Amino acid dipepetide frequency for Mycolicibacterium anyangense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.616AlaAla: 20.616 ± 0.145	0.986AlaCys: 0.986 ± 0.023	8.547AlaAsp: 8.547 ± 0.076	7.445AlaGlu: 7.445 ± 0.075	3.475AlaPhe: 3.475 ± 0.041	11.976AlaGly: 11.976 ± 0.112	2.537AlaHis: 2.537 ± 0.037	5.546AlaIle: 5.546 ± 0.055	3.014AlaLys: 3.014 ± 0.05	13.179AlaLeu: 13.179 ± 0.118	2.907AlaMet: 2.907 ± 0.04	2.693AlaAsn: 2.693 ± 0.04	6.568AlaPro: 6.568 ± 0.08	4.104AlaGln: 4.104 ± 0.05	8.154AlaArg: 8.154 ± 0.08	5.896AlaSer: 5.896 ± 0.062	7.482AlaThr: 7.482 ± 0.076	12.083AlaVal: 12.083 ± 0.078	1.581AlaTrp: 1.581 ± 0.03	2.366AlaTyr: 2.366 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	1.084CysAla: 1.084 ± 0.027	0.086CysCys: 0.086 ± 0.008	0.513CysAsp: 0.513 ± 0.016	0.406CysGlu: 0.406 ± 0.016	0.242CysPhe: 0.242 ± 0.011	0.924CysGly: 0.924 ± 0.023	0.159CysHis: 0.159 ± 0.009	0.294CysIle: 0.294 ± 0.013	0.116CysLys: 0.116 ± 0.008	0.621CysLeu: 0.621 ± 0.021	0.127CysMet: 0.127 ± 0.008	0.184CysAsn: 0.184 ± 0.01	0.5CysPro: 0.5 ± 0.017	0.227CysGln: 0.227 ± 0.011	0.554CysArg: 0.554 ± 0.019	0.491CysSer: 0.491 ± 0.018	0.519CysThr: 0.519 ± 0.018	0.639CysVal: 0.639 ± 0.02	0.128CysTrp: 0.128 ± 0.009	0.211CysTyr: 0.211 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.409AspAla: 7.409 ± 0.072	0.444AspCys: 0.444 ± 0.015	4.116AspAsp: 4.116 ± 0.053	3.793AspGlu: 3.793 ± 0.053	1.818AspPhe: 1.818 ± 0.034	5.896AspGly: 5.896 ± 0.063	1.397AspHis: 1.397 ± 0.027	2.72AspIle: 2.72 ± 0.041	1.314AspLys: 1.314 ± 0.027	6.063AspLeu: 6.063 ± 0.065	1.041AspMet: 1.041 ± 0.026	1.35AspAsn: 1.35 ± 0.027	4.423AspPro: 4.423 ± 0.05	1.86AspGln: 1.86 ± 0.034	4.333AspArg: 4.333 ± 0.045	2.954AspSer: 2.954 ± 0.045	3.334AspThr: 3.334 ± 0.045	5.24AspVal: 5.24 ± 0.064	1.004AspTrp: 1.004 ± 0.025	1.383AspTyr: 1.383 ± 0.029	0.0AspXaa: 0.0 ± 0.0
Glu	5.784GluAla: 5.784 ± 0.069	0.34GluCys: 0.34 ± 0.015	2.382GluAsp: 2.382 ± 0.042	2.317GluGlu: 2.317 ± 0.044	1.756GluPhe: 1.756 ± 0.032	3.119GluGly: 3.119 ± 0.041	1.446GluHis: 1.446 ± 0.031	2.563GluIle: 2.563 ± 0.042	1.296GluLys: 1.296 ± 0.035	6.321GluLeu: 6.321 ± 0.068	1.03GluMet: 1.03 ± 0.026	1.054GluAsn: 1.054 ± 0.024	2.938GluPro: 2.938 ± 0.05	2.21GluGln: 2.21 ± 0.037	4.007GluArg: 4.007 ± 0.057	2.62GluSer: 2.62 ± 0.039	2.458GluThr: 2.458 ± 0.041	4.316GluVal: 4.316 ± 0.05	0.659GluTrp: 0.659 ± 0.019	1.089GluTyr: 1.089 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.047PheAla: 4.047 ± 0.05	0.31PheCys: 0.31 ± 0.013	2.384PheAsp: 2.384 ± 0.037	1.494PheGlu: 1.494 ± 0.031	1.097PhePhe: 1.097 ± 0.028	3.535PheGly: 3.535 ± 0.042	0.659PheHis: 0.659 ± 0.021	1.145PheIle: 1.145 ± 0.032	0.545PheLys: 0.545 ± 0.017	2.658PheLeu: 2.658 ± 0.041	0.487PheMet: 0.487 ± 0.017	0.791PheAsn: 0.791 ± 0.022	1.409PhePro: 1.409 ± 0.03	0.691PheGln: 0.691 ± 0.02	1.643PheArg: 1.643 ± 0.027	1.753PheSer: 1.753 ± 0.033	2.18PheThr: 2.18 ± 0.035	2.592PheVal: 2.592 ± 0.039	0.479PheTrp: 0.479 ± 0.017	0.752PheTyr: 0.752 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	10.309GlyAla: 10.309 ± 0.11	0.806GlyCys: 0.806 ± 0.025	4.892GlyAsp: 4.892 ± 0.053	4.2GlyGlu: 4.2 ± 0.057	3.097GlyPhe: 3.097 ± 0.043	8.461GlyGly: 8.461 ± 0.228	2.038GlyHis: 2.038 ± 0.034	4.283GlyIle: 4.283 ± 0.046	2.24GlyLys: 2.24 ± 0.041	8.838GlyLeu: 8.838 ± 0.078	2.09GlyMet: 2.09 ± 0.041	2.169GlyAsn: 2.169 ± 0.063	4.629GlyPro: 4.629 ± 0.063	3.083GlyGln: 3.083 ± 0.05	6.103GlyArg: 6.103 ± 0.051	5.503GlySer: 5.503 ± 0.065	5.584GlyThr: 5.584 ± 0.083	7.793GlyVal: 7.793 ± 0.071	1.668GlyTrp: 1.668 ± 0.029	2.423GlyTyr: 2.423 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	2.345HisAla: 2.345 ± 0.041	0.227HisCys: 0.227 ± 0.012	1.327HisAsp: 1.327 ± 0.029	1.014HisGlu: 1.014 ± 0.028	0.674HisPhe: 0.674 ± 0.022	2.067HisGly: 2.067 ± 0.034	0.678HisHis: 0.678 ± 0.026	0.84HisIle: 0.84 ± 0.022	0.349HisLys: 0.349 ± 0.014	2.112HisLeu: 2.112 ± 0.034	0.347HisMet: 0.347 ± 0.014	0.507HisAsn: 0.507 ± 0.018	1.641HisPro: 1.641 ± 0.031	0.7HisGln: 0.7 ± 0.019	1.821HisArg: 1.821 ± 0.035	1.132HisSer: 1.132 ± 0.027	1.238HisThr: 1.238 ± 0.026	1.663HisVal: 1.663 ± 0.036	0.383HisTrp: 0.383 ± 0.016	0.565HisTyr: 0.565 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.599IleAla: 6.599 ± 0.068	0.403IleCys: 0.403 ± 0.015	3.414IleAsp: 3.414 ± 0.045	2.512IleGlu: 2.512 ± 0.038	1.12IlePhe: 1.12 ± 0.025	4.709IleGly: 4.709 ± 0.054	0.798IleHis: 0.798 ± 0.024	1.575IleIle: 1.575 ± 0.033	0.934IleLys: 0.934 ± 0.024	3.275IleLeu: 3.275 ± 0.046	0.632IleMet: 0.632 ± 0.02	1.221IleAsn: 1.221 ± 0.026	2.46IlePro: 2.46 ± 0.039	0.997IleGln: 0.997 ± 0.027	2.629IleArg: 2.629 ± 0.036	2.496IleSer: 2.496 ± 0.038	2.985IleThr: 2.985 ± 0.046	3.855IleVal: 3.855 ± 0.047	0.522IleTrp: 0.522 ± 0.016	0.856IleTyr: 0.856 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	2.77LysAla: 2.77 ± 0.046	0.103LysCys: 0.103 ± 0.008	1.139LysAsp: 1.139 ± 0.026	0.907LysGlu: 0.907 ± 0.025	0.64LysPhe: 0.64 ± 0.019	1.581LysGly: 1.581 ± 0.038	0.471LysHis: 0.471 ± 0.018	1.026LysIle: 1.026 ± 0.023	0.676LysLys: 0.676 ± 0.028	2.156LysLeu: 2.156 ± 0.041	0.472LysMet: 0.472 ± 0.016	0.523LysAsn: 0.523 ± 0.019	1.433LysPro: 1.433 ± 0.033	0.719LysGln: 0.719 ± 0.022	1.502LysArg: 1.502 ± 0.031	1.233LysSer: 1.233 ± 0.027	1.353LysThr: 1.353 ± 0.028	1.968LysVal: 1.968 ± 0.037	0.315LysTrp: 0.315 ± 0.015	0.488LysTyr: 0.488 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	14.21LeuAla: 14.21 ± 0.115	0.811LeuCys: 0.811 ± 0.021	6.544LeuAsp: 6.544 ± 0.067	4.249LeuGlu: 4.249 ± 0.049	2.809LeuPhe: 2.809 ± 0.044	8.917LeuGly: 8.917 ± 0.083	2.024LeuHis: 2.024 ± 0.035	4.243LeuIle: 4.243 ± 0.047	1.837LeuLys: 1.837 ± 0.032	9.596LeuLeu: 9.596 ± 0.102	1.752LeuMet: 1.752 ± 0.034	2.174LeuAsn: 2.174 ± 0.034	5.876LeuPro: 5.876 ± 0.052	2.625LeuGln: 2.625 ± 0.04	7.257LeuArg: 7.257 ± 0.082	5.906LeuSer: 5.906 ± 0.061	6.448LeuThr: 6.448 ± 0.063	8.511LeuVal: 8.511 ± 0.079	1.216LeuTrp: 1.216 ± 0.029	1.713LeuTyr: 1.713 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	2.657MetAla: 2.657 ± 0.036	0.188MetCys: 0.188 ± 0.009	0.863MetAsp: 0.863 ± 0.022	0.641MetGlu: 0.641 ± 0.018	0.648MetPhe: 0.648 ± 0.021	1.531MetGly: 1.531 ± 0.027	0.387MetHis: 0.387 ± 0.014	0.941MetIle: 0.941 ± 0.024	0.443MetLys: 0.443 ± 0.016	2.061MetLeu: 2.061 ± 0.037	0.4MetMet: 0.4 ± 0.015	0.472MetAsn: 0.472 ± 0.017	1.204MetPro: 1.204 ± 0.028	0.538MetGln: 0.538 ± 0.017	1.458MetArg: 1.458 ± 0.029	1.527MetSer: 1.527 ± 0.03	1.834MetThr: 1.834 ± 0.037	1.652MetVal: 1.652 ± 0.033	0.272MetTrp: 0.272 ± 0.012	0.356MetTyr: 0.356 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.714AsnAla: 2.714 ± 0.042	0.208AsnCys: 0.208 ± 0.011	1.262AsnAsp: 1.262 ± 0.028	0.947AsnGlu: 0.947 ± 0.024	0.704AsnPhe: 0.704 ± 0.023	2.391AsnGly: 2.391 ± 0.073	0.474AsnHis: 0.474 ± 0.016	1.013AsnIle: 1.013 ± 0.03	0.465AsnLys: 0.465 ± 0.018	2.156AsnLeu: 2.156 ± 0.035	0.417AsnMet: 0.417 ± 0.016	0.611AsnAsn: 0.611 ± 0.02	1.851AsnPro: 1.851 ± 0.035	0.708AsnGln: 0.708 ± 0.024	1.539AsnArg: 1.539 ± 0.038	1.253AsnSer: 1.253 ± 0.028	1.399AsnThr: 1.399 ± 0.03	1.842AsnVal: 1.842 ± 0.033	0.394AsnTrp: 0.394 ± 0.013	0.597AsnTyr: 0.597 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	7.699ProAla: 7.699 ± 0.087	0.31ProCys: 0.31 ± 0.014	4.317ProAsp: 4.317 ± 0.058	3.478ProGlu: 3.478 ± 0.039	1.631ProPhe: 1.631 ± 0.033	5.802ProGly: 5.802 ± 0.075	1.193ProHis: 1.193 ± 0.028	2.267ProIle: 2.267 ± 0.036	1.294ProLys: 1.294 ± 0.031	4.929ProLeu: 4.929 ± 0.052	1.212ProMet: 1.212 ± 0.027	1.365ProAsn: 1.365 ± 0.031	3.635ProPro: 3.635 ± 0.083	1.924ProGln: 1.924 ± 0.037	3.249ProArg: 3.249 ± 0.045	3.158ProSer: 3.158 ± 0.044	3.555ProThr: 3.555 ± 0.049	5.254ProVal: 5.254 ± 0.062	0.85ProTrp: 0.85 ± 0.024	1.214ProTyr: 1.214 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.764GlnAla: 3.764 ± 0.048	0.255GlnCys: 0.255 ± 0.014	1.273GlnAsp: 1.273 ± 0.023	1.077GlnGlu: 1.077 ± 0.025	0.975GlnPhe: 0.975 ± 0.024	2.141GlnGly: 2.141 ± 0.037	0.741GlnHis: 0.741 ± 0.022	1.62GlnIle: 1.62 ± 0.031	0.663GlnLys: 0.663 ± 0.021	3.556GlnLeu: 3.556 ± 0.055	0.701GlnMet: 0.701 ± 0.021	0.688GlnAsn: 0.688 ± 0.02	1.912GlnPro: 1.912 ± 0.036	1.357GlnGln: 1.357 ± 0.027	2.75GlnArg: 2.75 ± 0.036	1.604GlnSer: 1.604 ± 0.033	1.687GlnThr: 1.687 ± 0.033	2.634GlnVal: 2.634 ± 0.041	0.663GlnTrp: 0.663 ± 0.015	0.679GlnTyr: 0.679 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	7.919ArgAla: 7.919 ± 0.081	0.56ArgCys: 0.56 ± 0.02	4.003ArgAsp: 4.003 ± 0.047	3.532ArgGlu: 3.532 ± 0.058	2.26ArgPhe: 2.26 ± 0.041	4.951ArgGly: 4.951 ± 0.057	1.687ArgHis: 1.687 ± 0.034	3.375ArgIle: 3.375 ± 0.04	1.436ArgLys: 1.436 ± 0.028	7.221ArgLeu: 7.221 ± 0.074	1.669ArgMet: 1.669 ± 0.03	1.586ArgAsn: 1.586 ± 0.028	3.854ArgPro: 3.854 ± 0.053	2.252ArgGln: 2.252 ± 0.042	6.044ArgArg: 6.044 ± 0.08	3.936ArgSer: 3.936 ± 0.047	4.152ArgThr: 4.152 ± 0.053	5.261ArgVal: 5.261 ± 0.064	1.292ArgTrp: 1.292 ± 0.028	1.821ArgTyr: 1.821 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	7.387SerAla: 7.387 ± 0.079	0.396SerCys: 0.396 ± 0.016	3.314SerAsp: 3.314 ± 0.048	2.529SerGlu: 2.529 ± 0.038	1.785SerPhe: 1.785 ± 0.035	5.827SerGly: 5.827 ± 0.067	1.084SerHis: 1.084 ± 0.027	2.311SerIle: 2.311 ± 0.035	1.154SerLys: 1.154 ± 0.028	4.86SerLeu: 4.86 ± 0.053	1.379SerMet: 1.379 ± 0.027	1.153SerAsn: 1.153 ± 0.028	3.197SerPro: 3.197 ± 0.042	1.548SerGln: 1.548 ± 0.029	3.588SerArg: 3.588 ± 0.045	3.335SerSer: 3.335 ± 0.052	3.577SerThr: 3.577 ± 0.049	4.665SerVal: 4.665 ± 0.051	0.939SerTrp: 0.939 ± 0.023	1.295SerTyr: 1.295 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	8.175ThrAla: 8.175 ± 0.065	0.428ThrCys: 0.428 ± 0.015	3.737ThrAsp: 3.737 ± 0.053	3.14ThrGlu: 3.14 ± 0.048	1.945ThrPhe: 1.945 ± 0.033	6.027ThrGly: 6.027 ± 0.074	1.196ThrHis: 1.196 ± 0.026	2.607ThrIle: 2.607 ± 0.038	1.305ThrLys: 1.305 ± 0.027	5.826ThrLeu: 5.826 ± 0.052	1.223ThrMet: 1.223 ± 0.027	1.295ThrAsn: 1.295 ± 0.028	3.924ThrPro: 3.924 ± 0.048	1.503ThrGln: 1.503 ± 0.028	3.467ThrArg: 3.467 ± 0.043	3.411ThrSer: 3.411 ± 0.05	4.135ThrThr: 4.135 ± 0.069	6.291ThrVal: 6.291 ± 0.068	0.875ThrTrp: 0.875 ± 0.022	1.362ThrTyr: 1.362 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	11.706ValAla: 11.706 ± 0.091	0.775ValCys: 0.775 ± 0.02	5.709ValAsp: 5.709 ± 0.059	4.383ValGlu: 4.383 ± 0.057	2.59ValPhe: 2.59 ± 0.04	7.2ValGly: 7.2 ± 0.073	1.811ValHis: 1.811 ± 0.032	4.202ValIle: 4.202 ± 0.052	1.712ValLys: 1.712 ± 0.035	9.159ValLeu: 9.159 ± 0.077	1.606ValMet: 1.606 ± 0.037	2.142ValAsn: 2.142 ± 0.038	4.759ValPro: 4.759 ± 0.062	2.233ValGln: 2.233 ± 0.041	5.725ValArg: 5.725 ± 0.055	4.93ValSer: 4.93 ± 0.056	5.738ValThr: 5.738 ± 0.058	8.787ValVal: 8.787 ± 0.081	1.088ValTrp: 1.088 ± 0.025	1.552ValTyr: 1.552 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.578TrpAla: 1.578 ± 0.032	0.15TrpCys: 0.15 ± 0.011	0.765TrpAsp: 0.765 ± 0.021	0.621TrpGlu: 0.621 ± 0.02	0.562TrpPhe: 0.562 ± 0.017	1.046TrpGly: 1.046 ± 0.027	0.366TrpHis: 0.366 ± 0.014	0.689TrpIle: 0.689 ± 0.022	0.311TrpLys: 0.311 ± 0.014	1.777TrpLeu: 1.777 ± 0.039	0.307TrpMet: 0.307 ± 0.014	0.439TrpAsn: 0.439 ± 0.017	0.851TrpPro: 0.851 ± 0.023	0.678TrpGln: 0.678 ± 0.018	1.237TrpArg: 1.237 ± 0.033	0.967TrpSer: 0.967 ± 0.022	0.913TrpThr: 0.913 ± 0.022	1.121TrpVal: 1.121 ± 0.027	0.352TrpTrp: 0.352 ± 0.015	0.328TrpTyr: 0.328 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.383TyrAla: 2.383 ± 0.037	0.238TyrCys: 0.238 ± 0.011	1.394TyrAsp: 1.394 ± 0.031	1.022TyrGlu: 1.022 ± 0.024	0.822TyrPhe: 0.822 ± 0.022	2.111TyrGly: 2.111 ± 0.036	0.483TyrHis: 0.483 ± 0.016	0.731TyrIle: 0.731 ± 0.02	0.372TyrLys: 0.372 ± 0.017	2.354TyrLeu: 2.354 ± 0.041	0.273TyrMet: 0.273 ± 0.013	0.525TyrAsn: 0.525 ± 0.019	1.273TyrPro: 1.273 ± 0.033	0.782TyrGln: 0.782 ± 0.019	1.752TyrArg: 1.752 ± 0.037	1.216TyrSer: 1.216 ± 0.027	1.304TyrThr: 1.304 ± 0.032	1.638TyrVal: 1.638 ± 0.033	0.376TyrTrp: 0.376 ± 0.016	0.53TyrTyr: 0.53 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5421 proteins (1769607 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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