Amino acid dipepetide frequency for Aeromonas phage phiARM81ld

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.853AlaAla: 12.853 ± 1.421
0.884AlaCys: 0.884 ± 0.211
6.12AlaAsp: 6.12 ± 0.563
8.228AlaGlu: 8.228 ± 0.67
2.38AlaPhe: 2.38 ± 0.442
10.473AlaGly: 10.473 ± 1.657
2.04AlaHis: 2.04 ± 0.302
5.032AlaIle: 5.032 ± 0.527
6.12AlaLys: 6.12 ± 0.719
9.113AlaLeu: 9.113 ± 0.707
4.284AlaMet: 4.284 ± 0.696
3.808AlaAsn: 3.808 ± 0.461
4.216AlaPro: 4.216 ± 0.67
3.536AlaGln: 3.536 ± 0.39
5.508AlaArg: 5.508 ± 0.656
5.304AlaSer: 5.304 ± 0.676
5.236AlaThr: 5.236 ± 0.651
7.072AlaVal: 7.072 ± 0.727
1.972AlaTrp: 1.972 ± 0.304
2.312AlaTyr: 2.312 ± 0.562
0.0AlaXaa: 0.0 ± 0.0
Cys
1.02CysAla: 1.02 ± 0.269
0.068CysCys: 0.068 ± 0.081
0.68CysAsp: 0.68 ± 0.197
0.612CysGlu: 0.612 ± 0.227
0.204CysPhe: 0.204 ± 0.127
1.156CysGly: 1.156 ± 0.439
0.408CysHis: 0.408 ± 0.141
0.612CysIle: 0.612 ± 0.22
0.748CysLys: 0.748 ± 0.328
0.408CysLeu: 0.408 ± 0.16
0.068CysMet: 0.068 ± 0.067
0.136CysAsn: 0.136 ± 0.095
0.884CysPro: 0.884 ± 0.285
0.544CysGln: 0.544 ± 0.169
1.02CysArg: 1.02 ± 0.304
1.088CysSer: 1.088 ± 0.282
0.544CysThr: 0.544 ± 0.162
0.544CysVal: 0.544 ± 0.193
0.272CysTrp: 0.272 ± 0.14
0.476CysTyr: 0.476 ± 0.189
0.0CysXaa: 0.0 ± 0.0
Asp
6.324AspAla: 6.324 ± 0.574
0.816AspCys: 0.816 ± 0.237
3.264AspAsp: 3.264 ± 0.506
4.624AspGlu: 4.624 ± 0.595
1.564AspPhe: 1.564 ± 0.334
6.324AspGly: 6.324 ± 0.686
0.476AspHis: 0.476 ± 0.197
3.196AspIle: 3.196 ± 0.454
3.06AspLys: 3.06 ± 0.527
5.304AspLeu: 5.304 ± 0.529
1.972AspMet: 1.972 ± 0.376
1.836AspAsn: 1.836 ± 0.33
3.264AspPro: 3.264 ± 0.391
3.128AspGln: 3.128 ± 0.463
3.468AspArg: 3.468 ± 0.497
2.652AspSer: 2.652 ± 0.441
3.264AspThr: 3.264 ± 0.549
4.284AspVal: 4.284 ± 0.498
0.952AspTrp: 0.952 ± 0.21
1.7AspTyr: 1.7 ± 0.362
0.0AspXaa: 0.0 ± 0.0
Glu
7.004GluAla: 7.004 ± 0.739
0.952GluCys: 0.952 ± 0.272
3.196GluAsp: 3.196 ± 0.449
4.08GluGlu: 4.08 ± 0.725
2.244GluPhe: 2.244 ± 0.401
3.128GluGly: 3.128 ± 0.447
1.02GluHis: 1.02 ± 0.302
2.72GluIle: 2.72 ± 0.43
3.332GluLys: 3.332 ± 0.574
7.82GluLeu: 7.82 ± 0.738
1.904GluMet: 1.904 ± 0.355
1.564GluAsn: 1.564 ± 0.362
2.176GluPro: 2.176 ± 0.445
4.284GluGln: 4.284 ± 0.548
4.964GluArg: 4.964 ± 0.516
3.06GluSer: 3.06 ± 0.4
3.536GluThr: 3.536 ± 0.378
4.216GluVal: 4.216 ± 0.514
1.564GluTrp: 1.564 ± 0.376
1.02GluTyr: 1.02 ± 0.248
0.0GluXaa: 0.0 ± 0.0
Phe
2.924PheAla: 2.924 ± 0.458
0.408PheCys: 0.408 ± 0.185
2.584PheAsp: 2.584 ± 0.346
1.836PheGlu: 1.836 ± 0.279
1.156PhePhe: 1.156 ± 0.295
3.06PheGly: 3.06 ± 0.394
0.204PheHis: 0.204 ± 0.116
2.312PheIle: 2.312 ± 0.45
1.972PheLys: 1.972 ± 0.313
2.584PheLeu: 2.584 ± 0.411
0.544PheMet: 0.544 ± 0.168
0.748PheAsn: 0.748 ± 0.28
1.428PhePro: 1.428 ± 0.303
0.476PheGln: 0.476 ± 0.154
1.292PheArg: 1.292 ± 0.27
2.04PheSer: 2.04 ± 0.335
1.156PheThr: 1.156 ± 0.311
1.836PheVal: 1.836 ± 0.398
0.408PheTrp: 0.408 ± 0.143
0.68PheTyr: 0.68 ± 0.303
0.0PheXaa: 0.0 ± 0.0
Gly
7.684GlyAla: 7.684 ± 1.428
0.952GlyCys: 0.952 ± 0.331
4.828GlyAsp: 4.828 ± 0.471
6.12GlyGlu: 6.12 ± 0.739
2.652GlyPhe: 2.652 ± 0.366
7.004GlyGly: 7.004 ± 0.901
2.244GlyHis: 2.244 ± 0.339
4.352GlyIle: 4.352 ± 0.5
4.76GlyLys: 4.76 ± 0.53
6.732GlyLeu: 6.732 ± 0.649
2.244GlyMet: 2.244 ± 0.382
2.516GlyAsn: 2.516 ± 0.501
1.7GlyPro: 1.7 ± 0.344
3.944GlyGln: 3.944 ± 0.496
5.78GlyArg: 5.78 ± 0.556
5.236GlySer: 5.236 ± 0.417
4.08GlyThr: 4.08 ± 0.425
5.236GlyVal: 5.236 ± 0.452
1.428GlyTrp: 1.428 ± 0.231
2.788GlyTyr: 2.788 ± 0.467
0.0GlyXaa: 0.0 ± 0.0
His
1.904HisAla: 1.904 ± 0.462
0.408HisCys: 0.408 ± 0.144
1.564HisAsp: 1.564 ± 0.352
0.952HisGlu: 0.952 ± 0.212
0.612HisPhe: 0.612 ± 0.229
1.972HisGly: 1.972 ± 0.459
0.816HisHis: 0.816 ± 0.243
1.156HisIle: 1.156 ± 0.243
0.612HisLys: 0.612 ± 0.194
2.312HisLeu: 2.312 ± 0.424
0.748HisMet: 0.748 ± 0.22
0.544HisAsn: 0.544 ± 0.178
1.156HisPro: 1.156 ± 0.289
0.748HisGln: 0.748 ± 0.212
1.02HisArg: 1.02 ± 0.31
0.884HisSer: 0.884 ± 0.258
0.884HisThr: 0.884 ± 0.196
1.088HisVal: 1.088 ± 0.322
0.544HisTrp: 0.544 ± 0.158
0.68HisTyr: 0.68 ± 0.189
0.0HisXaa: 0.0 ± 0.0
Ile
5.44IleAla: 5.44 ± 0.631
0.544IleCys: 0.544 ± 0.185
5.372IleAsp: 5.372 ± 0.504
3.74IleGlu: 3.74 ± 0.581
1.02IlePhe: 1.02 ± 0.205
3.332IleGly: 3.332 ± 0.444
1.224IleHis: 1.224 ± 0.272
2.584IleIle: 2.584 ± 0.395
2.992IleLys: 2.992 ± 0.41
2.312IleLeu: 2.312 ± 0.455
0.884IleMet: 0.884 ± 0.289
2.312IleAsn: 2.312 ± 0.297
2.72IlePro: 2.72 ± 0.411
1.836IleGln: 1.836 ± 0.385
2.924IleArg: 2.924 ± 0.382
2.992IleSer: 2.992 ± 0.472
2.856IleThr: 2.856 ± 0.567
3.128IleVal: 3.128 ± 0.526
0.408IleTrp: 0.408 ± 0.169
1.088IleTyr: 1.088 ± 0.289
0.0IleXaa: 0.0 ± 0.0
Lys
6.596LysAla: 6.596 ± 0.735
0.204LysCys: 0.204 ± 0.185
2.244LysAsp: 2.244 ± 0.35
3.468LysGlu: 3.468 ± 0.546
1.836LysPhe: 1.836 ± 0.41
4.488LysGly: 4.488 ± 0.508
1.36LysHis: 1.36 ± 0.302
2.72LysIle: 2.72 ± 0.453
3.604LysLys: 3.604 ± 0.556
3.944LysLeu: 3.944 ± 0.422
1.768LysMet: 1.768 ± 0.32
1.836LysAsn: 1.836 ± 0.401
2.72LysPro: 2.72 ± 0.463
1.972LysGln: 1.972 ± 0.387
2.992LysArg: 2.992 ± 0.453
3.06LysSer: 3.06 ± 0.424
2.992LysThr: 2.992 ± 0.456
3.468LysVal: 3.468 ± 0.581
0.68LysTrp: 0.68 ± 0.194
1.156LysTyr: 1.156 ± 0.226
0.0LysXaa: 0.0 ± 0.0
Leu
11.425LeuAla: 11.425 ± 1.161
0.748LeuCys: 0.748 ± 0.227
5.168LeuAsp: 5.168 ± 0.523
4.556LeuGlu: 4.556 ± 0.666
2.448LeuPhe: 2.448 ± 0.432
7.14LeuGly: 7.14 ± 0.941
1.428LeuHis: 1.428 ± 0.388
3.944LeuIle: 3.944 ± 0.496
4.488LeuLys: 4.488 ± 0.539
7.48LeuLeu: 7.48 ± 0.896
2.448LeuMet: 2.448 ± 0.397
3.536LeuAsn: 3.536 ± 0.51
5.44LeuPro: 5.44 ± 0.677
3.536LeuGln: 3.536 ± 0.432
6.256LeuArg: 6.256 ± 0.667
5.78LeuSer: 5.78 ± 0.616
5.44LeuThr: 5.44 ± 0.59
6.8LeuVal: 6.8 ± 0.654
0.816LeuTrp: 0.816 ± 0.237
1.564LeuTyr: 1.564 ± 0.342
0.0LeuXaa: 0.0 ± 0.0
Met
3.468MetAla: 3.468 ± 0.391
0.204MetCys: 0.204 ± 0.127
1.428MetAsp: 1.428 ± 0.259
1.632MetGlu: 1.632 ± 0.337
0.952MetPhe: 0.952 ± 0.22
1.564MetGly: 1.564 ± 0.241
0.68MetHis: 0.68 ± 0.174
1.224MetIle: 1.224 ± 0.28
2.38MetLys: 2.38 ± 0.424
2.72MetLeu: 2.72 ± 0.409
1.36MetMet: 1.36 ± 0.384
1.088MetAsn: 1.088 ± 0.265
1.768MetPro: 1.768 ± 0.253
1.02MetGln: 1.02 ± 0.219
1.292MetArg: 1.292 ± 0.297
2.04MetSer: 2.04 ± 0.357
2.72MetThr: 2.72 ± 0.375
1.632MetVal: 1.632 ± 0.254
0.34MetTrp: 0.34 ± 0.162
0.612MetTyr: 0.612 ± 0.206
0.0MetXaa: 0.0 ± 0.0
Asn
3.332AsnAla: 3.332 ± 0.562
0.544AsnCys: 0.544 ± 0.241
1.768AsnAsp: 1.768 ± 0.305
1.836AsnGlu: 1.836 ± 0.413
1.088AsnPhe: 1.088 ± 0.196
2.924AsnGly: 2.924 ± 0.489
0.748AsnHis: 0.748 ± 0.234
1.428AsnIle: 1.428 ± 0.3
1.496AsnLys: 1.496 ± 0.348
3.128AsnLeu: 3.128 ± 0.41
0.748AsnMet: 0.748 ± 0.183
0.884AsnAsn: 0.884 ± 0.282
2.448AsnPro: 2.448 ± 0.382
1.836AsnGln: 1.836 ± 0.379
2.312AsnArg: 2.312 ± 0.358
1.7AsnSer: 1.7 ± 0.382
1.7AsnThr: 1.7 ± 0.476
1.632AsnVal: 1.632 ± 0.326
0.272AsnTrp: 0.272 ± 0.131
0.816AsnTyr: 0.816 ± 0.219
0.0AsnXaa: 0.0 ± 0.0
Pro
4.42ProAla: 4.42 ± 0.439
0.612ProCys: 0.612 ± 0.178
4.012ProAsp: 4.012 ± 0.537
3.332ProGlu: 3.332 ± 0.407
1.088ProPhe: 1.088 ± 0.241
3.196ProGly: 3.196 ± 0.436
1.224ProHis: 1.224 ± 0.256
2.38ProIle: 2.38 ± 0.485
1.632ProLys: 1.632 ± 0.353
4.08ProLeu: 4.08 ± 0.4
1.36ProMet: 1.36 ± 0.296
2.04ProAsn: 2.04 ± 0.332
1.564ProPro: 1.564 ± 0.354
1.088ProGln: 1.088 ± 0.22
2.652ProArg: 2.652 ± 0.502
3.06ProSer: 3.06 ± 0.447
2.924ProThr: 2.924 ± 0.342
3.264ProVal: 3.264 ± 0.556
0.748ProTrp: 0.748 ± 0.223
0.884ProTyr: 0.884 ± 0.292
0.0ProXaa: 0.0 ± 0.0
Gln
4.624GlnAla: 4.624 ± 0.689
0.476GlnCys: 0.476 ± 0.179
2.108GlnAsp: 2.108 ± 0.309
1.768GlnGlu: 1.768 ± 0.319
1.428GlnPhe: 1.428 ± 0.313
2.72GlnGly: 2.72 ± 0.429
0.748GlnHis: 0.748 ± 0.247
2.244GlnIle: 2.244 ± 0.389
1.428GlnLys: 1.428 ± 0.352
5.44GlnLeu: 5.44 ± 0.621
1.02GlnMet: 1.02 ± 0.305
0.884GlnAsn: 0.884 ± 0.212
2.38GlnPro: 2.38 ± 0.483
2.312GlnGln: 2.312 ± 0.403
2.788GlnArg: 2.788 ± 0.577
1.632GlnSer: 1.632 ± 0.36
2.448GlnThr: 2.448 ± 0.332
2.856GlnVal: 2.856 ± 0.397
1.02GlnTrp: 1.02 ± 0.274
1.36GlnTyr: 1.36 ± 0.295
0.0GlnXaa: 0.0 ± 0.0
Arg
5.576ArgAla: 5.576 ± 0.553
0.952ArgCys: 0.952 ± 0.308
2.856ArgAsp: 2.856 ± 0.414
4.148ArgGlu: 4.148 ± 0.483
2.448ArgPhe: 2.448 ± 0.391
5.032ArgGly: 5.032 ± 0.619
1.7ArgHis: 1.7 ± 0.434
2.584ArgIle: 2.584 ± 0.429
3.604ArgLys: 3.604 ± 0.505
6.8ArgLeu: 6.8 ± 0.728
2.04ArgMet: 2.04 ± 0.35
2.108ArgAsn: 2.108 ± 0.388
2.312ArgPro: 2.312 ± 0.493
3.332ArgGln: 3.332 ± 0.61
4.964ArgArg: 4.964 ± 0.597
3.06ArgSer: 3.06 ± 0.331
2.924ArgThr: 2.924 ± 0.563
3.944ArgVal: 3.944 ± 0.53
1.088ArgTrp: 1.088 ± 0.34
1.768ArgTyr: 1.768 ± 0.348
0.0ArgXaa: 0.0 ± 0.0
Ser
6.052SerAla: 6.052 ± 0.669
0.748SerCys: 0.748 ± 0.197
3.264SerAsp: 3.264 ± 0.533
3.196SerGlu: 3.196 ± 0.436
2.244SerPhe: 2.244 ± 0.374
5.1SerGly: 5.1 ± 0.584
1.428SerHis: 1.428 ± 0.286
2.312SerIle: 2.312 ± 0.254
2.516SerLys: 2.516 ± 0.397
5.508SerLeu: 5.508 ± 0.617
1.156SerMet: 1.156 ± 0.273
1.972SerAsn: 1.972 ± 0.382
2.72SerPro: 2.72 ± 0.375
2.652SerGln: 2.652 ± 0.428
3.74SerArg: 3.74 ± 0.454
4.08SerSer: 4.08 ± 0.588
2.516SerThr: 2.516 ± 0.484
2.72SerVal: 2.72 ± 0.404
1.156SerTrp: 1.156 ± 0.254
1.564SerTyr: 1.564 ± 0.255
0.0SerXaa: 0.0 ± 0.0
Thr
6.46ThrAla: 6.46 ± 0.74
0.544ThrCys: 0.544 ± 0.196
3.944ThrAsp: 3.944 ± 0.519
3.332ThrGlu: 3.332 ± 0.43
0.884ThrPhe: 0.884 ± 0.282
5.644ThrGly: 5.644 ± 0.622
0.612ThrHis: 0.612 ± 0.184
3.332ThrIle: 3.332 ± 0.57
2.856ThrLys: 2.856 ± 0.414
4.216ThrLeu: 4.216 ± 0.462
1.36ThrMet: 1.36 ± 0.32
1.564ThrAsn: 1.564 ± 0.266
3.196ThrPro: 3.196 ± 0.451
1.768ThrGln: 1.768 ± 0.301
3.264ThrArg: 3.264 ± 0.416
2.652ThrSer: 2.652 ± 0.425
3.332ThrThr: 3.332 ± 0.526
3.128ThrVal: 3.128 ± 0.536
1.088ThrTrp: 1.088 ± 0.322
1.428ThrTyr: 1.428 ± 0.319
0.0ThrXaa: 0.0 ± 0.0
Val
5.916ValAla: 5.916 ± 0.613
0.272ValCys: 0.272 ± 0.134
4.216ValAsp: 4.216 ± 0.578
3.876ValGlu: 3.876 ± 0.551
1.7ValPhe: 1.7 ± 0.255
4.896ValGly: 4.896 ± 0.559
1.36ValHis: 1.36 ± 0.305
3.536ValIle: 3.536 ± 0.527
4.012ValLys: 4.012 ± 0.515
5.984ValLeu: 5.984 ± 0.826
2.924ValMet: 2.924 ± 0.507
2.176ValAsn: 2.176 ± 0.409
1.768ValPro: 1.768 ± 0.325
1.836ValGln: 1.836 ± 0.388
3.944ValArg: 3.944 ± 0.612
3.196ValSer: 3.196 ± 0.483
4.352ValThr: 4.352 ± 0.376
5.44ValVal: 5.44 ± 0.758
1.02ValTrp: 1.02 ± 0.262
2.312ValTyr: 2.312 ± 0.483
0.0ValXaa: 0.0 ± 0.0
Trp
1.156TrpAla: 1.156 ± 0.283
0.34TrpCys: 0.34 ± 0.123
1.156TrpAsp: 1.156 ± 0.245
0.884TrpGlu: 0.884 ± 0.244
0.68TrpPhe: 0.68 ± 0.185
1.224TrpGly: 1.224 ± 0.285
0.272TrpHis: 0.272 ± 0.135
0.748TrpIle: 0.748 ± 0.233
0.476TrpLys: 0.476 ± 0.156
2.244TrpLeu: 2.244 ± 0.319
0.544TrpMet: 0.544 ± 0.187
0.408TrpAsn: 0.408 ± 0.183
0.68TrpPro: 0.68 ± 0.243
0.544TrpGln: 0.544 ± 0.185
1.7TrpArg: 1.7 ± 0.379
1.088TrpSer: 1.088 ± 0.313
0.544TrpThr: 0.544 ± 0.225
1.088TrpVal: 1.088 ± 0.294
0.204TrpTrp: 0.204 ± 0.116
0.34TrpTyr: 0.34 ± 0.156
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.312TyrAla: 2.312 ± 0.393
0.816TyrCys: 0.816 ± 0.227
1.7TyrAsp: 1.7 ± 0.395
1.564TyrGlu: 1.564 ± 0.344
1.02TyrPhe: 1.02 ± 0.329
1.904TyrGly: 1.904 ± 0.336
0.612TyrHis: 0.612 ± 0.202
1.292TyrIle: 1.292 ± 0.297
1.088TyrLys: 1.088 ± 0.257
2.312TyrLeu: 2.312 ± 0.378
0.68TyrMet: 0.68 ± 0.188
0.68TyrAsn: 0.68 ± 0.23
1.02TyrPro: 1.02 ± 0.299
1.292TyrGln: 1.292 ± 0.286
1.36TyrArg: 1.36 ± 0.259
2.04TyrSer: 2.04 ± 0.406
1.156TyrThr: 1.156 ± 0.333
1.36TyrVal: 1.36 ± 0.35
0.34TyrTrp: 0.34 ± 0.149
0.816TyrTyr: 0.816 ± 0.239
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 61 proteins (14706 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski