Amino acid dipepetide frequency for Rhizobium album

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.419AlaAla: 16.419 ± 0.135	1.024AlaCys: 1.024 ± 0.026	6.918AlaAsp: 6.918 ± 0.061	7.538AlaGlu: 7.538 ± 0.077	4.577AlaPhe: 4.577 ± 0.055	10.468AlaGly: 10.468 ± 0.087	2.028AlaHis: 2.028 ± 0.036	6.749AlaIle: 6.749 ± 0.069	4.282AlaLys: 4.282 ± 0.055	12.393AlaLeu: 12.393 ± 0.099	3.543AlaMet: 3.543 ± 0.04	3.023AlaAsn: 3.023 ± 0.037	4.471AlaPro: 4.471 ± 0.049	3.382AlaGln: 3.382 ± 0.045	7.779AlaArg: 7.779 ± 0.078	6.414AlaSer: 6.414 ± 0.056	5.877AlaThr: 5.877 ± 0.06	8.739AlaVal: 8.739 ± 0.076	1.354AlaTrp: 1.354 ± 0.028	2.666AlaTyr: 2.666 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	0.829CysAla: 0.829 ± 0.023	0.105CysCys: 0.105 ± 0.007	0.527CysAsp: 0.527 ± 0.018	0.472CysGlu: 0.472 ± 0.017	0.328CysPhe: 0.328 ± 0.014	0.939CysGly: 0.939 ± 0.022	0.231CysHis: 0.231 ± 0.012	0.417CysIle: 0.417 ± 0.016	0.213CysLys: 0.213 ± 0.011	0.827CysLeu: 0.827 ± 0.023	0.18CysMet: 0.18 ± 0.009	0.235CysAsn: 0.235 ± 0.011	0.389CysPro: 0.389 ± 0.016	0.224CysGln: 0.224 ± 0.011	0.634CysArg: 0.634 ± 0.017	0.468CysSer: 0.468 ± 0.016	0.394CysThr: 0.394 ± 0.017	0.548CysVal: 0.548 ± 0.017	0.117CysTrp: 0.117 ± 0.008	0.209CysTyr: 0.209 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	6.55AspAla: 6.55 ± 0.068	0.508AspCys: 0.508 ± 0.015	3.235AspAsp: 3.235 ± 0.052	3.544AspGlu: 3.544 ± 0.045	2.369AspPhe: 2.369 ± 0.033	5.272AspGly: 5.272 ± 0.056	1.252AspHis: 1.252 ± 0.029	3.617AspIle: 3.617 ± 0.04	1.907AspLys: 1.907 ± 0.032	5.899AspLeu: 5.899 ± 0.059	1.468AspMet: 1.468 ± 0.026	1.501AspAsn: 1.501 ± 0.029	3.214AspPro: 3.214 ± 0.041	1.658AspGln: 1.658 ± 0.03	4.262AspArg: 4.262 ± 0.052	2.191AspSer: 2.191 ± 0.037	2.697AspThr: 2.697 ± 0.039	4.274AspVal: 4.274 ± 0.049	0.938AspTrp: 0.938 ± 0.021	1.54AspTyr: 1.54 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	7.452GluAla: 7.452 ± 0.074	0.361GluCys: 0.361 ± 0.014	2.917GluAsp: 2.917 ± 0.04	3.609GluGlu: 3.609 ± 0.052	1.915GluPhe: 1.915 ± 0.032	4.158GluGly: 4.158 ± 0.05	1.105GluHis: 1.105 ± 0.024	3.968GluIle: 3.968 ± 0.051	2.919GluLys: 2.919 ± 0.042	5.127GluLeu: 5.127 ± 0.058	1.651GluMet: 1.651 ± 0.031	1.89GluAsn: 1.89 ± 0.031	2.585GluPro: 2.585 ± 0.041	2.174GluGln: 2.174 ± 0.034	4.773GluArg: 4.773 ± 0.064	2.418GluSer: 2.418 ± 0.038	3.872GluThr: 3.872 ± 0.053	3.655GluVal: 3.655 ± 0.043	0.737GluTrp: 0.737 ± 0.021	1.034GluTyr: 1.034 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.566PheAla: 4.566 ± 0.055	0.419PheCys: 0.419 ± 0.015	2.787PheAsp: 2.787 ± 0.037	2.242PheGlu: 2.242 ± 0.035	1.607PhePhe: 1.607 ± 0.031	3.803PheGly: 3.803 ± 0.048	0.818PheHis: 0.818 ± 0.021	1.898PheIle: 1.898 ± 0.032	1.166PheLys: 1.166 ± 0.026	3.536PheLeu: 3.536 ± 0.051	0.847PheMet: 0.847 ± 0.021	1.147PheAsn: 1.147 ± 0.025	1.624PhePro: 1.624 ± 0.03	1.067PheGln: 1.067 ± 0.022	2.403PheArg: 2.403 ± 0.036	2.617PheSer: 2.617 ± 0.039	1.961PheThr: 1.961 ± 0.033	2.924PheVal: 2.924 ± 0.04	0.568PheTrp: 0.568 ± 0.02	0.989PheTyr: 0.989 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	8.5GlyAla: 8.5 ± 0.07	0.791GlyCys: 0.791 ± 0.019	4.344GlyAsp: 4.344 ± 0.052	4.887GlyGlu: 4.887 ± 0.052	3.675GlyPhe: 3.675 ± 0.047	7.037GlyGly: 7.037 ± 0.068	1.815GlyHis: 1.815 ± 0.036	5.109GlyIle: 5.109 ± 0.054	3.726GlyLys: 3.726 ± 0.047	8.706GlyLeu: 8.706 ± 0.075	2.361GlyMet: 2.361 ± 0.038	2.477GlyAsn: 2.477 ± 0.037	3.077GlyPro: 3.077 ± 0.038	2.76GlyGln: 2.76 ± 0.039	5.945GlyArg: 5.945 ± 0.06	4.805GlySer: 4.805 ± 0.05	4.557GlyThr: 4.557 ± 0.052	5.913GlyVal: 5.913 ± 0.055	1.255GlyTrp: 1.255 ± 0.03	2.387GlyTyr: 2.387 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	2.211HisAla: 2.211 ± 0.034	0.226HisCys: 0.226 ± 0.011	1.252HisAsp: 1.252 ± 0.024	1.061HisGlu: 1.061 ± 0.025	0.948HisPhe: 0.948 ± 0.02	1.914HisGly: 1.914 ± 0.034	0.569HisHis: 0.569 ± 0.022	1.004HisIle: 1.004 ± 0.024	0.533HisLys: 0.533 ± 0.015	2.002HisLeu: 2.002 ± 0.034	0.538HisMet: 0.538 ± 0.016	0.489HisAsn: 0.489 ± 0.016	1.274HisPro: 1.274 ± 0.025	0.559HisGln: 0.559 ± 0.017	1.376HisArg: 1.376 ± 0.027	0.953HisSer: 0.953 ± 0.024	0.839HisThr: 0.839 ± 0.023	1.467HisVal: 1.467 ± 0.028	0.281HisTrp: 0.281 ± 0.011	0.531HisTyr: 0.531 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.689IleAla: 7.689 ± 0.07	0.558IleCys: 0.558 ± 0.017	3.95IleAsp: 3.95 ± 0.049	3.784IleGlu: 3.784 ± 0.05	1.969IlePhe: 1.969 ± 0.037	5.409IleGly: 5.409 ± 0.062	1.051IleHis: 1.051 ± 0.021	2.615IleIle: 2.615 ± 0.04	1.627IleLys: 1.627 ± 0.029	4.909IleLeu: 4.909 ± 0.059	1.101IleMet: 1.101 ± 0.025	1.624IleAsn: 1.624 ± 0.03	2.42IlePro: 2.42 ± 0.034	1.305IleGln: 1.305 ± 0.025	3.639IleArg: 3.639 ± 0.047	3.36IleSer: 3.36 ± 0.044	2.843IleThr: 2.843 ± 0.035	4.618IleVal: 4.618 ± 0.049	0.63IleTrp: 0.63 ± 0.02	1.256IleTyr: 1.256 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	4.775LysAla: 4.775 ± 0.056	0.173LysCys: 0.173 ± 0.009	2.006LysAsp: 2.006 ± 0.036	1.927LysGlu: 1.927 ± 0.039	1.019LysPhe: 1.019 ± 0.024	2.849LysGly: 2.849 ± 0.041	0.66LysHis: 0.66 ± 0.018	2.101LysIle: 2.101 ± 0.034	1.575LysLys: 1.575 ± 0.035	3.579LysLeu: 3.579 ± 0.044	0.907LysMet: 0.907 ± 0.022	1.06LysAsn: 1.06 ± 0.026	2.256LysPro: 2.256 ± 0.038	1.215LysGln: 1.215 ± 0.027	2.501LysArg: 2.501 ± 0.04	2.2LysSer: 2.2 ± 0.032	2.338LysThr: 2.338 ± 0.039	2.677LysVal: 2.677 ± 0.044	0.374LysTrp: 0.374 ± 0.015	0.693LysTyr: 0.693 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	12.616LeuAla: 12.616 ± 0.096	0.867LeuCys: 0.867 ± 0.022	5.996LeuAsp: 5.996 ± 0.056	5.169LeuGlu: 5.169 ± 0.057	3.726LeuPhe: 3.726 ± 0.055	7.884LeuGly: 7.884 ± 0.068	1.804LeuHis: 1.804 ± 0.034	5.004LeuIle: 5.004 ± 0.06	4.114LeuLys: 4.114 ± 0.05	9.25LeuLeu: 9.25 ± 0.095	2.399LeuMet: 2.399 ± 0.042	2.621LeuAsn: 2.621 ± 0.037	5.2LeuPro: 5.2 ± 0.06	2.984LeuGln: 2.984 ± 0.042	6.187LeuArg: 6.187 ± 0.054	6.968LeuSer: 6.968 ± 0.068	5.535LeuThr: 5.535 ± 0.054	7.224LeuVal: 7.224 ± 0.07	1.061LeuTrp: 1.061 ± 0.029	2.081LeuTyr: 2.081 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	3.161MetAla: 3.161 ± 0.039	0.149MetCys: 0.149 ± 0.008	1.214MetAsp: 1.214 ± 0.023	1.233MetGlu: 1.233 ± 0.024	0.771MetPhe: 0.771 ± 0.021	1.699MetGly: 1.699 ± 0.03	0.434MetHis: 0.434 ± 0.015	1.511MetIle: 1.511 ± 0.031	1.095MetLys: 1.095 ± 0.025	2.569MetLeu: 2.569 ± 0.041	0.738MetMet: 0.738 ± 0.021	0.863MetAsn: 0.863 ± 0.019	1.522MetPro: 1.522 ± 0.03	0.926MetGln: 0.926 ± 0.022	1.802MetArg: 1.802 ± 0.032	1.799MetSer: 1.799 ± 0.031	1.985MetThr: 1.985 ± 0.028	1.84MetVal: 1.84 ± 0.034	0.201MetTrp: 0.201 ± 0.011	0.315MetTyr: 0.315 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.344AsnAla: 3.344 ± 0.044	0.234AsnCys: 0.234 ± 0.012	1.619AsnAsp: 1.619 ± 0.03	1.389AsnGlu: 1.389 ± 0.027	1.078AsnPhe: 1.078 ± 0.025	2.712AsnGly: 2.712 ± 0.044	0.554AsnHis: 0.554 ± 0.017	1.579AsnIle: 1.579 ± 0.028	0.791AsnLys: 0.791 ± 0.023	2.727AsnLeu: 2.727 ± 0.04	0.662AsnMet: 0.662 ± 0.017	0.814AsnAsn: 0.814 ± 0.024	1.828AsnPro: 1.828 ± 0.029	0.827AsnGln: 0.827 ± 0.022	2.038AsnArg: 2.038 ± 0.033	1.457AsnSer: 1.457 ± 0.027	1.372AsnThr: 1.372 ± 0.024	1.975AsnVal: 1.975 ± 0.035	0.458AsnTrp: 0.458 ± 0.015	0.703AsnTyr: 0.703 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	5.646ProAla: 5.646 ± 0.059	0.28ProCys: 0.28 ± 0.013	3.409ProAsp: 3.409 ± 0.044	3.512ProGlu: 3.512 ± 0.044	1.961ProPhe: 1.961 ± 0.033	4.026ProGly: 4.026 ± 0.045	1.018ProHis: 1.018 ± 0.024	2.283ProIle: 2.283 ± 0.034	1.752ProLys: 1.752 ± 0.031	4.476ProLeu: 4.476 ± 0.051	1.148ProMet: 1.148 ± 0.025	1.314ProAsn: 1.314 ± 0.026	2.097ProPro: 2.097 ± 0.036	1.598ProGln: 1.598 ± 0.034	2.483ProArg: 2.483 ± 0.037	2.662ProSer: 2.662 ± 0.037	2.321ProThr: 2.321 ± 0.034	4.051ProVal: 4.051 ± 0.052	0.627ProTrp: 0.627 ± 0.02	1.144ProTyr: 1.144 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	4.022GlnAla: 4.022 ± 0.05	0.197GlnCys: 0.197 ± 0.011	1.492GlnAsp: 1.492 ± 0.025	1.644GlnGlu: 1.644 ± 0.035	1.104GlnPhe: 1.104 ± 0.024	2.205GlnGly: 2.205 ± 0.034	0.611GlnHis: 0.611 ± 0.015	1.878GlnIle: 1.878 ± 0.036	1.294GlnLys: 1.294 ± 0.029	2.822GlnLeu: 2.822 ± 0.039	0.961GlnMet: 0.961 ± 0.026	0.932GlnAsn: 0.932 ± 0.026	1.689GlnPro: 1.689 ± 0.029	1.428GlnGln: 1.428 ± 0.033	2.257GlnArg: 2.257 ± 0.04	1.875GlnSer: 1.875 ± 0.033	1.721GlnThr: 1.721 ± 0.032	2.156GlnVal: 2.156 ± 0.033	0.408GlnTrp: 0.408 ± 0.015	0.619GlnTyr: 0.619 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	6.92ArgAla: 6.92 ± 0.06	0.488ArgCys: 0.488 ± 0.017	3.949ArgAsp: 3.949 ± 0.043	3.971ArgGlu: 3.971 ± 0.054	2.857ArgPhe: 2.857 ± 0.038	4.434ArgGly: 4.434 ± 0.053	1.726ArgHis: 1.726 ± 0.038	4.148ArgIle: 4.148 ± 0.049	2.604ArgLys: 2.604 ± 0.037	7.443ArgLeu: 7.443 ± 0.072	1.886ArgMet: 1.886 ± 0.034	2.074ArgAsn: 2.074 ± 0.03	3.194ArgPro: 3.194 ± 0.04	2.733ArgGln: 2.733 ± 0.047	5.327ArgArg: 5.327 ± 0.065	3.879ArgSer: 3.879 ± 0.046	3.3ArgThr: 3.3 ± 0.042	4.102ArgVal: 4.102 ± 0.047	0.905ArgTrp: 0.905 ± 0.024	1.721ArgTyr: 1.721 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	6.306SerAla: 6.306 ± 0.059	0.435SerCys: 0.435 ± 0.014	3.149SerAsp: 3.149 ± 0.038	3.088SerGlu: 3.088 ± 0.041	2.528SerPhe: 2.528 ± 0.038	5.84SerGly: 5.84 ± 0.058	1.162SerHis: 1.162 ± 0.024	3.235SerIle: 3.235 ± 0.04	1.859SerLys: 1.859 ± 0.032	5.703SerLeu: 5.703 ± 0.052	1.458SerMet: 1.458 ± 0.027	1.548SerAsn: 1.548 ± 0.029	2.724SerPro: 2.724 ± 0.034	1.718SerGln: 1.718 ± 0.032	3.745SerArg: 3.745 ± 0.043	3.3SerSer: 3.3 ± 0.05	2.91SerThr: 2.91 ± 0.042	4.323SerVal: 4.323 ± 0.051	0.749SerTrp: 0.749 ± 0.018	1.4SerTyr: 1.4 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	6.361ThrAla: 6.361 ± 0.055	0.424ThrCys: 0.424 ± 0.017	2.868ThrAsp: 2.868 ± 0.039	2.868ThrGlu: 2.868 ± 0.035	2.123ThrPhe: 2.123 ± 0.034	5.065ThrGly: 5.065 ± 0.047	1.021ThrHis: 1.021 ± 0.025	3.261ThrIle: 3.261 ± 0.037	1.668ThrLys: 1.668 ± 0.028	5.641ThrLeu: 5.641 ± 0.056	1.282ThrMet: 1.282 ± 0.025	1.379ThrAsn: 1.379 ± 0.029	3.025ThrPro: 3.025 ± 0.039	1.481ThrGln: 1.481 ± 0.03	3.159ThrArg: 3.159 ± 0.041	2.935ThrSer: 2.935 ± 0.041	2.964ThrThr: 2.964 ± 0.046	4.492ThrVal: 4.492 ± 0.054	0.623ThrTrp: 0.623 ± 0.019	1.283ThrTyr: 1.283 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	8.699ValAla: 8.699 ± 0.079	0.636ValCys: 0.636 ± 0.019	4.079ValAsp: 4.079 ± 0.043	4.554ValGlu: 4.554 ± 0.056	2.909ValPhe: 2.909 ± 0.039	5.429ValGly: 5.429 ± 0.06	1.374ValHis: 1.374 ± 0.029	4.209ValIle: 4.209 ± 0.049	2.551ValLys: 2.551 ± 0.036	7.249ValLeu: 7.249 ± 0.073	1.863ValMet: 1.863 ± 0.031	2.083ValAsn: 2.083 ± 0.031	3.512ValPro: 3.512 ± 0.042	1.97ValGln: 1.97 ± 0.033	4.637ValArg: 4.637 ± 0.051	4.724ValSer: 4.724 ± 0.047	4.524ValThr: 4.524 ± 0.05	5.776ValVal: 5.776 ± 0.062	0.845ValTrp: 0.845 ± 0.02	1.534ValTyr: 1.534 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.11TrpAla: 1.11 ± 0.028	0.139TrpCys: 0.139 ± 0.01	0.623TrpAsp: 0.623 ± 0.018	0.544TrpGlu: 0.544 ± 0.015	0.533TrpPhe: 0.533 ± 0.017	0.811TrpGly: 0.811 ± 0.023	0.316TrpHis: 0.316 ± 0.013	0.71TrpIle: 0.71 ± 0.021	0.527TrpLys: 0.527 ± 0.014	1.515TrpLeu: 1.515 ± 0.028	0.344TrpMet: 0.344 ± 0.012	0.463TrpAsn: 0.463 ± 0.016	0.631TrpPro: 0.631 ± 0.019	0.553TrpGln: 0.553 ± 0.017	0.984TrpArg: 0.984 ± 0.023	0.861TrpSer: 0.861 ± 0.021	0.768TrpThr: 0.768 ± 0.02	0.747TrpVal: 0.747 ± 0.02	0.219TrpTrp: 0.219 ± 0.011	0.322TrpTyr: 0.322 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.469TyrAla: 2.469 ± 0.036	0.271TyrCys: 0.271 ± 0.011	1.562TyrAsp: 1.562 ± 0.031	1.283TyrGlu: 1.283 ± 0.026	0.993TyrPhe: 0.993 ± 0.023	2.169TyrGly: 2.169 ± 0.032	0.478TyrHis: 0.478 ± 0.017	1.06TyrIle: 1.06 ± 0.024	0.681TyrLys: 0.681 ± 0.018	2.319TyrLeu: 2.319 ± 0.034	0.49TyrMet: 0.49 ± 0.016	0.629TyrAsn: 0.629 ± 0.017	1.075TyrPro: 1.075 ± 0.024	0.754TyrGln: 0.754 ± 0.021	1.73TyrArg: 1.73 ± 0.029	1.291TyrSer: 1.291 ± 0.026	1.149TyrThr: 1.149 ± 0.025	1.657TyrVal: 1.657 ± 0.027	0.368TyrTrp: 0.368 ± 0.014	0.606TyrTyr: 0.606 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6427 proteins (1993445 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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