis: 1.577 ± 0.62
2.103TyrIle: 2.103 ± 0.869
4.732TyrLys: 4.732 ± 1.061
4.732TyrLeu: 4.732 ± 1.073
0.526TyrMet: 0.526 ± 0.376
2.629TyrAsn: 2.629 ± 0.912
2.366TyrPro: 2.366 ± 0.756
2.103TyrGln: 2.103 ± 0.572
2.892TyrArg: 2.892 ± 0.753
2.892TyrSer: 2.892 ± 0.76
2.629TyrThr: 2.629 ± 0.651
1.052TyrVal: 1.052 ± 0.433
0.263TyrTrp: 0.263 ± 0.228
2.366TyrTyr: 2.366 ± 0.682
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 22 proteins (3805 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski