Amino acid dipepetide frequency for Sphingosinicella ginsenosidimutans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.344AlaAla: 22.344 ± 0.254	1.078AlaCys: 1.078 ± 0.039	8.226AlaAsp: 8.226 ± 0.107	8.485AlaGlu: 8.485 ± 0.114	4.674AlaPhe: 4.674 ± 0.078	12.739AlaGly: 12.739 ± 0.155	2.542AlaHis: 2.542 ± 0.055	7.177AlaIle: 7.177 ± 0.095	3.11AlaLys: 3.11 ± 0.076	14.724AlaLeu: 14.724 ± 0.163	3.73AlaMet: 3.73 ± 0.07	3.134AlaAsn: 3.134 ± 0.069	7.506AlaPro: 7.506 ± 0.129	4.393AlaGln: 4.393 ± 0.079	12.091AlaArg: 12.091 ± 0.17	6.342AlaSer: 6.342 ± 0.09	6.507AlaThr: 6.507 ± 0.093	8.505AlaVal: 8.505 ± 0.114	1.83AlaTrp: 1.83 ± 0.051	2.655AlaTyr: 2.655 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	1.056CysAla: 1.056 ± 0.033	0.094CysCys: 0.094 ± 0.011	0.479CysAsp: 0.479 ± 0.024	0.338CysGlu: 0.338 ± 0.022	0.31CysPhe: 0.31 ± 0.021	0.88CysGly: 0.88 ± 0.032	0.244CysHis: 0.244 ± 0.023	0.325CysIle: 0.325 ± 0.018	0.106CysLys: 0.106 ± 0.01	0.671CysLeu: 0.671 ± 0.025	0.12CysMet: 0.12 ± 0.011	0.182CysAsn: 0.182 ± 0.014	0.466CysPro: 0.466 ± 0.027	0.194CysGln: 0.194 ± 0.017	0.615CysArg: 0.615 ± 0.024	0.37CysSer: 0.37 ± 0.021	0.352CysThr: 0.352 ± 0.021	0.505CysVal: 0.505 ± 0.021	0.105CysTrp: 0.105 ± 0.011	0.159CysTyr: 0.159 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.909AspAla: 7.909 ± 0.087	0.457AspCys: 0.457 ± 0.021	3.241AspAsp: 3.241 ± 0.065	3.608AspGlu: 3.608 ± 0.072	2.194AspPhe: 2.194 ± 0.056	5.654AspGly: 5.654 ± 0.095	1.345AspHis: 1.345 ± 0.043	2.75AspIle: 2.75 ± 0.054	1.215AspLys: 1.215 ± 0.038	5.868AspLeu: 5.868 ± 0.089	1.308AspMet: 1.308 ± 0.036	1.291AspAsn: 1.291 ± 0.041	4.314AspPro: 4.314 ± 0.066	1.827AspGln: 1.827 ± 0.054	5.483AspArg: 5.483 ± 0.092	2.443AspSer: 2.443 ± 0.055	2.272AspThr: 2.272 ± 0.048	3.903AspVal: 3.903 ± 0.065	1.131AspTrp: 1.131 ± 0.033	1.691AspTyr: 1.691 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	8.899GluAla: 8.899 ± 0.123	0.305GluCys: 0.305 ± 0.018	2.693GluAsp: 2.693 ± 0.057	3.225GluGlu: 3.225 ± 0.069	1.373GluPhe: 1.373 ± 0.038	4.718GluGly: 4.718 ± 0.084	1.051GluHis: 1.051 ± 0.039	3.098GluIle: 3.098 ± 0.061	1.505GluLys: 1.505 ± 0.053	4.855GluLeu: 4.855 ± 0.083	1.371GluMet: 1.371 ± 0.04	1.251GluAsn: 1.251 ± 0.038	2.569GluPro: 2.569 ± 0.06	1.877GluGln: 1.877 ± 0.043	5.396GluArg: 5.396 ± 0.097	2.464GluSer: 2.464 ± 0.052	3.285GluThr: 3.285 ± 0.061	3.69GluVal: 3.69 ± 0.076	0.756GluTrp: 0.756 ± 0.03	0.84GluTyr: 0.84 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.949PheAla: 4.949 ± 0.072	0.289PheCys: 0.289 ± 0.02	2.558PheAsp: 2.558 ± 0.054	2.011PheGlu: 2.011 ± 0.048	1.246PhePhe: 1.246 ± 0.042	3.555PheGly: 3.555 ± 0.077	0.724PheHis: 0.724 ± 0.032	1.33PheIle: 1.33 ± 0.039	0.616PheLys: 0.616 ± 0.026	3.12PheLeu: 3.12 ± 0.068	0.663PheMet: 0.663 ± 0.032	0.967PheAsn: 0.967 ± 0.035	1.551PhePro: 1.551 ± 0.044	0.875PheGln: 0.875 ± 0.031	2.314PheArg: 2.314 ± 0.051	1.863PheSer: 1.863 ± 0.048	1.88PheThr: 1.88 ± 0.046	2.588PheVal: 2.588 ± 0.059	0.529PheTrp: 0.529 ± 0.025	0.877PheTyr: 0.877 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	11.242GlyAla: 11.242 ± 0.132	0.823GlyCys: 0.823 ± 0.028	5.238GlyAsp: 5.238 ± 0.084	5.189GlyGlu: 5.189 ± 0.097	3.519GlyPhe: 3.519 ± 0.075	8.747GlyGly: 8.747 ± 0.175	2.053GlyHis: 2.053 ± 0.053	4.318GlyIle: 4.318 ± 0.075	2.316GlyLys: 2.316 ± 0.058	8.914GlyLeu: 8.914 ± 0.115	2.092GlyMet: 2.092 ± 0.052	2.18GlyAsn: 2.18 ± 0.06	4.321GlyPro: 4.321 ± 0.089	2.951GlyGln: 2.951 ± 0.069	7.945GlyArg: 7.945 ± 0.105	4.582GlySer: 4.582 ± 0.092	4.874GlyThr: 4.874 ± 0.103	5.93GlyVal: 5.93 ± 0.095	1.718GlyTrp: 1.718 ± 0.053	2.172GlyTyr: 2.172 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	2.377HisAla: 2.377 ± 0.056	0.202HisCys: 0.202 ± 0.017	1.227HisAsp: 1.227 ± 0.043	1.027HisGlu: 1.027 ± 0.035	0.82HisPhe: 0.82 ± 0.032	1.999HisGly: 1.999 ± 0.05	0.532HisHis: 0.532 ± 0.026	0.866HisIle: 0.866 ± 0.033	0.383HisLys: 0.383 ± 0.021	1.977HisLeu: 1.977 ± 0.04	0.462HisMet: 0.462 ± 0.022	0.461HisAsn: 0.461 ± 0.023	1.393HisPro: 1.393 ± 0.043	0.555HisGln: 0.555 ± 0.028	1.704HisArg: 1.704 ± 0.047	0.902HisSer: 0.902 ± 0.036	0.589HisThr: 0.589 ± 0.026	1.628HisVal: 1.628 ± 0.045	0.363HisTrp: 0.363 ± 0.022	0.604HisTyr: 0.604 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	8.197IleAla: 8.197 ± 0.093	0.412IleCys: 0.412 ± 0.023	3.972IleAsp: 3.972 ± 0.071	3.74IleGlu: 3.74 ± 0.081	1.452IlePhe: 1.452 ± 0.041	5.241IleGly: 5.241 ± 0.078	0.928IleHis: 0.928 ± 0.037	1.675IleIle: 1.675 ± 0.049	0.856IleLys: 0.856 ± 0.036	4.071IleLeu: 4.071 ± 0.071	0.78IleMet: 0.78 ± 0.029	1.213IleAsn: 1.213 ± 0.041	2.226IlePro: 2.226 ± 0.05	1.209IleGln: 1.209 ± 0.04	3.489IleArg: 3.489 ± 0.058	2.298IleSer: 2.298 ± 0.058	2.047IleThr: 2.047 ± 0.054	4.415IleVal: 4.415 ± 0.073	0.577IleTrp: 0.577 ± 0.027	0.939IleTyr: 0.939 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.304LysAla: 3.304 ± 0.071	0.123LysCys: 0.123 ± 0.011	1.167LysAsp: 1.167 ± 0.044	1.022LysGlu: 1.022 ± 0.044	0.556LysPhe: 0.556 ± 0.024	2.006LysGly: 2.006 ± 0.058	0.417LysHis: 0.417 ± 0.024	1.198LysIle: 1.198 ± 0.039	0.79LysLys: 0.79 ± 0.035	2.462LysLeu: 2.462 ± 0.057	0.557LysMet: 0.557 ± 0.027	0.49LysAsn: 0.49 ± 0.025	1.366LysPro: 1.366 ± 0.041	0.612LysGln: 0.612 ± 0.027	1.851LysArg: 1.851 ± 0.05	1.115LysSer: 1.115 ± 0.046	1.252LysThr: 1.252 ± 0.04	1.666LysVal: 1.666 ± 0.048	0.281LysTrp: 0.281 ± 0.017	0.447LysTyr: 0.447 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	15.248LeuAla: 15.248 ± 0.168	0.721LeuCys: 0.721 ± 0.03	6.446LeuAsp: 6.446 ± 0.096	4.565LeuGlu: 4.565 ± 0.078	3.557LeuPhe: 3.557 ± 0.078	8.462LeuGly: 8.462 ± 0.106	1.826LeuHis: 1.826 ± 0.041	5.006LeuIle: 5.006 ± 0.102	2.646LeuLys: 2.646 ± 0.067	9.285LeuLeu: 9.285 ± 0.144	1.92LeuMet: 1.92 ± 0.057	2.266LeuAsn: 2.266 ± 0.051	5.384LeuPro: 5.384 ± 0.095	2.338LeuGln: 2.338 ± 0.049	7.314LeuArg: 7.314 ± 0.099	5.373LeuSer: 5.373 ± 0.074	5.056LeuThr: 5.056 ± 0.074	7.366LeuVal: 7.366 ± 0.094	1.246LeuTrp: 1.246 ± 0.039	1.98LeuTyr: 1.98 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	3.038MetAla: 3.038 ± 0.063	0.139MetCys: 0.139 ± 0.012	1.075MetAsp: 1.075 ± 0.035	1.006MetGlu: 1.006 ± 0.033	0.627MetPhe: 0.627 ± 0.027	1.679MetGly: 1.679 ± 0.041	0.375MetHis: 0.375 ± 0.021	1.32MetIle: 1.32 ± 0.038	0.773MetLys: 0.773 ± 0.028	2.333MetLeu: 2.333 ± 0.049	0.577MetMet: 0.577 ± 0.027	0.649MetAsn: 0.649 ± 0.029	1.349MetPro: 1.349 ± 0.039	0.627MetGln: 0.627 ± 0.028	1.893MetArg: 1.893 ± 0.047	1.36MetSer: 1.36 ± 0.041	1.532MetThr: 1.532 ± 0.041	1.388MetVal: 1.388 ± 0.038	0.205MetTrp: 0.205 ± 0.015	0.236MetTyr: 0.236 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.077AsnAla: 3.077 ± 0.067	0.208AsnCys: 0.208 ± 0.018	1.3AsnAsp: 1.3 ± 0.041	1.079AsnGlu: 1.079 ± 0.037	0.892AsnPhe: 0.892 ± 0.038	2.365AsnGly: 2.365 ± 0.073	0.465AsnHis: 0.465 ± 0.023	1.203AsnIle: 1.203 ± 0.042	0.451AsnLys: 0.451 ± 0.023	2.484AsnLeu: 2.484 ± 0.06	0.494AsnMet: 0.494 ± 0.023	0.637AsnAsn: 0.637 ± 0.029	1.773AsnPro: 1.773 ± 0.051	0.741AsnGln: 0.741 ± 0.031	1.906AsnArg: 1.906 ± 0.048	1.108AsnSer: 1.108 ± 0.036	0.946AsnThr: 0.946 ± 0.04	1.875AsnVal: 1.875 ± 0.049	0.367AsnTrp: 0.367 ± 0.021	0.637AsnTyr: 0.637 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	8.351ProAla: 8.351 ± 0.128	0.381ProCys: 0.381 ± 0.021	4.087ProAsp: 4.087 ± 0.08	3.561ProGlu: 3.561 ± 0.062	1.894ProPhe: 1.894 ± 0.047	5.358ProGly: 5.358 ± 0.075	1.168ProHis: 1.168 ± 0.038	2.632ProIle: 2.632 ± 0.054	1.17ProLys: 1.17 ± 0.036	4.833ProLeu: 4.833 ± 0.084	1.133ProMet: 1.133 ± 0.034	1.312ProAsn: 1.312 ± 0.039	3.645ProPro: 3.645 ± 0.111	1.759ProGln: 1.759 ± 0.045	3.746ProArg: 3.746 ± 0.076	2.686ProSer: 2.686 ± 0.063	2.536ProThr: 2.536 ± 0.052	4.283ProVal: 4.283 ± 0.071	0.681ProTrp: 0.681 ± 0.03	1.131ProTyr: 1.131 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.331GlnAla: 4.331 ± 0.079	0.195GlnCys: 0.195 ± 0.015	1.373GlnAsp: 1.373 ± 0.04	1.178GlnGlu: 1.178 ± 0.041	0.969GlnPhe: 0.969 ± 0.036	2.51GlnGly: 2.51 ± 0.054	0.568GlnHis: 0.568 ± 0.025	1.631GlnIle: 1.631 ± 0.046	0.642GlnLys: 0.642 ± 0.033	2.995GlnLeu: 2.995 ± 0.062	0.739GlnMet: 0.739 ± 0.032	0.694GlnAsn: 0.694 ± 0.035	1.905GlnPro: 1.905 ± 0.055	1.212GlnGln: 1.212 ± 0.06	2.681GlnArg: 2.681 ± 0.06	1.611GlnSer: 1.611 ± 0.042	1.551GlnThr: 1.551 ± 0.049	2.115GlnVal: 2.115 ± 0.048	0.408GlnTrp: 0.408 ± 0.019	0.564GlnTyr: 0.564 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	11.044ArgAla: 11.044 ± 0.135	0.564ArgCys: 0.564 ± 0.025	4.696ArgAsp: 4.696 ± 0.082	4.472ArgGlu: 4.472 ± 0.078	3.324ArgPhe: 3.324 ± 0.057	6.132ArgGly: 6.132 ± 0.092	1.813ArgHis: 1.813 ± 0.046	4.85ArgIle: 4.85 ± 0.067	1.796ArgLys: 1.796 ± 0.05	9.312ArgLeu: 9.312 ± 0.124	2.046ArgMet: 2.046 ± 0.052	1.895ArgAsn: 1.895 ± 0.049	4.718ArgPro: 4.718 ± 0.081	2.648ArgGln: 2.648 ± 0.061	7.665ArgArg: 7.665 ± 0.117	3.773ArgSer: 3.773 ± 0.072	3.855ArgThr: 3.855 ± 0.067	5.078ArgVal: 5.078 ± 0.075	1.413ArgTrp: 1.413 ± 0.045	1.957ArgTyr: 1.957 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	6.282SerAla: 6.282 ± 0.096	0.398SerCys: 0.398 ± 0.024	2.839SerAsp: 2.839 ± 0.049	2.36SerGlu: 2.36 ± 0.054	1.929SerPhe: 1.929 ± 0.045	5.349SerGly: 5.349 ± 0.093	0.897SerHis: 0.897 ± 0.03	2.546SerIle: 2.546 ± 0.059	0.974SerLys: 0.974 ± 0.036	4.861SerLeu: 4.861 ± 0.075	0.95SerMet: 0.95 ± 0.033	1.232SerAsn: 1.232 ± 0.043	2.738SerPro: 2.738 ± 0.054	1.441SerGln: 1.441 ± 0.04	3.92SerArg: 3.92 ± 0.057	2.492SerSer: 2.492 ± 0.103	2.398SerThr: 2.398 ± 0.06	3.355SerVal: 3.355 ± 0.07	0.787SerTrp: 0.787 ± 0.028	1.171SerTyr: 1.171 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	6.028ThrAla: 6.028 ± 0.089	0.361ThrCys: 0.361 ± 0.022	2.756ThrAsp: 2.756 ± 0.054	2.207ThrGlu: 2.207 ± 0.052	1.691ThrPhe: 1.691 ± 0.048	5.172ThrGly: 5.172 ± 0.1	0.919ThrHis: 0.919 ± 0.03	2.875ThrIle: 2.875 ± 0.06	0.982ThrLys: 0.982 ± 0.035	5.342ThrLeu: 5.342 ± 0.079	1.072ThrMet: 1.072 ± 0.033	1.256ThrAsn: 1.256 ± 0.043	3.391ThrPro: 3.391 ± 0.067	1.384ThrGln: 1.384 ± 0.04	3.659ThrArg: 3.659 ± 0.059	2.495ThrSer: 2.495 ± 0.052	2.48ThrThr: 2.48 ± 0.061	3.71ThrVal: 3.71 ± 0.067	0.631ThrTrp: 0.631 ± 0.026	1.126ThrTyr: 1.126 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	9.977ValAla: 9.977 ± 0.115	0.504ValCys: 0.504 ± 0.027	4.321ValAsp: 4.321 ± 0.072	4.337ValGlu: 4.337 ± 0.077	2.049ValPhe: 2.049 ± 0.054	5.475ValGly: 5.475 ± 0.092	1.393ValHis: 1.393 ± 0.041	3.466ValIle: 3.466 ± 0.058	1.602ValLys: 1.602 ± 0.05	6.111ValLeu: 6.111 ± 0.086	1.453ValMet: 1.453 ± 0.045	1.924ValAsn: 1.924 ± 0.056	3.907ValPro: 3.907 ± 0.064	1.964ValGln: 1.964 ± 0.056	5.715ValArg: 5.715 ± 0.079	3.75ValSer: 3.75 ± 0.075	4.365ValThr: 4.365 ± 0.079	5.074ValVal: 5.074 ± 0.086	0.806ValTrp: 0.806 ± 0.033	1.353ValTyr: 1.353 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.434TrpAla: 1.434 ± 0.052	0.119TrpCys: 0.119 ± 0.011	0.726TrpAsp: 0.726 ± 0.026	0.608TrpGlu: 0.608 ± 0.025	0.568TrpPhe: 0.568 ± 0.023	0.975TrpGly: 0.975 ± 0.033	0.382TrpHis: 0.382 ± 0.024	0.745TrpIle: 0.745 ± 0.03	0.335TrpLys: 0.335 ± 0.02	1.745TrpLeu: 1.745 ± 0.048	0.369TrpMet: 0.369 ± 0.02	0.425TrpAsn: 0.425 ± 0.022	0.787TrpPro: 0.787 ± 0.028	0.567TrpGln: 0.567 ± 0.024	1.555TrpArg: 1.555 ± 0.05	0.849TrpSer: 0.849 ± 0.036	0.863TrpThr: 0.863 ± 0.03	0.833TrpVal: 0.833 ± 0.031	0.283TrpTrp: 0.283 ± 0.018	0.288TrpTyr: 0.288 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.703TyrAla: 2.703 ± 0.047	0.2TyrCys: 0.2 ± 0.016	1.486TyrAsp: 1.486 ± 0.048	1.203TyrGlu: 1.203 ± 0.038	0.86TyrPhe: 0.86 ± 0.036	2.11TyrGly: 2.11 ± 0.052	0.427TyrHis: 0.427 ± 0.018	0.727TyrIle: 0.727 ± 0.03	0.412TyrLys: 0.412 ± 0.023	2.041TyrLeu: 2.041 ± 0.056	0.347TyrMet: 0.347 ± 0.022	0.55TyrAsn: 0.55 ± 0.027	1.037TyrPro: 1.037 ± 0.033	0.697TyrGln: 0.697 ± 0.031	2.11TyrArg: 2.11 ± 0.053	1.048TyrSer: 1.048 ± 0.037	0.895TyrThr: 0.895 ± 0.033	1.636TyrVal: 1.636 ± 0.052	0.336TyrTrp: 0.336 ± 0.021	0.641TyrTyr: 0.641 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2928 proteins (924825 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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