Amino acid dipepetide frequency for Rattus norvegicus polyomavirus 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.192AlaAla: 4.192 ± 1.725
3.049AlaCys: 3.049 ± 1.31
2.287AlaAsp: 2.287 ± 0.935
3.049AlaGlu: 3.049 ± 1.234
0.381AlaPhe: 0.381 ± 0.334
2.287AlaGly: 2.287 ± 0.884
2.668AlaHis: 2.668 ± 1.23
2.668AlaIle: 2.668 ± 1.209
3.049AlaLys: 3.049 ± 1.477
6.86AlaLeu: 6.86 ± 1.445
1.143AlaMet: 1.143 ± 0.857
2.287AlaAsn: 2.287 ± 1.265
3.811AlaPro: 3.811 ± 0.512
4.192AlaGln: 4.192 ± 1.265
1.905AlaArg: 1.905 ± 0.998
2.668AlaSer: 2.668 ± 0.709
2.287AlaThr: 2.287 ± 1.632
6.098AlaVal: 6.098 ± 1.235
0.381AlaTrp: 0.381 ± 0.261
3.049AlaTyr: 3.049 ± 0.729
0.0AlaXaa: 0.0 ± 0.0
Cys
0.762CysAla: 0.762 ± 0.369
0.762CysCys: 0.762 ± 0.522
0.381CysAsp: 0.381 ± 0.334
0.381CysGlu: 0.381 ± 0.261
1.905CysPhe: 1.905 ± 0.579
1.143CysGly: 1.143 ± 0.58
0.0CysHis: 0.0 ± 0.0
1.524CysIle: 1.524 ± 0.559
1.143CysLys: 1.143 ± 0.546
6.86CysLeu: 6.86 ± 2.761
0.381CysMet: 0.381 ± 0.351
1.143CysAsn: 1.143 ± 0.652
1.524CysPro: 1.524 ± 0.45
1.143CysGln: 1.143 ± 0.655
1.905CysArg: 1.905 ± 0.579
1.905CysSer: 1.905 ± 0.579
1.905CysThr: 1.905 ± 0.579
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
1.524CysTyr: 1.524 ± 0.559
0.0CysXaa: 0.0 ± 0.0
Asp
1.143AspAla: 1.143 ± 0.49
1.524AspCys: 1.524 ± 0.559
1.524AspAsp: 1.524 ± 1.044
1.143AspGlu: 1.143 ± 0.546
2.668AspPhe: 2.668 ± 0.797
3.811AspGly: 3.811 ± 0.612
0.762AspHis: 0.762 ± 0.353
5.335AspIle: 5.335 ± 1.22
6.098AspLys: 6.098 ± 1.43
5.335AspLeu: 5.335 ± 0.826
1.143AspMet: 1.143 ± 0.783
1.143AspAsn: 1.143 ± 0.783
4.954AspPro: 4.954 ± 1.086
0.762AspGln: 0.762 ± 0.429
1.524AspArg: 1.524 ± 0.729
1.905AspSer: 1.905 ± 0.727
1.143AspThr: 1.143 ± 0.437
5.335AspVal: 5.335 ± 1.783
3.43AspTrp: 3.43 ± 1.177
0.762AspTyr: 0.762 ± 0.54
0.0AspXaa: 0.0 ± 0.0
Glu
3.43GluAla: 3.43 ± 1.346
1.905GluCys: 1.905 ± 0.579
2.287GluAsp: 2.287 ± 1.108
8.765GluGlu: 8.765 ± 1.342
3.049GluPhe: 3.049 ± 0.932
5.335GluGly: 5.335 ± 2.039
0.762GluHis: 0.762 ± 0.353
0.762GluIle: 0.762 ± 0.486
3.811GluLys: 3.811 ± 1.322
2.668GluLeu: 2.668 ± 1.07
1.524GluMet: 1.524 ± 0.405
4.573GluAsn: 4.573 ± 0.946
2.287GluPro: 2.287 ± 0.874
1.524GluGln: 1.524 ± 0.569
1.143GluArg: 1.143 ± 0.49
1.905GluSer: 1.905 ± 0.981
2.287GluThr: 2.287 ± 0.626
3.43GluVal: 3.43 ± 0.44
0.0GluTrp: 0.0 ± 0.0
2.287GluTyr: 2.287 ± 0.924
0.0GluXaa: 0.0 ± 0.0
Phe
1.905PheAla: 1.905 ± 1.014
0.381PheCys: 0.381 ± 0.261
0.381PheAsp: 0.381 ± 0.261
2.287PheGlu: 2.287 ± 0.95
0.762PhePhe: 0.762 ± 0.522
4.954PheGly: 4.954 ± 1.753
1.905PheHis: 1.905 ± 0.759
1.905PheIle: 1.905 ± 0.579
1.143PheLys: 1.143 ± 0.783
3.049PheLeu: 3.049 ± 0.812
0.381PheMet: 0.381 ± 0.261
0.762PheAsn: 0.762 ± 0.369
1.905PhePro: 1.905 ± 0.494
1.905PheGln: 1.905 ± 0.738
0.381PheArg: 0.381 ± 0.407
3.049PheSer: 3.049 ± 0.685
3.811PheThr: 3.811 ± 1.102
0.762PheVal: 0.762 ± 0.522
0.0PheTrp: 0.0 ± 0.0
0.381PheTyr: 0.381 ± 0.261
0.0PheXaa: 0.0 ± 0.0
Gly
2.668GlyAla: 2.668 ± 1.058
1.143GlyCys: 1.143 ± 0.667
8.765GlyAsp: 8.765 ± 2.132
4.192GlyGlu: 4.192 ± 0.53
2.668GlyPhe: 2.668 ± 1.041
9.527GlyGly: 9.527 ± 1.255
3.049GlyHis: 3.049 ± 0.812
2.668GlyIle: 2.668 ± 0.709
1.905GlyLys: 1.905 ± 0.721
8.765GlyLeu: 8.765 ± 2.157
0.381GlyMet: 0.381 ± 0.261
3.049GlyAsn: 3.049 ± 0.361
3.43GlyPro: 3.43 ± 0.827
6.86GlyGln: 6.86 ± 1.924
4.573GlyArg: 4.573 ± 0.647
3.811GlySer: 3.811 ± 1.679
1.905GlyThr: 1.905 ± 0.891
4.954GlyVal: 4.954 ± 1.552
1.524GlyTrp: 1.524 ± 0.726
0.381GlyTyr: 0.381 ± 0.334
0.0GlyXaa: 0.0 ± 0.0
His
2.668HisAla: 2.668 ± 0.797
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
1.905HisGlu: 1.905 ± 0.759
0.0HisPhe: 0.0 ± 0.0
3.43HisGly: 3.43 ± 0.574
1.143HisHis: 1.143 ± 0.659
0.762HisIle: 0.762 ± 0.429
0.381HisLys: 0.381 ± 0.355
1.143HisLeu: 1.143 ± 0.783
0.762HisMet: 0.762 ± 0.668
0.0HisAsn: 0.0 ± 0.0
3.049HisPro: 3.049 ± 1.35
4.573HisGln: 4.573 ± 2.122
2.287HisArg: 2.287 ± 0.622
2.287HisSer: 2.287 ± 0.954
0.381HisThr: 0.381 ± 0.261
0.381HisVal: 0.381 ± 0.261
0.762HisTrp: 0.762 ± 0.369
0.762HisTyr: 0.762 ± 0.522
0.0HisXaa: 0.0 ± 0.0
Ile
3.049IleAla: 3.049 ± 1.375
0.762IleCys: 0.762 ± 0.353
3.049IleAsp: 3.049 ± 0.704
3.43IleGlu: 3.43 ± 1.282
0.381IlePhe: 0.381 ± 0.261
0.762IleGly: 0.762 ± 0.486
0.381IleHis: 0.381 ± 0.334
1.524IleIle: 1.524 ± 0.723
0.762IleLys: 0.762 ± 0.668
5.335IleLeu: 5.335 ± 1.423
1.143IleMet: 1.143 ± 0.546
3.049IleAsn: 3.049 ± 0.641
4.954IlePro: 4.954 ± 0.709
1.524IleGln: 1.524 ± 0.45
1.524IleArg: 1.524 ± 0.81
3.43IleSer: 3.43 ± 1.343
3.43IleThr: 3.43 ± 0.576
3.811IleVal: 3.811 ± 0.851
1.143IleTrp: 1.143 ± 0.546
3.811IleTyr: 3.811 ± 1.249
0.0IleXaa: 0.0 ± 0.0
Lys
5.335LysAla: 5.335 ± 1.663
0.762LysCys: 0.762 ± 0.369
1.905LysAsp: 1.905 ± 0.894
3.43LysGlu: 3.43 ± 0.843
2.668LysPhe: 2.668 ± 0.797
4.573LysGly: 4.573 ± 1.216
2.668LysHis: 2.668 ± 0.797
3.43LysIle: 3.43 ± 1.145
4.192LysLys: 4.192 ± 1.125
3.811LysLeu: 3.811 ± 0.88
0.0LysMet: 0.0 ± 0.0
1.143LysAsn: 1.143 ± 0.654
2.287LysPro: 2.287 ± 1.108
0.762LysGln: 0.762 ± 0.522
3.049LysArg: 3.049 ± 0.889
3.43LysSer: 3.43 ± 0.697
1.905LysThr: 1.905 ± 0.894
1.143LysVal: 1.143 ± 0.654
0.762LysTrp: 0.762 ± 0.522
1.905LysTyr: 1.905 ± 0.754
0.0LysXaa: 0.0 ± 0.0
Leu
6.86LeuAla: 6.86 ± 1.448
3.811LeuCys: 3.811 ± 1.517
11.433LeuAsp: 11.433 ± 1.847
3.811LeuGlu: 3.811 ± 1.922
4.954LeuPhe: 4.954 ± 1.554
7.241LeuGly: 7.241 ± 1.809
1.905LeuHis: 1.905 ± 0.759
4.573LeuIle: 4.573 ± 1.09
5.716LeuLys: 5.716 ± 1.908
14.482LeuLeu: 14.482 ± 2.631
3.049LeuMet: 3.049 ± 1.35
6.098LeuAsn: 6.098 ± 1.43
6.098LeuPro: 6.098 ± 1.902
5.335LeuGln: 5.335 ± 0.67
5.716LeuArg: 5.716 ± 1.12
3.049LeuSer: 3.049 ± 0.777
4.573LeuThr: 4.573 ± 0.801
4.573LeuVal: 4.573 ± 0.464
3.43LeuTrp: 3.43 ± 1.223
4.192LeuTyr: 4.192 ± 0.763
0.0LeuXaa: 0.0 ± 0.0
Met
1.905MetAla: 1.905 ± 0.623
0.762MetCys: 0.762 ± 0.522
2.668MetAsp: 2.668 ± 0.794
1.524MetGlu: 1.524 ± 0.745
0.381MetPhe: 0.381 ± 0.334
1.905MetGly: 1.905 ± 0.799
0.381MetHis: 0.381 ± 0.261
1.143MetIle: 1.143 ± 0.731
0.0MetLys: 0.0 ± 0.0
3.43MetLeu: 3.43 ± 1.389
0.0MetMet: 0.0 ± 0.0
0.762MetAsn: 0.762 ± 0.369
2.668MetPro: 2.668 ± 0.727
5.335MetGln: 5.335 ± 1.429
0.381MetArg: 0.381 ± 0.334
0.381MetSer: 0.381 ± 0.261
0.762MetThr: 0.762 ± 0.369
0.0MetVal: 0.0 ± 0.0
0.381MetTrp: 0.381 ± 0.334
0.381MetTyr: 0.381 ± 0.407
0.0MetXaa: 0.0 ± 0.0
Asn
3.811AsnAla: 3.811 ± 1.035
1.905AsnCys: 1.905 ± 0.579
0.762AsnAsp: 0.762 ± 0.369
1.143AsnGlu: 1.143 ± 0.654
2.287AsnPhe: 2.287 ± 0.53
1.905AsnGly: 1.905 ± 1.014
0.381AsnHis: 0.381 ± 0.355
1.905AsnIle: 1.905 ± 1.306
3.049AsnLys: 3.049 ± 0.807
3.811AsnLeu: 3.811 ± 1.06
1.524AsnMet: 1.524 ± 0.572
1.905AsnAsn: 1.905 ± 0.579
4.954AsnPro: 4.954 ± 0.568
1.143AsnGln: 1.143 ± 0.654
1.905AsnArg: 1.905 ± 0.438
3.049AsnSer: 3.049 ± 1.221
4.573AsnThr: 4.573 ± 1.502
3.049AsnVal: 3.049 ± 0.889
0.381AsnTrp: 0.381 ± 0.355
2.287AsnTyr: 2.287 ± 0.74
0.0AsnXaa: 0.0 ± 0.0
Pro
4.573ProAla: 4.573 ± 0.679
1.905ProCys: 1.905 ± 0.549
5.335ProAsp: 5.335 ± 0.594
4.573ProGlu: 4.573 ± 0.444
0.0ProPhe: 0.0 ± 0.0
6.479ProGly: 6.479 ± 1.657
0.762ProHis: 0.762 ± 0.353
4.954ProIle: 4.954 ± 1.687
2.668ProLys: 2.668 ± 0.867
6.098ProLeu: 6.098 ± 1.152
0.381ProMet: 0.381 ± 0.334
0.381ProAsn: 0.381 ± 0.261
6.86ProPro: 6.86 ± 2.072
1.524ProGln: 1.524 ± 0.81
3.811ProArg: 3.811 ± 1.363
5.335ProSer: 5.335 ± 1.574
1.905ProThr: 1.905 ± 0.742
3.811ProVal: 3.811 ± 1.506
0.762ProTrp: 0.762 ± 0.54
0.762ProTyr: 0.762 ± 0.668
0.0ProXaa: 0.0 ± 0.0
Gln
2.287GlnAla: 2.287 ± 0.64
0.381GlnCys: 0.381 ± 0.261
1.143GlnAsp: 1.143 ± 0.51
1.524GlnGlu: 1.524 ± 1.115
1.524GlnPhe: 1.524 ± 0.771
1.524GlnGly: 1.524 ± 0.726
1.524GlnHis: 1.524 ± 0.841
3.811GlnIle: 3.811 ± 0.911
3.811GlnLys: 3.811 ± 0.774
6.098GlnLeu: 6.098 ± 1.139
2.668GlnMet: 2.668 ± 1.048
3.811GlnAsn: 3.811 ± 0.512
1.524GlnPro: 1.524 ± 0.771
3.43GlnGln: 3.43 ± 1.04
3.43GlnArg: 3.43 ± 1.581
6.098GlnSer: 6.098 ± 0.688
3.049GlnThr: 3.049 ± 0.704
4.192GlnVal: 4.192 ± 0.689
0.0GlnTrp: 0.0 ± 0.0
2.287GlnTyr: 2.287 ± 0.739
0.0GlnXaa: 0.0 ± 0.0
Arg
0.762ArgAla: 0.762 ± 0.54
0.0ArgCys: 0.0 ± 0.0
3.811ArgAsp: 3.811 ± 1.462
1.905ArgGlu: 1.905 ± 0.682
1.524ArgPhe: 1.524 ± 1.044
3.811ArgGly: 3.811 ± 0.908
0.762ArgHis: 0.762 ± 0.353
0.381ArgIle: 0.381 ± 0.355
1.905ArgLys: 1.905 ± 0.894
7.622ArgLeu: 7.622 ± 2.068
4.954ArgMet: 4.954 ± 1.135
2.287ArgAsn: 2.287 ± 0.849
1.905ArgPro: 1.905 ± 0.432
4.954ArgGln: 4.954 ± 1.758
5.716ArgArg: 5.716 ± 2.02
3.049ArgSer: 3.049 ± 1.658
4.192ArgThr: 4.192 ± 1.893
2.287ArgVal: 2.287 ± 1.265
1.143ArgTrp: 1.143 ± 0.546
2.287ArgTyr: 2.287 ± 1.287
0.0ArgXaa: 0.0 ± 0.0
Ser
2.668SerAla: 2.668 ± 1.067
0.0SerCys: 0.0 ± 0.0
2.287SerAsp: 2.287 ± 0.95
1.905SerGlu: 1.905 ± 1.306
2.287SerPhe: 2.287 ± 1.218
4.954SerGly: 4.954 ± 1.762
0.381SerHis: 0.381 ± 0.355
2.668SerIle: 2.668 ± 0.855
0.762SerLys: 0.762 ± 0.668
7.622SerLeu: 7.622 ± 1.102
1.524SerMet: 1.524 ± 0.463
2.287SerAsn: 2.287 ± 1.265
3.811SerPro: 3.811 ± 1.236
3.811SerGln: 3.811 ± 0.88
3.811SerArg: 3.811 ± 0.512
5.716SerSer: 5.716 ± 1.561
6.479SerThr: 6.479 ± 1.162
4.573SerVal: 4.573 ± 1.622
0.381SerTrp: 0.381 ± 0.355
1.905SerTyr: 1.905 ± 0.715
0.0SerXaa: 0.0 ± 0.0
Thr
2.668ThrAla: 2.668 ± 1.531
3.811ThrCys: 3.811 ± 1.091
0.381ThrAsp: 0.381 ± 0.261
3.811ThrGlu: 3.811 ± 1.195
2.287ThrPhe: 2.287 ± 0.704
3.811ThrGly: 3.811 ± 0.877
1.143ThrHis: 1.143 ± 0.49
3.811ThrIle: 3.811 ± 2.085
4.573ThrLys: 4.573 ± 1.394
6.86ThrLeu: 6.86 ± 0.721
0.762ThrMet: 0.762 ± 0.473
2.668ThrAsn: 2.668 ± 0.721
3.811ThrPro: 3.811 ± 0.962
1.143ThrGln: 1.143 ± 0.546
3.43ThrArg: 3.43 ± 0.91
1.905ThrSer: 1.905 ± 0.727
3.43ThrThr: 3.43 ± 1.229
4.192ThrVal: 4.192 ± 1.283
0.762ThrTrp: 0.762 ± 0.54
0.381ThrTyr: 0.381 ± 0.334
0.0ThrXaa: 0.0 ± 0.0
Val
3.43ValAla: 3.43 ± 0.808
1.143ValCys: 1.143 ± 0.546
1.524ValAsp: 1.524 ± 0.559
3.43ValGlu: 3.43 ± 1.114
0.0ValPhe: 0.0 ± 0.0
3.43ValGly: 3.43 ± 1.174
2.287ValHis: 2.287 ± 0.53
2.287ValIle: 2.287 ± 1.714
3.43ValLys: 3.43 ± 1.444
7.241ValLeu: 7.241 ± 0.682
0.762ValMet: 0.762 ± 0.668
4.573ValAsn: 4.573 ± 1.311
1.905ValPro: 1.905 ± 0.438
2.287ValGln: 2.287 ± 0.924
5.335ValArg: 5.335 ± 1.729
4.573ValSer: 4.573 ± 1.349
4.573ValThr: 4.573 ± 1.351
2.287ValVal: 2.287 ± 0.74
0.381ValTrp: 0.381 ± 0.529
1.143ValTyr: 1.143 ± 0.437
0.0ValXaa: 0.0 ± 0.0
Trp
0.762TrpAla: 0.762 ± 0.54
0.0TrpCys: 0.0 ± 0.0
1.143TrpAsp: 1.143 ± 0.59
0.762TrpGlu: 0.762 ± 0.369
1.143TrpPhe: 1.143 ± 0.652
2.287TrpGly: 2.287 ± 0.739
1.143TrpHis: 1.143 ± 0.546
0.762TrpIle: 0.762 ± 0.611
0.762TrpLys: 0.762 ± 0.522
2.287TrpLeu: 2.287 ± 1.305
0.762TrpMet: 0.762 ± 0.54
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.762TrpGln: 0.762 ± 0.522
2.287TrpArg: 2.287 ± 1.026
0.381TrpSer: 0.381 ± 0.261
1.905TrpThr: 1.905 ± 0.759
1.143TrpVal: 1.143 ± 0.546
1.905TrpTrp: 1.905 ± 0.549
0.381TrpTyr: 0.381 ± 0.261
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.43TyrAla: 3.43 ± 1.453
2.287TyrCys: 2.287 ± 0.704
0.381TyrAsp: 0.381 ± 0.261
0.762TyrGlu: 0.762 ± 0.668
1.143TyrPhe: 1.143 ± 0.654
3.049TyrGly: 3.049 ± 1.112
2.668TyrHis: 2.668 ± 0.682
0.381TyrIle: 0.381 ± 0.334
0.0TyrLys: 0.0 ± 0.0
1.524TyrLeu: 1.524 ± 0.693
1.524TyrMet: 1.524 ± 0.667
3.811TyrAsn: 3.811 ± 1.038
1.143TyrPro: 1.143 ± 0.754
1.143TyrGln: 1.143 ± 0.659
1.143TyrArg: 1.143 ± 0.49
2.287TyrSer: 2.287 ± 0.717
1.143TyrThr: 1.143 ± 0.51
0.0TyrVal: 0.0 ± 0.0
3.049TyrTrp: 3.049 ± 0.713
1.905TyrTyr: 1.905 ± 0.623
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 8 proteins (2625 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski