Amino acid dipepetide frequency for Xanthomonas phage vB_XveM_DIBBI

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.526AlaAla: 10.526 ± 1.025
0.933AlaCys: 0.933 ± 0.254
6.129AlaAsp: 6.129 ± 0.558
7.128AlaGlu: 7.128 ± 0.862
3.264AlaPhe: 3.264 ± 0.504
8.594AlaGly: 8.594 ± 0.634
1.332AlaHis: 1.332 ± 0.31
5.729AlaIle: 5.729 ± 0.611
5.196AlaLys: 5.196 ± 0.594
7.794AlaLeu: 7.794 ± 0.808
2.865AlaMet: 2.865 ± 0.406
3.731AlaAsn: 3.731 ± 0.625
2.398AlaPro: 2.398 ± 0.414
3.331AlaGln: 3.331 ± 0.428
4.597AlaArg: 4.597 ± 0.634
5.729AlaSer: 5.729 ± 0.723
4.597AlaThr: 4.597 ± 0.563
6.595AlaVal: 6.595 ± 0.692
1.466AlaTrp: 1.466 ± 0.391
3.131AlaTyr: 3.131 ± 0.491
0.0AlaXaa: 0.0 ± 0.0
Cys
0.733CysAla: 0.733 ± 0.209
0.2CysCys: 0.2 ± 0.116
0.2CysAsp: 0.2 ± 0.105
0.866CysGlu: 0.866 ± 0.314
0.4CysPhe: 0.4 ± 0.159
0.733CysGly: 0.733 ± 0.188
0.333CysHis: 0.333 ± 0.122
0.999CysIle: 0.999 ± 0.32
0.466CysLys: 0.466 ± 0.154
0.799CysLeu: 0.799 ± 0.189
0.2CysMet: 0.2 ± 0.098
0.4CysAsn: 0.4 ± 0.163
0.333CysPro: 0.333 ± 0.168
0.533CysGln: 0.533 ± 0.215
0.533CysArg: 0.533 ± 0.179
0.4CysSer: 0.4 ± 0.153
0.2CysThr: 0.2 ± 0.096
0.333CysVal: 0.333 ± 0.148
0.2CysTrp: 0.2 ± 0.108
0.4CysTyr: 0.4 ± 0.149
0.0CysXaa: 0.0 ± 0.0
Asp
6.595AspAla: 6.595 ± 0.679
0.933AspCys: 0.933 ± 0.273
4.597AspAsp: 4.597 ± 0.636
3.398AspGlu: 3.398 ± 0.45
2.332AspPhe: 2.332 ± 0.386
6.995AspGly: 6.995 ± 0.816
1.332AspHis: 1.332 ± 0.285
3.398AspIle: 3.398 ± 0.458
3.664AspLys: 3.664 ± 0.399
4.93AspLeu: 4.93 ± 0.724
1.532AspMet: 1.532 ± 0.287
2.065AspAsn: 2.065 ± 0.302
1.799AspPro: 1.799 ± 0.305
2.198AspGln: 2.198 ± 0.398
2.798AspArg: 2.798 ± 0.494
3.597AspSer: 3.597 ± 0.43
3.264AspThr: 3.264 ± 0.408
4.463AspVal: 4.463 ± 0.514
0.933AspTrp: 0.933 ± 0.218
2.132AspTyr: 2.132 ± 0.366
0.0AspXaa: 0.0 ± 0.0
Glu
5.663GluAla: 5.663 ± 0.645
0.533GluCys: 0.533 ± 0.14
2.798GluAsp: 2.798 ± 0.414
3.797GluGlu: 3.797 ± 0.567
2.731GluPhe: 2.731 ± 0.454
3.731GluGly: 3.731 ± 0.488
1.599GluHis: 1.599 ± 0.333
3.331GluIle: 3.331 ± 0.607
4.197GluLys: 4.197 ± 0.573
5.263GluLeu: 5.263 ± 0.668
2.132GluMet: 2.132 ± 0.306
2.198GluAsn: 2.198 ± 0.31
1.466GluPro: 1.466 ± 0.283
3.064GluGln: 3.064 ± 0.464
4.064GluArg: 4.064 ± 0.538
2.931GluSer: 2.931 ± 0.484
3.131GluThr: 3.131 ± 0.467
3.731GluVal: 3.731 ± 0.412
1.266GluTrp: 1.266 ± 0.24
2.332GluTyr: 2.332 ± 0.425
0.0GluXaa: 0.0 ± 0.0
Phe
3.264PheAla: 3.264 ± 0.429
0.733PheCys: 0.733 ± 0.235
3.264PheAsp: 3.264 ± 0.463
2.332PheGlu: 2.332 ± 0.392
1.199PhePhe: 1.199 ± 0.315
3.398PheGly: 3.398 ± 0.636
0.666PheHis: 0.666 ± 0.216
2.598PheIle: 2.598 ± 0.472
1.665PheLys: 1.665 ± 0.405
2.198PheLeu: 2.198 ± 0.416
1.066PheMet: 1.066 ± 0.221
2.132PheAsn: 2.132 ± 0.332
1.266PhePro: 1.266 ± 0.254
0.999PheGln: 0.999 ± 0.291
2.332PheArg: 2.332 ± 0.393
2.665PheSer: 2.665 ± 0.361
1.932PheThr: 1.932 ± 0.375
1.732PheVal: 1.732 ± 0.389
0.4PheTrp: 0.4 ± 0.169
1.066PheTyr: 1.066 ± 0.254
0.0PheXaa: 0.0 ± 0.0
Gly
6.862GlyAla: 6.862 ± 0.841
0.333GlyCys: 0.333 ± 0.173
4.73GlyAsp: 4.73 ± 0.627
4.53GlyGlu: 4.53 ± 0.6
2.731GlyPhe: 2.731 ± 0.49
6.395GlyGly: 6.395 ± 1.005
1.199GlyHis: 1.199 ± 0.305
4.863GlyIle: 4.863 ± 0.504
5.463GlyLys: 5.463 ± 0.678
4.93GlyLeu: 4.93 ± 0.674
2.598GlyMet: 2.598 ± 0.33
4.597GlyAsn: 4.597 ± 0.576
2.132GlyPro: 2.132 ± 0.336
3.398GlyGln: 3.398 ± 0.556
4.53GlyArg: 4.53 ± 0.457
5.796GlySer: 5.796 ± 0.672
3.93GlyThr: 3.93 ± 0.718
6.262GlyVal: 6.262 ± 0.543
0.999GlyTrp: 0.999 ± 0.231
3.198GlyTyr: 3.198 ± 0.458
0.0GlyXaa: 0.0 ± 0.0
His
2.132HisAla: 2.132 ± 0.431
0.2HisCys: 0.2 ± 0.126
1.332HisAsp: 1.332 ± 0.264
0.933HisGlu: 0.933 ± 0.279
0.666HisPhe: 0.666 ± 0.192
2.065HisGly: 2.065 ± 0.325
0.533HisHis: 0.533 ± 0.162
1.199HisIle: 1.199 ± 0.247
0.666HisLys: 0.666 ± 0.196
1.332HisLeu: 1.332 ± 0.317
0.133HisMet: 0.133 ± 0.09
1.133HisAsn: 1.133 ± 0.269
1.066HisPro: 1.066 ± 0.281
0.866HisGln: 0.866 ± 0.258
1.266HisArg: 1.266 ± 0.346
0.799HisSer: 0.799 ± 0.244
0.999HisThr: 0.999 ± 0.325
1.066HisVal: 1.066 ± 0.238
0.2HisTrp: 0.2 ± 0.118
1.133HisTyr: 1.133 ± 0.213
0.0HisXaa: 0.0 ± 0.0
Ile
6.662IleAla: 6.662 ± 0.677
0.4IleCys: 0.4 ± 0.189
4.197IleAsp: 4.197 ± 0.466
4.13IleGlu: 4.13 ± 0.415
2.065IlePhe: 2.065 ± 0.302
4.13IleGly: 4.13 ± 0.535
0.999IleHis: 0.999 ± 0.246
3.93IleIle: 3.93 ± 0.554
4.064IleLys: 4.064 ± 0.488
3.464IleLeu: 3.464 ± 0.498
1.532IleMet: 1.532 ± 0.295
2.665IleAsn: 2.665 ± 0.466
2.265IlePro: 2.265 ± 0.314
2.598IleGln: 2.598 ± 0.437
3.997IleArg: 3.997 ± 0.443
4.597IleSer: 4.597 ± 0.507
4.463IleThr: 4.463 ± 0.44
4.13IleVal: 4.13 ± 0.482
1.133IleTrp: 1.133 ± 0.234
1.799IleTyr: 1.799 ± 0.376
0.0IleXaa: 0.0 ± 0.0
Lys
6.395LysAla: 6.395 ± 0.596
0.533LysCys: 0.533 ± 0.181
3.531LysAsp: 3.531 ± 0.585
3.398LysGlu: 3.398 ± 0.562
2.132LysPhe: 2.132 ± 0.361
3.331LysGly: 3.331 ± 0.423
1.332LysHis: 1.332 ± 0.275
3.464LysIle: 3.464 ± 0.525
3.664LysLys: 3.664 ± 0.533
4.197LysLeu: 4.197 ± 0.526
2.798LysMet: 2.798 ± 0.423
2.132LysAsn: 2.132 ± 0.336
2.065LysPro: 2.065 ± 0.395
2.531LysGln: 2.531 ± 0.325
3.264LysArg: 3.264 ± 0.511
3.331LysSer: 3.331 ± 0.501
3.198LysThr: 3.198 ± 0.432
3.797LysVal: 3.797 ± 0.465
0.799LysTrp: 0.799 ± 0.248
1.665LysTyr: 1.665 ± 0.335
0.0LysXaa: 0.0 ± 0.0
Leu
6.795LeuAla: 6.795 ± 0.831
0.666LeuCys: 0.666 ± 0.192
4.397LeuAsp: 4.397 ± 0.491
3.997LeuGlu: 3.997 ± 0.506
2.265LeuPhe: 2.265 ± 0.387
4.397LeuGly: 4.397 ± 0.69
1.133LeuHis: 1.133 ± 0.305
4.863LeuIle: 4.863 ± 0.564
4.463LeuLys: 4.463 ± 0.571
4.397LeuLeu: 4.397 ± 0.577
2.065LeuMet: 2.065 ± 0.367
4.397LeuAsn: 4.397 ± 0.582
2.931LeuPro: 2.931 ± 0.468
2.531LeuGln: 2.531 ± 0.308
3.331LeuArg: 3.331 ± 0.41
6.195LeuSer: 6.195 ± 0.651
5.396LeuThr: 5.396 ± 0.478
5.13LeuVal: 5.13 ± 0.578
1.133LeuTrp: 1.133 ± 0.296
1.999LeuTyr: 1.999 ± 0.335
0.0LeuXaa: 0.0 ± 0.0
Met
3.331MetAla: 3.331 ± 0.468
0.133MetCys: 0.133 ± 0.092
1.532MetAsp: 1.532 ± 0.284
0.799MetGlu: 0.799 ± 0.24
0.799MetPhe: 0.799 ± 0.253
1.799MetGly: 1.799 ± 0.338
0.533MetHis: 0.533 ± 0.164
2.465MetIle: 2.465 ± 0.366
2.398MetLys: 2.398 ± 0.412
1.999MetLeu: 1.999 ± 0.325
0.666MetMet: 0.666 ± 0.188
1.133MetAsn: 1.133 ± 0.274
1.399MetPro: 1.399 ± 0.299
1.199MetGln: 1.199 ± 0.302
1.732MetArg: 1.732 ± 0.37
1.932MetSer: 1.932 ± 0.47
1.865MetThr: 1.865 ± 0.286
1.799MetVal: 1.799 ± 0.32
0.466MetTrp: 0.466 ± 0.146
0.6MetTyr: 0.6 ± 0.206
0.0MetXaa: 0.0 ± 0.0
Asn
4.663AsnAla: 4.663 ± 0.531
0.266AsnCys: 0.266 ± 0.161
2.598AsnAsp: 2.598 ± 0.406
2.665AsnGlu: 2.665 ± 0.48
2.065AsnPhe: 2.065 ± 0.376
3.864AsnGly: 3.864 ± 0.549
1.332AsnHis: 1.332 ± 0.271
3.198AsnIle: 3.198 ± 0.502
2.065AsnLys: 2.065 ± 0.423
3.797AsnLeu: 3.797 ± 0.497
1.266AsnMet: 1.266 ± 0.254
2.931AsnAsn: 2.931 ± 0.415
2.065AsnPro: 2.065 ± 0.301
1.932AsnGln: 1.932 ± 0.392
2.198AsnArg: 2.198 ± 0.405
2.531AsnSer: 2.531 ± 0.434
2.998AsnThr: 2.998 ± 0.443
3.198AsnVal: 3.198 ± 0.397
0.266AsnTrp: 0.266 ± 0.121
1.332AsnTyr: 1.332 ± 0.259
0.0AsnXaa: 0.0 ± 0.0
Pro
3.664ProAla: 3.664 ± 0.516
0.2ProCys: 0.2 ± 0.106
3.064ProAsp: 3.064 ± 0.467
2.465ProGlu: 2.465 ± 0.392
1.466ProPhe: 1.466 ± 0.294
3.198ProGly: 3.198 ± 0.461
0.333ProHis: 0.333 ± 0.135
2.398ProIle: 2.398 ± 0.418
1.599ProLys: 1.599 ± 0.311
1.932ProLeu: 1.932 ± 0.327
0.666ProMet: 0.666 ± 0.209
1.799ProAsn: 1.799 ± 0.356
1.199ProPro: 1.199 ± 0.248
1.199ProGln: 1.199 ± 0.35
1.399ProArg: 1.399 ± 0.255
1.799ProSer: 1.799 ± 0.349
1.732ProThr: 1.732 ± 0.3
3.464ProVal: 3.464 ± 0.449
0.4ProTrp: 0.4 ± 0.148
0.933ProTyr: 0.933 ± 0.202
0.0ProXaa: 0.0 ± 0.0
Gln
3.531GlnAla: 3.531 ± 0.441
0.333GlnCys: 0.333 ± 0.136
1.932GlnAsp: 1.932 ± 0.369
2.265GlnGlu: 2.265 ± 0.34
1.466GlnPhe: 1.466 ± 0.312
2.731GlnGly: 2.731 ± 0.434
1.133GlnHis: 1.133 ± 0.295
2.931GlnIle: 2.931 ± 0.427
1.665GlnLys: 1.665 ± 0.302
3.864GlnLeu: 3.864 ± 0.393
1.199GlnMet: 1.199 ± 0.254
1.732GlnAsn: 1.732 ± 0.322
1.133GlnPro: 1.133 ± 0.259
2.398GlnGln: 2.398 ± 0.408
3.331GlnArg: 3.331 ± 0.421
1.999GlnSer: 1.999 ± 0.349
2.531GlnThr: 2.531 ± 0.4
2.665GlnVal: 2.665 ± 0.402
0.466GlnTrp: 0.466 ± 0.16
1.199GlnTyr: 1.199 ± 0.294
0.0GlnXaa: 0.0 ± 0.0
Arg
4.93ArgAla: 4.93 ± 0.584
1.199ArgCys: 1.199 ± 0.355
2.865ArgAsp: 2.865 ± 0.339
2.798ArgGlu: 2.798 ± 0.484
2.731ArgPhe: 2.731 ± 0.456
3.398ArgGly: 3.398 ± 0.413
1.133ArgHis: 1.133 ± 0.342
3.864ArgIle: 3.864 ± 0.443
4.264ArgLys: 4.264 ± 0.541
4.463ArgLeu: 4.463 ± 0.618
1.665ArgMet: 1.665 ± 0.303
2.132ArgAsn: 2.132 ± 0.415
1.799ArgPro: 1.799 ± 0.303
2.798ArgGln: 2.798 ± 0.387
3.264ArgArg: 3.264 ± 0.439
3.464ArgSer: 3.464 ± 0.446
2.398ArgThr: 2.398 ± 0.336
4.663ArgVal: 4.663 ± 0.65
0.533ArgTrp: 0.533 ± 0.209
2.065ArgTyr: 2.065 ± 0.408
0.0ArgXaa: 0.0 ± 0.0
Ser
5.13SerAla: 5.13 ± 0.474
0.266SerCys: 0.266 ± 0.131
4.197SerAsp: 4.197 ± 0.54
4.13SerGlu: 4.13 ± 0.489
2.665SerPhe: 2.665 ± 0.399
6.062SerGly: 6.062 ± 0.598
1.266SerHis: 1.266 ± 0.275
3.464SerIle: 3.464 ± 0.494
2.798SerLys: 2.798 ± 0.401
5.13SerLeu: 5.13 ± 0.539
1.799SerMet: 1.799 ± 0.296
3.198SerAsn: 3.198 ± 0.389
2.265SerPro: 2.265 ± 0.389
2.865SerGln: 2.865 ± 0.42
3.731SerArg: 3.731 ± 0.463
2.465SerSer: 2.465 ± 0.409
3.264SerThr: 3.264 ± 0.522
4.463SerVal: 4.463 ± 0.601
0.666SerTrp: 0.666 ± 0.199
2.065SerTyr: 2.065 ± 0.312
0.0SerXaa: 0.0 ± 0.0
Thr
5.663ThrAla: 5.663 ± 0.722
0.466ThrCys: 0.466 ± 0.151
4.13ThrAsp: 4.13 ± 0.487
3.131ThrGlu: 3.131 ± 0.421
1.799ThrPhe: 1.799 ± 0.334
6.329ThrGly: 6.329 ± 0.67
1.266ThrHis: 1.266 ± 0.277
3.997ThrIle: 3.997 ± 0.45
3.064ThrLys: 3.064 ± 0.429
4.33ThrLeu: 4.33 ± 0.488
1.399ThrMet: 1.399 ± 0.322
2.265ThrAsn: 2.265 ± 0.408
2.731ThrPro: 2.731 ± 0.475
1.932ThrGln: 1.932 ± 0.402
2.665ThrArg: 2.665 ± 0.373
3.064ThrSer: 3.064 ± 0.449
3.731ThrThr: 3.731 ± 0.545
3.864ThrVal: 3.864 ± 0.468
0.6ThrTrp: 0.6 ± 0.181
1.999ThrTyr: 1.999 ± 0.291
0.0ThrXaa: 0.0 ± 0.0
Val
5.13ValAla: 5.13 ± 0.606
0.733ValCys: 0.733 ± 0.213
4.53ValAsp: 4.53 ± 0.442
4.13ValGlu: 4.13 ± 0.515
2.398ValPhe: 2.398 ± 0.32
4.53ValGly: 4.53 ± 0.482
0.933ValHis: 0.933 ± 0.252
4.73ValIle: 4.73 ± 0.535
4.13ValLys: 4.13 ± 0.534
3.997ValLeu: 3.997 ± 0.438
1.732ValMet: 1.732 ± 0.383
4.463ValAsn: 4.463 ± 0.559
2.665ValPro: 2.665 ± 0.382
1.799ValGln: 1.799 ± 0.339
3.464ValArg: 3.464 ± 0.407
5.729ValSer: 5.729 ± 0.688
5.396ValThr: 5.396 ± 0.697
4.397ValVal: 4.397 ± 0.485
1.133ValTrp: 1.133 ± 0.298
2.798ValTyr: 2.798 ± 0.419
0.0ValXaa: 0.0 ± 0.0
Trp
1.332TrpAla: 1.332 ± 0.366
0.067TrpCys: 0.067 ± 0.067
1.199TrpAsp: 1.199 ± 0.24
0.733TrpGlu: 0.733 ± 0.224
0.333TrpPhe: 0.333 ± 0.158
0.666TrpGly: 0.666 ± 0.216
0.533TrpHis: 0.533 ± 0.16
0.733TrpIle: 0.733 ± 0.188
0.933TrpLys: 0.933 ± 0.226
1.266TrpLeu: 1.266 ± 0.307
0.2TrpMet: 0.2 ± 0.101
0.6TrpAsn: 0.6 ± 0.177
0.4TrpPro: 0.4 ± 0.18
0.666TrpGln: 0.666 ± 0.223
1.399TrpArg: 1.399 ± 0.284
0.533TrpSer: 0.533 ± 0.24
0.866TrpThr: 0.866 ± 0.258
0.866TrpVal: 0.866 ± 0.257
0.067TrpTrp: 0.067 ± 0.063
0.2TrpTyr: 0.2 ± 0.123
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.132TyrAla: 2.132 ± 0.356
0.133TyrCys: 0.133 ± 0.093
1.732TyrAsp: 1.732 ± 0.32
2.332TyrGlu: 2.332 ± 0.368
1.399TyrPhe: 1.399 ± 0.3
3.131TyrGly: 3.131 ± 0.507
0.799TyrHis: 0.799 ± 0.213
1.066TyrIle: 1.066 ± 0.199
1.133TyrLys: 1.133 ± 0.273
2.398TyrLeu: 2.398 ± 0.397
0.999TyrMet: 0.999 ± 0.247
1.532TyrAsn: 1.532 ± 0.296
1.532TyrPro: 1.532 ± 0.386
1.665TyrGln: 1.665 ± 0.28
2.531TyrArg: 2.531 ± 0.479
2.332TyrSer: 2.332 ± 0.368
2.531TyrThr: 2.531 ± 0.343
2.198TyrVal: 2.198 ± 0.426
0.466TyrTrp: 0.466 ± 0.177
0.999TyrTyr: 0.999 ± 0.282
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 81 proteins (15012 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski