Amino acid dipepetide frequency for Steroidobacter denitrificans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.698AlaAla: 16.698 ± 0.177	1.259AlaCys: 1.259 ± 0.035	6.25AlaAsp: 6.25 ± 0.091	6.615AlaGlu: 6.615 ± 0.088	3.61AlaPhe: 3.61 ± 0.06	10.499AlaGly: 10.499 ± 0.113	2.606AlaHis: 2.606 ± 0.048	5.478AlaIle: 5.478 ± 0.08	2.971AlaLys: 2.971 ± 0.067	13.265AlaLeu: 13.265 ± 0.144	2.972AlaMet: 2.972 ± 0.054	2.694AlaAsn: 2.694 ± 0.055	5.109AlaPro: 5.109 ± 0.074	5.006AlaGln: 5.006 ± 0.084	9.57AlaArg: 9.57 ± 0.116	6.07AlaSer: 6.07 ± 0.08	5.263AlaThr: 5.263 ± 0.072	8.109AlaVal: 8.109 ± 0.098	1.578AlaTrp: 1.578 ± 0.048	2.559AlaTyr: 2.559 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	1.109CysAla: 1.109 ± 0.04	0.135CysCys: 0.135 ± 0.01	0.565CysAsp: 0.565 ± 0.022	0.595CysGlu: 0.595 ± 0.027	0.314CysPhe: 0.314 ± 0.019	1.013CysGly: 1.013 ± 0.034	0.279CysHis: 0.279 ± 0.019	0.467CysIle: 0.467 ± 0.022	0.22CysLys: 0.22 ± 0.016	0.909CysLeu: 0.909 ± 0.035	0.223CysMet: 0.223 ± 0.014	0.222CysAsn: 0.222 ± 0.017	0.476CysPro: 0.476 ± 0.026	0.267CysGln: 0.267 ± 0.015	0.817CysArg: 0.817 ± 0.029	0.576CysSer: 0.576 ± 0.022	0.46CysThr: 0.46 ± 0.022	0.711CysVal: 0.711 ± 0.031	0.128CysTrp: 0.128 ± 0.012	0.229CysTyr: 0.229 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.613AspAla: 6.613 ± 0.092	0.515AspCys: 0.515 ± 0.026	2.822AspAsp: 2.822 ± 0.055	3.623AspGlu: 3.623 ± 0.061	2.136AspPhe: 2.136 ± 0.05	4.492AspGly: 4.492 ± 0.081	1.194AspHis: 1.194 ± 0.034	2.948AspIle: 2.948 ± 0.058	1.394AspLys: 1.394 ± 0.037	5.819AspLeu: 5.819 ± 0.081	1.2AspMet: 1.2 ± 0.04	1.135AspAsn: 1.135 ± 0.034	3.321AspPro: 3.321 ± 0.054	1.664AspGln: 1.664 ± 0.043	4.182AspArg: 4.182 ± 0.069	2.614AspSer: 2.614 ± 0.051	2.837AspThr: 2.837 ± 0.05	4.016AspVal: 4.016 ± 0.064	0.912AspTrp: 0.912 ± 0.029	1.542AspTyr: 1.542 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	6.875GluAla: 6.875 ± 0.097	0.491GluCys: 0.491 ± 0.024	2.711GluAsp: 2.711 ± 0.059	3.07GluGlu: 3.07 ± 0.067	2.142GluPhe: 2.142 ± 0.055	3.669GluGly: 3.669 ± 0.059	1.597GluHis: 1.597 ± 0.039	3.432GluIle: 3.432 ± 0.06	1.763GluLys: 1.763 ± 0.044	6.693GluLeu: 6.693 ± 0.093	1.37GluMet: 1.37 ± 0.036	1.509GluAsn: 1.509 ± 0.039	2.625GluPro: 2.625 ± 0.054	3.032GluGln: 3.032 ± 0.064	6.007GluArg: 6.007 ± 0.099	2.973GluSer: 2.973 ± 0.059	2.933GluThr: 2.933 ± 0.057	4.185GluVal: 4.185 ± 0.057	0.722GluTrp: 0.722 ± 0.028	1.431GluTyr: 1.431 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.866PheAla: 3.866 ± 0.065	0.394PheCys: 0.394 ± 0.023	2.532PheAsp: 2.532 ± 0.049	2.235PheGlu: 2.235 ± 0.044	1.251PhePhe: 1.251 ± 0.042	3.17PheGly: 3.17 ± 0.057	0.791PheHis: 0.791 ± 0.029	1.703PheIle: 1.703 ± 0.043	0.962PheLys: 0.962 ± 0.036	3.13PheLeu: 3.13 ± 0.058	0.829PheMet: 0.829 ± 0.027	0.959PheAsn: 0.959 ± 0.031	1.448PhePro: 1.448 ± 0.04	1.107PheGln: 1.107 ± 0.035	2.195PheArg: 2.195 ± 0.047	2.09PheSer: 2.09 ± 0.051	1.856PheThr: 1.856 ± 0.047	2.54PheVal: 2.54 ± 0.054	0.478PheTrp: 0.478 ± 0.025	0.905PheTyr: 0.905 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	8.526GlyAla: 8.526 ± 0.099	0.902GlyCys: 0.902 ± 0.033	3.911GlyAsp: 3.911 ± 0.073	4.794GlyGlu: 4.794 ± 0.064	3.099GlyPhe: 3.099 ± 0.056	6.536GlyGly: 6.536 ± 0.109	1.857GlyHis: 1.857 ± 0.049	4.489GlyIle: 4.489 ± 0.076	2.808GlyLys: 2.808 ± 0.059	8.224GlyLeu: 8.224 ± 0.104	2.248GlyMet: 2.248 ± 0.047	2.027GlyAsn: 2.027 ± 0.047	2.932GlyPro: 2.932 ± 0.063	2.988GlyGln: 2.988 ± 0.059	6.616GlyArg: 6.616 ± 0.087	4.621GlySer: 4.621 ± 0.071	4.48GlyThr: 4.48 ± 0.066	6.085GlyVal: 6.085 ± 0.084	1.305GlyTrp: 1.305 ± 0.035	2.349GlyTyr: 2.349 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	2.689HisAla: 2.689 ± 0.056	0.286HisCys: 0.286 ± 0.017	1.347HisAsp: 1.347 ± 0.032	1.373HisGlu: 1.373 ± 0.039	0.857HisPhe: 0.857 ± 0.028	2.115HisGly: 2.115 ± 0.047	0.602HisHis: 0.602 ± 0.028	1.054HisIle: 1.054 ± 0.037	0.525HisLys: 0.525 ± 0.023	2.231HisLeu: 2.231 ± 0.044	0.51HisMet: 0.51 ± 0.022	0.524HisAsn: 0.524 ± 0.025	1.51HisPro: 1.51 ± 0.039	0.707HisGln: 0.707 ± 0.024	1.759HisArg: 1.759 ± 0.041	1.152HisSer: 1.152 ± 0.034	1.095HisThr: 1.095 ± 0.037	1.645HisVal: 1.645 ± 0.042	0.398HisTrp: 0.398 ± 0.019	0.649HisTyr: 0.649 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.534IleAla: 6.534 ± 0.087	0.5IleCys: 0.5 ± 0.022	3.843IleAsp: 3.843 ± 0.066	4.035IleGlu: 4.035 ± 0.068	1.487IlePhe: 1.487 ± 0.043	4.603IleGly: 4.603 ± 0.082	1.148IleHis: 1.148 ± 0.037	2.143IleIle: 2.143 ± 0.056	1.381IleLys: 1.381 ± 0.044	4.399IleLeu: 4.399 ± 0.068	0.917IleMet: 0.917 ± 0.036	1.336IleAsn: 1.336 ± 0.04	2.36IlePro: 2.36 ± 0.051	1.523IleGln: 1.523 ± 0.035	3.714IleArg: 3.714 ± 0.065	2.689IleSer: 2.689 ± 0.052	2.487IleThr: 2.487 ± 0.047	4.323IleVal: 4.323 ± 0.061	0.503IleTrp: 0.503 ± 0.023	1.16IleTyr: 1.16 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	3.012LysAla: 3.012 ± 0.068	0.163LysCys: 0.163 ± 0.014	1.477LysAsp: 1.477 ± 0.041	1.535LysGlu: 1.535 ± 0.044	0.849LysPhe: 0.849 ± 0.033	1.886LysGly: 1.886 ± 0.048	0.599LysHis: 0.599 ± 0.025	1.54LysIle: 1.54 ± 0.04	1.041LysLys: 1.041 ± 0.038	3.051LysLeu: 3.051 ± 0.055	0.645LysMet: 0.645 ± 0.025	0.776LysAsn: 0.776 ± 0.025	1.6LysPro: 1.6 ± 0.043	1.12LysGln: 1.12 ± 0.037	2.247LysArg: 2.247 ± 0.058	1.589LysSer: 1.589 ± 0.042	1.583LysThr: 1.583 ± 0.042	2.009LysVal: 2.009 ± 0.05	0.293LysTrp: 0.293 ± 0.018	0.697LysTyr: 0.697 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	13.596LeuAla: 13.596 ± 0.134	1.007LeuCys: 1.007 ± 0.034	6.387LeuAsp: 6.387 ± 0.098	6.663LeuGlu: 6.663 ± 0.095	3.391LeuPhe: 3.391 ± 0.067	8.354LeuGly: 8.354 ± 0.106	2.45LeuHis: 2.45 ± 0.055	5.048LeuIle: 5.048 ± 0.071	3.24LeuLys: 3.24 ± 0.064	11.209LeuLeu: 11.209 ± 0.147	2.273LeuMet: 2.273 ± 0.043	2.639LeuAsn: 2.639 ± 0.053	5.732LeuPro: 5.732 ± 0.086	4.284LeuGln: 4.284 ± 0.076	8.849LeuArg: 8.849 ± 0.116	6.372LeuSer: 6.372 ± 0.086	5.355LeuThr: 5.355 ± 0.067	7.053LeuVal: 7.053 ± 0.099	1.217LeuTrp: 1.217 ± 0.039	2.259LeuTyr: 2.259 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	2.472MetAla: 2.472 ± 0.046	0.175MetCys: 0.175 ± 0.014	1.205MetAsp: 1.205 ± 0.034	1.162MetGlu: 1.162 ± 0.033	0.702MetPhe: 0.702 ± 0.029	1.566MetGly: 1.566 ± 0.043	0.611MetHis: 0.611 ± 0.025	1.164MetIle: 1.164 ± 0.033	0.874MetLys: 0.874 ± 0.028	2.618MetLeu: 2.618 ± 0.048	0.547MetMet: 0.547 ± 0.025	0.885MetAsn: 0.885 ± 0.031	1.522MetPro: 1.522 ± 0.036	1.119MetGln: 1.119 ± 0.037	1.972MetArg: 1.972 ± 0.045	1.692MetSer: 1.692 ± 0.044	1.481MetThr: 1.481 ± 0.035	1.387MetVal: 1.387 ± 0.033	0.207MetTrp: 0.207 ± 0.014	0.41MetTyr: 0.41 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.973AsnAla: 2.973 ± 0.054	0.244AsnCys: 0.244 ± 0.016	1.346AsnAsp: 1.346 ± 0.033	1.367AsnGlu: 1.367 ± 0.037	0.888AsnPhe: 0.888 ± 0.031	1.945AsnGly: 1.945 ± 0.046	0.495AsnHis: 0.495 ± 0.021	1.376AsnIle: 1.376 ± 0.038	0.601AsnLys: 0.601 ± 0.025	2.733AsnLeu: 2.733 ± 0.056	0.55AsnMet: 0.55 ± 0.023	0.589AsnAsn: 0.589 ± 0.027	1.74AsnPro: 1.74 ± 0.043	0.801AsnGln: 0.801 ± 0.03	1.903AsnArg: 1.903 ± 0.039	1.195AsnSer: 1.195 ± 0.036	1.273AsnThr: 1.273 ± 0.033	1.873AsnVal: 1.873 ± 0.051	0.38AsnTrp: 0.38 ± 0.02	0.685AsnTyr: 0.685 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	6.445ProAla: 6.445 ± 0.089	0.363ProCys: 0.363 ± 0.02	3.135ProAsp: 3.135 ± 0.048	3.454ProGlu: 3.454 ± 0.057	1.653ProPhe: 1.653 ± 0.042	4.675ProGly: 4.675 ± 0.078	1.093ProHis: 1.093 ± 0.031	2.218ProIle: 2.218 ± 0.043	1.206ProLys: 1.206 ± 0.034	4.83ProLeu: 4.83 ± 0.081	1.274ProMet: 1.274 ± 0.034	1.152ProAsn: 1.152 ± 0.036	2.585ProPro: 2.585 ± 0.056	2.098ProGln: 2.098 ± 0.05	3.409ProArg: 3.409 ± 0.058	2.611ProSer: 2.611 ± 0.05	2.178ProThr: 2.178 ± 0.047	3.973ProVal: 3.973 ± 0.069	0.634ProTrp: 0.634 ± 0.026	1.158ProTyr: 1.158 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	5.08GlnAla: 5.08 ± 0.08	0.325GlnCys: 0.325 ± 0.02	1.901GlnAsp: 1.901 ± 0.044	2.101GlnGlu: 2.101 ± 0.053	1.2GlnPhe: 1.2 ± 0.034	2.911GlnGly: 2.911 ± 0.062	0.916GlnHis: 0.916 ± 0.031	2.058GlnIle: 2.058 ± 0.045	0.991GlnLys: 0.991 ± 0.031	4.265GlnLeu: 4.265 ± 0.073	0.84GlnMet: 0.84 ± 0.027	0.801GlnAsn: 0.801 ± 0.03	1.919GlnPro: 1.919 ± 0.044	1.854GlnGln: 1.854 ± 0.046	3.522GlnArg: 3.522 ± 0.063	1.944GlnSer: 1.944 ± 0.051	1.758GlnThr: 1.758 ± 0.045	2.809GlnVal: 2.809 ± 0.059	0.623GlnTrp: 0.623 ± 0.027	0.819GlnTyr: 0.819 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	8.099ArgAla: 8.099 ± 0.107	0.777ArgCys: 0.777 ± 0.029	4.103ArgAsp: 4.103 ± 0.065	5.118ArgGlu: 5.118 ± 0.082	3.241ArgPhe: 3.241 ± 0.053	5.42ArgGly: 5.42 ± 0.076	2.098ArgHis: 2.098 ± 0.048	4.86ArgIle: 4.86 ± 0.072	2.353ArgLys: 2.353 ± 0.054	9.432ArgLeu: 9.432 ± 0.125	2.182ArgMet: 2.182 ± 0.05	2.161ArgAsn: 2.161 ± 0.045	3.735ArgPro: 3.735 ± 0.069	3.318ArgGln: 3.318 ± 0.059	7.466ArgArg: 7.466 ± 0.102	4.482ArgSer: 4.482 ± 0.066	3.915ArgThr: 3.915 ± 0.064	5.262ArgVal: 5.262 ± 0.072	1.286ArgTrp: 1.286 ± 0.04	2.351ArgTyr: 2.351 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	6.174SerAla: 6.174 ± 0.068	0.548SerCys: 0.548 ± 0.023	2.707SerAsp: 2.707 ± 0.054	2.783SerGlu: 2.783 ± 0.06	2.079SerPhe: 2.079 ± 0.05	5.377SerGly: 5.377 ± 0.08	1.118SerHis: 1.118 ± 0.033	2.94SerIle: 2.94 ± 0.052	1.413SerLys: 1.413 ± 0.039	6.018SerLeu: 6.018 ± 0.087	1.473SerMet: 1.473 ± 0.037	1.328SerAsn: 1.328 ± 0.038	2.729SerPro: 2.729 ± 0.051	1.83SerGln: 1.83 ± 0.047	4.241SerArg: 4.241 ± 0.067	3.316SerSer: 3.316 ± 0.071	2.829SerThr: 2.829 ± 0.052	3.888SerVal: 3.888 ± 0.07	0.748SerTrp: 0.748 ± 0.027	1.419SerTyr: 1.419 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	5.774ThrAla: 5.774 ± 0.084	0.416ThrCys: 0.416 ± 0.022	2.632ThrAsp: 2.632 ± 0.049	2.376ThrGlu: 2.376 ± 0.048	1.557ThrPhe: 1.557 ± 0.031	4.736ThrGly: 4.736 ± 0.072	1.153ThrHis: 1.153 ± 0.036	2.559ThrIle: 2.559 ± 0.051	1.024ThrLys: 1.024 ± 0.035	6.067ThrLeu: 6.067 ± 0.077	1.07ThrMet: 1.07 ± 0.032	1.206ThrAsn: 1.206 ± 0.035	3.144ThrPro: 3.144 ± 0.056	1.856ThrGln: 1.856 ± 0.047	3.86ThrArg: 3.86 ± 0.068	2.724ThrSer: 2.724 ± 0.054	2.575ThrThr: 2.575 ± 0.065	3.647ThrVal: 3.647 ± 0.062	0.597ThrTrp: 0.597 ± 0.023	1.177ThrTyr: 1.177 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	7.888ValAla: 7.888 ± 0.1	0.745ValCys: 0.745 ± 0.028	4.095ValAsp: 4.095 ± 0.061	4.3ValGlu: 4.3 ± 0.067	2.458ValPhe: 2.458 ± 0.044	4.976ValGly: 4.976 ± 0.08	1.579ValHis: 1.579 ± 0.039	3.804ValIle: 3.804 ± 0.066	1.951ValLys: 1.951 ± 0.047	7.896ValLeu: 7.896 ± 0.098	1.729ValMet: 1.729 ± 0.041	2.027ValAsn: 2.027 ± 0.047	3.806ValPro: 3.806 ± 0.075	2.532ValGln: 2.532 ± 0.051	5.834ValArg: 5.834 ± 0.075	4.127ValSer: 4.127 ± 0.061	3.946ValThr: 3.946 ± 0.077	5.371ValVal: 5.371 ± 0.099	0.824ValTrp: 0.824 ± 0.031	1.546ValTyr: 1.546 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.151TrpAla: 1.151 ± 0.039	0.157TrpCys: 0.157 ± 0.014	0.623TrpAsp: 0.623 ± 0.021	0.596TrpGlu: 0.596 ± 0.022	0.524TrpPhe: 0.524 ± 0.024	0.787TrpGly: 0.787 ± 0.032	0.34TrpHis: 0.34 ± 0.018	0.763TrpIle: 0.763 ± 0.026	0.388TrpLys: 0.388 ± 0.019	1.907TrpLeu: 1.907 ± 0.053	0.393TrpMet: 0.393 ± 0.021	0.445TrpAsn: 0.445 ± 0.023	0.684TrpPro: 0.684 ± 0.027	0.65TrpGln: 0.65 ± 0.03	1.21TrpArg: 1.21 ± 0.037	0.813TrpSer: 0.813 ± 0.031	0.643TrpThr: 0.643 ± 0.022	0.789TrpVal: 0.789 ± 0.029	0.201TrpTrp: 0.201 ± 0.017	0.321TrpTyr: 0.321 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.606TyrAla: 2.606 ± 0.058	0.314TyrCys: 0.314 ± 0.018	1.388TyrAsp: 1.388 ± 0.042	1.435TyrGlu: 1.435 ± 0.039	1.006TyrPhe: 1.006 ± 0.034	2.067TyrGly: 2.067 ± 0.046	0.504TyrHis: 0.504 ± 0.022	1.039TyrIle: 1.039 ± 0.037	0.608TyrLys: 0.608 ± 0.027	2.681TyrLeu: 2.681 ± 0.059	0.525TyrMet: 0.525 ± 0.022	0.542TyrAsn: 0.542 ± 0.025	1.166TyrPro: 1.166 ± 0.032	0.882TyrGln: 0.882 ± 0.028	2.284TyrArg: 2.284 ± 0.054	1.309TyrSer: 1.309 ± 0.043	1.201TyrThr: 1.201 ± 0.034	1.76TyrVal: 1.76 ± 0.044	0.349TyrTrp: 0.349 ± 0.02	0.707TyrTyr: 0.707 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2956 proteins (988673 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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