Amino acid dipepetide frequency for Circoviridae 13 LDMD-2013

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.866AlaAla: 3.866 ± 1.8
0.0AlaCys: 0.0 ± 0.0
5.155AlaAsp: 5.155 ± 1.025
2.577AlaGlu: 2.577 ± 1.549
5.155AlaPhe: 5.155 ± 1.036
1.289AlaGly: 1.289 ± 0.774
2.577AlaHis: 2.577 ± 2.574
3.866AlaIle: 3.866 ± 0.262
3.866AlaLys: 3.866 ± 0.262
2.577AlaLeu: 2.577 ± 2.574
0.0AlaMet: 0.0 ± 0.0
2.577AlaAsn: 2.577 ± 1.549
2.577AlaPro: 2.577 ± 1.549
2.577AlaGln: 2.577 ± 1.549
6.443AlaArg: 6.443 ± 2.312
6.443AlaSer: 6.443 ± 0.251
1.289AlaThr: 1.289 ± 0.774
2.577AlaVal: 2.577 ± 0.513
0.0AlaTrp: 0.0 ± 0.0
1.289AlaTyr: 1.289 ± 1.287
0.0AlaXaa: 0.0 ± 0.0
Cys
1.289CysAla: 1.289 ± 0.774
0.0CysCys: 0.0 ± 0.0
1.289CysAsp: 1.289 ± 0.774
1.289CysGlu: 1.289 ± 1.287
2.577CysPhe: 2.577 ± 2.574
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
2.577CysLys: 2.577 ± 0.513
1.289CysLeu: 1.289 ± 0.774
0.0CysMet: 0.0 ± 0.0
1.289CysAsn: 1.289 ± 0.774
1.289CysPro: 1.289 ± 1.287
1.289CysGln: 1.289 ± 0.774
1.289CysArg: 1.289 ± 0.774
1.289CysSer: 1.289 ± 0.774
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
3.866AspAla: 3.866 ± 2.323
2.577AspCys: 2.577 ± 1.549
5.155AspAsp: 5.155 ± 1.025
7.732AspGlu: 7.732 ± 3.599
2.577AspPhe: 2.577 ± 2.574
3.866AspGly: 3.866 ± 1.8
1.289AspHis: 1.289 ± 0.774
1.289AspIle: 1.289 ± 1.287
0.0AspLys: 0.0 ± 0.0
5.155AspLeu: 5.155 ± 1.025
0.0AspMet: 0.0 ± 0.0
2.577AspAsn: 2.577 ± 1.549
1.289AspPro: 1.289 ± 1.287
2.577AspGln: 2.577 ± 1.549
2.577AspArg: 2.577 ± 0.513
1.289AspSer: 1.289 ± 0.774
2.577AspThr: 2.577 ± 0.513
5.155AspVal: 5.155 ± 3.097
2.577AspTrp: 2.577 ± 1.549
5.155AspTyr: 5.155 ± 1.036
0.0AspXaa: 0.0 ± 0.0
Glu
5.155GluAla: 5.155 ± 5.148
1.289GluCys: 1.289 ± 0.774
2.577GluAsp: 2.577 ± 2.574
7.732GluGlu: 7.732 ± 5.661
2.577GluPhe: 2.577 ± 2.574
2.577GluGly: 2.577 ± 2.574
1.289GluHis: 1.289 ± 1.287
2.577GluIle: 2.577 ± 1.549
3.866GluLys: 3.866 ± 0.262
1.289GluLeu: 1.289 ± 0.774
3.866GluMet: 3.866 ± 1.231
1.289GluAsn: 1.289 ± 1.287
1.289GluPro: 1.289 ± 1.287
1.289GluGln: 1.289 ± 1.287
3.866GluArg: 3.866 ± 1.8
2.577GluSer: 2.577 ± 0.513
5.155GluThr: 5.155 ± 1.036
5.155GluVal: 5.155 ± 1.025
2.577GluTrp: 2.577 ± 0.513
1.289GluTyr: 1.289 ± 1.287
0.0GluXaa: 0.0 ± 0.0
Phe
1.289PheAla: 1.289 ± 1.287
0.0PheCys: 0.0 ± 0.0
3.866PheAsp: 3.866 ± 1.8
2.577PheGlu: 2.577 ± 0.513
1.289PhePhe: 1.289 ± 1.287
6.443PheGly: 6.443 ± 0.251
0.0PheHis: 0.0 ± 0.0
3.866PheIle: 3.866 ± 2.323
1.289PheLys: 1.289 ± 1.287
0.0PheLeu: 0.0 ± 0.0
1.289PheMet: 1.289 ± 0.774
0.0PheAsn: 0.0 ± 0.0
2.577PhePro: 2.577 ± 1.549
2.577PheGln: 2.577 ± 1.549
3.866PheArg: 3.866 ± 0.262
1.289PheSer: 1.289 ± 1.287
3.866PheThr: 3.866 ± 0.262
3.866PheVal: 3.866 ± 1.8
1.289PheTrp: 1.289 ± 1.287
1.289PheTyr: 1.289 ± 0.774
0.0PheXaa: 0.0 ± 0.0
Gly
2.577GlyAla: 2.577 ± 0.513
1.289GlyCys: 1.289 ± 0.774
1.289GlyAsp: 1.289 ± 1.287
3.866GlyGlu: 3.866 ± 3.861
0.0GlyPhe: 0.0 ± 0.0
2.577GlyGly: 2.577 ± 0.513
3.866GlyHis: 3.866 ± 0.262
1.289GlyIle: 1.289 ± 1.287
5.155GlyLys: 5.155 ± 1.036
6.443GlyLeu: 6.443 ± 3.872
2.577GlyMet: 2.577 ± 1.98
1.289GlyAsn: 1.289 ± 0.774
3.866GlyPro: 3.866 ± 0.262
2.577GlyGln: 2.577 ± 0.513
1.289GlyArg: 1.289 ± 1.287
6.443GlySer: 6.443 ± 2.312
5.155GlyThr: 5.155 ± 1.036
2.577GlyVal: 2.577 ± 0.513
2.577GlyTrp: 2.577 ± 0.513
5.155GlyTyr: 5.155 ± 1.025
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
3.866HisGlu: 3.866 ± 1.8
0.0HisPhe: 0.0 ± 0.0
5.155HisGly: 5.155 ± 1.036
0.0HisHis: 0.0 ± 0.0
3.866HisIle: 3.866 ± 0.262
0.0HisLys: 0.0 ± 0.0
2.577HisLeu: 2.577 ± 2.574
1.289HisMet: 1.289 ± 0.774
0.0HisAsn: 0.0 ± 0.0
2.577HisPro: 2.577 ± 1.549
1.289HisGln: 1.289 ± 0.774
3.866HisArg: 3.866 ± 1.8
1.289HisSer: 1.289 ± 0.774
0.0HisThr: 0.0 ± 0.0
1.289HisVal: 1.289 ± 1.287
0.0HisTrp: 0.0 ± 0.0
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
5.155IleAla: 5.155 ± 1.036
0.0IleCys: 0.0 ± 0.0
7.732IleAsp: 7.732 ± 0.523
6.443IleGlu: 6.443 ± 6.435
2.577IlePhe: 2.577 ± 0.513
2.577IleGly: 2.577 ± 1.549
0.0IleHis: 0.0 ± 0.0
2.577IleIle: 2.577 ± 1.549
9.021IleLys: 9.021 ± 3.359
1.289IleLeu: 1.289 ± 0.774
1.289IleMet: 1.289 ± 0.774
2.577IleAsn: 2.577 ± 1.549
1.289IlePro: 1.289 ± 1.287
1.289IleGln: 1.289 ± 0.774
2.577IleArg: 2.577 ± 1.549
3.866IleSer: 3.866 ± 0.262
2.577IleThr: 2.577 ± 0.513
0.0IleVal: 0.0 ± 0.0
0.0IleTrp: 0.0 ± 0.0
3.866IleTyr: 3.866 ± 1.8
0.0IleXaa: 0.0 ± 0.0
Lys
3.866LysAla: 3.866 ± 0.262
1.289LysCys: 1.289 ± 0.774
5.155LysAsp: 5.155 ± 1.036
0.0LysGlu: 0.0 ± 0.0
6.443LysPhe: 6.443 ± 3.872
5.155LysGly: 5.155 ± 1.036
1.289LysHis: 1.289 ± 0.774
3.866LysIle: 3.866 ± 2.323
10.309LysLys: 10.309 ± 4.133
2.577LysLeu: 2.577 ± 0.513
1.289LysMet: 1.289 ± 0.774
1.289LysAsn: 1.289 ± 1.287
3.866LysPro: 3.866 ± 0.262
7.732LysGln: 7.732 ± 4.646
11.598LysArg: 11.598 ± 4.908
6.443LysSer: 6.443 ± 0.251
2.577LysThr: 2.577 ± 2.574
5.155LysVal: 5.155 ± 1.025
0.0LysTrp: 0.0 ± 0.0
3.866LysTyr: 3.866 ± 1.8
0.0LysXaa: 0.0 ± 0.0
Leu
3.866LeuAla: 3.866 ± 0.262
1.289LeuCys: 1.289 ± 1.287
3.866LeuAsp: 3.866 ± 0.262
0.0LeuGlu: 0.0 ± 0.0
1.289LeuPhe: 1.289 ± 1.287
5.155LeuGly: 5.155 ± 3.097
1.289LeuHis: 1.289 ± 1.287
2.577LeuIle: 2.577 ± 1.549
2.577LeuLys: 2.577 ± 0.513
6.443LeuLeu: 6.443 ± 0.251
1.289LeuMet: 1.289 ± 1.287
3.866LeuAsn: 3.866 ± 0.262
3.866LeuPro: 3.866 ± 2.323
3.866LeuGln: 3.866 ± 1.8
1.289LeuArg: 1.289 ± 0.774
5.155LeuSer: 5.155 ± 3.097
6.443LeuThr: 6.443 ± 0.251
2.577LeuVal: 2.577 ± 0.513
1.289LeuTrp: 1.289 ± 0.774
0.0LeuTyr: 0.0 ± 0.0
0.0LeuXaa: 0.0 ± 0.0
Met
1.289MetAla: 1.289 ± 1.287
0.0MetCys: 0.0 ± 0.0
0.0MetAsp: 0.0 ± 0.0
0.0MetGlu: 0.0 ± 0.0
0.0MetPhe: 0.0 ± 0.0
1.289MetGly: 1.289 ± 1.287
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
2.577MetLys: 2.577 ± 1.549
2.577MetLeu: 2.577 ± 1.549
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
2.577MetPro: 2.577 ± 1.549
2.577MetGln: 2.577 ± 1.549
3.866MetArg: 3.866 ± 1.8
1.289MetSer: 1.289 ± 1.287
1.289MetThr: 1.289 ± 0.774
0.0MetVal: 0.0 ± 0.0
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
5.155AsnAla: 5.155 ± 1.036
0.0AsnCys: 0.0 ± 0.0
2.577AsnAsp: 2.577 ± 0.513
1.289AsnGlu: 1.289 ± 1.287
2.577AsnPhe: 2.577 ± 1.549
0.0AsnGly: 0.0 ± 0.0
1.289AsnHis: 1.289 ± 0.774
2.577AsnIle: 2.577 ± 0.513
1.289AsnLys: 1.289 ± 0.774
3.866AsnLeu: 3.866 ± 2.323
0.0AsnMet: 0.0 ± 0.0
2.577AsnAsn: 2.577 ± 0.513
2.577AsnPro: 2.577 ± 1.549
1.289AsnGln: 1.289 ± 0.774
1.289AsnArg: 1.289 ± 1.287
1.289AsnSer: 1.289 ± 0.774
2.577AsnThr: 2.577 ± 1.549
1.289AsnVal: 1.289 ± 0.774
0.0AsnTrp: 0.0 ± 0.0
2.577AsnTyr: 2.577 ± 0.513
0.0AsnXaa: 0.0 ± 0.0
Pro
2.577ProAla: 2.577 ± 0.513
1.289ProCys: 1.289 ± 0.774
1.289ProAsp: 1.289 ± 0.774
0.0ProGlu: 0.0 ± 0.0
0.0ProPhe: 0.0 ± 0.0
0.0ProGly: 0.0 ± 0.0
1.289ProHis: 1.289 ± 1.287
1.289ProIle: 1.289 ± 1.287
2.577ProLys: 2.577 ± 0.513
3.866ProLeu: 3.866 ± 2.323
1.289ProMet: 1.289 ± 1.287
1.289ProAsn: 1.289 ± 1.287
6.443ProPro: 6.443 ± 0.251
1.289ProGln: 1.289 ± 0.774
5.155ProArg: 5.155 ± 1.025
6.443ProSer: 6.443 ± 3.872
6.443ProThr: 6.443 ± 0.251
5.155ProVal: 5.155 ± 1.025
0.0ProTrp: 0.0 ± 0.0
3.866ProTyr: 3.866 ± 2.323
0.0ProXaa: 0.0 ± 0.0
Gln
0.0GlnAla: 0.0 ± 0.0
0.0GlnCys: 0.0 ± 0.0
0.0GlnAsp: 0.0 ± 0.0
5.155GlnGlu: 5.155 ± 1.036
0.0GlnPhe: 0.0 ± 0.0
9.021GlnGly: 9.021 ± 2.825
0.0GlnHis: 0.0 ± 0.0
3.866GlnIle: 3.866 ± 2.323
3.866GlnLys: 3.866 ± 0.262
2.577GlnLeu: 2.577 ± 1.549
1.289GlnMet: 1.289 ± 0.774
2.577GlnAsn: 2.577 ± 1.549
0.0GlnPro: 0.0 ± 0.0
2.577GlnGln: 2.577 ± 0.513
2.577GlnArg: 2.577 ± 0.513
1.289GlnSer: 1.289 ± 0.774
2.577GlnThr: 2.577 ± 1.549
1.289GlnVal: 1.289 ± 0.774
1.289GlnTrp: 1.289 ± 1.287
5.155GlnTyr: 5.155 ± 3.097
0.0GlnXaa: 0.0 ± 0.0
Arg
7.732ArgAla: 7.732 ± 0.523
2.577ArgCys: 2.577 ± 0.513
3.866ArgAsp: 3.866 ± 2.323
7.732ArgGlu: 7.732 ± 3.599
1.289ArgPhe: 1.289 ± 1.287
3.866ArgGly: 3.866 ± 1.8
1.289ArgHis: 1.289 ± 0.774
5.155ArgIle: 5.155 ± 1.036
3.866ArgLys: 3.866 ± 0.262
2.577ArgLeu: 2.577 ± 2.574
1.289ArgMet: 1.289 ± 1.287
5.155ArgAsn: 5.155 ± 1.036
0.0ArgPro: 0.0 ± 0.0
2.577ArgGln: 2.577 ± 1.549
10.309ArgArg: 10.309 ± 0.011
2.577ArgSer: 2.577 ± 1.549
3.866ArgThr: 3.866 ± 1.8
6.443ArgVal: 6.443 ± 0.251
0.0ArgTrp: 0.0 ± 0.0
3.866ArgTyr: 3.866 ± 0.262
0.0ArgXaa: 0.0 ± 0.0
Ser
2.577SerAla: 2.577 ± 0.513
0.0SerCys: 0.0 ± 0.0
6.443SerAsp: 6.443 ± 0.251
2.577SerGlu: 2.577 ± 0.513
6.443SerPhe: 6.443 ± 1.81
1.289SerGly: 1.289 ± 0.774
3.866SerHis: 3.866 ± 2.323
0.0SerIle: 0.0 ± 0.0
7.732SerLys: 7.732 ± 2.585
5.155SerLeu: 5.155 ± 3.097
0.0SerMet: 0.0 ± 0.0
1.289SerAsn: 1.289 ± 1.287
3.866SerPro: 3.866 ± 0.262
1.289SerGln: 1.289 ± 1.287
5.155SerArg: 5.155 ± 1.036
5.155SerSer: 5.155 ± 1.025
5.155SerThr: 5.155 ± 1.036
2.577SerVal: 2.577 ± 0.513
0.0SerTrp: 0.0 ± 0.0
3.866SerTyr: 3.866 ± 0.262
0.0SerXaa: 0.0 ± 0.0
Thr
1.289ThrAla: 1.289 ± 0.774
1.289ThrCys: 1.289 ± 0.774
1.289ThrAsp: 1.289 ± 1.287
1.289ThrGlu: 1.289 ± 0.774
1.289ThrPhe: 1.289 ± 0.774
5.155ThrGly: 5.155 ± 1.025
2.577ThrHis: 2.577 ± 0.513
3.866ThrIle: 3.866 ± 0.262
9.021ThrLys: 9.021 ± 5.42
1.289ThrLeu: 1.289 ± 1.287
1.289ThrMet: 1.289 ± 0.774
3.866ThrAsn: 3.866 ± 2.323
2.577ThrPro: 2.577 ± 0.513
2.577ThrGln: 2.577 ± 1.549
5.155ThrArg: 5.155 ± 1.025
1.289ThrSer: 1.289 ± 1.287
2.577ThrThr: 2.577 ± 1.549
3.866ThrVal: 3.866 ± 3.861
3.866ThrTrp: 3.866 ± 1.8
5.155ThrTyr: 5.155 ± 3.097
0.0ThrXaa: 0.0 ± 0.0
Val
5.155ValAla: 5.155 ± 1.036
0.0ValCys: 0.0 ± 0.0
5.155ValAsp: 5.155 ± 3.097
3.866ValGlu: 3.866 ± 1.8
0.0ValPhe: 0.0 ± 0.0
1.289ValGly: 1.289 ± 0.774
2.577ValHis: 2.577 ± 0.513
5.155ValIle: 5.155 ± 3.087
6.443ValLys: 6.443 ± 2.312
3.866ValLeu: 3.866 ± 1.8
0.0ValMet: 0.0 ± 0.0
1.289ValAsn: 1.289 ± 0.774
2.577ValPro: 2.577 ± 2.574
2.577ValGln: 2.577 ± 2.574
1.289ValArg: 1.289 ± 1.287
2.577ValSer: 2.577 ± 1.549
2.577ValThr: 2.577 ± 1.549
2.577ValVal: 2.577 ± 2.574
0.0ValTrp: 0.0 ± 0.0
3.866ValTyr: 3.866 ± 1.8
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
2.577TrpCys: 2.577 ± 2.574
1.289TrpAsp: 1.289 ± 0.774
0.0TrpGlu: 0.0 ± 0.0
1.289TrpPhe: 1.289 ± 1.287
1.289TrpGly: 1.289 ± 1.287
1.289TrpHis: 1.289 ± 0.774
2.577TrpIle: 2.577 ± 0.513
3.866TrpLys: 3.866 ± 0.262
0.0TrpLeu: 0.0 ± 0.0
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
1.289TrpSer: 1.289 ± 0.774
0.0TrpThr: 0.0 ± 0.0
1.289TrpVal: 1.289 ± 1.287
0.0TrpTrp: 0.0 ± 0.0
1.289TrpTyr: 1.289 ± 1.287
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.0TyrAla: 0.0 ± 0.0
1.289TyrCys: 1.289 ± 1.287
1.289TyrAsp: 1.289 ± 0.774
1.289TyrGlu: 1.289 ± 0.774
5.155TyrPhe: 5.155 ± 1.036
5.155TyrGly: 5.155 ± 1.036
1.289TyrHis: 1.289 ± 1.287
6.443TyrIle: 6.443 ± 2.312
3.866TyrLys: 3.866 ± 2.323
2.577TyrLeu: 2.577 ± 0.513
0.0TyrMet: 0.0 ± 0.0
1.289TyrAsn: 1.289 ± 0.774
6.443TyrPro: 6.443 ± 0.251
1.289TyrGln: 1.289 ± 1.287
2.577TyrArg: 2.577 ± 1.549
5.155TyrSer: 5.155 ± 1.036
3.866TyrThr: 3.866 ± 0.262
0.0TyrVal: 0.0 ± 0.0
2.577TyrTrp: 2.577 ± 2.574
2.577TyrTyr: 2.577 ± 1.549
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (777 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski