Amino acid dipepetide frequency for Measles morbillivirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.181AlaAla: 4.181 ± 1.0
1.045AlaCys: 1.045 ± 0.388
2.352AlaAsp: 2.352 ± 0.817
3.397AlaGlu: 3.397 ± 1.487
2.613AlaPhe: 2.613 ± 0.791
2.613AlaGly: 2.613 ± 0.619
1.307AlaHis: 1.307 ± 0.553
3.658AlaIle: 3.658 ± 0.88
2.874AlaLys: 2.874 ± 0.414
6.533AlaLeu: 6.533 ± 0.75
1.568AlaMet: 1.568 ± 0.684
2.613AlaAsn: 2.613 ± 0.722
3.136AlaPro: 3.136 ± 1.036
1.045AlaGln: 1.045 ± 0.433
3.92AlaArg: 3.92 ± 1.472
4.442AlaSer: 4.442 ± 2.334
2.09AlaThr: 2.09 ± 0.882
5.226AlaVal: 5.226 ± 1.938
0.784AlaTrp: 0.784 ± 0.511
2.09AlaTyr: 2.09 ± 1.225
0.0AlaXaa: 0.0 ± 0.0
Cys
1.045CysAla: 1.045 ± 0.274
0.261CysCys: 0.261 ± 0.153
0.261CysAsp: 0.261 ± 0.153
0.784CysGlu: 0.784 ± 0.288
1.829CysPhe: 1.829 ± 0.468
1.045CysGly: 1.045 ± 0.612
1.045CysHis: 1.045 ± 0.572
0.784CysIle: 0.784 ± 0.349
1.045CysLys: 1.045 ± 0.885
1.045CysLeu: 1.045 ± 0.38
0.261CysMet: 0.261 ± 0.297
0.784CysAsn: 0.784 ± 0.391
0.523CysPro: 0.523 ± 0.306
1.307CysGln: 1.307 ± 0.765
0.523CysArg: 0.523 ± 0.464
1.045CysSer: 1.045 ± 0.388
0.523CysThr: 0.523 ± 0.249
2.09CysVal: 2.09 ± 0.597
0.0CysTrp: 0.0 ± 0.0
0.784CysTyr: 0.784 ± 0.391
0.0CysXaa: 0.0 ± 0.0
Asp
2.352AspAla: 2.352 ± 0.922
0.784AspCys: 0.784 ± 0.288
4.181AspAsp: 4.181 ± 0.891
2.352AspGlu: 2.352 ± 0.335
0.784AspPhe: 0.784 ± 0.447
2.352AspGly: 2.352 ± 0.241
2.09AspHis: 2.09 ± 0.759
3.92AspIle: 3.92 ± 1.158
2.874AspLys: 2.874 ± 0.732
6.794AspLeu: 6.794 ± 1.204
0.784AspMet: 0.784 ± 0.394
3.92AspAsn: 3.92 ± 0.721
3.658AspPro: 3.658 ± 0.713
1.829AspGln: 1.829 ± 0.607
3.658AspArg: 3.658 ± 0.765
3.658AspSer: 3.658 ± 0.503
2.874AspThr: 2.874 ± 0.414
4.965AspVal: 4.965 ± 0.779
0.523AspTrp: 0.523 ± 0.341
1.307AspTyr: 1.307 ± 0.352
0.0AspXaa: 0.0 ± 0.0
Glu
2.874GluAla: 2.874 ± 0.603
1.307GluCys: 1.307 ± 0.804
3.397GluAsp: 3.397 ± 0.653
3.397GluGlu: 3.397 ± 1.399
2.09GluPhe: 2.09 ± 0.715
2.874GluGly: 2.874 ± 1.522
1.307GluHis: 1.307 ± 0.767
4.181GluIle: 4.181 ± 0.862
3.397GluLys: 3.397 ± 0.944
6.533GluLeu: 6.533 ± 1.339
0.261GluMet: 0.261 ± 0.153
1.307GluAsn: 1.307 ± 0.274
2.352GluPro: 2.352 ± 0.872
1.568GluGln: 1.568 ± 0.277
1.307GluArg: 1.307 ± 0.413
4.703GluSer: 4.703 ± 1.331
5.487GluThr: 5.487 ± 1.585
3.397GluVal: 3.397 ± 0.377
1.568GluTrp: 1.568 ± 0.426
0.523GluTyr: 0.523 ± 0.249
0.0GluXaa: 0.0 ± 0.0
Phe
1.045PheAla: 1.045 ± 0.433
0.523PheCys: 0.523 ± 0.249
1.307PheAsp: 1.307 ± 0.519
1.045PheGlu: 1.045 ± 0.388
1.568PhePhe: 1.568 ± 0.919
1.307PheGly: 1.307 ± 0.398
1.045PheHis: 1.045 ± 0.274
3.397PheIle: 3.397 ± 1.694
2.09PheLys: 2.09 ± 0.744
3.658PheLeu: 3.658 ± 1.02
1.045PheMet: 1.045 ± 1.017
2.09PheAsn: 2.09 ± 0.8
0.784PhePro: 0.784 ± 0.307
1.307PheGln: 1.307 ± 0.481
3.136PheArg: 3.136 ± 1.496
1.829PheSer: 1.829 ± 0.423
2.09PheThr: 2.09 ± 0.775
3.136PheVal: 3.136 ± 1.178
1.045PheTrp: 1.045 ± 0.612
1.045PheTyr: 1.045 ± 0.641
0.0PheXaa: 0.0 ± 0.0
Gly
2.09GlyAla: 2.09 ± 1.215
0.523GlyCys: 0.523 ± 0.306
4.181GlyAsp: 4.181 ± 0.409
3.136GlyGlu: 3.136 ± 1.577
3.397GlyPhe: 3.397 ± 0.623
4.181GlyGly: 4.181 ± 1.328
2.09GlyHis: 2.09 ± 0.597
2.352GlyIle: 2.352 ± 0.378
2.874GlyLys: 2.874 ± 1.305
8.362GlyLeu: 8.362 ± 0.97
2.874GlyMet: 2.874 ± 0.871
2.613GlyAsn: 2.613 ± 0.366
2.613GlyPro: 2.613 ± 1.177
2.352GlyGln: 2.352 ± 0.978
4.181GlyArg: 4.181 ± 1.881
6.794GlySer: 6.794 ± 0.545
2.874GlyThr: 2.874 ± 1.164
4.703GlyVal: 4.703 ± 1.868
0.261GlyTrp: 0.261 ± 0.153
2.352GlyTyr: 2.352 ± 0.285
0.0GlyXaa: 0.0 ± 0.0
His
2.352HisAla: 2.352 ± 0.522
0.784HisCys: 0.784 ± 0.459
1.829HisAsp: 1.829 ± 1.072
1.568HisGlu: 1.568 ± 0.614
0.523HisPhe: 0.523 ± 0.249
1.307HisGly: 1.307 ± 0.583
0.523HisHis: 0.523 ± 0.306
2.613HisIle: 2.613 ± 0.791
0.523HisLys: 0.523 ± 0.249
2.613HisLeu: 2.613 ± 0.608
0.784HisMet: 0.784 ± 0.288
0.523HisAsn: 0.523 ± 0.249
1.307HisPro: 1.307 ± 0.515
1.307HisGln: 1.307 ± 0.413
2.352HisArg: 2.352 ± 0.898
1.829HisSer: 1.829 ± 0.465
1.307HisThr: 1.307 ± 0.765
0.784HisVal: 0.784 ± 0.307
0.261HisTrp: 0.261 ± 0.383
1.307HisTyr: 1.307 ± 0.59
0.0HisXaa: 0.0 ± 0.0
Ile
3.92IleAla: 3.92 ± 0.277
0.261IleCys: 0.261 ± 0.153
3.136IleAsp: 3.136 ± 1.034
3.92IleGlu: 3.92 ± 0.903
1.568IlePhe: 1.568 ± 0.919
5.749IleGly: 5.749 ± 1.479
2.613IleHis: 2.613 ± 0.686
4.181IleIle: 4.181 ± 0.938
6.271IleLys: 6.271 ± 1.006
4.442IleLeu: 4.442 ± 1.995
1.568IleMet: 1.568 ± 1.019
5.226IleAsn: 5.226 ± 0.518
3.92IlePro: 3.92 ± 0.649
2.613IleGln: 2.613 ± 0.674
3.92IleArg: 3.92 ± 0.518
6.271IleSer: 6.271 ± 1.771
4.181IleThr: 4.181 ± 0.562
3.92IleVal: 3.92 ± 1.082
0.0IleTrp: 0.0 ± 0.0
2.613IleTyr: 2.613 ± 0.791
0.0IleXaa: 0.0 ± 0.0
Lys
2.874LysAla: 2.874 ± 0.612
0.523LysCys: 0.523 ± 0.306
3.92LysAsp: 3.92 ± 0.711
4.965LysGlu: 4.965 ± 1.495
2.09LysPhe: 2.09 ± 0.473
4.965LysGly: 4.965 ± 1.01
0.784LysHis: 0.784 ± 0.459
4.442LysIle: 4.442 ± 1.474
3.136LysLys: 3.136 ± 1.236
6.794LysLeu: 6.794 ± 1.106
2.09LysMet: 2.09 ± 1.553
1.307LysAsn: 1.307 ± 0.274
1.568LysPro: 1.568 ± 1.599
1.307LysGln: 1.307 ± 0.491
2.613LysArg: 2.613 ± 0.64
3.92LysSer: 3.92 ± 0.432
2.09LysThr: 2.09 ± 1.383
3.397LysVal: 3.397 ± 1.086
0.261LysTrp: 0.261 ± 0.297
1.829LysTyr: 1.829 ± 0.816
0.0LysXaa: 0.0 ± 0.0
Leu
8.884LeuAla: 8.884 ± 1.482
2.09LeuCys: 2.09 ± 0.498
5.226LeuAsp: 5.226 ± 0.312
6.01LeuGlu: 6.01 ± 0.675
3.92LeuPhe: 3.92 ± 0.711
6.794LeuGly: 6.794 ± 2.132
3.397LeuHis: 3.397 ± 1.086
7.578LeuIle: 7.578 ± 2.697
8.884LeuLys: 8.884 ± 1.419
9.929LeuLeu: 9.929 ± 1.154
3.92LeuMet: 3.92 ± 0.734
3.397LeuAsn: 3.397 ± 0.724
2.874LeuPro: 2.874 ± 0.912
2.613LeuGln: 2.613 ± 1.511
5.487LeuArg: 5.487 ± 1.482
9.407LeuSer: 9.407 ± 2.433
5.749LeuThr: 5.749 ± 0.962
6.533LeuVal: 6.533 ± 1.576
1.568LeuTrp: 1.568 ± 1.313
3.397LeuTyr: 3.397 ± 1.284
0.0LeuXaa: 0.0 ± 0.0
Met
1.568MetAla: 1.568 ± 0.614
0.0MetCys: 0.0 ± 0.0
1.045MetAsp: 1.045 ± 0.372
0.523MetGlu: 0.523 ± 0.249
1.045MetPhe: 1.045 ± 0.643
1.568MetGly: 1.568 ± 0.277
0.261MetHis: 0.261 ± 0.153
1.829MetIle: 1.829 ± 0.331
1.568MetLys: 1.568 ± 0.671
2.874MetLeu: 2.874 ± 1.028
0.0MetMet: 0.0 ± 0.0
1.568MetAsn: 1.568 ± 0.471
0.784MetPro: 0.784 ± 0.459
0.261MetGln: 0.261 ± 0.297
1.045MetArg: 1.045 ± 0.612
2.352MetSer: 2.352 ± 0.939
3.658MetThr: 3.658 ± 0.163
1.829MetVal: 1.829 ± 0.727
0.784MetTrp: 0.784 ± 0.364
1.568MetTyr: 1.568 ± 0.486
0.0MetXaa: 0.0 ± 0.0
Asn
2.613AsnAla: 2.613 ± 1.367
1.045AsnCys: 1.045 ± 0.498
2.09AsnAsp: 2.09 ± 0.445
2.352AsnGlu: 2.352 ± 0.798
1.307AsnPhe: 1.307 ± 0.386
2.613AsnGly: 2.613 ± 0.671
0.784AsnHis: 0.784 ± 0.426
3.136AsnIle: 3.136 ± 1.493
0.523AsnLys: 0.523 ± 0.306
5.749AsnLeu: 5.749 ± 0.799
1.307AsnMet: 1.307 ± 0.515
1.829AsnAsn: 1.829 ± 0.549
3.397AsnPro: 3.397 ± 1.098
2.874AsnGln: 2.874 ± 0.26
1.829AsnArg: 1.829 ± 0.801
2.874AsnSer: 2.874 ± 0.799
1.307AsnThr: 1.307 ± 0.8
3.397AsnVal: 3.397 ± 0.717
0.784AsnTrp: 0.784 ± 0.459
1.307AsnTyr: 1.307 ± 0.515
0.0AsnXaa: 0.0 ± 0.0
Pro
2.09ProAla: 2.09 ± 0.518
0.261ProCys: 0.261 ± 0.368
2.352ProAsp: 2.352 ± 1.149
3.136ProGlu: 3.136 ± 0.554
0.784ProPhe: 0.784 ± 0.288
3.92ProGly: 3.92 ± 1.801
1.045ProHis: 1.045 ± 0.388
4.965ProIle: 4.965 ± 1.121
2.352ProLys: 2.352 ± 0.738
4.442ProLeu: 4.442 ± 1.884
1.045ProMet: 1.045 ± 0.388
1.307ProAsn: 1.307 ± 0.274
3.397ProPro: 3.397 ± 1.122
2.09ProGln: 2.09 ± 1.456
2.613ProArg: 2.613 ± 0.776
4.703ProSer: 4.703 ± 1.63
2.613ProThr: 2.613 ± 0.856
2.613ProVal: 2.613 ± 0.67
0.261ProTrp: 0.261 ± 0.472
2.613ProTyr: 2.613 ± 0.949
0.0ProXaa: 0.0 ± 0.0
Gln
3.136GlnAla: 3.136 ± 1.486
1.307GlnCys: 1.307 ± 0.59
2.09GlnAsp: 2.09 ± 0.518
1.307GlnGlu: 1.307 ± 1.312
0.784GlnPhe: 0.784 ± 0.526
2.613GlnGly: 2.613 ± 0.372
0.523GlnHis: 0.523 ± 0.341
2.09GlnIle: 2.09 ± 0.901
1.307GlnLys: 1.307 ± 0.846
3.658GlnLeu: 3.658 ± 1.241
0.784GlnMet: 0.784 ± 0.307
1.829GlnAsn: 1.829 ± 0.673
1.829GlnPro: 1.829 ± 0.702
1.829GlnGln: 1.829 ± 0.574
2.613GlnArg: 2.613 ± 0.67
1.568GlnSer: 1.568 ± 0.52
0.784GlnThr: 0.784 ± 0.364
2.352GlnVal: 2.352 ± 0.707
0.523GlnTrp: 0.523 ± 0.306
0.523GlnTyr: 0.523 ± 0.593
0.0GlnXaa: 0.0 ± 0.0
Arg
4.703ArgAla: 4.703 ± 1.152
0.784ArgCys: 0.784 ± 0.391
3.397ArgAsp: 3.397 ± 0.727
3.92ArgGlu: 3.92 ± 0.895
1.568ArgPhe: 1.568 ± 0.486
3.658ArgGly: 3.658 ± 1.038
2.09ArgHis: 2.09 ± 0.387
3.397ArgIle: 3.397 ± 1.261
3.397ArgLys: 3.397 ± 1.145
7.578ArgLeu: 7.578 ± 0.922
1.829ArgMet: 1.829 ± 0.449
1.568ArgAsn: 1.568 ± 0.349
1.829ArgPro: 1.829 ± 0.574
1.829ArgGln: 1.829 ± 0.607
3.136ArgArg: 3.136 ± 0.833
5.487ArgSer: 5.487 ± 1.414
1.829ArgThr: 1.829 ± 0.801
3.658ArgVal: 3.658 ± 0.814
0.0ArgTrp: 0.0 ± 0.0
2.09ArgTyr: 2.09 ± 0.901
0.0ArgXaa: 0.0 ± 0.0
Ser
3.92SerAla: 3.92 ± 1.375
1.045SerCys: 1.045 ± 0.388
4.442SerAsp: 4.442 ± 1.514
2.874SerGlu: 2.874 ± 0.912
3.136SerPhe: 3.136 ± 0.933
8.1SerGly: 8.1 ± 1.981
2.09SerHis: 2.09 ± 0.943
5.226SerIle: 5.226 ± 1.025
4.181SerLys: 4.181 ± 0.466
7.839SerLeu: 7.839 ± 0.569
2.09SerMet: 2.09 ± 0.383
4.181SerAsn: 4.181 ± 1.219
3.397SerPro: 3.397 ± 1.088
2.874SerGln: 2.874 ± 0.649
6.533SerArg: 6.533 ± 1.084
7.316SerSer: 7.316 ± 1.639
6.271SerThr: 6.271 ± 0.762
4.442SerVal: 4.442 ± 1.014
1.568SerTrp: 1.568 ± 0.471
1.568SerTyr: 1.568 ± 0.575
0.0SerXaa: 0.0 ± 0.0
Thr
3.136ThrAla: 3.136 ± 1.348
1.568ThrCys: 1.568 ± 0.349
3.92ThrAsp: 3.92 ± 0.774
3.136ThrGlu: 3.136 ± 1.278
0.784ThrPhe: 0.784 ± 0.391
3.658ThrGly: 3.658 ± 0.918
1.045ThrHis: 1.045 ± 0.498
4.181ThrIle: 4.181 ± 1.298
1.307ThrLys: 1.307 ± 0.765
5.749ThrLeu: 5.749 ± 1.887
1.307ThrMet: 1.307 ± 0.402
3.136ThrAsn: 3.136 ± 1.116
2.874ThrPro: 2.874 ± 1.213
1.307ThrGln: 1.307 ± 0.399
3.397ThrArg: 3.397 ± 0.909
4.181ThrSer: 4.181 ± 0.36
3.658ThrThr: 3.658 ± 0.965
2.613ThrVal: 2.613 ± 0.67
1.307ThrTrp: 1.307 ± 0.515
2.874ThrTyr: 2.874 ± 0.734
0.0ThrXaa: 0.0 ± 0.0
Val
2.613ValAla: 2.613 ± 0.259
0.784ValCys: 0.784 ± 0.391
2.613ValAsp: 2.613 ± 0.673
4.181ValGlu: 4.181 ± 0.678
2.874ValPhe: 2.874 ± 1.054
3.397ValGly: 3.397 ± 0.508
1.307ValHis: 1.307 ± 0.517
7.316ValIle: 7.316 ± 1.204
3.397ValLys: 3.397 ± 0.847
7.055ValLeu: 7.055 ± 1.292
0.784ValMet: 0.784 ± 0.288
2.09ValAsn: 2.09 ± 0.7
4.965ValPro: 4.965 ± 0.909
1.568ValGln: 1.568 ± 0.614
3.658ValArg: 3.658 ± 1.367
5.487ValSer: 5.487 ± 1.451
3.658ValThr: 3.658 ± 1.02
1.829ValVal: 1.829 ± 1.187
0.261ValTrp: 0.261 ± 0.297
3.658ValTyr: 3.658 ± 0.537
0.0ValXaa: 0.0 ± 0.0
Trp
1.568TrpAla: 1.568 ± 0.575
0.523TrpCys: 0.523 ± 0.593
0.784TrpAsp: 0.784 ± 0.447
0.261TrpGlu: 0.261 ± 0.383
1.045TrpPhe: 1.045 ± 0.442
0.523TrpGly: 0.523 ± 0.341
0.261TrpHis: 0.261 ± 0.153
0.523TrpIle: 0.523 ± 0.512
0.784TrpLys: 0.784 ± 0.288
0.784TrpLeu: 0.784 ± 0.288
0.0TrpMet: 0.0 ± 0.0
0.784TrpAsn: 0.784 ± 0.364
0.784TrpPro: 0.784 ± 0.364
0.261TrpGln: 0.261 ± 0.383
0.784TrpArg: 0.784 ± 0.867
0.784TrpSer: 0.784 ± 0.307
0.523TrpThr: 0.523 ± 0.303
0.784TrpVal: 0.784 ± 0.288
0.0TrpTrp: 0.0 ± 0.0
0.261TrpTyr: 0.261 ± 0.153
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.523TyrAla: 0.523 ± 0.303
1.568TyrCys: 1.568 ± 0.395
3.397TyrAsp: 3.397 ± 0.653
1.568TyrGlu: 1.568 ± 0.919
0.784TyrPhe: 0.784 ± 0.288
1.568TyrGly: 1.568 ± 0.575
0.784TyrHis: 0.784 ± 0.459
0.523TyrIle: 0.523 ± 0.306
2.09TyrLys: 2.09 ± 0.775
5.226TyrLeu: 5.226 ± 1.572
1.568TyrMet: 1.568 ± 0.781
1.045TyrAsn: 1.045 ± 0.372
2.613TyrPro: 2.613 ± 0.868
1.307TyrGln: 1.307 ± 0.402
1.045TyrArg: 1.045 ± 0.388
4.442TyrSer: 4.442 ± 1.347
1.568TyrThr: 1.568 ± 0.395
1.829TyrVal: 1.829 ± 0.682
0.261TyrTrp: 0.261 ± 0.297
1.045TyrTyr: 1.045 ± 0.372
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (3828 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski