Amino acid dipepetide frequency for Sphingomonas ginsenosidivorax

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.477AlaAla: 20.477 ± 0.195	1.067AlaCys: 1.067 ± 0.035	8.268AlaAsp: 8.268 ± 0.096	7.017AlaGlu: 7.017 ± 0.086	4.574AlaPhe: 4.574 ± 0.064	12.06AlaGly: 12.06 ± 0.107	2.385AlaHis: 2.385 ± 0.044	7.154AlaIle: 7.154 ± 0.075	4.181AlaLys: 4.181 ± 0.065	13.906AlaLeu: 13.906 ± 0.159	3.829AlaMet: 3.829 ± 0.066	3.305AlaAsn: 3.305 ± 0.063	6.724AlaPro: 6.724 ± 0.096	4.422AlaGln: 4.422 ± 0.07	10.231AlaArg: 10.231 ± 0.133	6.669AlaSer: 6.669 ± 0.098	8.157AlaThr: 8.157 ± 0.095	9.691AlaVal: 9.691 ± 0.092	1.725AlaTrp: 1.725 ± 0.047	2.705AlaTyr: 2.705 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.959CysAla: 0.959 ± 0.031	0.074CysCys: 0.074 ± 0.009	0.506CysAsp: 0.506 ± 0.021	0.334CysGlu: 0.334 ± 0.016	0.262CysPhe: 0.262 ± 0.015	0.801CysGly: 0.801 ± 0.029	0.164CysHis: 0.164 ± 0.013	0.327CysIle: 0.327 ± 0.016	0.144CysLys: 0.144 ± 0.01	0.622CysLeu: 0.622 ± 0.024	0.151CysMet: 0.151 ± 0.011	0.188CysAsn: 0.188 ± 0.011	0.361CysPro: 0.361 ± 0.018	0.163CysGln: 0.163 ± 0.012	0.507CysArg: 0.507 ± 0.025	0.41CysSer: 0.41 ± 0.021	0.408CysThr: 0.408 ± 0.019	0.583CysVal: 0.583 ± 0.027	0.092CysTrp: 0.092 ± 0.008	0.154CysTyr: 0.154 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	8.962AspAla: 8.962 ± 0.104	0.448AspCys: 0.448 ± 0.019	3.682AspAsp: 3.682 ± 0.069	3.115AspGlu: 3.115 ± 0.053	2.115AspPhe: 2.115 ± 0.048	6.055AspGly: 6.055 ± 0.071	1.285AspHis: 1.285 ± 0.031	2.871AspIle: 2.871 ± 0.045	1.528AspLys: 1.528 ± 0.042	5.926AspLeu: 5.926 ± 0.063	1.297AspMet: 1.297 ± 0.032	1.199AspAsn: 1.199 ± 0.036	3.914AspPro: 3.914 ± 0.062	1.81AspGln: 1.81 ± 0.04	5.311AspArg: 5.311 ± 0.079	2.316AspSer: 2.316 ± 0.051	3.226AspThr: 3.226 ± 0.061	4.522AspVal: 4.522 ± 0.066	1.201AspTrp: 1.201 ± 0.029	1.579AspTyr: 1.579 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	6.843GluAla: 6.843 ± 0.096	0.253GluCys: 0.253 ± 0.015	2.572GluAsp: 2.572 ± 0.053	2.192GluGlu: 2.192 ± 0.055	1.317GluPhe: 1.317 ± 0.032	3.995GluGly: 3.995 ± 0.065	1.031GluHis: 1.031 ± 0.029	2.644GluIle: 2.644 ± 0.048	1.455GluLys: 1.455 ± 0.04	4.377GluLeu: 4.377 ± 0.07	1.199GluMet: 1.199 ± 0.036	1.102GluAsn: 1.102 ± 0.033	2.401GluPro: 2.401 ± 0.048	1.727GluGln: 1.727 ± 0.035	4.58GluArg: 4.58 ± 0.067	2.045GluSer: 2.045 ± 0.042	3.349GluThr: 3.349 ± 0.058	3.223GluVal: 3.223 ± 0.061	0.657GluTrp: 0.657 ± 0.023	0.832GluTyr: 0.832 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	5.127PheAla: 5.127 ± 0.064	0.292PheCys: 0.292 ± 0.015	2.671PheAsp: 2.671 ± 0.048	1.826PheGlu: 1.826 ± 0.036	1.143PhePhe: 1.143 ± 0.031	3.701PheGly: 3.701 ± 0.067	0.694PheHis: 0.694 ± 0.027	1.206PheIle: 1.206 ± 0.032	0.795PheLys: 0.795 ± 0.026	2.913PheLeu: 2.913 ± 0.054	0.682PheMet: 0.682 ± 0.024	0.949PheAsn: 0.949 ± 0.031	1.444PhePro: 1.444 ± 0.032	0.864PheGln: 0.864 ± 0.027	2.174PheArg: 2.174 ± 0.045	1.79PheSer: 1.79 ± 0.037	2.068PheThr: 2.068 ± 0.049	2.761PheVal: 2.761 ± 0.05	0.502PheTrp: 0.502 ± 0.02	0.857PheTyr: 0.857 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	10.611GlyAla: 10.611 ± 0.106	0.802GlyCys: 0.802 ± 0.025	5.277GlyAsp: 5.277 ± 0.077	4.406GlyGlu: 4.406 ± 0.061	3.612GlyPhe: 3.612 ± 0.058	8.702GlyGly: 8.702 ± 0.136	1.806GlyHis: 1.806 ± 0.038	4.697GlyIle: 4.697 ± 0.061	2.942GlyLys: 2.942 ± 0.058	8.711GlyLeu: 8.711 ± 0.086	2.269GlyMet: 2.269 ± 0.047	2.314GlyAsn: 2.314 ± 0.074	3.699GlyPro: 3.699 ± 0.063	2.885GlyGln: 2.885 ± 0.055	6.694GlyArg: 6.694 ± 0.08	4.876GlySer: 4.876 ± 0.075	5.684GlyThr: 5.684 ± 0.103	6.896GlyVal: 6.896 ± 0.085	1.64GlyTrp: 1.64 ± 0.04	2.551GlyTyr: 2.551 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.56HisAla: 2.56 ± 0.055	0.174HisCys: 0.174 ± 0.01	1.329HisAsp: 1.329 ± 0.032	0.886HisGlu: 0.886 ± 0.025	0.72HisPhe: 0.72 ± 0.025	1.989HisGly: 1.989 ± 0.043	0.491HisHis: 0.491 ± 0.023	0.823HisIle: 0.823 ± 0.027	0.367HisLys: 0.367 ± 0.017	1.772HisLeu: 1.772 ± 0.038	0.401HisMet: 0.401 ± 0.017	0.403HisAsn: 0.403 ± 0.017	1.258HisPro: 1.258 ± 0.035	0.489HisGln: 0.489 ± 0.021	1.481HisArg: 1.481 ± 0.036	0.816HisSer: 0.816 ± 0.025	0.767HisThr: 0.767 ± 0.025	1.488HisVal: 1.488 ± 0.03	0.349HisTrp: 0.349 ± 0.018	0.509HisTyr: 0.509 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	8.188IleAla: 8.188 ± 0.094	0.38IleCys: 0.38 ± 0.018	4.095IleAsp: 4.095 ± 0.062	3.157IleGlu: 3.157 ± 0.058	1.33IlePhe: 1.33 ± 0.034	5.266IleGly: 5.266 ± 0.06	0.827IleHis: 0.827 ± 0.025	1.708IleIle: 1.708 ± 0.04	1.096IleLys: 1.096 ± 0.03	3.884IleLeu: 3.884 ± 0.059	0.75IleMet: 0.75 ± 0.025	1.194IleAsn: 1.194 ± 0.035	2.157IlePro: 2.157 ± 0.041	1.11IleGln: 1.11 ± 0.036	3.149IleArg: 3.149 ± 0.052	2.17IleSer: 2.17 ± 0.047	2.624IleThr: 2.624 ± 0.059	4.585IleVal: 4.585 ± 0.064	0.578IleTrp: 0.578 ± 0.023	0.869IleTyr: 0.869 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	3.751LysAla: 3.751 ± 0.072	0.14LysCys: 0.14 ± 0.011	1.413LysAsp: 1.413 ± 0.038	0.883LysGlu: 0.883 ± 0.031	0.811LysPhe: 0.811 ± 0.027	2.45LysGly: 2.45 ± 0.047	0.454LysHis: 0.454 ± 0.022	1.267LysIle: 1.267 ± 0.035	0.916LysLys: 0.916 ± 0.036	2.844LysLeu: 2.844 ± 0.051	0.684LysMet: 0.684 ± 0.026	0.608LysAsn: 0.608 ± 0.024	1.98LysPro: 1.98 ± 0.045	0.797LysGln: 0.797 ± 0.028	2.163LysArg: 2.163 ± 0.045	1.38LysSer: 1.38 ± 0.037	1.826LysThr: 1.826 ± 0.044	1.992LysVal: 1.992 ± 0.044	0.317LysTrp: 0.317 ± 0.015	0.547LysTyr: 0.547 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	14.289LeuAla: 14.289 ± 0.147	0.714LeuCys: 0.714 ± 0.024	6.415LeuAsp: 6.415 ± 0.071	4.223LeuGlu: 4.223 ± 0.066	3.473LeuPhe: 3.473 ± 0.054	8.448LeuGly: 8.448 ± 0.092	1.724LeuHis: 1.724 ± 0.041	4.403LeuIle: 4.403 ± 0.063	2.818LeuLys: 2.818 ± 0.052	8.83LeuLeu: 8.83 ± 0.132	1.972LeuMet: 1.972 ± 0.043	2.265LeuAsn: 2.265 ± 0.05	5.558LeuPro: 5.558 ± 0.075	2.43LeuGln: 2.43 ± 0.049	6.578LeuArg: 6.578 ± 0.076	5.576LeuSer: 5.576 ± 0.075	5.722LeuThr: 5.722 ± 0.068	7.618LeuVal: 7.618 ± 0.09	1.228LeuTrp: 1.228 ± 0.035	2.017LeuTyr: 2.017 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.076MetAla: 3.076 ± 0.057	0.134MetCys: 0.134 ± 0.011	1.015MetAsp: 1.015 ± 0.029	0.851MetGlu: 0.851 ± 0.027	0.646MetPhe: 0.646 ± 0.026	1.728MetGly: 1.728 ± 0.047	0.405MetHis: 0.405 ± 0.019	1.322MetIle: 1.322 ± 0.035	0.815MetLys: 0.815 ± 0.027	2.513MetLeu: 2.513 ± 0.05	0.605MetMet: 0.605 ± 0.023	0.579MetAsn: 0.579 ± 0.024	1.472MetPro: 1.472 ± 0.037	0.665MetGln: 0.665 ± 0.025	1.767MetArg: 1.767 ± 0.037	1.299MetSer: 1.299 ± 0.032	1.924MetThr: 1.924 ± 0.047	1.629MetVal: 1.629 ± 0.037	0.203MetTrp: 0.203 ± 0.012	0.299MetTyr: 0.299 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.291AsnAla: 3.291 ± 0.062	0.203AsnCys: 0.203 ± 0.015	1.484AsnAsp: 1.484 ± 0.056	0.906AsnGlu: 0.906 ± 0.027	0.87AsnPhe: 0.87 ± 0.032	2.364AsnGly: 2.364 ± 0.06	0.429AsnHis: 0.429 ± 0.019	1.209AsnIle: 1.209 ± 0.031	0.557AsnLys: 0.557 ± 0.022	2.346AsnLeu: 2.346 ± 0.052	0.451AsnMet: 0.451 ± 0.017	0.638AsnAsn: 0.638 ± 0.035	1.677AsnPro: 1.677 ± 0.041	0.708AsnGln: 0.708 ± 0.027	1.739AsnArg: 1.739 ± 0.035	1.161AsnSer: 1.161 ± 0.037	1.276AsnThr: 1.276 ± 0.047	1.817AsnVal: 1.817 ± 0.049	0.39AsnTrp: 0.39 ± 0.02	0.713AsnTyr: 0.713 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	7.566ProAla: 7.566 ± 0.098	0.304ProCys: 0.304 ± 0.016	3.857ProAsp: 3.857 ± 0.061	3.032ProGlu: 3.032 ± 0.059	1.864ProPhe: 1.864 ± 0.041	4.908ProGly: 4.908 ± 0.065	1.006ProHis: 1.006 ± 0.033	2.59ProIle: 2.59 ± 0.05	1.488ProLys: 1.488 ± 0.039	4.839ProLeu: 4.839 ± 0.065	1.213ProMet: 1.213 ± 0.03	1.33ProAsn: 1.33 ± 0.035	2.761ProPro: 2.761 ± 0.072	1.579ProGln: 1.579 ± 0.037	3.223ProArg: 3.223 ± 0.053	2.782ProSer: 2.782 ± 0.048	3.027ProThr: 3.027 ± 0.054	4.515ProVal: 4.515 ± 0.067	0.694ProTrp: 0.694 ± 0.023	1.13ProTyr: 1.13 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.085GlnAla: 4.085 ± 0.068	0.186GlnCys: 0.186 ± 0.013	1.468GlnAsp: 1.468 ± 0.031	0.975GlnGlu: 0.975 ± 0.029	1.057GlnPhe: 1.057 ± 0.029	2.434GlnGly: 2.434 ± 0.048	0.546GlnHis: 0.546 ± 0.025	1.6GlnIle: 1.6 ± 0.036	0.757GlnLys: 0.757 ± 0.027	2.809GlnLeu: 2.809 ± 0.051	0.75GlnMet: 0.75 ± 0.023	0.686GlnAsn: 0.686 ± 0.028	1.769GlnPro: 1.769 ± 0.043	1.004GlnGln: 1.004 ± 0.028	2.436GlnArg: 2.436 ± 0.051	1.595GlnSer: 1.595 ± 0.036	1.747GlnThr: 1.747 ± 0.04	2.297GlnVal: 2.297 ± 0.043	0.371GlnTrp: 0.371 ± 0.019	0.625GlnTyr: 0.625 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	9.338ArgAla: 9.338 ± 0.114	0.473ArgCys: 0.473 ± 0.021	4.699ArgAsp: 4.699 ± 0.063	3.527ArgGlu: 3.527 ± 0.063	3.102ArgPhe: 3.102 ± 0.057	5.469ArgGly: 5.469 ± 0.066	1.671ArgHis: 1.671 ± 0.038	4.252ArgIle: 4.252 ± 0.066	1.732ArgLys: 1.732 ± 0.039	7.99ArgLeu: 7.99 ± 0.11	1.951ArgMet: 1.951 ± 0.04	1.747ArgAsn: 1.747 ± 0.041	3.818ArgPro: 3.818 ± 0.062	2.271ArgGln: 2.271 ± 0.042	5.919ArgArg: 5.919 ± 0.097	3.681ArgSer: 3.681 ± 0.061	4.113ArgThr: 4.113 ± 0.057	5.333ArgVal: 5.333 ± 0.079	1.212ArgTrp: 1.212 ± 0.034	1.979ArgTyr: 1.979 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	6.323SerAla: 6.323 ± 0.072	0.35SerCys: 0.35 ± 0.019	3.017SerAsp: 3.017 ± 0.055	2.217SerGlu: 2.217 ± 0.036	2.017SerPhe: 2.017 ± 0.046	5.372SerGly: 5.372 ± 0.079	0.88SerHis: 0.88 ± 0.028	2.593SerIle: 2.593 ± 0.049	1.316SerLys: 1.316 ± 0.035	4.84SerLeu: 4.84 ± 0.061	1.056SerMet: 1.056 ± 0.028	1.352SerAsn: 1.352 ± 0.036	2.742SerPro: 2.742 ± 0.049	1.378SerGln: 1.378 ± 0.036	3.423SerArg: 3.423 ± 0.058	2.61SerSer: 2.61 ± 0.05	2.778SerThr: 2.778 ± 0.059	3.944SerVal: 3.944 ± 0.063	0.745SerTrp: 0.745 ± 0.023	1.326SerTyr: 1.326 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	7.594ThrAla: 7.594 ± 0.101	0.365ThrCys: 0.365 ± 0.015	3.287ThrAsp: 3.287 ± 0.067	2.379ThrGlu: 2.379 ± 0.046	1.821ThrPhe: 1.821 ± 0.044	6.049ThrGly: 6.049 ± 0.096	1.006ThrHis: 1.006 ± 0.03	3.376ThrIle: 3.376 ± 0.054	1.429ThrLys: 1.429 ± 0.038	6.67ThrLeu: 6.67 ± 0.083	1.298ThrMet: 1.298 ± 0.036	1.432ThrAsn: 1.432 ± 0.046	4.032ThrPro: 4.032 ± 0.068	1.664ThrGln: 1.664 ± 0.042	4.062ThrArg: 4.062 ± 0.057	2.906ThrSer: 2.906 ± 0.054	3.512ThrThr: 3.512 ± 0.059	4.667ThrVal: 4.667 ± 0.085	0.649ThrTrp: 0.649 ± 0.024	1.338ThrTyr: 1.338 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	11.095ValAla: 11.095 ± 0.12	0.522ValCys: 0.522 ± 0.02	4.894ValAsp: 4.894 ± 0.074	4.309ValGlu: 4.309 ± 0.062	2.346ValPhe: 2.346 ± 0.044	6.115ValGly: 6.115 ± 0.08	1.439ValHis: 1.439 ± 0.036	3.606ValIle: 3.606 ± 0.056	1.909ValLys: 1.909 ± 0.042	6.843ValLeu: 6.843 ± 0.082	1.677ValMet: 1.677 ± 0.04	1.948ValAsn: 1.948 ± 0.054	4.168ValPro: 4.168 ± 0.063	2.023ValGln: 2.023 ± 0.048	5.534ValArg: 5.534 ± 0.074	4.145ValSer: 4.145 ± 0.065	5.196ValThr: 5.196 ± 0.095	6.14ValVal: 6.14 ± 0.08	0.879ValTrp: 0.879 ± 0.028	1.423ValTyr: 1.423 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.419TrpAla: 1.419 ± 0.033	0.121TrpCys: 0.121 ± 0.011	0.792TrpAsp: 0.792 ± 0.029	0.502TrpGlu: 0.502 ± 0.021	0.564TrpPhe: 0.564 ± 0.021	0.934TrpGly: 0.934 ± 0.028	0.356TrpHis: 0.356 ± 0.018	0.672TrpIle: 0.672 ± 0.026	0.429TrpLys: 0.429 ± 0.021	1.605TrpLeu: 1.605 ± 0.04	0.337TrpMet: 0.337 ± 0.015	0.399TrpAsn: 0.399 ± 0.018	0.721TrpPro: 0.721 ± 0.025	0.543TrpGln: 0.543 ± 0.02	1.361TrpArg: 1.361 ± 0.03	0.876TrpSer: 0.876 ± 0.031	0.996TrpThr: 0.996 ± 0.032	0.862TrpVal: 0.862 ± 0.027	0.273TrpTrp: 0.273 ± 0.017	0.301TrpTyr: 0.301 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.996TyrAla: 2.996 ± 0.054	0.206TyrCys: 0.206 ± 0.013	1.621TyrAsp: 1.621 ± 0.037	1.057TyrGlu: 1.057 ± 0.03	0.815TyrPhe: 0.815 ± 0.029	2.236TyrGly: 2.236 ± 0.048	0.472TyrHis: 0.472 ± 0.016	0.796TyrIle: 0.796 ± 0.029	0.55TyrLys: 0.55 ± 0.025	2.061TyrLeu: 2.061 ± 0.038	0.373TyrMet: 0.373 ± 0.019	0.593TyrAsn: 0.593 ± 0.023	1.051TyrPro: 1.051 ± 0.033	0.666TyrGln: 0.666 ± 0.025	1.944TyrArg: 1.944 ± 0.042	1.178TyrSer: 1.178 ± 0.039	1.135TyrThr: 1.135 ± 0.046	1.647TyrVal: 1.647 ± 0.03	0.357TyrTrp: 0.357 ± 0.017	0.641TyrTyr: 0.641 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3625 proteins (1204017 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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