Amino acid dipepetide frequency for Hubei leech virus 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.957AlaAla: 10.957 ± 3.079
2.922AlaCys: 2.922 ± 1.849
3.652AlaAsp: 3.652 ± 2.547
2.191AlaGlu: 2.191 ± 1.296
2.191AlaPhe: 2.191 ± 1.164
10.226AlaGly: 10.226 ± 2.229
0.73AlaHis: 0.73 ± 0.709
5.113AlaIle: 5.113 ± 1.883
6.574AlaLys: 6.574 ± 1.717
6.574AlaLeu: 6.574 ± 1.425
2.191AlaMet: 2.191 ± 0.893
2.191AlaAsn: 2.191 ± 0.22
5.844AlaPro: 5.844 ± 1.357
3.652AlaGln: 3.652 ± 1.414
5.113AlaArg: 5.113 ± 0.076
9.496AlaSer: 9.496 ± 3.373
4.383AlaThr: 4.383 ± 1.253
6.574AlaVal: 6.574 ± 2.724
4.383AlaTrp: 4.383 ± 1.031
2.922AlaTyr: 2.922 ± 0.882
0.0AlaXaa: 0.0 ± 0.0
Cys
1.461CysAla: 1.461 ± 0.568
0.0CysCys: 0.0 ± 0.0
0.73CysAsp: 0.73 ± 0.49
1.461CysGlu: 1.461 ± 0.543
1.461CysPhe: 1.461 ± 0.981
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
1.461CysLeu: 1.461 ± 1.418
0.0CysMet: 0.0 ± 0.0
0.73CysAsn: 0.73 ± 0.709
2.191CysPro: 2.191 ± 1.032
0.0CysGln: 0.0 ± 0.0
0.73CysArg: 0.73 ± 0.709
2.191CysSer: 2.191 ± 0.754
1.461CysThr: 1.461 ± 0.543
0.73CysVal: 0.73 ± 0.49
0.0CysTrp: 0.0 ± 0.0
0.73CysTyr: 0.73 ± 0.709
0.0CysXaa: 0.0 ± 0.0
Asp
5.113AspAla: 5.113 ± 2.162
0.0AspCys: 0.0 ± 0.0
2.922AspAsp: 2.922 ± 1.151
2.191AspGlu: 2.191 ± 0.754
2.922AspPhe: 2.922 ± 1.849
8.035AspGly: 8.035 ± 2.144
1.461AspHis: 1.461 ± 0.543
0.73AspIle: 0.73 ± 0.49
1.461AspLys: 1.461 ± 0.568
5.844AspLeu: 5.844 ± 1.162
0.0AspMet: 0.0 ± 0.0
0.73AspAsn: 0.73 ± 0.709
2.191AspPro: 2.191 ± 0.893
3.652AspGln: 3.652 ± 1.22
2.922AspArg: 2.922 ± 1.087
1.461AspSer: 1.461 ± 0.543
2.922AspThr: 2.922 ± 1.961
2.191AspVal: 2.191 ± 1.032
0.0AspTrp: 0.0 ± 0.0
0.73AspTyr: 0.73 ± 0.574
0.0AspXaa: 0.0 ± 0.0
Glu
8.035GluAla: 8.035 ± 0.878
0.73GluCys: 0.73 ± 0.49
2.922GluAsp: 2.922 ± 0.882
2.191GluGlu: 2.191 ± 1.164
1.461GluPhe: 1.461 ± 0.568
5.113GluGly: 5.113 ± 0.829
0.73GluHis: 0.73 ± 0.709
2.922GluIle: 2.922 ± 0.882
0.73GluLys: 0.73 ± 0.709
5.113GluLeu: 5.113 ± 0.076
0.73GluMet: 0.73 ± 0.577
4.383GluAsn: 4.383 ± 0.439
3.652GluPro: 3.652 ± 1.22
0.0GluGln: 0.0 ± 0.0
5.844GluArg: 5.844 ± 2.174
1.461GluSer: 1.461 ± 0.543
3.652GluThr: 3.652 ± 1.965
2.922GluVal: 2.922 ± 0.274
0.0GluTrp: 0.0 ± 0.0
0.73GluTyr: 0.73 ± 0.709
0.0GluXaa: 0.0 ± 0.0
Phe
2.191PheAla: 2.191 ± 0.22
0.73PheCys: 0.73 ± 0.49
1.461PheAsp: 1.461 ± 0.543
2.922PheGlu: 2.922 ± 0.678
1.461PhePhe: 1.461 ± 0.543
2.922PheGly: 2.922 ± 0.678
0.73PheHis: 0.73 ± 0.709
2.191PheIle: 2.191 ± 0.754
2.922PheLys: 2.922 ± 1.151
4.383PheLeu: 4.383 ± 0.439
1.461PheMet: 1.461 ± 0.981
0.73PheAsn: 0.73 ± 0.709
1.461PhePro: 1.461 ± 0.543
0.0PheGln: 0.0 ± 0.0
0.73PheArg: 0.73 ± 0.574
1.461PheSer: 1.461 ± 0.709
2.191PheThr: 2.191 ± 0.22
5.844PheVal: 5.844 ± 3.222
0.73PheTrp: 0.73 ± 0.709
0.73PheTyr: 0.73 ± 0.709
0.0PheXaa: 0.0 ± 0.0
Gly
5.113GlyAla: 5.113 ± 1.984
0.73GlyCys: 0.73 ± 0.574
4.383GlyAsp: 4.383 ± 0.707
5.844GlyGlu: 5.844 ± 1.147
3.652GlyPhe: 3.652 ± 0.763
5.844GlyGly: 5.844 ± 0.547
0.73GlyHis: 0.73 ± 0.709
2.191GlyIle: 2.191 ± 0.22
2.191GlyLys: 2.191 ± 1.164
3.652GlyLeu: 3.652 ± 1.564
3.652GlyMet: 3.652 ± 0.607
3.652GlyAsn: 3.652 ± 1.585
6.574GlyPro: 6.574 ± 1.037
3.652GlyGln: 3.652 ± 2.111
6.574GlyArg: 6.574 ± 1.596
9.496GlySer: 9.496 ± 1.732
4.383GlyThr: 4.383 ± 1.705
7.305GlyVal: 7.305 ± 3.215
3.652GlyTrp: 3.652 ± 0.928
0.0GlyTyr: 0.0 ± 0.0
0.0GlyXaa: 0.0 ± 0.0
His
2.191HisAla: 2.191 ± 1.032
0.73HisCys: 0.73 ± 0.709
2.191HisAsp: 2.191 ± 1.164
0.0HisGlu: 0.0 ± 0.0
0.0HisPhe: 0.0 ± 0.0
0.73HisGly: 0.73 ± 0.709
0.0HisHis: 0.0 ± 0.0
0.73HisIle: 0.73 ± 0.709
0.73HisLys: 0.73 ± 0.49
1.461HisLeu: 1.461 ± 0.709
0.0HisMet: 0.0 ± 0.0
0.73HisAsn: 0.73 ± 0.709
1.461HisPro: 1.461 ± 0.568
0.73HisGln: 0.73 ± 0.709
1.461HisArg: 1.461 ± 0.709
2.191HisSer: 2.191 ± 1.164
0.73HisThr: 0.73 ± 0.709
1.461HisVal: 1.461 ± 0.543
0.73HisTrp: 0.73 ± 0.49
0.73HisTyr: 0.73 ± 0.49
0.0HisXaa: 0.0 ± 0.0
Ile
5.113IleAla: 5.113 ± 2.739
0.0IleCys: 0.0 ± 0.0
2.191IleAsp: 2.191 ± 0.22
0.73IleGlu: 0.73 ± 0.709
0.0IlePhe: 0.0 ± 0.0
2.922IleGly: 2.922 ± 1.087
0.73IleHis: 0.73 ± 0.709
0.73IleIle: 0.73 ± 0.709
1.461IleLys: 1.461 ± 0.543
2.191IleLeu: 2.191 ± 0.22
1.461IleMet: 1.461 ± 0.568
0.73IleAsn: 0.73 ± 0.574
4.383IlePro: 4.383 ± 1.705
1.461IleGln: 1.461 ± 0.981
2.922IleArg: 2.922 ± 0.882
2.191IleSer: 2.191 ± 0.893
2.191IleThr: 2.191 ± 1.296
2.922IleVal: 2.922 ± 1.151
1.461IleTrp: 1.461 ± 0.709
0.73IleTyr: 0.73 ± 0.574
0.0IleXaa: 0.0 ± 0.0
Lys
2.191LysAla: 2.191 ± 1.164
0.73LysCys: 0.73 ± 0.709
0.0LysAsp: 0.0 ± 0.0
2.922LysGlu: 2.922 ± 0.274
1.461LysPhe: 1.461 ± 0.543
2.922LysGly: 2.922 ± 1.136
0.0LysHis: 0.0 ± 0.0
0.73LysIle: 0.73 ± 0.49
4.383LysLys: 4.383 ± 2.068
3.652LysLeu: 3.652 ± 1.673
0.73LysMet: 0.73 ± 0.709
0.73LysAsn: 0.73 ± 0.49
0.73LysPro: 0.73 ± 0.709
1.461LysGln: 1.461 ± 1.418
3.652LysArg: 3.652 ± 0.49
2.191LysSer: 2.191 ± 0.22
5.113LysThr: 5.113 ± 2.594
4.383LysVal: 4.383 ± 1.253
0.0LysTrp: 0.0 ± 0.0
0.0LysTyr: 0.0 ± 0.0
0.0LysXaa: 0.0 ± 0.0
Leu
9.496LeuAla: 9.496 ± 2.359
0.0LeuCys: 0.0 ± 0.0
5.113LeuAsp: 5.113 ± 1.114
6.574LeuGlu: 6.574 ± 1.425
3.652LeuPhe: 3.652 ± 1.6
9.496LeuGly: 9.496 ± 2.839
2.191LeuHis: 2.191 ± 1.078
2.191LeuIle: 2.191 ± 0.22
2.922LeuLys: 2.922 ± 1.151
8.035LeuLeu: 8.035 ± 0.337
2.191LeuMet: 2.191 ± 0.849
0.73LeuAsn: 0.73 ± 0.49
8.035LeuPro: 8.035 ± 0.878
1.461LeuGln: 1.461 ± 0.981
8.766LeuArg: 8.766 ± 1.713
5.844LeuSer: 5.844 ± 1.254
3.652LeuThr: 3.652 ± 0.928
2.922LeuVal: 2.922 ± 1.136
2.922LeuTrp: 2.922 ± 0.274
3.652LeuTyr: 3.652 ± 1.585
0.0LeuXaa: 0.0 ± 0.0
Met
1.461MetAla: 1.461 ± 0.568
0.0MetCys: 0.0 ± 0.0
2.922MetAsp: 2.922 ± 1.087
1.461MetGlu: 1.461 ± 0.568
0.73MetPhe: 0.73 ± 0.574
0.73MetGly: 0.73 ± 0.49
0.73MetHis: 0.73 ± 0.49
0.0MetIle: 0.0 ± 0.0
0.73MetLys: 0.73 ± 0.574
0.73MetLeu: 0.73 ± 0.49
0.0MetMet: 0.0 ± 0.0
0.73MetAsn: 0.73 ± 0.574
1.461MetPro: 1.461 ± 0.568
0.0MetGln: 0.0 ± 0.0
0.73MetArg: 0.73 ± 0.574
3.652MetSer: 3.652 ± 0.49
3.652MetThr: 3.652 ± 1.6
0.73MetVal: 0.73 ± 0.574
0.73MetTrp: 0.73 ± 0.709
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
0.73AsnAla: 0.73 ± 0.49
0.73AsnCys: 0.73 ± 0.709
1.461AsnAsp: 1.461 ± 0.709
0.73AsnGlu: 0.73 ± 0.574
1.461AsnPhe: 1.461 ± 0.709
2.922AsnGly: 2.922 ± 1.151
0.0AsnHis: 0.0 ± 0.0
0.73AsnIle: 0.73 ± 0.49
1.461AsnLys: 1.461 ± 0.543
3.652AsnLeu: 3.652 ± 1.673
0.73AsnMet: 0.73 ± 0.574
0.0AsnAsn: 0.0 ± 0.0
2.922AsnPro: 2.922 ± 1.136
0.73AsnGln: 0.73 ± 0.574
0.73AsnArg: 0.73 ± 0.574
2.922AsnSer: 2.922 ± 1.087
2.191AsnThr: 2.191 ± 1.296
2.191AsnVal: 2.191 ± 0.22
0.73AsnTrp: 0.73 ± 0.709
0.73AsnTyr: 0.73 ± 0.49
0.0AsnXaa: 0.0 ± 0.0
Pro
4.383ProAla: 4.383 ± 0.707
0.73ProCys: 0.73 ± 0.574
3.652ProAsp: 3.652 ± 1.732
2.922ProGlu: 2.922 ± 1.151
2.922ProPhe: 2.922 ± 0.274
7.305ProGly: 7.305 ± 0.91
0.73ProHis: 0.73 ± 0.574
2.922ProIle: 2.922 ± 1.324
1.461ProLys: 1.461 ± 0.568
5.113ProLeu: 5.113 ± 2.739
0.73ProMet: 0.73 ± 0.574
3.652ProAsn: 3.652 ± 1.6
2.922ProPro: 2.922 ± 0.882
5.844ProGln: 5.844 ± 2.165
2.922ProArg: 2.922 ± 1.087
5.844ProSer: 5.844 ± 1.521
5.844ProThr: 5.844 ± 2.587
2.922ProVal: 2.922 ± 1.965
1.461ProTrp: 1.461 ± 0.543
0.0ProTyr: 0.0 ± 0.0
0.0ProXaa: 0.0 ± 0.0
Gln
3.652GlnAla: 3.652 ± 0.928
0.0GlnCys: 0.0 ± 0.0
0.0GlnAsp: 0.0 ± 0.0
0.73GlnGlu: 0.73 ± 0.49
0.0GlnPhe: 0.0 ± 0.0
3.652GlnGly: 3.652 ± 1.414
1.461GlnHis: 1.461 ± 0.709
1.461GlnIle: 1.461 ± 0.568
0.0GlnLys: 0.0 ± 0.0
2.922GlnLeu: 2.922 ± 0.274
0.73GlnMet: 0.73 ± 0.574
1.461GlnAsn: 1.461 ± 0.543
3.652GlnPro: 3.652 ± 1.564
3.652GlnGln: 3.652 ± 1.237
4.383GlnArg: 4.383 ± 0.707
2.191GlnSer: 2.191 ± 1.032
2.191GlnThr: 2.191 ± 0.22
3.652GlnVal: 3.652 ± 2.127
1.461GlnTrp: 1.461 ± 1.418
1.461GlnTyr: 1.461 ± 0.568
0.0GlnXaa: 0.0 ± 0.0
Arg
8.766ArgAla: 8.766 ± 2.487
0.73ArgCys: 0.73 ± 0.709
3.652ArgAsp: 3.652 ± 1.414
5.844ArgGlu: 5.844 ± 2.174
5.113ArgPhe: 5.113 ± 1.984
3.652ArgGly: 3.652 ± 0.49
1.461ArgHis: 1.461 ± 1.418
2.191ArgIle: 2.191 ± 1.296
2.922ArgLys: 2.922 ± 0.274
9.496ArgLeu: 9.496 ± 2.738
1.461ArgMet: 1.461 ± 0.568
0.73ArgAsn: 0.73 ± 0.574
2.191ArgPro: 2.191 ± 1.032
0.73ArgGln: 0.73 ± 0.49
10.226ArgArg: 10.226 ± 2.076
6.574ArgSer: 6.574 ± 1.037
2.922ArgThr: 2.922 ± 1.151
4.383ArgVal: 4.383 ± 0.646
0.73ArgTrp: 0.73 ± 0.709
0.73ArgTyr: 0.73 ± 0.49
0.0ArgXaa: 0.0 ± 0.0
Ser
5.844SerAla: 5.844 ± 1.147
0.0SerCys: 0.0 ± 0.0
2.191SerAsp: 2.191 ± 0.754
4.383SerGlu: 4.383 ± 0.646
4.383SerPhe: 4.383 ± 1.806
8.035SerGly: 8.035 ± 1.355
2.191SerHis: 2.191 ± 0.893
1.461SerIle: 1.461 ± 0.981
3.652SerLys: 3.652 ± 0.928
6.574SerLeu: 6.574 ± 2.789
2.191SerMet: 2.191 ± 1.296
0.73SerAsn: 0.73 ± 0.49
6.574SerPro: 6.574 ± 0.548
2.191SerGln: 2.191 ± 0.22
2.922SerArg: 2.922 ± 1.151
6.574SerSer: 6.574 ± 1.596
7.305SerThr: 7.305 ± 1.813
5.844SerVal: 5.844 ± 2.25
0.73SerTrp: 0.73 ± 0.49
1.461SerTyr: 1.461 ± 0.568
0.0SerXaa: 0.0 ± 0.0
Thr
7.305ThrAla: 7.305 ± 0.182
2.922ThrCys: 2.922 ± 1.961
1.461ThrAsp: 1.461 ± 0.981
4.383ThrGlu: 4.383 ± 1.505
2.191ThrPhe: 2.191 ± 0.893
3.652ThrGly: 3.652 ± 0.928
2.922ThrHis: 2.922 ± 1.087
5.113ThrIle: 5.113 ± 1.636
0.73ThrLys: 0.73 ± 0.709
5.844ThrLeu: 5.844 ± 1.162
0.73ThrMet: 0.73 ± 0.49
0.73ThrAsn: 0.73 ± 0.574
2.922ThrPro: 2.922 ± 1.136
2.191ThrGln: 2.191 ± 1.032
2.922ThrArg: 2.922 ± 1.136
2.922ThrSer: 2.922 ± 1.151
3.652ThrThr: 3.652 ± 1.237
5.113ThrVal: 5.113 ± 2.114
2.922ThrTrp: 2.922 ± 1.57
2.922ThrTyr: 2.922 ± 0.678
0.0ThrXaa: 0.0 ± 0.0
Val
10.226ValAla: 10.226 ± 2.943
2.191ValCys: 2.191 ± 0.754
3.652ValAsp: 3.652 ± 0.598
1.461ValGlu: 1.461 ± 0.568
2.191ValPhe: 2.191 ± 1.471
1.461ValGly: 1.461 ± 0.543
1.461ValHis: 1.461 ± 0.981
4.383ValIle: 4.383 ± 2.063
2.922ValLys: 2.922 ± 1.136
6.574ValLeu: 6.574 ± 1.596
0.73ValMet: 0.73 ± 0.49
1.461ValAsn: 1.461 ± 0.543
2.922ValPro: 2.922 ± 1.961
5.844ValGln: 5.844 ± 2.165
6.574ValArg: 6.574 ± 1.866
2.922ValSer: 2.922 ± 0.882
4.383ValThr: 4.383 ± 0.707
5.844ValVal: 5.844 ± 2.25
1.461ValTrp: 1.461 ± 0.709
1.461ValTyr: 1.461 ± 0.709
0.0ValXaa: 0.0 ± 0.0
Trp
2.191TrpAla: 2.191 ± 2.126
0.73TrpCys: 0.73 ± 0.49
2.922TrpAsp: 2.922 ± 1.087
2.922TrpGlu: 2.922 ± 1.418
0.0TrpPhe: 0.0 ± 0.0
2.191TrpGly: 2.191 ± 1.032
0.73TrpHis: 0.73 ± 0.709
0.73TrpIle: 0.73 ± 0.49
0.73TrpLys: 0.73 ± 0.574
2.922TrpLeu: 2.922 ± 1.087
0.0TrpMet: 0.0 ± 0.0
2.191TrpAsn: 2.191 ± 0.22
0.73TrpPro: 0.73 ± 0.709
0.0TrpGln: 0.0 ± 0.0
1.461TrpArg: 1.461 ± 0.543
2.922TrpSer: 2.922 ± 1.57
0.73TrpThr: 0.73 ± 0.709
1.461TrpVal: 1.461 ± 0.709
0.0TrpTrp: 0.0 ± 0.0
0.73TrpTyr: 0.73 ± 0.574
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.461TyrAla: 1.461 ± 0.543
0.73TyrCys: 0.73 ± 0.574
0.0TyrAsp: 0.0 ± 0.0
2.191TyrGlu: 2.191 ± 1.164
0.0TyrPhe: 0.0 ± 0.0
1.461TyrGly: 1.461 ± 0.543
0.0TyrHis: 0.0 ± 0.0
0.0TyrIle: 0.0 ± 0.0
0.0TyrLys: 0.0 ± 0.0
3.652TyrLeu: 3.652 ± 2.111
0.73TyrMet: 0.73 ± 0.49
0.73TyrAsn: 0.73 ± 0.574
1.461TyrPro: 1.461 ± 0.709
1.461TyrGln: 1.461 ± 0.568
2.922TyrArg: 2.922 ± 1.087
0.73TyrSer: 0.73 ± 0.574
0.0TyrThr: 0.0 ± 0.0
0.73TyrVal: 0.73 ± 0.574
2.191TyrTrp: 2.191 ± 1.164
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (1370 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski