Amino acid dipepetide frequency for Avian infectious bursal disease virus (isolate Chicken/UK/UK661/1989) (IBDV) (Gumboro disease virus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.337AlaAla: 8.337 ± 2.37
0.49AlaCys: 0.49 ± 0.367
3.433AlaAsp: 3.433 ± 0.828
3.923AlaGlu: 3.923 ± 1.354
2.452AlaPhe: 2.452 ± 0.622
6.376AlaGly: 6.376 ± 2.059
3.433AlaHis: 3.433 ± 1.38
2.452AlaIle: 2.452 ± 1.069
3.433AlaLys: 3.433 ± 0.922
8.337AlaLeu: 8.337 ± 2.048
4.904AlaMet: 4.904 ± 1.243
4.414AlaAsn: 4.414 ± 2.528
4.414AlaPro: 4.414 ± 0.703
2.943AlaGln: 2.943 ± 0.696
3.433AlaArg: 3.433 ± 0.789
6.866AlaSer: 6.866 ± 1.352
8.337AlaThr: 8.337 ± 1.948
5.885AlaVal: 5.885 ± 1.766
0.49AlaTrp: 0.49 ± 0.367
3.433AlaTyr: 3.433 ± 0.922
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.49CysCys: 0.49 ± 0.367
0.49CysAsp: 0.49 ± 0.333
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
1.471CysGly: 1.471 ± 2.841
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.49CysLys: 0.49 ± 0.367
0.981CysLeu: 0.981 ± 1.406
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.981CysPro: 0.981 ± 1.406
0.0CysGln: 0.0 ± 0.0
0.49CysArg: 0.49 ± 0.333
1.471CysSer: 1.471 ± 2.841
1.471CysThr: 1.471 ± 1.447
0.49CysVal: 0.49 ± 0.333
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
3.433AspAla: 3.433 ± 2.406
1.962AspCys: 1.962 ± 4.257
3.433AspAsp: 3.433 ± 0.789
2.943AspGlu: 2.943 ± 0.696
0.49AspPhe: 0.49 ± 0.333
2.452AspGly: 2.452 ± 1.069
0.0AspHis: 0.0 ± 0.0
2.452AspIle: 2.452 ± 1.223
3.923AspLys: 3.923 ± 1.354
6.866AspLeu: 6.866 ± 3.111
0.49AspMet: 0.49 ± 0.333
2.452AspAsn: 2.452 ± 0.71
5.395AspPro: 5.395 ± 1.49
3.433AspGln: 3.433 ± 0.789
1.962AspArg: 1.962 ± 1.412
1.962AspSer: 1.962 ± 0.464
1.471AspThr: 1.471 ± 0.999
2.943AspVal: 2.943 ± 0.696
0.981AspTrp: 0.981 ± 0.232
2.943AspTyr: 2.943 ± 0.883
0.0AspXaa: 0.0 ± 0.0
Glu
6.376GluAla: 6.376 ± 2.268
0.0GluCys: 0.0 ± 0.0
3.923GluAsp: 3.923 ± 0.928
1.962GluGlu: 1.962 ± 0.864
2.452GluPhe: 2.452 ± 1.223
4.414GluGly: 4.414 ± 1.324
0.0GluHis: 0.0 ± 0.0
1.962GluIle: 1.962 ± 1.332
3.433GluLys: 3.433 ± 0.922
5.395GluLeu: 5.395 ± 0.397
1.471GluMet: 1.471 ± 0.711
2.452GluAsn: 2.452 ± 0.71
2.452GluPro: 2.452 ± 2.622
1.962GluGln: 1.962 ± 1.202
2.943GluArg: 2.943 ± 1.031
2.943GluSer: 2.943 ± 2.605
3.923GluThr: 3.923 ± 0.928
4.414GluVal: 4.414 ± 0.58
1.471GluTrp: 1.471 ± 0.515
2.452GluTyr: 2.452 ± 0.622
0.0GluXaa: 0.0 ± 0.0
Phe
1.962PheAla: 1.962 ± 0.747
0.49PheCys: 0.49 ± 0.367
2.452PheAsp: 2.452 ± 1.547
2.452PheGlu: 2.452 ± 1.223
0.49PhePhe: 0.49 ± 0.333
1.471PheGly: 1.471 ± 0.515
0.0PheHis: 0.0 ± 0.0
2.452PheIle: 2.452 ± 1.069
1.962PheLys: 1.962 ± 0.464
2.452PheLeu: 2.452 ± 1.223
0.981PheMet: 0.981 ± 0.666
2.452PheAsn: 2.452 ± 1.223
4.414PhePro: 4.414 ± 0.703
1.962PheGln: 1.962 ± 1.332
1.962PheArg: 1.962 ± 0.747
0.981PheSer: 0.981 ± 0.666
0.0PheThr: 0.0 ± 0.0
0.0PheVal: 0.0 ± 0.0
0.0PheTrp: 0.0 ± 0.0
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
6.376GlyAla: 6.376 ± 3.121
0.981GlyCys: 0.981 ± 1.406
3.433GlyAsp: 3.433 ± 0.828
4.904GlyGlu: 4.904 ± 1.42
2.452GlyPhe: 2.452 ± 0.622
4.904GlyGly: 4.904 ± 0.437
1.471GlyHis: 1.471 ± 1.348
4.414GlyIle: 4.414 ± 1.045
0.981GlyLys: 0.981 ± 0.232
6.376GlyLeu: 6.376 ± 1.592
0.49GlyMet: 0.49 ± 0.367
2.452GlyAsn: 2.452 ± 1.069
3.433GlyPro: 3.433 ± 1.181
3.923GlyGln: 3.923 ± 0.669
5.395GlyArg: 5.395 ± 1.119
5.885GlySer: 5.885 ± 2.241
3.923GlyThr: 3.923 ± 1.053
6.376GlyVal: 6.376 ± 1.702
1.471GlyTrp: 1.471 ± 1.1
3.433GlyTyr: 3.433 ± 0.828
0.0GlyXaa: 0.0 ± 0.0
His
0.981HisAla: 0.981 ± 0.666
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
0.0HisGlu: 0.0 ± 0.0
0.0HisPhe: 0.0 ± 0.0
0.981HisGly: 0.981 ± 0.666
0.49HisHis: 0.49 ± 1.458
0.0HisIle: 0.0 ± 0.0
0.981HisLys: 0.981 ± 1.406
1.962HisLeu: 1.962 ± 1.467
0.49HisMet: 0.49 ± 0.367
0.981HisAsn: 0.981 ± 0.666
0.981HisPro: 0.981 ± 1.406
0.0HisGln: 0.0 ± 0.0
3.433HisArg: 3.433 ± 1.38
2.452HisSer: 2.452 ± 4.239
1.962HisThr: 1.962 ± 4.257
0.49HisVal: 0.49 ± 0.333
0.0HisTrp: 0.0 ± 0.0
0.49HisTyr: 0.49 ± 0.333
0.0HisXaa: 0.0 ± 0.0
Ile
3.923IleAla: 3.923 ± 1.219
0.0IleCys: 0.0 ± 0.0
2.452IleAsp: 2.452 ± 0.622
3.433IleGlu: 3.433 ± 1.375
0.0IlePhe: 0.0 ± 0.0
3.433IleGly: 3.433 ± 1.181
0.981IleHis: 0.981 ± 0.666
0.49IleIle: 0.49 ± 0.333
2.943IleLys: 2.943 ± 0.696
3.923IleLeu: 3.923 ± 1.053
1.471IleMet: 1.471 ± 0.515
2.452IleAsn: 2.452 ± 0.71
3.433IlePro: 3.433 ± 1.726
0.0IleGln: 0.0 ± 0.0
3.433IleArg: 3.433 ± 1.181
1.962IleSer: 1.962 ± 0.864
4.414IleThr: 4.414 ± 1.814
4.414IleVal: 4.414 ± 1.814
0.0IleTrp: 0.0 ± 0.0
2.943IleTyr: 2.943 ± 0.696
0.0IleXaa: 0.0 ± 0.0
Lys
4.414LysAla: 4.414 ± 2.086
0.0LysCys: 0.0 ± 0.0
3.433LysAsp: 3.433 ± 0.828
2.452LysGlu: 2.452 ± 1.223
1.471LysPhe: 1.471 ± 0.515
2.943LysGly: 2.943 ± 1.586
1.471LysHis: 1.471 ± 1.348
2.943LysIle: 2.943 ± 1.031
1.471LysLys: 1.471 ± 0.515
4.904LysLeu: 4.904 ± 1.42
1.962LysMet: 1.962 ± 0.747
1.962LysAsn: 1.962 ± 0.864
5.395LysPro: 5.395 ± 2.282
1.471LysGln: 1.471 ± 1.1
1.962LysArg: 1.962 ± 1.202
4.414LysSer: 4.414 ± 1.546
1.962LysThr: 1.962 ± 0.864
2.943LysVal: 2.943 ± 1.031
0.981LysTrp: 0.981 ± 1.406
1.962LysTyr: 1.962 ± 0.464
0.0LysXaa: 0.0 ± 0.0
Leu
8.828LeuAla: 8.828 ± 2.292
0.49LeuCys: 0.49 ± 1.458
4.414LeuAsp: 4.414 ± 1.026
4.904LeuGlu: 4.904 ± 1.243
4.414LeuPhe: 4.414 ± 0.703
5.885LeuGly: 5.885 ± 1.446
1.471LeuHis: 1.471 ± 1.447
3.433LeuIle: 3.433 ± 1.181
5.885LeuLys: 5.885 ± 2.592
9.318LeuLeu: 9.318 ± 3.094
2.943LeuMet: 2.943 ± 0.901
5.395LeuAsn: 5.395 ± 0.518
7.847LeuPro: 7.847 ± 1.366
5.395LeuGln: 5.395 ± 5.078
4.904LeuArg: 4.904 ± 1.243
9.318LeuSer: 9.318 ± 1.213
5.885LeuThr: 5.885 ± 1.446
6.866LeuVal: 6.866 ± 2.246
0.0LeuTrp: 0.0 ± 0.0
0.49LeuTyr: 0.49 ± 0.367
0.0LeuXaa: 0.0 ± 0.0
Met
2.452MetAla: 2.452 ± 0.71
0.0MetCys: 0.0 ± 0.0
0.49MetAsp: 0.49 ± 0.333
2.452MetGlu: 2.452 ± 1.069
0.981MetPhe: 0.981 ± 0.232
1.471MetGly: 1.471 ± 0.515
0.0MetHis: 0.0 ± 0.0
1.962MetIle: 1.962 ± 1.467
1.962MetLys: 1.962 ± 0.464
2.452MetLeu: 2.452 ± 1.008
0.0MetMet: 0.0 ± 0.0
1.471MetAsn: 1.471 ± 0.515
0.981MetPro: 0.981 ± 0.666
0.49MetGln: 0.49 ± 0.367
0.981MetArg: 0.981 ± 0.232
1.962MetSer: 1.962 ± 0.464
1.471MetThr: 1.471 ± 0.999
0.981MetVal: 0.981 ± 1.364
0.49MetTrp: 0.49 ± 0.333
0.49MetTyr: 0.49 ± 0.367
0.0MetXaa: 0.0 ± 0.0
Asn
4.904AsnAla: 4.904 ± 1.159
1.471AsnCys: 1.471 ± 2.841
0.981AsnAsp: 0.981 ± 1.364
1.471AsnGlu: 1.471 ± 0.515
1.962AsnPhe: 1.962 ± 0.747
3.923AsnGly: 3.923 ± 1.494
0.981AsnHis: 0.981 ± 0.232
3.923AsnIle: 3.923 ± 1.219
2.452AsnLys: 2.452 ± 1.834
6.376AsnLeu: 6.376 ± 2.059
0.0AsnMet: 0.0 ± 0.0
1.962AsnAsn: 1.962 ± 1.575
3.923AsnPro: 3.923 ± 0.669
1.471AsnGln: 1.471 ± 0.515
1.962AsnArg: 1.962 ± 1.575
1.962AsnSer: 1.962 ± 0.464
1.962AsnThr: 1.962 ± 0.464
2.943AsnVal: 2.943 ± 0.883
0.49AsnTrp: 0.49 ± 0.333
2.452AsnTyr: 2.452 ± 1.069
0.0AsnXaa: 0.0 ± 0.0
Pro
3.433ProAla: 3.433 ± 0.909
0.0ProCys: 0.0 ± 0.0
4.904ProAsp: 4.904 ± 1.293
5.885ProGlu: 5.885 ± 2.02
1.471ProPhe: 1.471 ± 0.441
5.885ProGly: 5.885 ± 2.792
0.49ProHis: 0.49 ± 0.333
3.433ProIle: 3.433 ± 1.726
6.866ProLys: 6.866 ± 1.844
4.904ProLeu: 4.904 ± 1.42
0.981ProMet: 0.981 ± 0.733
4.904ProAsn: 4.904 ± 1.243
5.885ProPro: 5.885 ± 1.446
2.452ProGln: 2.452 ± 0.622
2.943ProArg: 2.943 ± 2.496
4.414ProSer: 4.414 ± 1.626
6.376ProThr: 6.376 ± 1.653
5.395ProVal: 5.395 ± 1.732
1.962ProTrp: 1.962 ± 4.292
1.471ProTyr: 1.471 ± 0.441
0.0ProXaa: 0.0 ± 0.0
Gln
5.885GlnAla: 5.885 ± 0.207
0.0GlnCys: 0.0 ± 0.0
1.471GlnAsp: 1.471 ± 0.515
0.981GlnGlu: 0.981 ± 0.232
1.471GlnPhe: 1.471 ± 1.232
1.962GlnGly: 1.962 ± 0.464
0.49GlnHis: 0.49 ± 0.367
2.452GlnIle: 2.452 ± 0.71
0.49GlnLys: 0.49 ± 0.367
2.943GlnLeu: 2.943 ± 2.464
2.452GlnMet: 2.452 ± 0.682
1.962GlnAsn: 1.962 ± 0.747
2.943GlnPro: 2.943 ± 1.031
0.49GlnGln: 0.49 ± 0.333
2.452GlnArg: 2.452 ± 1.069
1.962GlnSer: 1.962 ± 0.464
2.452GlnThr: 2.452 ± 1.008
1.962GlnVal: 1.962 ± 2.69
0.981GlnTrp: 0.981 ± 1.406
0.981GlnTyr: 0.981 ± 0.666
0.0GlnXaa: 0.0 ± 0.0
Arg
5.395ArgAla: 5.395 ± 2.417
0.0ArgCys: 0.0 ± 0.0
2.943ArgAsp: 2.943 ± 4.027
4.414ArgGlu: 4.414 ± 1.235
0.981ArgPhe: 0.981 ± 0.666
3.923ArgGly: 3.923 ± 1.053
0.981ArgHis: 0.981 ± 1.406
1.962ArgIle: 1.962 ± 0.747
0.49ArgLys: 0.49 ± 1.458
6.376ArgLeu: 6.376 ± 0.387
0.981ArgMet: 0.981 ± 0.232
2.452ArgAsn: 2.452 ± 0.71
3.923ArgPro: 3.923 ± 0.928
3.923ArgGln: 3.923 ± 1.728
2.452ArgArg: 2.452 ± 1.008
6.866ArgSer: 6.866 ± 3.195
1.471ArgThr: 1.471 ± 1.232
2.943ArgVal: 2.943 ± 1.215
0.49ArgTrp: 0.49 ± 0.333
1.471ArgTyr: 1.471 ± 1.1
0.0ArgXaa: 0.0 ± 0.0
Ser
5.885SerAla: 5.885 ± 1.63
0.981SerCys: 0.981 ± 0.733
5.395SerAsp: 5.395 ± 3.599
6.376SerGlu: 6.376 ± 3.236
0.981SerPhe: 0.981 ± 0.666
6.866SerGly: 6.866 ± 0.692
0.981SerHis: 0.981 ± 1.406
4.904SerIle: 4.904 ± 1.243
5.885SerLys: 5.885 ± 1.63
6.376SerLeu: 6.376 ± 1.653
0.981SerMet: 0.981 ± 0.733
4.414SerAsn: 4.414 ± 1.026
3.923SerPro: 3.923 ± 1.219
1.962SerGln: 1.962 ± 1.412
3.923SerArg: 3.923 ± 1.354
3.923SerSer: 3.923 ± 0.928
3.923SerThr: 3.923 ± 0.928
2.452SerVal: 2.452 ± 1.126
0.49SerTrp: 0.49 ± 0.333
1.471SerTyr: 1.471 ± 0.999
0.0SerXaa: 0.0 ± 0.0
Thr
6.376ThrAla: 6.376 ± 1.702
0.981ThrCys: 0.981 ± 0.232
3.433ThrAsp: 3.433 ± 0.909
0.981ThrGlu: 0.981 ± 1.364
2.452ThrPhe: 2.452 ± 0.71
6.376ThrGly: 6.376 ± 1.653
0.981ThrHis: 0.981 ± 0.733
2.943ThrIle: 2.943 ± 1.396
2.943ThrLys: 2.943 ± 1.01
7.357ThrLeu: 7.357 ± 2.207
0.49ThrMet: 0.49 ± 0.333
0.981ThrAsn: 0.981 ± 1.364
3.433ThrPro: 3.433 ± 0.909
1.962ThrGln: 1.962 ± 0.747
4.904ThrArg: 4.904 ± 1.42
5.395ThrSer: 5.395 ± 1.926
0.981ThrThr: 0.981 ± 0.666
4.414ThrVal: 4.414 ± 1.814
1.471ThrTrp: 1.471 ± 1.1
1.962ThrTyr: 1.962 ± 0.864
0.0ThrXaa: 0.0 ± 0.0
Val
6.376ValAla: 6.376 ± 2.56
0.0ValCys: 0.0 ± 0.0
2.452ValAsp: 2.452 ± 0.622
4.414ValGlu: 4.414 ± 2.086
2.452ValPhe: 2.452 ± 1.069
4.414ValGly: 4.414 ± 1.142
1.962ValHis: 1.962 ± 2.69
1.962ValIle: 1.962 ± 1.332
1.962ValLys: 1.962 ± 1.575
4.904ValLeu: 4.904 ± 1.42
0.49ValMet: 0.49 ± 0.367
1.962ValAsn: 1.962 ± 0.464
6.376ValPro: 6.376 ± 1.592
1.471ValGln: 1.471 ± 0.515
3.923ValArg: 3.923 ± 3.86
3.923ValSer: 3.923 ± 1.599
5.395ValThr: 5.395 ± 2.464
4.414ValVal: 4.414 ± 1.324
1.471ValTrp: 1.471 ± 0.441
3.433ValTyr: 3.433 ± 1.181
0.0ValXaa: 0.0 ± 0.0
Trp
0.981TrpAla: 0.981 ± 0.232
0.0TrpCys: 0.0 ± 0.0
0.981TrpAsp: 0.981 ± 0.666
0.49TrpGlu: 0.49 ± 1.458
0.49TrpPhe: 0.49 ± 0.367
0.0TrpGly: 0.0 ± 0.0
0.49TrpHis: 0.49 ± 1.458
0.981TrpIle: 0.981 ± 0.232
0.0TrpLys: 0.0 ± 0.0
1.471TrpLeu: 1.471 ± 2.804
0.49TrpMet: 0.49 ± 0.367
0.981TrpAsn: 0.981 ± 0.733
0.981TrpPro: 0.981 ± 0.232
0.49TrpGln: 0.49 ± 0.333
0.49TrpArg: 0.49 ± 1.458
2.452TrpSer: 2.452 ± 1.223
0.0TrpThr: 0.0 ± 0.0
1.471TrpVal: 1.471 ± 0.515
0.49TrpTrp: 0.49 ± 1.458
0.981TrpTyr: 0.981 ± 0.733
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.471TyrAla: 1.471 ± 0.441
0.49TyrCys: 0.49 ± 0.333
1.471TyrAsp: 1.471 ± 0.441
2.452TyrGlu: 2.452 ± 0.622
1.471TyrPhe: 1.471 ± 0.441
3.923TyrGly: 3.923 ± 1.494
0.0TyrHis: 0.0 ± 0.0
0.981TyrIle: 0.981 ± 0.733
1.962TyrLys: 1.962 ± 0.864
4.414TyrLeu: 4.414 ± 1.045
0.981TyrMet: 0.981 ± 0.232
1.471TyrAsn: 1.471 ± 0.999
2.943TyrPro: 2.943 ± 1.586
0.981TyrGln: 0.981 ± 0.666
0.49TyrArg: 0.49 ± 0.367
0.981TyrSer: 0.981 ± 0.733
3.433TyrThr: 3.433 ± 1.181
1.962TyrVal: 1.962 ± 0.464
0.981TyrTrp: 0.981 ± 0.232
0.981TyrTyr: 0.981 ± 0.733
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (2040 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski