Amino acid dipepetide frequency for Listeria floridensis FSL S10-1187

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.94AlaAla: 6.94 ± 0.135
0.497AlaCys: 0.497 ± 0.029
4.587AlaAsp: 4.587 ± 0.102
6.083AlaGlu: 6.083 ± 0.118
3.691AlaPhe: 3.691 ± 0.077
5.931AlaGly: 5.931 ± 0.097
1.274AlaHis: 1.274 ± 0.045
5.759AlaIle: 5.759 ± 0.105
5.674AlaLys: 5.674 ± 0.091
7.578AlaLeu: 7.578 ± 0.128
1.976AlaMet: 1.976 ± 0.063
3.1AlaAsn: 3.1 ± 0.078
2.276AlaPro: 2.276 ± 0.059
2.322AlaGln: 2.322 ± 0.068
3.208AlaArg: 3.208 ± 0.073
4.737AlaSer: 4.737 ± 0.092
4.088AlaThr: 4.088 ± 0.097
6.109AlaVal: 6.109 ± 0.1
0.619AlaTrp: 0.619 ± 0.03
2.551AlaTyr: 2.551 ± 0.068
0.0AlaXaa: 0.0 ± 0.0
Cys
0.37CysAla: 0.37 ± 0.022
0.092CysCys: 0.092 ± 0.011
0.305CysAsp: 0.305 ± 0.022
0.348CysGlu: 0.348 ± 0.024
0.388CysPhe: 0.388 ± 0.024
0.569CysGly: 0.569 ± 0.032
0.134CysHis: 0.134 ± 0.014
0.374CysIle: 0.374 ± 0.022
0.23CysLys: 0.23 ± 0.016
0.595CysLeu: 0.595 ± 0.032
0.133CysMet: 0.133 ± 0.013
0.207CysAsn: 0.207 ± 0.016
0.277CysPro: 0.277 ± 0.021
0.152CysGln: 0.152 ± 0.015
0.281CysArg: 0.281 ± 0.017
0.407CysSer: 0.407 ± 0.024
0.321CysThr: 0.321 ± 0.022
0.344CysVal: 0.344 ± 0.02
0.05CysTrp: 0.05 ± 0.009
0.248CysTyr: 0.248 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
4.308AspAla: 4.308 ± 0.08
0.277AspCys: 0.277 ± 0.02
2.578AspAsp: 2.578 ± 0.072
4.428AspGlu: 4.428 ± 0.08
2.943AspPhe: 2.943 ± 0.064
3.982AspGly: 3.982 ± 0.09
0.981AspHis: 0.981 ± 0.035
3.713AspIle: 3.713 ± 0.083
3.471AspLys: 3.471 ± 0.084
4.96AspLeu: 4.96 ± 0.095
1.242AspMet: 1.242 ± 0.04
1.757AspAsn: 1.757 ± 0.048
2.039AspPro: 2.039 ± 0.056
2.011AspGln: 2.011 ± 0.062
2.268AspArg: 2.268 ± 0.061
2.967AspSer: 2.967 ± 0.066
2.911AspThr: 2.911 ± 0.082
3.89AspVal: 3.89 ± 0.081
0.64AspTrp: 0.64 ± 0.036
2.471AspTyr: 2.471 ± 0.06
0.0AspXaa: 0.0 ± 0.0
Glu
6.315GluAla: 6.315 ± 0.106
0.281GluCys: 0.281 ± 0.018
3.353GluAsp: 3.353 ± 0.075
5.843GluGlu: 5.843 ± 0.111
2.803GluPhe: 2.803 ± 0.068
3.856GluGly: 3.856 ± 0.079
1.322GluHis: 1.322 ± 0.044
5.452GluIle: 5.452 ± 0.106
6.581GluLys: 6.581 ± 0.106
7.68GluLeu: 7.68 ± 0.119
2.315GluMet: 2.315 ± 0.054
3.639GluAsn: 3.639 ± 0.073
1.974GluPro: 1.974 ± 0.055
3.225GluGln: 3.225 ± 0.077
3.721GluArg: 3.721 ± 0.093
3.333GluSer: 3.333 ± 0.069
4.405GluThr: 4.405 ± 0.073
5.01GluVal: 5.01 ± 0.091
0.671GluTrp: 0.671 ± 0.028
1.98GluTyr: 1.98 ± 0.062
0.0GluXaa: 0.0 ± 0.0
Phe
3.436PheAla: 3.436 ± 0.077
0.361PheCys: 0.361 ± 0.022
2.821PheAsp: 2.821 ± 0.065
3.075PheGlu: 3.075 ± 0.081
2.605PhePhe: 2.605 ± 0.079
3.512PheGly: 3.512 ± 0.082
0.923PheHis: 0.923 ± 0.035
3.592PheIle: 3.592 ± 0.088
2.532PheLys: 2.532 ± 0.059
4.863PheLeu: 4.863 ± 0.112
1.28PheMet: 1.28 ± 0.043
1.736PheAsn: 1.736 ± 0.05
1.674PhePro: 1.674 ± 0.049
1.468PheGln: 1.468 ± 0.047
1.72PheArg: 1.72 ± 0.05
3.368PheSer: 3.368 ± 0.079
2.673PheThr: 2.673 ± 0.067
3.447PheVal: 3.447 ± 0.07
0.546PheTrp: 0.546 ± 0.031
1.904PheTyr: 1.904 ± 0.06
0.0PheXaa: 0.0 ± 0.0
Gly
5.281GlyAla: 5.281 ± 0.089
0.427GlyCys: 0.427 ± 0.025
3.38GlyAsp: 3.38 ± 0.076
4.682GlyGlu: 4.682 ± 0.083
3.493GlyPhe: 3.493 ± 0.077
4.763GlyGly: 4.763 ± 0.106
1.202GlyHis: 1.202 ± 0.044
5.564GlyIle: 5.564 ± 0.094
5.43GlyLys: 5.43 ± 0.097
6.422GlyLeu: 6.422 ± 0.106
1.957GlyMet: 1.957 ± 0.055
3.038GlyAsn: 3.038 ± 0.104
1.411GlyPro: 1.411 ± 0.045
2.094GlyGln: 2.094 ± 0.059
2.737GlyArg: 2.737 ± 0.067
4.214GlySer: 4.214 ± 0.081
4.575GlyThr: 4.575 ± 0.158
4.915GlyVal: 4.915 ± 0.103
0.687GlyTrp: 0.687 ± 0.033
2.697GlyTyr: 2.697 ± 0.06
0.0GlyXaa: 0.0 ± 0.0
His
1.267HisAla: 1.267 ± 0.038
0.136HisCys: 0.136 ± 0.013
1.0HisAsp: 1.0 ± 0.031
1.265HisGlu: 1.265 ± 0.04
1.056HisPhe: 1.056 ± 0.044
1.282HisGly: 1.282 ± 0.043
0.472HisHis: 0.472 ± 0.025
1.194HisIle: 1.194 ± 0.044
0.91HisLys: 0.91 ± 0.032
1.871HisLeu: 1.871 ± 0.056
0.366HisMet: 0.366 ± 0.024
0.61HisAsn: 0.61 ± 0.03
0.869HisPro: 0.869 ± 0.037
0.702HisGln: 0.702 ± 0.034
0.721HisArg: 0.721 ± 0.033
1.037HisSer: 1.037 ± 0.043
0.911HisThr: 0.911 ± 0.038
1.293HisVal: 1.293 ± 0.037
0.144HisTrp: 0.144 ± 0.014
0.793HisTyr: 0.793 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
6.063IleAla: 6.063 ± 0.105
0.548IleCys: 0.548 ± 0.027
4.026IleAsp: 4.026 ± 0.071
5.182IleGlu: 5.182 ± 0.095
3.272IlePhe: 3.272 ± 0.072
5.645IleGly: 5.645 ± 0.104
1.346IleHis: 1.346 ± 0.039
5.016IleIle: 5.016 ± 0.111
4.154IleLys: 4.154 ± 0.082
7.059IleLeu: 7.059 ± 0.117
1.654IleMet: 1.654 ± 0.055
2.826IleAsn: 2.826 ± 0.07
3.168IlePro: 3.168 ± 0.082
2.563IleGln: 2.563 ± 0.061
3.254IleArg: 3.254 ± 0.075
4.682IleSer: 4.682 ± 0.088
4.156IleThr: 4.156 ± 0.102
5.086IleVal: 5.086 ± 0.083
0.661IleTrp: 0.661 ± 0.034
2.349IleTyr: 2.349 ± 0.055
0.0IleXaa: 0.0 ± 0.0
Lys
5.397LysAla: 5.397 ± 0.091
0.259LysCys: 0.259 ± 0.021
3.642LysAsp: 3.642 ± 0.084
6.025LysGlu: 6.025 ± 0.102
2.189LysPhe: 2.189 ± 0.055
3.82LysGly: 3.82 ± 0.077
1.079LysHis: 1.079 ± 0.038
4.819LysIle: 4.819 ± 0.094
6.197LysLys: 6.197 ± 0.129
6.12LysLeu: 6.12 ± 0.104
2.338LysMet: 2.338 ± 0.054
3.69LysAsn: 3.69 ± 0.078
2.315LysPro: 2.315 ± 0.059
3.329LysGln: 3.329 ± 0.078
3.687LysArg: 3.687 ± 0.089
3.398LysSer: 3.398 ± 0.061
4.337LysThr: 4.337 ± 0.084
4.523LysVal: 4.523 ± 0.092
0.718LysTrp: 0.718 ± 0.03
2.056LysTyr: 2.056 ± 0.054
0.0LysXaa: 0.0 ± 0.0
Leu
8.091LeuAla: 8.091 ± 0.114
0.594LeuCys: 0.594 ± 0.029
5.385LeuAsp: 5.385 ± 0.079
6.968LeuGlu: 6.968 ± 0.116
4.9LeuPhe: 4.9 ± 0.111
6.323LeuGly: 6.323 ± 0.092
1.749LeuHis: 1.749 ± 0.054
6.827LeuIle: 6.827 ± 0.136
6.437LeuLys: 6.437 ± 0.108
9.777LeuLeu: 9.777 ± 0.172
2.413LeuMet: 2.413 ± 0.064
4.14LeuAsn: 4.14 ± 0.084
3.818LeuPro: 3.818 ± 0.084
2.972LeuGln: 2.972 ± 0.075
3.936LeuArg: 3.936 ± 0.069
6.815LeuSer: 6.815 ± 0.114
5.969LeuThr: 5.969 ± 0.1
6.646LeuVal: 6.646 ± 0.101
0.714LeuTrp: 0.714 ± 0.039
2.994LeuTyr: 2.994 ± 0.064
0.0LeuXaa: 0.0 ± 0.0
Met
2.043MetAla: 2.043 ± 0.05
0.108MetCys: 0.108 ± 0.012
1.407MetAsp: 1.407 ± 0.043
1.896MetGlu: 1.896 ± 0.053
0.998MetPhe: 0.998 ± 0.043
1.58MetGly: 1.58 ± 0.052
0.382MetHis: 0.382 ± 0.022
1.914MetIle: 1.914 ± 0.058
2.398MetLys: 2.398 ± 0.053
2.581MetLeu: 2.581 ± 0.059
0.758MetMet: 0.758 ± 0.038
1.335MetAsn: 1.335 ± 0.039
1.027MetPro: 1.027 ± 0.041
0.985MetGln: 0.985 ± 0.037
1.208MetArg: 1.208 ± 0.043
1.391MetSer: 1.391 ± 0.048
1.755MetThr: 1.755 ± 0.045
1.518MetVal: 1.518 ± 0.05
0.157MetTrp: 0.157 ± 0.015
0.641MetTyr: 0.641 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
3.052AsnAla: 3.052 ± 0.077
0.281AsnCys: 0.281 ± 0.021
2.157AsnAsp: 2.157 ± 0.06
3.021AsnGlu: 3.021 ± 0.076
1.841AsnPhe: 1.841 ± 0.052
3.586AsnGly: 3.586 ± 0.107
0.824AsnHis: 0.824 ± 0.03
2.887AsnIle: 2.887 ± 0.059
2.691AsnLys: 2.691 ± 0.067
4.11AsnLeu: 4.11 ± 0.082
1.125AsnMet: 1.125 ± 0.041
1.694AsnAsn: 1.694 ± 0.048
2.051AsnPro: 2.051 ± 0.07
1.984AsnGln: 1.984 ± 0.053
2.001AsnArg: 2.001 ± 0.06
2.325AsnSer: 2.325 ± 0.058
2.075AsnThr: 2.075 ± 0.062
2.956AsnVal: 2.956 ± 0.072
0.537AsnTrp: 0.537 ± 0.03
1.763AsnTyr: 1.763 ± 0.066
0.0AsnXaa: 0.0 ± 0.0
Pro
2.434ProAla: 2.434 ± 0.057
0.178ProCys: 0.178 ± 0.016
2.125ProAsp: 2.125 ± 0.057
3.058ProGlu: 3.058 ± 0.069
1.929ProPhe: 1.929 ± 0.047
2.096ProGly: 2.096 ± 0.061
0.725ProHis: 0.725 ± 0.032
2.424ProIle: 2.424 ± 0.058
2.209ProLys: 2.209 ± 0.049
3.356ProLeu: 3.356 ± 0.073
0.686ProMet: 0.686 ± 0.031
1.793ProAsn: 1.793 ± 0.051
0.832ProPro: 0.832 ± 0.035
1.027ProGln: 1.027 ± 0.036
1.137ProArg: 1.137 ± 0.039
2.026ProSer: 2.026 ± 0.052
1.861ProThr: 1.861 ± 0.059
2.798ProVal: 2.798 ± 0.071
0.266ProTrp: 0.266 ± 0.02
1.247ProTyr: 1.247 ± 0.046
0.0ProXaa: 0.0 ± 0.0
Gln
3.414GlnAla: 3.414 ± 0.104
0.106GlnCys: 0.106 ± 0.013
1.791GlnAsp: 1.791 ± 0.05
2.646GlnGlu: 2.646 ± 0.074
1.671GlnPhe: 1.671 ± 0.051
1.932GlnGly: 1.932 ± 0.052
0.51GlnHis: 0.51 ± 0.022
2.827GlnIle: 2.827 ± 0.066
2.836GlnLys: 2.836 ± 0.059
3.408GlnLeu: 3.408 ± 0.078
1.094GlnMet: 1.094 ± 0.037
1.767GlnAsn: 1.767 ± 0.044
1.037GlnPro: 1.037 ± 0.039
1.229GlnGln: 1.229 ± 0.042
1.19GlnArg: 1.19 ± 0.041
1.723GlnSer: 1.723 ± 0.044
2.204GlnThr: 2.204 ± 0.056
2.654GlnVal: 2.654 ± 0.068
0.233GlnTrp: 0.233 ± 0.015
1.019GlnTyr: 1.019 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
3.028ArgAla: 3.028 ± 0.071
0.216ArgCys: 0.216 ± 0.017
2.253ArgAsp: 2.253 ± 0.062
3.573ArgGlu: 3.573 ± 0.079
2.166ArgPhe: 2.166 ± 0.063
2.653ArgGly: 2.653 ± 0.056
0.777ArgHis: 0.777 ± 0.032
3.279ArgIle: 3.279 ± 0.077
3.223ArgLys: 3.223 ± 0.068
4.232ArgLeu: 4.232 ± 0.078
1.265ArgMet: 1.265 ± 0.047
1.795ArgAsn: 1.795 ± 0.056
1.216ArgPro: 1.216 ± 0.042
1.461ArgGln: 1.461 ± 0.048
1.929ArgArg: 1.929 ± 0.057
2.357ArgSer: 2.357 ± 0.065
2.123ArgThr: 2.123 ± 0.055
2.891ArgVal: 2.891 ± 0.066
0.287ArgTrp: 0.287 ± 0.022
1.685ArgTyr: 1.685 ± 0.049
0.0ArgXaa: 0.0 ± 0.0
Ser
4.247SerAla: 4.247 ± 0.083
0.342SerCys: 0.342 ± 0.025
3.409SerAsp: 3.409 ± 0.07
4.228SerGlu: 4.228 ± 0.081
3.296SerPhe: 3.296 ± 0.071
5.205SerGly: 5.205 ± 0.082
1.055SerHis: 1.055 ± 0.043
4.397SerIle: 4.397 ± 0.094
4.003SerLys: 4.003 ± 0.075
5.85SerLeu: 5.85 ± 0.092
1.332SerMet: 1.332 ± 0.047
2.467SerAsn: 2.467 ± 0.073
1.824SerPro: 1.824 ± 0.05
1.758SerGln: 1.758 ± 0.058
2.415SerArg: 2.415 ± 0.062
3.985SerSer: 3.985 ± 0.091
3.036SerThr: 3.036 ± 0.082
4.034SerVal: 4.034 ± 0.086
0.542SerTrp: 0.542 ± 0.028
2.337SerTyr: 2.337 ± 0.049
0.0SerXaa: 0.0 ± 0.0
Thr
4.848ThrAla: 4.848 ± 0.122
0.291ThrCys: 0.291 ± 0.019
3.273ThrAsp: 3.273 ± 0.09
3.925ThrGlu: 3.925 ± 0.076
2.783ThrPhe: 2.783 ± 0.07
4.71ThrGly: 4.71 ± 0.102
0.953ThrHis: 0.953 ± 0.037
4.48ThrIle: 4.48 ± 0.12
3.692ThrLys: 3.692 ± 0.078
5.484ThrLeu: 5.484 ± 0.083
1.307ThrMet: 1.307 ± 0.042
2.472ThrAsn: 2.472 ± 0.054
2.184ThrPro: 2.184 ± 0.065
1.602ThrGln: 1.602 ± 0.047
1.972ThrArg: 1.972 ± 0.058
3.418ThrSer: 3.418 ± 0.084
3.265ThrThr: 3.265 ± 0.08
4.6ThrVal: 4.6 ± 0.14
0.507ThrTrp: 0.507 ± 0.026
2.072ThrTyr: 2.072 ± 0.073
0.0ThrXaa: 0.0 ± 0.0
Val
5.513ValAla: 5.513 ± 0.087
0.507ValCys: 0.507 ± 0.028
3.843ValAsp: 3.843 ± 0.081
4.749ValGlu: 4.749 ± 0.09
3.195ValPhe: 3.195 ± 0.073
4.542ValGly: 4.542 ± 0.09
1.201ValHis: 1.201 ± 0.04
5.335ValIle: 5.335 ± 0.102
4.735ValLys: 4.735 ± 0.086
6.864ValLeu: 6.864 ± 0.107
1.735ValMet: 1.735 ± 0.054
3.043ValAsn: 3.043 ± 0.092
2.672ValPro: 2.672 ± 0.06
2.265ValGln: 2.265 ± 0.065
2.975ValArg: 2.975 ± 0.077
4.89ValSer: 4.89 ± 0.099
4.638ValThr: 4.638 ± 0.124
5.376ValVal: 5.376 ± 0.114
0.59ValTrp: 0.59 ± 0.031
2.197ValTyr: 2.197 ± 0.063
0.0ValXaa: 0.0 ± 0.0
Trp
0.539TrpAla: 0.539 ± 0.027
0.068TrpCys: 0.068 ± 0.009
0.512TrpAsp: 0.512 ± 0.031
0.47TrpGlu: 0.47 ± 0.025
0.431TrpPhe: 0.431 ± 0.028
0.588TrpGly: 0.588 ± 0.029
0.205TrpHis: 0.205 ± 0.017
0.778TrpIle: 0.778 ± 0.032
0.641TrpLys: 0.641 ± 0.028
1.031TrpLeu: 1.031 ± 0.047
0.267TrpMet: 0.267 ± 0.019
0.51TrpAsn: 0.51 ± 0.031
0.221TrpPro: 0.221 ± 0.019
0.413TrpGln: 0.413 ± 0.023
0.389TrpArg: 0.389 ± 0.025
0.507TrpSer: 0.507 ± 0.026
0.487TrpThr: 0.487 ± 0.027
0.577TrpVal: 0.577 ± 0.029
0.098TrpTrp: 0.098 ± 0.011
0.282TrpTyr: 0.282 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.415TyrAla: 2.415 ± 0.063
0.26TyrCys: 0.26 ± 0.017
1.988TyrAsp: 1.988 ± 0.067
2.291TyrGlu: 2.291 ± 0.06
1.888TyrPhe: 1.888 ± 0.055
2.392TyrGly: 2.392 ± 0.064
0.785TyrHis: 0.785 ± 0.036
2.079TyrIle: 2.079 ± 0.058
1.896TyrLys: 1.896 ± 0.052
3.629TyrLeu: 3.629 ± 0.07
0.84TyrMet: 0.84 ± 0.034
1.342TyrAsn: 1.342 ± 0.044
1.324TyrPro: 1.324 ± 0.049
1.725TyrGln: 1.725 ± 0.051
1.658TyrArg: 1.658 ± 0.048
2.181TyrSer: 2.181 ± 0.078
2.049TyrThr: 2.049 ± 0.064
2.197TyrVal: 2.197 ± 0.053
0.347TyrTrp: 0.347 ± 0.026
1.343TyrTyr: 1.343 ± 0.05
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2904 proteins (737768 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski