Amino acid dipepetide frequency for Arthrobacter sp. SW1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.679AlaAla: 21.679 ± 0.199	0.847AlaCys: 0.847 ± 0.027	6.768AlaAsp: 6.768 ± 0.076	8.521AlaGlu: 8.521 ± 0.112	4.073AlaPhe: 4.073 ± 0.063	13.644AlaGly: 13.644 ± 0.125	2.217AlaHis: 2.217 ± 0.046	5.06AlaIle: 5.06 ± 0.071	4.106AlaLys: 4.106 ± 0.072	13.322AlaLeu: 13.322 ± 0.128	2.92AlaMet: 2.92 ± 0.054	2.689AlaAsn: 2.689 ± 0.046	6.474AlaPro: 6.474 ± 0.1	3.685AlaGln: 3.685 ± 0.067	7.878AlaArg: 7.878 ± 0.104	7.132AlaSer: 7.132 ± 0.088	6.275AlaThr: 6.275 ± 0.083	12.059AlaVal: 12.059 ± 0.13	1.757AlaTrp: 1.757 ± 0.036	2.414AlaTyr: 2.414 ± 0.049	0.001AlaXaa: 0.001 ± 0.001
Cys	0.715CysAla: 0.715 ± 0.02	0.063CysCys: 0.063 ± 0.006	0.345CysAsp: 0.345 ± 0.018	0.313CysGlu: 0.313 ± 0.017	0.227CysPhe: 0.227 ± 0.012	0.746CysGly: 0.746 ± 0.025	0.128CysHis: 0.128 ± 0.01	0.262CysIle: 0.262 ± 0.016	0.12CysLys: 0.12 ± 0.011	0.616CysLeu: 0.616 ± 0.022	0.097CysMet: 0.097 ± 0.008	0.131CysAsn: 0.131 ± 0.012	0.36CysPro: 0.36 ± 0.016	0.156CysGln: 0.156 ± 0.012	0.427CysArg: 0.427 ± 0.024	0.407CysSer: 0.407 ± 0.019	0.418CysThr: 0.418 ± 0.018	0.448CysVal: 0.448 ± 0.019	0.106CysTrp: 0.106 ± 0.009	0.159CysTyr: 0.159 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.519AspAla: 7.519 ± 0.09	0.331AspCys: 0.331 ± 0.015	2.981AspAsp: 2.981 ± 0.05	3.277AspGlu: 3.277 ± 0.057	1.928AspPhe: 1.928 ± 0.044	6.025AspGly: 6.025 ± 0.081	1.129AspHis: 1.129 ± 0.037	2.411AspIle: 2.411 ± 0.051	1.435AspLys: 1.435 ± 0.037	4.922AspLeu: 4.922 ± 0.074	0.946AspMet: 0.946 ± 0.031	1.148AspAsn: 1.148 ± 0.032	3.776AspPro: 3.776 ± 0.066	1.196AspGln: 1.196 ± 0.031	3.076AspArg: 3.076 ± 0.056	2.908AspSer: 2.908 ± 0.044	2.648AspThr: 2.648 ± 0.052	4.596AspVal: 4.596 ± 0.072	0.892AspTrp: 0.892 ± 0.027	1.298AspTyr: 1.298 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	7.732GluAla: 7.732 ± 0.11	0.328GluCys: 0.328 ± 0.017	3.106GluAsp: 3.106 ± 0.058	3.786GluGlu: 3.786 ± 0.07	1.864GluPhe: 1.864 ± 0.043	4.23GluGly: 4.23 ± 0.067	1.445GluHis: 1.445 ± 0.034	2.568GluIle: 2.568 ± 0.051	1.804GluLys: 1.804 ± 0.04	7.52GluLeu: 7.52 ± 0.105	0.925GluMet: 0.925 ± 0.033	1.495GluAsn: 1.495 ± 0.035	2.94GluPro: 2.94 ± 0.053	2.405GluGln: 2.405 ± 0.052	4.402GluArg: 4.402 ± 0.066	3.092GluSer: 3.092 ± 0.056	2.978GluThr: 2.978 ± 0.052	4.128GluVal: 4.128 ± 0.066	0.83GluTrp: 0.83 ± 0.03	1.124GluTyr: 1.124 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	4.284PheAla: 4.284 ± 0.068	0.247PheCys: 0.247 ± 0.014	2.111PheAsp: 2.111 ± 0.041	1.899PheGlu: 1.899 ± 0.043	1.243PhePhe: 1.243 ± 0.039	3.528PheGly: 3.528 ± 0.067	0.658PheHis: 0.658 ± 0.023	1.383PheIle: 1.383 ± 0.039	0.86PheLys: 0.86 ± 0.033	3.171PheLeu: 3.171 ± 0.058	0.625PheMet: 0.625 ± 0.023	0.897PheAsn: 0.897 ± 0.029	1.557PhePro: 1.557 ± 0.037	0.874PheGln: 0.874 ± 0.029	1.97PheArg: 1.97 ± 0.043	2.039PheSer: 2.039 ± 0.038	2.262PheThr: 2.262 ± 0.045	2.523PheVal: 2.523 ± 0.051	0.479PheTrp: 0.479 ± 0.02	0.731PheTyr: 0.731 ± 0.025	0.001PheXaa: 0.001 ± 0.001
Gly	10.415GlyAla: 10.415 ± 0.126	0.633GlyCys: 0.633 ± 0.024	4.149GlyAsp: 4.149 ± 0.067	4.777GlyGlu: 4.777 ± 0.064	3.413GlyPhe: 3.413 ± 0.057	8.216GlyGly: 8.216 ± 0.105	2.032GlyHis: 2.032 ± 0.049	4.777GlyIle: 4.777 ± 0.076	3.412GlyLys: 3.412 ± 0.061	9.711GlyLeu: 9.711 ± 0.107	2.133GlyMet: 2.133 ± 0.043	2.521GlyAsn: 2.521 ± 0.054	4.175GlyPro: 4.175 ± 0.061	2.902GlyGln: 2.902 ± 0.062	6.082GlyArg: 6.082 ± 0.075	6.047GlySer: 6.047 ± 0.068	6.222GlyThr: 6.222 ± 0.084	7.362GlyVal: 7.362 ± 0.086	1.602GlyTrp: 1.602 ± 0.042	2.371GlyTyr: 2.371 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.279HisAla: 2.279 ± 0.046	0.187HisCys: 0.187 ± 0.013	1.161HisAsp: 1.161 ± 0.03	1.154HisGlu: 1.154 ± 0.033	0.668HisPhe: 0.668 ± 0.022	2.131HisGly: 2.131 ± 0.042	0.575HisHis: 0.575 ± 0.024	0.797HisIle: 0.797 ± 0.026	0.455HisLys: 0.455 ± 0.02	1.943HisLeu: 1.943 ± 0.045	0.414HisMet: 0.414 ± 0.02	0.451HisAsn: 0.451 ± 0.02	1.412HisPro: 1.412 ± 0.037	0.552HisGln: 0.552 ± 0.02	1.475HisArg: 1.475 ± 0.04	1.191HisSer: 1.191 ± 0.035	0.959HisThr: 0.959 ± 0.029	1.483HisVal: 1.483 ± 0.038	0.327HisTrp: 0.327 ± 0.017	0.477HisTyr: 0.477 ± 0.02	0.001HisXaa: 0.001 ± 0.001
Ile	6.03IleAla: 6.03 ± 0.07	0.339IleCys: 0.339 ± 0.017	2.596IleAsp: 2.596 ± 0.049	2.384IleGlu: 2.384 ± 0.05	1.374IlePhe: 1.374 ± 0.038	4.136IleGly: 4.136 ± 0.068	0.792IleHis: 0.792 ± 0.025	1.785IleIle: 1.785 ± 0.049	1.216IleLys: 1.216 ± 0.036	3.932IleLeu: 3.932 ± 0.064	0.764IleMet: 0.764 ± 0.029	1.237IleAsn: 1.237 ± 0.033	2.279IlePro: 2.279 ± 0.049	1.141IleGln: 1.141 ± 0.03	2.684IleArg: 2.684 ± 0.052	2.561IleSer: 2.561 ± 0.053	2.669IleThr: 2.669 ± 0.052	3.581IleVal: 3.581 ± 0.057	0.461IleTrp: 0.461 ± 0.02	0.83IleTyr: 0.83 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	4.048LysAla: 4.048 ± 0.074	0.122LysCys: 0.122 ± 0.01	1.924LysAsp: 1.924 ± 0.039	1.726LysGlu: 1.726 ± 0.037	0.801LysPhe: 0.801 ± 0.028	2.286LysGly: 2.286 ± 0.054	0.664LysHis: 0.664 ± 0.025	1.331LysIle: 1.331 ± 0.039	1.079LysLys: 1.079 ± 0.036	2.979LysLeu: 2.979 ± 0.053	0.638LysMet: 0.638 ± 0.022	0.791LysAsn: 0.791 ± 0.026	1.745LysPro: 1.745 ± 0.041	0.964LysGln: 0.964 ± 0.033	1.812LysArg: 1.812 ± 0.041	1.54LysSer: 1.54 ± 0.043	1.62LysThr: 1.62 ± 0.042	2.568LysVal: 2.568 ± 0.048	0.321LysTrp: 0.321 ± 0.018	0.691LysTyr: 0.691 ± 0.024	0.001LysXaa: 0.001 ± 0.001
Leu	15.002LeuAla: 15.002 ± 0.139	0.661LeuCys: 0.661 ± 0.03	6.256LeuAsp: 6.256 ± 0.078	5.89LeuGlu: 5.89 ± 0.084	3.026LeuPhe: 3.026 ± 0.061	9.802LeuGly: 9.802 ± 0.088	2.0LeuHis: 2.0 ± 0.041	4.08LeuIle: 4.08 ± 0.063	2.874LeuLys: 2.874 ± 0.05	11.125LeuLeu: 11.125 ± 0.159	1.92LeuMet: 1.92 ± 0.041	2.442LeuAsn: 2.442 ± 0.056	5.925LeuPro: 5.925 ± 0.073	2.848LeuGln: 2.848 ± 0.054	6.947LeuArg: 6.947 ± 0.094	6.364LeuSer: 6.364 ± 0.07	5.334LeuThr: 5.334 ± 0.062	8.315LeuVal: 8.315 ± 0.091	1.291LeuTrp: 1.291 ± 0.037	1.711LeuTyr: 1.711 ± 0.037	0.001LeuXaa: 0.001 ± 0.001
Met	2.642MetAla: 2.642 ± 0.045	0.114MetCys: 0.114 ± 0.01	1.056MetAsp: 1.056 ± 0.03	0.925MetGlu: 0.925 ± 0.032	0.63MetPhe: 0.63 ± 0.023	1.634MetGly: 1.634 ± 0.038	0.344MetHis: 0.344 ± 0.019	0.859MetIle: 0.859 ± 0.029	0.623MetLys: 0.623 ± 0.022	1.96MetLeu: 1.96 ± 0.041	0.368MetMet: 0.368 ± 0.02	0.587MetAsn: 0.587 ± 0.024	1.14MetPro: 1.14 ± 0.029	0.536MetGln: 0.536 ± 0.02	1.169MetArg: 1.169 ± 0.031	1.543MetSer: 1.543 ± 0.035	1.474MetThr: 1.474 ± 0.039	1.639MetVal: 1.639 ± 0.042	0.201MetTrp: 0.201 ± 0.013	0.335MetTyr: 0.335 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.897AsnAla: 2.897 ± 0.054	0.18AsnCys: 0.18 ± 0.012	1.273AsnAsp: 1.273 ± 0.036	1.198AsnGlu: 1.198 ± 0.032	0.843AsnPhe: 0.843 ± 0.03	2.559AsnGly: 2.559 ± 0.056	0.514AsnHis: 0.514 ± 0.022	1.062AsnIle: 1.062 ± 0.029	0.758AsnLys: 0.758 ± 0.027	2.243AsnLeu: 2.243 ± 0.046	0.447AsnMet: 0.447 ± 0.02	0.724AsnAsn: 0.724 ± 0.027	1.893AsnPro: 1.893 ± 0.041	0.662AsnGln: 0.662 ± 0.026	1.406AsnArg: 1.406 ± 0.035	1.369AsnSer: 1.369 ± 0.039	1.351AsnThr: 1.351 ± 0.038	1.892AsnVal: 1.892 ± 0.038	0.398AsnTrp: 0.398 ± 0.019	0.615AsnTyr: 0.615 ± 0.025	0.001AsnXaa: 0.001 ± 0.001
Pro	8.291ProAla: 8.291 ± 0.087	0.217ProCys: 0.217 ± 0.014	3.491ProAsp: 3.491 ± 0.054	4.454ProGlu: 4.454 ± 0.058	1.702ProPhe: 1.702 ± 0.041	5.794ProGly: 5.794 ± 0.081	1.074ProHis: 1.074 ± 0.031	1.503ProIle: 1.503 ± 0.039	1.448ProLys: 1.448 ± 0.037	5.025ProLeu: 5.025 ± 0.06	0.975ProMet: 0.975 ± 0.033	1.156ProAsn: 1.156 ± 0.033	2.156ProPro: 2.156 ± 0.05	1.674ProGln: 1.674 ± 0.039	2.87ProArg: 2.87 ± 0.056	3.072ProSer: 3.072 ± 0.05	2.508ProThr: 2.508 ± 0.05	5.052ProVal: 5.052 ± 0.071	0.798ProTrp: 0.798 ± 0.029	1.116ProTyr: 1.116 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.937GlnAla: 3.937 ± 0.065	0.153GlnCys: 0.153 ± 0.012	1.558GlnAsp: 1.558 ± 0.04	1.685GlnGlu: 1.685 ± 0.04	0.876GlnPhe: 0.876 ± 0.025	2.373GlnGly: 2.373 ± 0.044	0.678GlnHis: 0.678 ± 0.026	1.309GlnIle: 1.309 ± 0.037	0.837GlnLys: 0.837 ± 0.031	3.67GlnLeu: 3.67 ± 0.065	0.58GlnMet: 0.58 ± 0.022	0.672GlnAsn: 0.672 ± 0.027	1.704GlnPro: 1.704 ± 0.044	1.303GlnGln: 1.303 ± 0.038	2.167GlnArg: 2.167 ± 0.047	1.53GlnSer: 1.53 ± 0.034	1.28GlnThr: 1.28 ± 0.034	2.152GlnVal: 2.152 ± 0.05	0.489GlnTrp: 0.489 ± 0.026	0.647GlnTyr: 0.647 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	6.723ArgAla: 6.723 ± 0.093	0.387ArgCys: 0.387 ± 0.02	3.241ArgAsp: 3.241 ± 0.058	4.061ArgGlu: 4.061 ± 0.074	2.23ArgPhe: 2.23 ± 0.039	4.74ArgGly: 4.74 ± 0.067	1.514ArgHis: 1.514 ± 0.04	3.459ArgIle: 3.459 ± 0.058	2.179ArgLys: 2.179 ± 0.041	6.776ArgLeu: 6.776 ± 0.095	1.47ArgMet: 1.47 ± 0.032	1.782ArgAsn: 1.782 ± 0.042	3.356ArgPro: 3.356 ± 0.068	2.205ArgGln: 2.205 ± 0.042	5.381ArgArg: 5.381 ± 0.09	3.845ArgSer: 3.845 ± 0.057	3.69ArgThr: 3.69 ± 0.055	4.506ArgVal: 4.506 ± 0.069	1.016ArgTrp: 1.016 ± 0.029	1.529ArgTyr: 1.529 ± 0.036	0.002ArgXaa: 0.002 ± 0.001
Ser	7.257SerAla: 7.257 ± 0.085	0.399SerCys: 0.399 ± 0.019	2.828SerAsp: 2.828 ± 0.049	3.023SerGlu: 3.023 ± 0.052	2.121SerPhe: 2.121 ± 0.04	6.525SerGly: 6.525 ± 0.082	1.061SerHis: 1.061 ± 0.031	2.443SerIle: 2.443 ± 0.051	1.704SerLys: 1.704 ± 0.044	5.799SerLeu: 5.799 ± 0.075	1.269SerMet: 1.269 ± 0.034	1.428SerAsn: 1.428 ± 0.038	3.172SerPro: 3.172 ± 0.056	1.603SerGln: 1.603 ± 0.038	3.717SerArg: 3.717 ± 0.061	3.694SerSer: 3.694 ± 0.071	3.336SerThr: 3.336 ± 0.063	4.637SerVal: 4.637 ± 0.065	0.922SerTrp: 0.922 ± 0.03	1.518SerTyr: 1.518 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	8.019ThrAla: 8.019 ± 0.104	0.26ThrCys: 0.26 ± 0.014	2.743ThrAsp: 2.743 ± 0.062	2.806ThrGlu: 2.806 ± 0.058	1.935ThrPhe: 1.935 ± 0.045	5.396ThrGly: 5.396 ± 0.068	0.971ThrHis: 0.971 ± 0.028	2.495ThrIle: 2.495 ± 0.054	1.48ThrLys: 1.48 ± 0.039	5.59ThrLeu: 5.59 ± 0.064	1.004ThrMet: 1.004 ± 0.029	1.088ThrAsn: 1.088 ± 0.034	3.646ThrPro: 3.646 ± 0.056	1.386ThrGln: 1.386 ± 0.034	2.857ThrArg: 2.857 ± 0.052	3.112ThrSer: 3.112 ± 0.05	3.379ThrThr: 3.379 ± 0.067	5.714ThrVal: 5.714 ± 0.081	0.664ThrTrp: 0.664 ± 0.025	0.956ThrTyr: 0.956 ± 0.03	0.001ThrXaa: 0.001 ± 0.001
Val	10.211ValAla: 10.211 ± 0.091	0.521ValCys: 0.521 ± 0.021	4.877ValAsp: 4.877 ± 0.068	5.013ValGlu: 5.013 ± 0.072	2.975ValPhe: 2.975 ± 0.055	6.134ValGly: 6.134 ± 0.091	1.638ValHis: 1.638 ± 0.039	3.756ValIle: 3.756 ± 0.055	2.217ValLys: 2.217 ± 0.049	9.423ValLeu: 9.423 ± 0.102	1.613ValMet: 1.613 ± 0.037	2.037ValAsn: 2.037 ± 0.048	4.949ValPro: 4.949 ± 0.063	2.259ValGln: 2.259 ± 0.042	5.249ValArg: 5.249 ± 0.07	4.922ValSer: 4.922 ± 0.065	5.039ValThr: 5.039 ± 0.085	7.969ValVal: 7.969 ± 0.093	0.968ValTrp: 0.968 ± 0.031	1.538ValTyr: 1.538 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.479TrpAla: 1.479 ± 0.034	0.111TrpCys: 0.111 ± 0.01	0.755TrpAsp: 0.755 ± 0.024	0.69TrpGlu: 0.69 ± 0.027	0.568TrpPhe: 0.568 ± 0.025	1.01TrpGly: 1.01 ± 0.032	0.331TrpHis: 0.331 ± 0.018	0.73TrpIle: 0.73 ± 0.026	0.463TrpLys: 0.463 ± 0.018	1.781TrpLeu: 1.781 ± 0.041	0.303TrpMet: 0.303 ± 0.018	0.482TrpAsn: 0.482 ± 0.022	0.639TrpPro: 0.639 ± 0.028	0.571TrpGln: 0.571 ± 0.021	0.959TrpArg: 0.959 ± 0.032	0.798TrpSer: 0.798 ± 0.024	0.852TrpThr: 0.852 ± 0.027	1.057TrpVal: 1.057 ± 0.028	0.276TrpTrp: 0.276 ± 0.015	0.292TrpTyr: 0.292 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.361TyrAla: 2.361 ± 0.049	0.145TyrCys: 0.145 ± 0.011	1.222TyrAsp: 1.222 ± 0.032	1.12TyrGlu: 1.12 ± 0.038	0.845TyrPhe: 0.845 ± 0.026	2.037TyrGly: 2.037 ± 0.043	0.328TyrHis: 0.328 ± 0.018	0.72TyrIle: 0.72 ± 0.025	0.581TyrLys: 0.581 ± 0.022	2.307TyrLeu: 2.307 ± 0.044	0.368TyrMet: 0.368 ± 0.018	0.526TyrAsn: 0.526 ± 0.023	1.081TyrPro: 1.081 ± 0.037	0.678TyrGln: 0.678 ± 0.026	1.562TyrArg: 1.562 ± 0.033	1.29TyrSer: 1.29 ± 0.035	1.21TyrThr: 1.21 ± 0.035	1.624TyrVal: 1.624 ± 0.036	0.349TyrTrp: 0.349 ± 0.016	0.541TyrTyr: 0.541 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.002XaaGly: 0.002 ± 0.002	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 3661 proteins (1202471 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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