Amino acid dipepetide frequency for Microcystis virus Ma-LMM01

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.711AlaAla: 6.711 ± 0.615
0.737AlaCys: 0.737 ± 0.161
3.903AlaAsp: 3.903 ± 0.317
3.624AlaGlu: 3.624 ± 0.27
2.39AlaPhe: 2.39 ± 0.201
5.357AlaGly: 5.357 ± 0.547
1.294AlaHis: 1.294 ± 0.159
5.476AlaIle: 5.476 ± 0.357
2.29AlaLys: 2.29 ± 0.278
7.965AlaLeu: 7.965 ± 0.433
1.593AlaMet: 1.593 ± 0.207
3.425AlaAsn: 3.425 ± 0.296
4.162AlaPro: 4.162 ± 0.356
2.489AlaGln: 2.489 ± 0.242
6.074AlaArg: 6.074 ± 0.388
5.078AlaSer: 5.078 ± 0.378
5.118AlaThr: 5.118 ± 0.412
5.038AlaVal: 5.038 ± 0.338
1.115AlaTrp: 1.115 ± 0.17
3.027AlaTyr: 3.027 ± 0.278
0.0AlaXaa: 0.0 ± 0.0
Cys
0.657CysAla: 0.657 ± 0.155
0.139CysCys: 0.139 ± 0.053
0.697CysAsp: 0.697 ± 0.139
0.398CysGlu: 0.398 ± 0.108
0.279CysPhe: 0.279 ± 0.072
0.737CysGly: 0.737 ± 0.153
0.299CysHis: 0.299 ± 0.088
0.458CysIle: 0.458 ± 0.105
0.259CysLys: 0.259 ± 0.086
0.876CysLeu: 0.876 ± 0.167
0.299CysMet: 0.299 ± 0.082
0.458CysAsn: 0.458 ± 0.101
0.657CysPro: 0.657 ± 0.16
0.378CysGln: 0.378 ± 0.098
0.697CysArg: 0.697 ± 0.143
0.677CysSer: 0.677 ± 0.157
0.478CysThr: 0.478 ± 0.091
0.518CysVal: 0.518 ± 0.122
0.159CysTrp: 0.159 ± 0.057
0.438CysTyr: 0.438 ± 0.121
0.0CysXaa: 0.0 ± 0.0
Asp
4.182AspAla: 4.182 ± 0.271
0.577AspCys: 0.577 ± 0.119
3.166AspAsp: 3.166 ± 0.335
3.266AspGlu: 3.266 ± 0.238
1.593AspPhe: 1.593 ± 0.145
3.883AspGly: 3.883 ± 0.289
0.597AspHis: 0.597 ± 0.129
5.058AspIle: 5.058 ± 0.274
3.385AspLys: 3.385 ± 0.308
5.317AspLeu: 5.317 ± 0.376
1.732AspMet: 1.732 ± 0.223
3.206AspAsn: 3.206 ± 0.235
2.509AspPro: 2.509 ± 0.229
1.215AspGln: 1.215 ± 0.167
2.629AspArg: 2.629 ± 0.336
4.52AspSer: 4.52 ± 0.346
3.803AspThr: 3.803 ± 0.327
3.286AspVal: 3.286 ± 0.253
1.175AspTrp: 1.175 ± 0.19
2.967AspTyr: 2.967 ± 0.261
0.0AspXaa: 0.0 ± 0.0
Glu
4.48GluAla: 4.48 ± 0.33
0.637GluCys: 0.637 ± 0.119
3.684GluAsp: 3.684 ± 0.354
3.784GluGlu: 3.784 ± 0.373
1.912GluPhe: 1.912 ± 0.205
3.883GluGly: 3.883 ± 0.278
0.856GluHis: 0.856 ± 0.143
3.664GluIle: 3.664 ± 0.369
1.513GluLys: 1.513 ± 0.218
6.452GluLeu: 6.452 ± 0.444
1.274GluMet: 1.274 ± 0.156
2.071GluAsn: 2.071 ± 0.245
2.051GluPro: 2.051 ± 0.214
1.951GluGln: 1.951 ± 0.247
3.644GluArg: 3.644 ± 0.349
3.405GluSer: 3.405 ± 0.233
2.589GluThr: 2.589 ± 0.217
3.983GluVal: 3.983 ± 0.362
1.115GluTrp: 1.115 ± 0.191
2.409GluTyr: 2.409 ± 0.209
0.0GluXaa: 0.0 ± 0.0
Phe
1.593PheAla: 1.593 ± 0.191
0.378PheCys: 0.378 ± 0.089
1.752PheAsp: 1.752 ± 0.191
1.653PheGlu: 1.653 ± 0.168
1.175PhePhe: 1.175 ± 0.161
1.732PheGly: 1.732 ± 0.218
0.697PheHis: 0.697 ± 0.119
2.21PheIle: 2.21 ± 0.182
1.334PheLys: 1.334 ± 0.161
2.808PheLeu: 2.808 ± 0.227
0.876PheMet: 0.876 ± 0.15
2.27PheAsn: 2.27 ± 0.22
0.976PhePro: 0.976 ± 0.135
1.215PheGln: 1.215 ± 0.171
1.593PheArg: 1.593 ± 0.157
2.171PheSer: 2.171 ± 0.216
2.21PheThr: 2.21 ± 0.222
1.454PheVal: 1.454 ± 0.213
0.259PheTrp: 0.259 ± 0.083
2.35PheTyr: 2.35 ± 0.279
0.0PheXaa: 0.0 ± 0.0
Gly
5.576GlyAla: 5.576 ± 0.539
0.538GlyCys: 0.538 ± 0.134
4.202GlyAsp: 4.202 ± 0.342
3.326GlyGlu: 3.326 ± 0.266
2.071GlyPhe: 2.071 ± 0.191
4.839GlyGly: 4.839 ± 0.381
0.876GlyHis: 0.876 ± 0.153
4.7GlyIle: 4.7 ± 0.343
2.569GlyLys: 2.569 ± 0.326
6.751GlyLeu: 6.751 ± 0.367
1.693GlyMet: 1.693 ± 0.249
3.385GlyAsn: 3.385 ± 0.279
3.007GlyPro: 3.007 ± 0.266
2.31GlyGln: 2.31 ± 0.252
4.48GlyArg: 4.48 ± 0.285
4.958GlySer: 4.958 ± 0.448
4.6GlyThr: 4.6 ± 0.413
4.301GlyVal: 4.301 ± 0.339
0.836GlyTrp: 0.836 ± 0.149
3.166GlyTyr: 3.166 ± 0.244
0.0GlyXaa: 0.0 ± 0.0
His
1.215HisAla: 1.215 ± 0.169
0.239HisCys: 0.239 ± 0.071
0.777HisAsp: 0.777 ± 0.13
0.797HisGlu: 0.797 ± 0.135
0.478HisPhe: 0.478 ± 0.104
1.075HisGly: 1.075 ± 0.163
0.339HisHis: 0.339 ± 0.106
1.414HisIle: 1.414 ± 0.213
0.797HisLys: 0.797 ± 0.145
1.653HisLeu: 1.653 ± 0.234
0.458HisMet: 0.458 ± 0.11
0.836HisAsn: 0.836 ± 0.132
0.617HisPro: 0.617 ± 0.117
0.418HisGln: 0.418 ± 0.114
0.976HisArg: 0.976 ± 0.139
0.936HisSer: 0.936 ± 0.158
1.055HisThr: 1.055 ± 0.16
1.195HisVal: 1.195 ± 0.188
0.259HisTrp: 0.259 ± 0.077
1.095HisTyr: 1.095 ± 0.162
0.0HisXaa: 0.0 ± 0.0
Ile
4.998IleAla: 4.998 ± 0.31
0.498IleCys: 0.498 ± 0.113
5.018IleAsp: 5.018 ± 0.399
4.938IleGlu: 4.938 ± 0.406
1.374IlePhe: 1.374 ± 0.13
4.242IleGly: 4.242 ± 0.345
1.274IleHis: 1.274 ± 0.211
4.779IleIle: 4.779 ± 0.432
2.589IleLys: 2.589 ± 0.27
5.317IleLeu: 5.317 ± 0.404
1.414IleMet: 1.414 ± 0.174
5.237IleAsn: 5.237 ± 0.304
3.445IlePro: 3.445 ± 0.277
2.629IleGln: 2.629 ± 0.245
4.142IleArg: 4.142 ± 0.317
4.958IleSer: 4.958 ± 0.326
5.098IleThr: 5.098 ± 0.32
4.341IleVal: 4.341 ± 0.325
0.538IleTrp: 0.538 ± 0.115
2.469IleTyr: 2.469 ± 0.276
0.0IleXaa: 0.0 ± 0.0
Lys
2.947LysAla: 2.947 ± 0.338
0.358LysCys: 0.358 ± 0.092
2.111LysAsp: 2.111 ± 0.241
2.509LysGlu: 2.509 ± 0.22
1.235LysPhe: 1.235 ± 0.162
2.409LysGly: 2.409 ± 0.327
0.816LysHis: 0.816 ± 0.138
2.21LysIle: 2.21 ± 0.192
1.892LysLys: 1.892 ± 0.372
3.983LysLeu: 3.983 ± 0.334
0.956LysMet: 0.956 ± 0.131
1.553LysAsn: 1.553 ± 0.197
1.792LysPro: 1.792 ± 0.219
1.633LysGln: 1.633 ± 0.21
2.29LysArg: 2.29 ± 0.265
2.31LysSer: 2.31 ± 0.265
2.409LysThr: 2.409 ± 0.24
2.549LysVal: 2.549 ± 0.248
0.498LysTrp: 0.498 ± 0.101
1.255LysTyr: 1.255 ± 0.202
0.0LysXaa: 0.0 ± 0.0
Leu
7.886LeuAla: 7.886 ± 0.393
1.035LeuCys: 1.035 ± 0.178
6.631LeuAsp: 6.631 ± 0.38
6.611LeuGlu: 6.611 ± 0.514
3.007LeuPhe: 3.007 ± 0.234
6.412LeuGly: 6.412 ± 0.491
1.394LeuHis: 1.394 ± 0.171
6.233LeuIle: 6.233 ± 0.405
3.345LeuLys: 3.345 ± 0.362
10.016LeuLeu: 10.016 ± 0.583
2.25LeuMet: 2.25 ± 0.241
4.56LeuAsn: 4.56 ± 0.37
5.018LeuPro: 5.018 ± 0.397
3.545LeuGln: 3.545 ± 0.338
5.158LeuArg: 5.158 ± 0.289
7.686LeuSer: 7.686 ± 0.426
6.133LeuThr: 6.133 ± 0.348
6.492LeuVal: 6.492 ± 0.359
0.976LeuTrp: 0.976 ± 0.15
4.242LeuTyr: 4.242 ± 0.324
0.0LeuXaa: 0.0 ± 0.0
Met
2.031MetAla: 2.031 ± 0.306
0.199MetCys: 0.199 ± 0.057
1.175MetAsp: 1.175 ± 0.167
1.235MetGlu: 1.235 ± 0.178
0.617MetPhe: 0.617 ± 0.094
2.19MetGly: 2.19 ± 0.298
0.438MetHis: 0.438 ± 0.093
1.115MetIle: 1.115 ± 0.163
1.155MetLys: 1.155 ± 0.164
1.971MetLeu: 1.971 ± 0.202
0.617MetMet: 0.617 ± 0.121
1.035MetAsn: 1.035 ± 0.169
1.095MetPro: 1.095 ± 0.126
0.956MetGln: 0.956 ± 0.145
1.593MetArg: 1.593 ± 0.22
1.872MetSer: 1.872 ± 0.186
1.812MetThr: 1.812 ± 0.251
1.215MetVal: 1.215 ± 0.156
0.438MetTrp: 0.438 ± 0.128
0.697MetTyr: 0.697 ± 0.114
0.0MetXaa: 0.0 ± 0.0
Asn
3.126AsnAla: 3.126 ± 0.227
0.418AsnCys: 0.418 ± 0.109
2.37AsnAsp: 2.37 ± 0.256
2.171AsnGlu: 2.171 ± 0.178
1.493AsnPhe: 1.493 ± 0.2
3.226AsnGly: 3.226 ± 0.387
0.757AsnHis: 0.757 ± 0.142
3.425AsnIle: 3.425 ± 0.274
2.31AsnLys: 2.31 ± 0.209
5.018AsnLeu: 5.018 ± 0.31
1.334AsnMet: 1.334 ± 0.164
3.684AsnAsn: 3.684 ± 0.24
2.768AsnPro: 2.768 ± 0.197
1.991AsnGln: 1.991 ± 0.226
3.266AsnArg: 3.266 ± 0.298
3.664AsnSer: 3.664 ± 0.309
3.784AsnThr: 3.784 ± 0.354
3.246AsnVal: 3.246 ± 0.265
0.976AsnTrp: 0.976 ± 0.155
3.106AsnTyr: 3.106 ± 0.273
0.0AsnXaa: 0.0 ± 0.0
Pro
3.843ProAla: 3.843 ± 0.316
0.398ProCys: 0.398 ± 0.102
2.748ProAsp: 2.748 ± 0.219
2.529ProGlu: 2.529 ± 0.269
1.474ProPhe: 1.474 ± 0.174
3.485ProGly: 3.485 ± 0.303
1.016ProHis: 1.016 ± 0.17
4.022ProIle: 4.022 ± 0.336
1.135ProLys: 1.135 ± 0.182
5.058ProLeu: 5.058 ± 0.298
0.757ProMet: 0.757 ± 0.143
2.529ProAsn: 2.529 ± 0.281
2.609ProPro: 2.609 ± 0.289
1.474ProGln: 1.474 ± 0.185
2.648ProArg: 2.648 ± 0.234
2.907ProSer: 2.907 ± 0.231
3.704ProThr: 3.704 ± 0.327
3.067ProVal: 3.067 ± 0.275
0.398ProTrp: 0.398 ± 0.113
1.812ProTyr: 1.812 ± 0.244
0.0ProXaa: 0.0 ± 0.0
Gln
3.286GlnAla: 3.286 ± 0.218
0.339GlnCys: 0.339 ± 0.088
1.593GlnAsp: 1.593 ± 0.19
2.29GlnGlu: 2.29 ± 0.216
1.354GlnPhe: 1.354 ± 0.165
2.39GlnGly: 2.39 ± 0.22
0.757GlnHis: 0.757 ± 0.128
1.673GlnIle: 1.673 ± 0.197
1.075GlnLys: 1.075 ± 0.144
3.963GlnLeu: 3.963 ± 0.378
0.697GlnMet: 0.697 ± 0.123
1.195GlnAsn: 1.195 ± 0.164
1.235GlnPro: 1.235 ± 0.169
1.573GlnGln: 1.573 ± 0.171
2.449GlnArg: 2.449 ± 0.238
2.589GlnSer: 2.589 ± 0.249
1.533GlnThr: 1.533 ± 0.179
2.469GlnVal: 2.469 ± 0.231
0.677GlnTrp: 0.677 ± 0.117
1.354GlnTyr: 1.354 ± 0.14
0.0GlnXaa: 0.0 ± 0.0
Arg
5.735ArgAla: 5.735 ± 0.374
0.577ArgCys: 0.577 ± 0.123
3.505ArgAsp: 3.505 ± 0.382
3.306ArgGlu: 3.306 ± 0.249
2.171ArgPhe: 2.171 ± 0.225
4.222ArgGly: 4.222 ± 0.333
0.856ArgHis: 0.856 ± 0.15
3.764ArgIle: 3.764 ± 0.274
1.872ArgLys: 1.872 ± 0.228
7.527ArgLeu: 7.527 ± 0.377
1.374ArgMet: 1.374 ± 0.164
2.609ArgAsn: 2.609 ± 0.222
3.067ArgPro: 3.067 ± 0.232
2.409ArgGln: 2.409 ± 0.216
4.421ArgArg: 4.421 ± 0.429
3.843ArgSer: 3.843 ± 0.304
3.166ArgThr: 3.166 ± 0.253
4.739ArgVal: 4.739 ± 0.292
1.075ArgTrp: 1.075 ± 0.142
2.429ArgTyr: 2.429 ± 0.252
0.0ArgXaa: 0.0 ± 0.0
Ser
5.237SerAla: 5.237 ± 0.361
0.637SerCys: 0.637 ± 0.151
3.963SerAsp: 3.963 ± 0.282
2.967SerGlu: 2.967 ± 0.294
1.912SerPhe: 1.912 ± 0.262
5.138SerGly: 5.138 ± 0.333
1.115SerHis: 1.115 ± 0.149
5.715SerIle: 5.715 ± 0.491
3.166SerLys: 3.166 ± 0.284
6.97SerLeu: 6.97 ± 0.431
2.051SerMet: 2.051 ± 0.247
3.923SerAsn: 3.923 ± 0.289
3.365SerPro: 3.365 ± 0.267
2.011SerGln: 2.011 ± 0.208
4.6SerArg: 4.6 ± 0.441
5.337SerSer: 5.337 ± 0.382
4.819SerThr: 4.819 ± 0.308
4.62SerVal: 4.62 ± 0.339
0.876SerTrp: 0.876 ± 0.143
2.429SerTyr: 2.429 ± 0.202
0.0SerXaa: 0.0 ± 0.0
Thr
5.177ThrAla: 5.177 ± 0.373
0.577ThrCys: 0.577 ± 0.15
3.425ThrAsp: 3.425 ± 0.259
2.867ThrGlu: 2.867 ± 0.243
1.912ThrPhe: 1.912 ± 0.175
4.6ThrGly: 4.6 ± 0.371
1.075ThrHis: 1.075 ± 0.139
5.257ThrIle: 5.257 ± 0.395
2.171ThrLys: 2.171 ± 0.287
5.914ThrLeu: 5.914 ± 0.446
1.235ThrMet: 1.235 ± 0.173
3.505ThrAsn: 3.505 ± 0.259
3.764ThrPro: 3.764 ± 0.327
2.23ThrGln: 2.23 ± 0.261
4.142ThrArg: 4.142 ± 0.295
4.7ThrSer: 4.7 ± 0.337
5.377ThrThr: 5.377 ± 0.442
3.983ThrVal: 3.983 ± 0.358
1.155ThrTrp: 1.155 ± 0.163
2.808ThrTyr: 2.808 ± 0.261
0.0ThrXaa: 0.0 ± 0.0
Val
4.421ValAla: 4.421 ± 0.325
0.558ValCys: 0.558 ± 0.111
4.5ValAsp: 4.5 ± 0.317
4.142ValGlu: 4.142 ± 0.317
1.932ValPhe: 1.932 ± 0.201
4.779ValGly: 4.779 ± 0.36
0.996ValHis: 0.996 ± 0.17
4.919ValIle: 4.919 ± 0.362
2.39ValLys: 2.39 ± 0.268
5.596ValLeu: 5.596 ± 0.328
1.294ValMet: 1.294 ± 0.237
3.286ValAsn: 3.286 ± 0.298
3.067ValPro: 3.067 ± 0.27
1.752ValGln: 1.752 ± 0.189
3.764ValArg: 3.764 ± 0.254
5.158ValSer: 5.158 ± 0.358
4.122ValThr: 4.122 ± 0.337
4.958ValVal: 4.958 ± 0.499
0.597ValTrp: 0.597 ± 0.129
2.409ValTyr: 2.409 ± 0.215
0.0ValXaa: 0.0 ± 0.0
Trp
1.155TrpAla: 1.155 ± 0.142
0.06TrpCys: 0.06 ± 0.032
0.657TrpAsp: 0.657 ± 0.158
0.697TrpGlu: 0.697 ± 0.129
0.577TrpPhe: 0.577 ± 0.108
1.294TrpGly: 1.294 ± 0.187
0.239TrpHis: 0.239 ± 0.062
0.816TrpIle: 0.816 ± 0.156
0.498TrpLys: 0.498 ± 0.126
1.115TrpLeu: 1.115 ± 0.173
0.319TrpMet: 0.319 ± 0.067
0.617TrpAsn: 0.617 ± 0.102
0.597TrpPro: 0.597 ± 0.124
0.657TrpGln: 0.657 ± 0.114
0.916TrpArg: 0.916 ± 0.155
1.135TrpSer: 1.135 ± 0.149
0.697TrpThr: 0.697 ± 0.133
0.936TrpVal: 0.936 ± 0.168
0.179TrpTrp: 0.179 ± 0.057
0.637TrpTyr: 0.637 ± 0.113
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.609TyrAla: 2.609 ± 0.226
0.657TyrCys: 0.657 ± 0.142
2.19TyrAsp: 2.19 ± 0.224
2.25TyrGlu: 2.25 ± 0.228
1.752TyrPhe: 1.752 ± 0.218
2.29TyrGly: 2.29 ± 0.215
0.936TyrHis: 0.936 ± 0.155
2.39TyrIle: 2.39 ± 0.219
1.971TyrLys: 1.971 ± 0.197
4.361TyrLeu: 4.361 ± 0.386
1.215TyrMet: 1.215 ± 0.161
2.748TyrAsn: 2.748 ± 0.264
1.812TyrPro: 1.812 ± 0.199
1.653TyrGln: 1.653 ± 0.164
3.186TyrArg: 3.186 ± 0.227
2.967TyrSer: 2.967 ± 0.202
3.365TyrThr: 3.365 ± 0.298
2.25TyrVal: 2.25 ± 0.25
0.498TyrTrp: 0.498 ± 0.122
2.37TyrTyr: 2.37 ± 0.306
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 184 proteins (50219 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski