Amino acid dipepetide frequency for Commensalibacter sp. MX01

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.267AlaAla: 7.267 ± 0.137
1.068AlaCys: 1.068 ± 0.04
3.884AlaAsp: 3.884 ± 0.08
4.286AlaGlu: 4.286 ± 0.099
3.286AlaPhe: 3.286 ± 0.071
5.93AlaGly: 5.93 ± 0.122
1.574AlaHis: 1.574 ± 0.049
6.07AlaIle: 6.07 ± 0.109
4.713AlaLys: 4.713 ± 0.082
8.884AlaLeu: 8.884 ± 0.138
2.099AlaMet: 2.099 ± 0.062
3.11AlaAsn: 3.11 ± 0.076
3.045AlaPro: 3.045 ± 0.071
3.875AlaGln: 3.875 ± 0.091
3.544AlaArg: 3.544 ± 0.07
4.987AlaSer: 4.987 ± 0.101
3.964AlaThr: 3.964 ± 0.074
5.255AlaVal: 5.255 ± 0.104
0.975AlaTrp: 0.975 ± 0.041
2.463AlaTyr: 2.463 ± 0.061
0.0AlaXaa: 0.0 ± 0.0
Cys
0.905CysAla: 0.905 ± 0.034
0.222CysCys: 0.222 ± 0.018
0.587CysAsp: 0.587 ± 0.03
0.509CysGlu: 0.509 ± 0.025
0.571CysPhe: 0.571 ± 0.03
0.928CysGly: 0.928 ± 0.036
0.293CysHis: 0.293 ± 0.022
0.895CysIle: 0.895 ± 0.034
0.49CysLys: 0.49 ± 0.032
1.162CysLeu: 1.162 ± 0.045
0.235CysMet: 0.235 ± 0.02
0.5CysAsn: 0.5 ± 0.025
0.51CysPro: 0.51 ± 0.03
0.421CysGln: 0.421 ± 0.029
0.478CysArg: 0.478 ± 0.026
0.723CysSer: 0.723 ± 0.035
0.469CysThr: 0.469 ± 0.03
0.688CysVal: 0.688 ± 0.031
0.169CysTrp: 0.169 ± 0.02
0.388CysTyr: 0.388 ± 0.028
0.0CysXaa: 0.0 ± 0.0
Asp
3.853AspAla: 3.853 ± 0.095
0.49AspCys: 0.49 ± 0.028
2.443AspAsp: 2.443 ± 0.066
2.862AspGlu: 2.862 ± 0.082
2.288AspPhe: 2.288 ± 0.055
3.539AspGly: 3.539 ± 0.084
1.403AspHis: 1.403 ± 0.045
4.222AspIle: 4.222 ± 0.076
3.09AspLys: 3.09 ± 0.085
5.091AspLeu: 5.091 ± 0.086
1.309AspMet: 1.309 ± 0.045
2.316AspAsn: 2.316 ± 0.064
2.561AspPro: 2.561 ± 0.063
2.68AspGln: 2.68 ± 0.063
2.46AspArg: 2.46 ± 0.064
2.606AspSer: 2.606 ± 0.062
2.562AspThr: 2.562 ± 0.063
3.262AspVal: 3.262 ± 0.079
0.733AspTrp: 0.733 ± 0.033
1.863AspTyr: 1.863 ± 0.058
0.0AspXaa: 0.0 ± 0.0
Glu
4.568GluAla: 4.568 ± 0.09
0.496GluCys: 0.496 ± 0.029
2.701GluAsp: 2.701 ± 0.071
3.498GluGlu: 3.498 ± 0.108
1.949GluPhe: 1.949 ± 0.06
3.186GluGly: 3.186 ± 0.076
1.312GluHis: 1.312 ± 0.047
4.226GluIle: 4.226 ± 0.088
4.129GluLys: 4.129 ± 0.079
5.114GluLeu: 5.114 ± 0.105
1.453GluMet: 1.453 ± 0.046
2.886GluAsn: 2.886 ± 0.066
1.704GluPro: 1.704 ± 0.05
3.069GluGln: 3.069 ± 0.085
2.615GluArg: 2.615 ± 0.076
2.466GluSer: 2.466 ± 0.069
3.012GluThr: 3.012 ± 0.076
3.333GluVal: 3.333 ± 0.081
0.825GluTrp: 0.825 ± 0.035
1.679GluTyr: 1.679 ± 0.053
0.0GluXaa: 0.0 ± 0.0
Phe
3.243PheAla: 3.243 ± 0.069
0.681PheCys: 0.681 ± 0.031
2.313PheAsp: 2.313 ± 0.057
2.064PheGlu: 2.064 ± 0.054
2.288PhePhe: 2.288 ± 0.065
3.061PheGly: 3.061 ± 0.075
0.826PheHis: 0.826 ± 0.038
3.41PheIle: 3.41 ± 0.094
2.151PheLys: 2.151 ± 0.046
4.206PheLeu: 4.206 ± 0.098
1.045PheMet: 1.045 ± 0.04
2.048PheAsn: 2.048 ± 0.059
1.784PhePro: 1.784 ± 0.051
1.385PheGln: 1.385 ± 0.048
1.494PheArg: 1.494 ± 0.045
3.351PheSer: 3.351 ± 0.068
2.371PheThr: 2.371 ± 0.063
2.715PheVal: 2.715 ± 0.076
0.615PheTrp: 0.615 ± 0.032
1.57PheTyr: 1.57 ± 0.061
0.0PheXaa: 0.0 ± 0.0
Gly
5.321GlyAla: 5.321 ± 0.102
0.918GlyCys: 0.918 ± 0.044
3.297GlyAsp: 3.297 ± 0.084
3.343GlyGlu: 3.343 ± 0.074
3.284GlyPhe: 3.284 ± 0.074
5.512GlyGly: 5.512 ± 0.151
1.491GlyHis: 1.491 ± 0.046
5.333GlyIle: 5.333 ± 0.099
4.486GlyLys: 4.486 ± 0.092
6.684GlyLeu: 6.684 ± 0.117
1.867GlyMet: 1.867 ± 0.062
3.186GlyAsn: 3.186 ± 0.114
1.992GlyPro: 1.992 ± 0.055
2.756GlyGln: 2.756 ± 0.075
3.259GlyArg: 3.259 ± 0.084
4.329GlySer: 4.329 ± 0.105
3.575GlyThr: 3.575 ± 0.088
4.74GlyVal: 4.74 ± 0.099
1.1GlyTrp: 1.1 ± 0.045
2.631GlyTyr: 2.631 ± 0.067
0.0GlyXaa: 0.0 ± 0.0
His
1.696HisAla: 1.696 ± 0.049
0.27HisCys: 0.27 ± 0.021
1.1HisAsp: 1.1 ± 0.046
1.039HisGlu: 1.039 ± 0.039
1.061HisPhe: 1.061 ± 0.042
1.511HisGly: 1.511 ± 0.05
0.771HisHis: 0.771 ± 0.038
1.765HisIle: 1.765 ± 0.051
1.21HisLys: 1.21 ± 0.041
2.174HisLeu: 2.174 ± 0.064
0.535HisMet: 0.535 ± 0.032
1.065HisAsn: 1.065 ± 0.042
1.296HisPro: 1.296 ± 0.048
1.167HisGln: 1.167 ± 0.044
0.975HisArg: 0.975 ± 0.036
1.402HisSer: 1.402 ± 0.046
1.095HisThr: 1.095 ± 0.04
1.287HisVal: 1.287 ± 0.048
0.335HisTrp: 0.335 ± 0.022
0.949HisTyr: 0.949 ± 0.041
0.0HisXaa: 0.0 ± 0.0
Ile
6.917IleAla: 6.917 ± 0.103
0.914IleCys: 0.914 ± 0.039
4.229IleAsp: 4.229 ± 0.086
4.527IleGlu: 4.527 ± 0.09
3.136IlePhe: 3.136 ± 0.086
5.477IleGly: 5.477 ± 0.116
1.631IleHis: 1.631 ± 0.049
6.181IleIle: 6.181 ± 0.127
4.177IleLys: 4.177 ± 0.086
7.734IleLeu: 7.734 ± 0.125
1.679IleMet: 1.679 ± 0.051
3.511IleAsn: 3.511 ± 0.105
3.713IlePro: 3.713 ± 0.087
3.093IleGln: 3.093 ± 0.081
3.014IleArg: 3.014 ± 0.069
5.094IleSer: 5.094 ± 0.097
4.621IleThr: 4.621 ± 0.097
4.721IleVal: 4.721 ± 0.099
0.915IleTrp: 0.915 ± 0.043
2.239IleTyr: 2.239 ± 0.061
0.0IleXaa: 0.0 ± 0.0
Lys
5.027LysAla: 5.027 ± 0.11
0.321LysCys: 0.321 ± 0.02
3.52LysAsp: 3.52 ± 0.076
4.333LysGlu: 4.333 ± 0.096
1.575LysPhe: 1.575 ± 0.051
3.75LysGly: 3.75 ± 0.091
1.188LysHis: 1.188 ± 0.05
4.84LysIle: 4.84 ± 0.099
4.552LysLys: 4.552 ± 0.099
5.085LysLeu: 5.085 ± 0.093
1.549LysMet: 1.549 ± 0.051
3.47LysAsn: 3.47 ± 0.072
2.466LysPro: 2.466 ± 0.06
2.989LysGln: 2.989 ± 0.071
2.76LysArg: 2.76 ± 0.069
3.163LysSer: 3.163 ± 0.08
3.476LysThr: 3.476 ± 0.066
3.387LysVal: 3.387 ± 0.077
0.616LysTrp: 0.616 ± 0.027
1.615LysTyr: 1.615 ± 0.05
0.0LysXaa: 0.0 ± 0.0
Leu
7.778LeuAla: 7.778 ± 0.127
1.336LeuCys: 1.336 ± 0.043
4.84LeuAsp: 4.84 ± 0.09
4.855LeuGlu: 4.855 ± 0.089
4.519LeuPhe: 4.519 ± 0.103
6.636LeuGly: 6.636 ± 0.112
2.201LeuHis: 2.201 ± 0.058
6.913LeuIle: 6.913 ± 0.127
5.777LeuLys: 5.777 ± 0.089
9.972LeuLeu: 9.972 ± 0.169
2.351LeuMet: 2.351 ± 0.063
4.82LeuAsn: 4.82 ± 0.1
5.101LeuPro: 5.101 ± 0.097
4.342LeuGln: 4.342 ± 0.096
4.57LeuArg: 4.57 ± 0.101
7.82LeuSer: 7.82 ± 0.116
5.84LeuThr: 5.84 ± 0.117
5.601LeuVal: 5.601 ± 0.103
1.186LeuTrp: 1.186 ± 0.046
3.027LeuTyr: 3.027 ± 0.071
0.0LeuXaa: 0.0 ± 0.0
Met
2.212MetAla: 2.212 ± 0.062
0.195MetCys: 0.195 ± 0.015
1.264MetAsp: 1.264 ± 0.05
1.058MetGlu: 1.058 ± 0.039
0.787MetPhe: 0.787 ± 0.039
1.798MetGly: 1.798 ± 0.054
0.487MetHis: 0.487 ± 0.027
1.849MetIle: 1.849 ± 0.057
1.309MetLys: 1.309 ± 0.044
2.239MetLeu: 2.239 ± 0.059
0.755MetMet: 0.755 ± 0.033
1.354MetAsn: 1.354 ± 0.045
1.287MetPro: 1.287 ± 0.051
1.208MetGln: 1.208 ± 0.041
1.159MetArg: 1.159 ± 0.05
1.682MetSer: 1.682 ± 0.052
1.564MetThr: 1.564 ± 0.051
1.657MetVal: 1.657 ± 0.052
0.195MetTrp: 0.195 ± 0.017
0.49MetTyr: 0.49 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
3.595AsnAla: 3.595 ± 0.088
0.447AsnCys: 0.447 ± 0.026
2.422AsnAsp: 2.422 ± 0.061
2.179AsnGlu: 2.179 ± 0.065
1.86AsnPhe: 1.86 ± 0.056
3.173AsnGly: 3.173 ± 0.127
1.132AsnHis: 1.132 ± 0.04
4.286AsnIle: 4.286 ± 0.103
2.979AsnLys: 2.979 ± 0.078
4.655AsnLeu: 4.655 ± 0.092
1.076AsnMet: 1.076 ± 0.044
2.718AsnAsn: 2.718 ± 0.111
2.437AsnPro: 2.437 ± 0.071
2.282AsnGln: 2.282 ± 0.064
1.973AsnArg: 1.973 ± 0.053
2.877AsnSer: 2.877 ± 0.103
2.661AsnThr: 2.661 ± 0.096
2.701AsnVal: 2.701 ± 0.085
0.586AsnTrp: 0.586 ± 0.031
1.589AsnTyr: 1.589 ± 0.053
0.0AsnXaa: 0.0 ± 0.0
Pro
3.167ProAla: 3.167 ± 0.071
0.41ProCys: 0.41 ± 0.026
2.642ProAsp: 2.642 ± 0.078
3.017ProGlu: 3.017 ± 0.081
2.068ProPhe: 2.068 ± 0.059
2.464ProGly: 2.464 ± 0.061
1.004ProHis: 1.004 ± 0.041
3.131ProIle: 3.131 ± 0.069
2.585ProLys: 2.585 ± 0.064
4.409ProLeu: 4.409 ± 0.084
0.952ProMet: 0.952 ± 0.037
2.014ProAsn: 2.014 ± 0.047
1.745ProPro: 1.745 ± 0.068
1.915ProGln: 1.915 ± 0.059
1.535ProArg: 1.535 ± 0.047
2.985ProSer: 2.985 ± 0.068
2.409ProThr: 2.409 ± 0.057
3.2ProVal: 3.2 ± 0.076
0.596ProTrp: 0.596 ± 0.03
1.551ProTyr: 1.551 ± 0.05
0.0ProXaa: 0.0 ± 0.0
Gln
3.967GlnAla: 3.967 ± 0.09
0.337GlnCys: 0.337 ± 0.022
2.319GlnAsp: 2.319 ± 0.063
2.896GlnGlu: 2.896 ± 0.068
1.785GlnPhe: 1.785 ± 0.056
2.913GlnGly: 2.913 ± 0.07
1.067GlnHis: 1.067 ± 0.044
3.317GlnIle: 3.317 ± 0.074
3.055GlnLys: 3.055 ± 0.082
4.135GlnLeu: 4.135 ± 0.092
1.038GlnMet: 1.038 ± 0.04
2.422GlnAsn: 2.422 ± 0.083
1.752GlnPro: 1.752 ± 0.053
2.759GlnGln: 2.759 ± 0.097
2.137GlnArg: 2.137 ± 0.055
2.807GlnSer: 2.807 ± 0.078
2.515GlnThr: 2.515 ± 0.073
2.45GlnVal: 2.45 ± 0.058
0.643GlnTrp: 0.643 ± 0.033
1.609GlnTyr: 1.609 ± 0.054
0.0GlnXaa: 0.0 ± 0.0
Arg
3.218ArgAla: 3.218 ± 0.086
0.414ArgCys: 0.414 ± 0.026
2.09ArgAsp: 2.09 ± 0.06
2.272ArgGlu: 2.272 ± 0.069
2.208ArgPhe: 2.208 ± 0.059
2.542ArgGly: 2.542 ± 0.067
1.121ArgHis: 1.121 ± 0.046
3.238ArgIle: 3.238 ± 0.074
2.539ArgLys: 2.539 ± 0.066
5.003ArgLeu: 5.003 ± 0.11
1.087ArgMet: 1.087 ± 0.038
2.013ArgAsn: 2.013 ± 0.052
1.979ArgPro: 1.979 ± 0.051
2.061ArgGln: 2.061 ± 0.066
2.416ArgArg: 2.416 ± 0.076
2.543ArgSer: 2.543 ± 0.061
1.97ArgThr: 1.97 ± 0.054
2.8ArgVal: 2.8 ± 0.074
0.598ArgTrp: 0.598 ± 0.029
1.546ArgTyr: 1.546 ± 0.052
0.0ArgXaa: 0.0 ± 0.0
Ser
4.741SerAla: 4.741 ± 0.082
0.711SerCys: 0.711 ± 0.036
3.203SerAsp: 3.203 ± 0.079
3.149SerGlu: 3.149 ± 0.073
3.295SerPhe: 3.295 ± 0.07
4.783SerGly: 4.783 ± 0.143
1.406SerHis: 1.406 ± 0.046
5.032SerIle: 5.032 ± 0.109
3.502SerLys: 3.502 ± 0.067
6.822SerLeu: 6.822 ± 0.115
1.532SerMet: 1.532 ± 0.047
2.808SerAsn: 2.808 ± 0.086
2.766SerPro: 2.766 ± 0.068
2.677SerGln: 2.677 ± 0.069
2.526SerArg: 2.526 ± 0.062
4.468SerSer: 4.468 ± 0.099
3.23SerThr: 3.23 ± 0.069
4.279SerVal: 4.279 ± 0.086
0.87SerTrp: 0.87 ± 0.038
2.087SerTyr: 2.087 ± 0.053
0.0SerXaa: 0.0 ± 0.0
Thr
4.318ThrAla: 4.318 ± 0.085
0.514ThrCys: 0.514 ± 0.027
2.823ThrAsp: 2.823 ± 0.074
2.76ThrGlu: 2.76 ± 0.072
1.988ThrPhe: 1.988 ± 0.052
4.226ThrGly: 4.226 ± 0.102
1.249ThrHis: 1.249 ± 0.043
4.463ThrIle: 4.463 ± 0.108
2.842ThrLys: 2.842 ± 0.069
5.819ThrLeu: 5.819 ± 0.11
1.199ThrMet: 1.199 ± 0.04
2.463ThrAsn: 2.463 ± 0.08
2.887ThrPro: 2.887 ± 0.06
2.447ThrGln: 2.447 ± 0.068
2.036ThrArg: 2.036 ± 0.062
3.457ThrSer: 3.457 ± 0.08
3.039ThrThr: 3.039 ± 0.077
3.528ThrVal: 3.528 ± 0.079
0.583ThrTrp: 0.583 ± 0.029
1.641ThrTyr: 1.641 ± 0.058
0.0ThrXaa: 0.0 ± 0.0
Val
5.263ValAla: 5.263 ± 0.109
0.816ValCys: 0.816 ± 0.036
3.472ValAsp: 3.472 ± 0.073
3.423ValGlu: 3.423 ± 0.093
2.594ValPhe: 2.594 ± 0.067
4.473ValGly: 4.473 ± 0.087
1.236ValHis: 1.236 ± 0.046
5.124ValIle: 5.124 ± 0.093
3.576ValLys: 3.576 ± 0.08
5.563ValLeu: 5.563 ± 0.111
1.778ValMet: 1.778 ± 0.052
2.728ValAsn: 2.728 ± 0.075
2.725ValPro: 2.725 ± 0.064
2.432ValGln: 2.432 ± 0.052
2.562ValArg: 2.562 ± 0.067
4.264ValSer: 4.264 ± 0.086
3.727ValThr: 3.727 ± 0.087
4.396ValVal: 4.396 ± 0.107
0.724ValTrp: 0.724 ± 0.033
1.742ValTyr: 1.742 ± 0.049
0.0ValXaa: 0.0 ± 0.0
Trp
0.821TrpAla: 0.821 ± 0.039
0.173TrpCys: 0.173 ± 0.013
0.637TrpAsp: 0.637 ± 0.029
0.589TrpGlu: 0.589 ± 0.027
0.582TrpPhe: 0.582 ± 0.032
0.909TrpGly: 0.909 ± 0.042
0.363TrpHis: 0.363 ± 0.022
0.971TrpIle: 0.971 ± 0.04
0.735TrpLys: 0.735 ± 0.03
1.535TrpLeu: 1.535 ± 0.051
0.35TrpMet: 0.35 ± 0.022
0.596TrpAsn: 0.596 ± 0.028
0.509TrpPro: 0.509 ± 0.029
0.705TrpGln: 0.705 ± 0.032
0.692TrpArg: 0.692 ± 0.031
0.765TrpSer: 0.765 ± 0.033
0.512TrpThr: 0.512 ± 0.025
0.872TrpVal: 0.872 ± 0.036
0.197TrpTrp: 0.197 ± 0.019
0.412TrpTyr: 0.412 ± 0.032
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.405TyrAla: 2.405 ± 0.064
0.41TyrCys: 0.41 ± 0.027
1.847TyrAsp: 1.847 ± 0.059
1.559TyrGlu: 1.559 ± 0.057
1.494TyrPhe: 1.494 ± 0.047
2.29TyrGly: 2.29 ± 0.065
0.949TyrHis: 0.949 ± 0.039
2.256TyrIle: 2.256 ± 0.058
1.785TyrLys: 1.785 ± 0.062
3.199TyrLeu: 3.199 ± 0.08
0.66TyrMet: 0.66 ± 0.031
1.6TyrAsn: 1.6 ± 0.057
1.542TyrPro: 1.542 ± 0.048
1.657TyrGln: 1.657 ± 0.055
1.453TyrArg: 1.453 ± 0.046
2.102TyrSer: 2.102 ± 0.057
1.672TyrThr: 1.672 ± 0.05
1.749TyrVal: 1.749 ± 0.058
0.461TyrTrp: 0.461 ± 0.025
1.253TyrTyr: 1.253 ± 0.048
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2060 proteins (686148 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski