Amino acid dipepetide frequency for Candidatus Synechococcus spongiarum LMB bulk10E

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.822AlaAla: 12.822 ± 0.535
1.609AlaCys: 1.609 ± 0.127
4.879AlaAsp: 4.879 ± 0.204
5.427AlaGlu: 5.427 ± 0.258
3.013AlaPhe: 3.013 ± 0.164
7.986AlaGly: 7.986 ± 0.278
2.183AlaHis: 2.183 ± 0.131
3.937AlaIle: 3.937 ± 0.186
2.362AlaLys: 2.362 ± 0.15
12.951AlaLeu: 12.951 ± 0.408
3.013AlaMet: 3.013 ± 0.181
2.268AlaAsn: 2.268 ± 0.156
4.622AlaPro: 4.622 ± 0.27
4.177AlaGln: 4.177 ± 0.212
7.49AlaArg: 7.49 ± 0.268
5.47AlaSer: 5.47 ± 0.214
5.153AlaThr: 5.153 ± 0.257
8.739AlaVal: 8.739 ± 0.293
1.472AlaTrp: 1.472 ± 0.107
1.892AlaTyr: 1.892 ± 0.103
0.0AlaXaa: 0.0 ± 0.0
Cys
1.044CysAla: 1.044 ± 0.115
0.454CysCys: 0.454 ± 0.079
0.608CysAsp: 0.608 ± 0.058
0.471CysGlu: 0.471 ± 0.061
0.565CysPhe: 0.565 ± 0.067
1.575CysGly: 1.575 ± 0.124
0.514CysHis: 0.514 ± 0.069
0.599CysIle: 0.599 ± 0.072
0.317CysLys: 0.317 ± 0.055
1.412CysLeu: 1.412 ± 0.12
0.188CysMet: 0.188 ± 0.041
0.419CysAsn: 0.419 ± 0.059
0.77CysPro: 0.77 ± 0.082
0.659CysGln: 0.659 ± 0.075
1.361CysArg: 1.361 ± 0.093
0.967CysSer: 0.967 ± 0.092
0.599CysThr: 0.599 ± 0.07
0.719CysVal: 0.719 ± 0.079
0.36CysTrp: 0.36 ± 0.061
0.385CysTyr: 0.385 ± 0.056
0.0CysXaa: 0.0 ± 0.0
Asp
4.87AspAla: 4.87 ± 0.2
0.702AspCys: 0.702 ± 0.084
2.131AspAsp: 2.131 ± 0.143
2.602AspGlu: 2.602 ± 0.157
1.806AspPhe: 1.806 ± 0.128
4.502AspGly: 4.502 ± 0.208
1.498AspHis: 1.498 ± 0.123
1.78AspIle: 1.78 ± 0.124
1.275AspLys: 1.275 ± 0.13
6.411AspLeu: 6.411 ± 0.284
0.822AspMet: 0.822 ± 0.078
1.284AspAsn: 1.284 ± 0.094
3.98AspPro: 3.98 ± 0.209
2.79AspGln: 2.79 ± 0.154
3.578AspArg: 3.578 ± 0.176
2.756AspSer: 2.756 ± 0.15
2.534AspThr: 2.534 ± 0.15
3.492AspVal: 3.492 ± 0.178
0.924AspTrp: 0.924 ± 0.074
1.198AspTyr: 1.198 ± 0.103
0.0AspXaa: 0.0 ± 0.0
Glu
6.428GluAla: 6.428 ± 0.232
0.411GluCys: 0.411 ± 0.057
3.304GluAsp: 3.304 ± 0.177
3.681GluGlu: 3.681 ± 0.23
1.558GluPhe: 1.558 ± 0.153
3.672GluGly: 3.672 ± 0.183
1.198GluHis: 1.198 ± 0.096
2.551GluIle: 2.551 ± 0.154
1.815GluLys: 1.815 ± 0.155
5.915GluLeu: 5.915 ± 0.239
1.233GluMet: 1.233 ± 0.139
1.335GluAsn: 1.335 ± 0.108
2.782GluPro: 2.782 ± 0.134
3.244GluGln: 3.244 ± 0.172
5.102GluArg: 5.102 ± 0.227
2.568GluSer: 2.568 ± 0.129
3.141GluThr: 3.141 ± 0.172
3.218GluVal: 3.218 ± 0.189
0.539GluTrp: 0.539 ± 0.072
0.83GluTyr: 0.83 ± 0.093
0.0GluXaa: 0.0 ± 0.0
Phe
3.039PheAla: 3.039 ± 0.184
0.556PheCys: 0.556 ± 0.07
1.969PheAsp: 1.969 ± 0.13
1.438PheGlu: 1.438 ± 0.115
1.061PhePhe: 1.061 ± 0.098
2.585PheGly: 2.585 ± 0.147
0.984PheHis: 0.984 ± 0.096
1.147PheIle: 1.147 ± 0.107
0.582PheLys: 0.582 ± 0.078
3.527PheLeu: 3.527 ± 0.204
0.522PheMet: 0.522 ± 0.063
1.079PheAsn: 1.079 ± 0.095
1.524PhePro: 1.524 ± 0.108
1.301PheGln: 1.301 ± 0.116
2.003PheArg: 2.003 ± 0.113
2.371PheSer: 2.371 ± 0.163
2.029PheThr: 2.029 ± 0.126
2.191PheVal: 2.191 ± 0.161
0.505PheTrp: 0.505 ± 0.074
0.753PheTyr: 0.753 ± 0.072
0.0PheXaa: 0.0 ± 0.0
Gly
7.481GlyAla: 7.481 ± 0.352
1.318GlyCys: 1.318 ± 0.113
4.263GlyAsp: 4.263 ± 0.187
4.588GlyGlu: 4.588 ± 0.213
3.253GlyPhe: 3.253 ± 0.175
6.334GlyGly: 6.334 ± 0.273
2.114GlyHis: 2.114 ± 0.173
3.715GlyIle: 3.715 ± 0.213
2.833GlyLys: 2.833 ± 0.148
10.588GlyLeu: 10.588 ± 0.351
1.866GlyMet: 1.866 ± 0.118
1.969GlyAsn: 1.969 ± 0.147
3.398GlyPro: 3.398 ± 0.225
3.946GlyGln: 3.946 ± 0.186
5.803GlyArg: 5.803 ± 0.236
5.221GlySer: 5.221 ± 0.227
4.228GlyThr: 4.228 ± 0.268
5.838GlyVal: 5.838 ± 0.244
1.489GlyTrp: 1.489 ± 0.13
2.071GlyTyr: 2.071 ± 0.118
0.0GlyXaa: 0.0 ± 0.0
His
1.866HisAla: 1.866 ± 0.136
0.539HisCys: 0.539 ± 0.065
0.924HisAsp: 0.924 ± 0.091
0.813HisGlu: 0.813 ± 0.086
0.813HisPhe: 0.813 ± 0.083
2.91HisGly: 2.91 ± 0.192
0.907HisHis: 0.907 ± 0.115
0.907HisIle: 0.907 ± 0.1
0.437HisLys: 0.437 ± 0.063
2.996HisLeu: 2.996 ± 0.168
0.462HisMet: 0.462 ± 0.059
0.728HisAsn: 0.728 ± 0.069
1.806HisPro: 1.806 ± 0.122
1.464HisGln: 1.464 ± 0.099
2.166HisArg: 2.166 ± 0.131
1.361HisSer: 1.361 ± 0.104
1.13HisThr: 1.13 ± 0.095
1.755HisVal: 1.755 ± 0.128
0.616HisTrp: 0.616 ± 0.077
0.805HisTyr: 0.805 ± 0.085
0.0HisXaa: 0.0 ± 0.0
Ile
3.912IleAla: 3.912 ± 0.176
0.762IleCys: 0.762 ± 0.077
2.063IleAsp: 2.063 ± 0.132
2.123IleGlu: 2.123 ± 0.181
1.061IlePhe: 1.061 ± 0.091
3.424IleGly: 3.424 ± 0.217
1.181IleHis: 1.181 ± 0.102
1.335IleIle: 1.335 ± 0.143
1.404IleLys: 1.404 ± 0.137
3.792IleLeu: 3.792 ± 0.199
0.548IleMet: 0.548 ± 0.08
1.455IleAsn: 1.455 ± 0.123
2.671IlePro: 2.671 ± 0.165
1.506IleGln: 1.506 ± 0.126
3.116IleArg: 3.116 ± 0.177
2.748IleSer: 2.748 ± 0.16
2.457IleThr: 2.457 ± 0.182
2.534IleVal: 2.534 ± 0.187
0.539IleTrp: 0.539 ± 0.073
0.924IleTyr: 0.924 ± 0.092
0.0IleXaa: 0.0 ± 0.0
Lys
3.141LysAla: 3.141 ± 0.194
0.24LysCys: 0.24 ± 0.045
1.643LysAsp: 1.643 ± 0.166
1.506LysGlu: 1.506 ± 0.162
0.659LysPhe: 0.659 ± 0.098
2.2LysGly: 2.2 ± 0.177
0.651LysHis: 0.651 ± 0.08
1.233LysIle: 1.233 ± 0.136
1.087LysLys: 1.087 ± 0.15
3.047LysLeu: 3.047 ± 0.189
0.411LysMet: 0.411 ± 0.067
0.847LysAsn: 0.847 ± 0.111
1.643LysPro: 1.643 ± 0.123
1.181LysGln: 1.181 ± 0.106
1.934LysArg: 1.934 ± 0.132
1.387LysSer: 1.387 ± 0.136
1.909LysThr: 1.909 ± 0.14
2.029LysVal: 2.029 ± 0.144
0.24LysTrp: 0.24 ± 0.042
0.479LysTyr: 0.479 ± 0.071
0.0LysXaa: 0.0 ± 0.0
Leu
13.182LeuAla: 13.182 ± 0.495
1.549LeuCys: 1.549 ± 0.136
6.18LeuAsp: 6.18 ± 0.248
7.746LeuGlu: 7.746 ± 0.286
2.85LeuPhe: 2.85 ± 0.145
9.775LeuGly: 9.775 ± 0.412
2.859LeuHis: 2.859 ± 0.177
3.997LeuIle: 3.997 ± 0.208
3.381LeuLys: 3.381 ± 0.197
14.714LeuLeu: 14.714 ± 0.568
2.217LeuMet: 2.217 ± 0.138
3.218LeuAsn: 3.218 ± 0.164
6.839LeuPro: 6.839 ± 0.259
5.658LeuGln: 5.658 ± 0.255
9.159LeuArg: 9.159 ± 0.351
7.087LeuSer: 7.087 ± 0.303
6.026LeuThr: 6.026 ± 0.269
9.535LeuVal: 9.535 ± 0.346
1.72LeuTrp: 1.72 ± 0.126
1.952LeuTyr: 1.952 ± 0.123
0.0LeuXaa: 0.0 ± 0.0
Met
3.244MetAla: 3.244 ± 0.185
0.111MetCys: 0.111 ± 0.027
1.37MetAsp: 1.37 ± 0.123
1.541MetGlu: 1.541 ± 0.114
0.488MetPhe: 0.488 ± 0.07
1.746MetGly: 1.746 ± 0.139
0.334MetHis: 0.334 ± 0.054
0.779MetIle: 0.779 ± 0.087
0.787MetLys: 0.787 ± 0.1
1.729MetLeu: 1.729 ± 0.133
0.334MetMet: 0.334 ± 0.057
0.642MetAsn: 0.642 ± 0.067
1.19MetPro: 1.19 ± 0.098
0.642MetGln: 0.642 ± 0.069
1.027MetArg: 1.027 ± 0.078
1.207MetSer: 1.207 ± 0.095
1.344MetThr: 1.344 ± 0.102
2.131MetVal: 2.131 ± 0.141
0.128MetTrp: 0.128 ± 0.042
0.223MetTyr: 0.223 ± 0.047
0.0MetXaa: 0.0 ± 0.0
Asn
2.191AsnAla: 2.191 ± 0.146
0.437AsnCys: 0.437 ± 0.064
1.173AsnAsp: 1.173 ± 0.113
0.967AsnGlu: 0.967 ± 0.105
0.702AsnPhe: 0.702 ± 0.076
2.285AsnGly: 2.285 ± 0.148
0.582AsnHis: 0.582 ± 0.067
0.882AsnIle: 0.882 ± 0.106
0.693AsnLys: 0.693 ± 0.082
3.415AsnLeu: 3.415 ± 0.176
0.539AsnMet: 0.539 ± 0.064
0.787AsnAsn: 0.787 ± 0.095
2.234AsnPro: 2.234 ± 0.14
1.267AsnGln: 1.267 ± 0.11
2.08AsnArg: 2.08 ± 0.131
1.78AsnSer: 1.78 ± 0.124
1.464AsnThr: 1.464 ± 0.129
1.678AsnVal: 1.678 ± 0.136
0.522AsnTrp: 0.522 ± 0.068
0.599AsnTyr: 0.599 ± 0.071
0.0AsnXaa: 0.0 ± 0.0
Pro
5.367ProAla: 5.367 ± 0.239
0.728ProCys: 0.728 ± 0.089
3.287ProAsp: 3.287 ± 0.173
3.706ProGlu: 3.706 ± 0.174
1.857ProPhe: 1.857 ± 0.134
4.982ProGly: 4.982 ± 0.253
1.429ProHis: 1.429 ± 0.116
1.909ProIle: 1.909 ± 0.136
1.173ProLys: 1.173 ± 0.115
6.771ProLeu: 6.771 ± 0.276
1.489ProMet: 1.489 ± 0.109
1.164ProAsn: 1.164 ± 0.097
3.698ProPro: 3.698 ± 0.224
2.534ProGln: 2.534 ± 0.148
4.083ProArg: 4.083 ± 0.194
3.501ProSer: 3.501 ± 0.173
3.116ProThr: 3.116 ± 0.175
4.519ProVal: 4.519 ± 0.206
1.31ProTrp: 1.31 ± 0.114
1.284ProTyr: 1.284 ± 0.095
0.0ProXaa: 0.0 ± 0.0
Gln
5.47GlnAla: 5.47 ± 0.204
0.377GlnCys: 0.377 ± 0.058
2.628GlnAsp: 2.628 ± 0.17
2.431GlnGlu: 2.431 ± 0.163
1.096GlnPhe: 1.096 ± 0.099
3.698GlnGly: 3.698 ± 0.176
1.138GlnHis: 1.138 ± 0.106
1.267GlnIle: 1.267 ± 0.107
1.198GlnLys: 1.198 ± 0.103
6.249GlnLeu: 6.249 ± 0.279
0.822GlnMet: 0.822 ± 0.094
0.882GlnAsn: 0.882 ± 0.086
3.347GlnPro: 3.347 ± 0.184
3.201GlnGln: 3.201 ± 0.208
4.614GlnArg: 4.614 ± 0.207
2.191GlnSer: 2.191 ± 0.146
1.952GlnThr: 1.952 ± 0.134
3.689GlnVal: 3.689 ± 0.179
0.89GlnTrp: 0.89 ± 0.086
0.651GlnTyr: 0.651 ± 0.075
0.0GlnXaa: 0.0 ± 0.0
Arg
5.196ArgAla: 5.196 ± 0.205
1.181ArgCys: 1.181 ± 0.095
3.527ArgAsp: 3.527 ± 0.194
3.92ArgGlu: 3.92 ± 0.203
3.244ArgPhe: 3.244 ± 0.173
5.067ArgGly: 5.067 ± 0.231
2.799ArgHis: 2.799 ± 0.154
3.612ArgIle: 3.612 ± 0.195
2.439ArgLys: 2.439 ± 0.166
10.229ArgLeu: 10.229 ± 0.339
1.344ArgMet: 1.344 ± 0.123
1.875ArgAsn: 1.875 ± 0.118
3.963ArgPro: 3.963 ± 0.166
5.179ArgGln: 5.179 ± 0.218
6.95ArgArg: 6.95 ± 0.327
4.639ArgSer: 4.639 ± 0.208
3.45ArgThr: 3.45 ± 0.176
4.579ArgVal: 4.579 ± 0.22
1.626ArgTrp: 1.626 ± 0.128
1.815ArgTyr: 1.815 ± 0.149
0.0ArgXaa: 0.0 ± 0.0
Ser
5.05SerAla: 5.05 ± 0.212
0.77SerCys: 0.77 ± 0.086
2.756SerAsp: 2.756 ± 0.152
2.594SerGlu: 2.594 ± 0.14
1.994SerPhe: 1.994 ± 0.136
5.786SerGly: 5.786 ± 0.231
1.498SerHis: 1.498 ± 0.119
2.422SerIle: 2.422 ± 0.152
1.387SerLys: 1.387 ± 0.115
6.728SerLeu: 6.728 ± 0.288
1.412SerMet: 1.412 ± 0.122
1.592SerAsn: 1.592 ± 0.139
3.732SerPro: 3.732 ± 0.216
2.405SerGln: 2.405 ± 0.138
5.042SerArg: 5.042 ± 0.229
4.023SerSer: 4.023 ± 0.235
3.364SerThr: 3.364 ± 0.166
4.151SerVal: 4.151 ± 0.216
1.044SerTrp: 1.044 ± 0.092
1.275SerTyr: 1.275 ± 0.1
0.0SerXaa: 0.0 ± 0.0
Thr
6.12ThrAla: 6.12 ± 0.285
0.77ThrCys: 0.77 ± 0.079
2.243ThrAsp: 2.243 ± 0.14
2.542ThrGlu: 2.542 ± 0.175
1.652ThrPhe: 1.652 ± 0.113
4.725ThrGly: 4.725 ± 0.255
1.13ThrHis: 1.13 ± 0.087
2.85ThrIle: 2.85 ± 0.145
1.181ThrLys: 1.181 ± 0.128
5.444ThrLeu: 5.444 ± 0.237
1.515ThrMet: 1.515 ± 0.102
1.395ThrAsn: 1.395 ± 0.143
3.432ThrPro: 3.432 ± 0.207
1.618ThrGln: 1.618 ± 0.126
3.236ThrArg: 3.236 ± 0.184
3.21ThrSer: 3.21 ± 0.189
3.963ThrThr: 3.963 ± 0.277
4.879ThrVal: 4.879 ± 0.235
0.865ThrTrp: 0.865 ± 0.089
1.096ThrTyr: 1.096 ± 0.104
0.0ThrXaa: 0.0 ± 0.0
Val
8.217ValAla: 8.217 ± 0.293
0.882ValCys: 0.882 ± 0.094
4.126ValAsp: 4.126 ± 0.209
4.605ValGlu: 4.605 ± 0.258
2.465ValPhe: 2.465 ± 0.142
5.572ValGly: 5.572 ± 0.257
1.558ValHis: 1.558 ± 0.13
3.099ValIle: 3.099 ± 0.204
2.063ValLys: 2.063 ± 0.235
8.996ValLeu: 8.996 ± 0.338
1.609ValMet: 1.609 ± 0.121
2.225ValAsn: 2.225 ± 0.123
4.023ValPro: 4.023 ± 0.18
3.141ValGln: 3.141 ± 0.186
4.716ValArg: 4.716 ± 0.204
4.314ValSer: 4.314 ± 0.195
4.28ValThr: 4.28 ± 0.213
6.54ValVal: 6.54 ± 0.261
0.83ValTrp: 0.83 ± 0.08
1.25ValTyr: 1.25 ± 0.099
0.0ValXaa: 0.0 ± 0.0
Trp
1.053TrpAla: 1.053 ± 0.085
0.257TrpCys: 0.257 ± 0.049
0.702TrpAsp: 0.702 ± 0.079
0.745TrpGlu: 0.745 ± 0.096
0.437TrpPhe: 0.437 ± 0.067
1.173TrpGly: 1.173 ± 0.1
0.402TrpHis: 0.402 ± 0.064
0.787TrpIle: 0.787 ± 0.08
0.462TrpLys: 0.462 ± 0.07
2.731TrpLeu: 2.731 ± 0.195
0.334TrpMet: 0.334 ± 0.057
0.488TrpAsn: 0.488 ± 0.07
0.839TrpPro: 0.839 ± 0.095
1.061TrpGln: 1.061 ± 0.111
1.404TrpArg: 1.404 ± 0.138
1.104TrpSer: 1.104 ± 0.104
0.693TrpThr: 0.693 ± 0.094
1.01TrpVal: 1.01 ± 0.112
0.317TrpTrp: 0.317 ± 0.064
0.308TrpTyr: 0.308 ± 0.049
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.78TyrAla: 1.78 ± 0.135
0.334TyrCys: 0.334 ± 0.05
1.164TyrAsp: 1.164 ± 0.094
1.079TyrGlu: 1.079 ± 0.098
0.591TyrPhe: 0.591 ± 0.072
2.32TyrGly: 2.32 ± 0.133
0.445TyrHis: 0.445 ± 0.071
0.745TyrIle: 0.745 ± 0.085
0.591TyrLys: 0.591 ± 0.08
2.003TyrLeu: 2.003 ± 0.145
0.308TyrMet: 0.308 ± 0.055
0.625TyrAsn: 0.625 ± 0.076
1.412TyrPro: 1.412 ± 0.121
0.813TyrGln: 0.813 ± 0.077
1.772TyrArg: 1.772 ± 0.125
1.121TyrSer: 1.121 ± 0.103
1.036TyrThr: 1.036 ± 0.125
1.284TyrVal: 1.284 ± 0.11
0.368TyrTrp: 0.368 ± 0.05
0.428TyrTyr: 0.428 ± 0.066
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 427 proteins (116829 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski