Amino acid dipepetide frequency for Schumannella sp. 10F1D-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.036AlaAla: 23.036 ± 0.263	0.498AlaCys: 0.498 ± 0.022	9.319AlaAsp: 9.319 ± 0.114	8.655AlaGlu: 8.655 ± 0.132	3.618AlaPhe: 3.618 ± 0.068	13.362AlaGly: 13.362 ± 0.149	2.398AlaHis: 2.398 ± 0.048	6.155AlaIle: 6.155 ± 0.09	2.897AlaLys: 2.897 ± 0.067	14.458AlaLeu: 14.458 ± 0.175	2.263AlaMet: 2.263 ± 0.056	2.334AlaAsn: 2.334 ± 0.06	7.408AlaPro: 7.408 ± 0.124	3.8AlaGln: 3.8 ± 0.067	9.727AlaArg: 9.727 ± 0.131	8.045AlaSer: 8.045 ± 0.111	8.127AlaThr: 8.127 ± 0.22	11.837AlaVal: 11.837 ± 0.121	1.779AlaTrp: 1.779 ± 0.045	2.187AlaTyr: 2.187 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.551CysAla: 0.551 ± 0.024	0.034CysCys: 0.034 ± 0.006	0.235CysAsp: 0.235 ± 0.015	0.193CysGlu: 0.193 ± 0.015	0.129CysPhe: 0.129 ± 0.013	0.455CysGly: 0.455 ± 0.021	0.074CysHis: 0.074 ± 0.009	0.124CysIle: 0.124 ± 0.011	0.05CysLys: 0.05 ± 0.007	0.348CysLeu: 0.348 ± 0.02	0.062CysMet: 0.062 ± 0.008	0.092CysAsn: 0.092 ± 0.009	0.233CysPro: 0.233 ± 0.018	0.116CysGln: 0.116 ± 0.011	0.287CysArg: 0.287 ± 0.018	0.309CysSer: 0.309 ± 0.019	0.254CysThr: 0.254 ± 0.017	0.34CysVal: 0.34 ± 0.018	0.073CysTrp: 0.073 ± 0.009	0.096CysTyr: 0.096 ± 0.009	0.001CysXaa: 0.001 ± 0.001
Asp	10.186AspAla: 10.186 ± 0.115	0.233AspCys: 0.233 ± 0.016	4.823AspAsp: 4.823 ± 0.084	4.307AspGlu: 4.307 ± 0.08	1.734AspPhe: 1.734 ± 0.044	6.465AspGly: 6.465 ± 0.109	1.201AspHis: 1.201 ± 0.037	2.164AspIle: 2.164 ± 0.053	1.007AspLys: 1.007 ± 0.039	6.045AspLeu: 6.045 ± 0.09	0.668AspMet: 0.668 ± 0.025	0.91AspAsn: 0.91 ± 0.029	4.302AspPro: 4.302 ± 0.067	1.568AspGln: 1.568 ± 0.044	4.802AspArg: 4.802 ± 0.089	2.91AspSer: 2.91 ± 0.057	2.9AspThr: 2.9 ± 0.072	5.065AspVal: 5.065 ± 0.078	0.98AspTrp: 0.98 ± 0.03	1.374AspTyr: 1.374 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	6.33GluAla: 6.33 ± 0.102	0.177GluCys: 0.177 ± 0.014	1.982GluAsp: 1.982 ± 0.045	2.419GluGlu: 2.419 ± 0.071	1.659GluPhe: 1.659 ± 0.047	3.742GluGly: 3.742 ± 0.071	1.476GluHis: 1.476 ± 0.04	2.647GluIle: 2.647 ± 0.053	1.482GluLys: 1.482 ± 0.044	7.204GluLeu: 7.204 ± 0.11	0.738GluMet: 0.738 ± 0.027	1.134GluAsn: 1.134 ± 0.037	3.024GluPro: 3.024 ± 0.063	2.314GluGln: 2.314 ± 0.052	5.143GluArg: 5.143 ± 0.096	2.9GluSer: 2.9 ± 0.058	2.848GluThr: 2.848 ± 0.059	4.434GluVal: 4.434 ± 0.079	0.754GluTrp: 0.754 ± 0.027	0.928GluTyr: 0.928 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	4.124PheAla: 4.124 ± 0.064	0.14PheCys: 0.14 ± 0.012	2.244PheAsp: 2.244 ± 0.058	1.525PheGlu: 1.525 ± 0.041	0.956PhePhe: 0.956 ± 0.039	3.325PheGly: 3.325 ± 0.074	0.5PheHis: 0.5 ± 0.019	1.074PheIle: 1.074 ± 0.036	0.453PheLys: 0.453 ± 0.027	2.708PheLeu: 2.708 ± 0.058	0.334PheMet: 0.334 ± 0.016	0.572PheAsn: 0.572 ± 0.023	1.348PhePro: 1.348 ± 0.039	0.723PheGln: 0.723 ± 0.027	1.822PheArg: 1.822 ± 0.047	1.779PheSer: 1.779 ± 0.044	2.013PheThr: 2.013 ± 0.064	2.572PheVal: 2.572 ± 0.056	0.433PheTrp: 0.433 ± 0.02	0.59PheTyr: 0.59 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	12.509GlyAla: 12.509 ± 0.14	0.513GlyCys: 0.513 ± 0.023	5.789GlyAsp: 5.789 ± 0.087	4.856GlyGlu: 4.856 ± 0.075	3.218GlyPhe: 3.218 ± 0.06	8.757GlyGly: 8.757 ± 0.167	1.627GlyHis: 1.627 ± 0.042	4.735GlyIle: 4.735 ± 0.069	2.019GlyLys: 2.019 ± 0.051	8.805GlyLeu: 8.805 ± 0.113	1.756GlyMet: 1.756 ± 0.043	1.621GlyAsn: 1.621 ± 0.074	3.765GlyPro: 3.765 ± 0.054	2.578GlyGln: 2.578 ± 0.067	6.567GlyArg: 6.567 ± 0.099	6.435GlySer: 6.435 ± 0.123	5.873GlyThr: 5.873 ± 0.174	8.525GlyVal: 8.525 ± 0.109	1.636GlyTrp: 1.636 ± 0.045	2.185GlyTyr: 2.185 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.268HisAla: 2.268 ± 0.054	0.083HisCys: 0.083 ± 0.009	1.311HisAsp: 1.311 ± 0.042	1.049HisGlu: 1.049 ± 0.034	0.503HisPhe: 0.503 ± 0.022	1.908HisGly: 1.908 ± 0.048	0.487HisHis: 0.487 ± 0.023	0.598HisIle: 0.598 ± 0.024	0.253HisLys: 0.253 ± 0.012	1.919HisLeu: 1.919 ± 0.045	0.254HisMet: 0.254 ± 0.017	0.291HisAsn: 0.291 ± 0.016	1.526HisPro: 1.526 ± 0.04	0.498HisGln: 0.498 ± 0.021	1.584HisArg: 1.584 ± 0.042	0.92HisSer: 0.92 ± 0.025	0.806HisThr: 0.806 ± 0.029	1.47HisVal: 1.47 ± 0.036	0.311HisTrp: 0.311 ± 0.019	0.391HisTyr: 0.391 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.048IleAla: 7.048 ± 0.092	0.207IleCys: 0.207 ± 0.015	3.438IleAsp: 3.438 ± 0.059	2.626IleGlu: 2.626 ± 0.057	1.009IlePhe: 1.009 ± 0.042	4.825IleGly: 4.825 ± 0.09	0.706IleHis: 0.706 ± 0.024	1.553IleIle: 1.553 ± 0.047	0.74IleLys: 0.74 ± 0.028	3.366IleLeu: 3.366 ± 0.074	0.514IleMet: 0.514 ± 0.02	0.847IleAsn: 0.847 ± 0.032	2.568IlePro: 2.568 ± 0.049	1.059IleGln: 1.059 ± 0.036	2.739IleArg: 2.739 ± 0.052	2.287IleSer: 2.287 ± 0.046	2.848IleThr: 2.848 ± 0.09	4.678IleVal: 4.678 ± 0.078	0.518IleTrp: 0.518 ± 0.022	0.749IleTyr: 0.749 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	2.484LysAla: 2.484 ± 0.058	0.056LysCys: 0.056 ± 0.007	1.116LysAsp: 1.116 ± 0.041	0.829LysGlu: 0.829 ± 0.033	0.49LysPhe: 0.49 ± 0.023	1.557LysGly: 1.557 ± 0.045	0.438LysHis: 0.438 ± 0.022	0.898LysIle: 0.898 ± 0.038	0.88LysLys: 0.88 ± 0.034	2.191LysLeu: 2.191 ± 0.046	0.32LysMet: 0.32 ± 0.017	0.589LysAsn: 0.589 ± 0.027	1.314LysPro: 1.314 ± 0.04	0.818LysGln: 0.818 ± 0.03	1.397LysArg: 1.397 ± 0.045	1.276LysSer: 1.276 ± 0.038	1.285LysThr: 1.285 ± 0.038	1.781LysVal: 1.781 ± 0.049	0.25LysTrp: 0.25 ± 0.015	0.434LysTyr: 0.434 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	14.989LeuAla: 14.989 ± 0.154	0.396LeuCys: 0.396 ± 0.021	7.155LeuAsp: 7.155 ± 0.099	5.095LeuGlu: 5.095 ± 0.101	2.747LeuPhe: 2.747 ± 0.064	9.806LeuGly: 9.806 ± 0.117	1.751LeuHis: 1.751 ± 0.038	4.348LeuIle: 4.348 ± 0.083	1.799LeuLys: 1.799 ± 0.052	10.557LeuLeu: 10.557 ± 0.159	1.261LeuMet: 1.261 ± 0.042	1.618LeuAsn: 1.618 ± 0.041	5.473LeuPro: 5.473 ± 0.077	2.42LeuGln: 2.42 ± 0.049	7.625LeuArg: 7.625 ± 0.111	5.537LeuSer: 5.537 ± 0.071	6.024LeuThr: 6.024 ± 0.094	9.483LeuVal: 9.483 ± 0.131	1.11LeuTrp: 1.11 ± 0.033	1.432LeuTyr: 1.432 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	1.725MetAla: 1.725 ± 0.039	0.081MetCys: 0.081 ± 0.008	0.652MetAsp: 0.652 ± 0.027	0.488MetGlu: 0.488 ± 0.023	0.385MetPhe: 0.385 ± 0.018	1.042MetGly: 1.042 ± 0.033	0.263MetHis: 0.263 ± 0.015	0.728MetIle: 0.728 ± 0.03	0.375MetLys: 0.375 ± 0.019	1.592MetLeu: 1.592 ± 0.043	0.232MetMet: 0.232 ± 0.016	0.356MetAsn: 0.356 ± 0.019	1.034MetPro: 1.034 ± 0.032	0.431MetGln: 0.431 ± 0.022	1.19MetArg: 1.19 ± 0.033	1.344MetSer: 1.344 ± 0.039	1.504MetThr: 1.504 ± 0.034	1.059MetVal: 1.059 ± 0.034	0.141MetTrp: 0.141 ± 0.014	0.212MetTyr: 0.212 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.337AsnAla: 2.337 ± 0.052	0.093AsnCys: 0.093 ± 0.009	1.069AsnAsp: 1.069 ± 0.043	0.807AsnGlu: 0.807 ± 0.026	0.565AsnPhe: 0.565 ± 0.028	1.946AsnGly: 1.946 ± 0.058	0.342AsnHis: 0.342 ± 0.018	0.694AsnIle: 0.694 ± 0.026	0.377AsnLys: 0.377 ± 0.019	1.761AsnLeu: 1.761 ± 0.044	0.256AsnMet: 0.256 ± 0.016	0.412AsnAsn: 0.412 ± 0.022	1.47AsnPro: 1.47 ± 0.035	0.551AsnGln: 0.551 ± 0.029	1.238AsnArg: 1.238 ± 0.037	0.989AsnSer: 0.989 ± 0.038	1.086AsnThr: 1.086 ± 0.082	1.685AsnVal: 1.685 ± 0.068	0.311AsnTrp: 0.311 ± 0.021	0.436AsnTyr: 0.436 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	8.175ProAla: 8.175 ± 0.126	0.152ProCys: 0.152 ± 0.012	3.933ProAsp: 3.933 ± 0.079	3.568ProGlu: 3.568 ± 0.074	1.661ProPhe: 1.661 ± 0.044	5.33ProGly: 5.33 ± 0.096	1.069ProHis: 1.069 ± 0.038	2.251ProIle: 2.251 ± 0.048	1.204ProLys: 1.204 ± 0.036	4.949ProLeu: 4.949 ± 0.068	0.732ProMet: 0.732 ± 0.027	1.02ProAsn: 1.02 ± 0.035	2.325ProPro: 2.325 ± 0.06	1.512ProGln: 1.512 ± 0.04	3.5ProArg: 3.5 ± 0.072	3.525ProSer: 3.525 ± 0.069	3.533ProThr: 3.533 ± 0.07	4.887ProVal: 4.887 ± 0.081	0.769ProTrp: 0.769 ± 0.032	0.916ProTyr: 0.916 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.197GlnAla: 3.197 ± 0.062	0.113GlnCys: 0.113 ± 0.011	1.045GlnAsp: 1.045 ± 0.032	1.104GlnGlu: 1.104 ± 0.035	0.812GlnPhe: 0.812 ± 0.027	2.055GlnGly: 2.055 ± 0.046	0.665GlnHis: 0.665 ± 0.029	1.412GlnIle: 1.412 ± 0.041	0.787GlnLys: 0.787 ± 0.029	3.456GlnLeu: 3.456 ± 0.063	0.411GlnMet: 0.411 ± 0.02	0.708GlnAsn: 0.708 ± 0.029	1.682GlnPro: 1.682 ± 0.056	1.307GlnGln: 1.307 ± 0.037	2.49GlnArg: 2.49 ± 0.059	1.564GlnSer: 1.564 ± 0.043	1.604GlnThr: 1.604 ± 0.04	2.26GlnVal: 2.26 ± 0.046	0.403GlnTrp: 0.403 ± 0.02	0.606GlnTyr: 0.606 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	9.473ArgAla: 9.473 ± 0.132	0.275ArgCys: 0.275 ± 0.019	4.59ArgAsp: 4.59 ± 0.082	4.304ArgGlu: 4.304 ± 0.083	2.4ArgPhe: 2.4 ± 0.051	5.715ArgGly: 5.715 ± 0.085	1.523ArgHis: 1.523 ± 0.047	3.789ArgIle: 3.789 ± 0.062	1.243ArgLys: 1.243 ± 0.035	7.728ArgLeu: 7.728 ± 0.113	1.443ArgMet: 1.443 ± 0.037	1.199ArgAsn: 1.199 ± 0.034	3.724ArgPro: 3.724 ± 0.07	1.976ArgGln: 1.976 ± 0.052	7.484ArgArg: 7.484 ± 0.141	4.215ArgSer: 4.215 ± 0.079	4.019ArgThr: 4.019 ± 0.061	6.098ArgVal: 6.098 ± 0.088	1.231ArgTrp: 1.231 ± 0.037	1.42ArgTyr: 1.42 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	8.438SerAla: 8.438 ± 0.115	0.258SerCys: 0.258 ± 0.017	3.475SerAsp: 3.475 ± 0.061	2.544SerGlu: 2.544 ± 0.054	1.776SerPhe: 1.776 ± 0.045	6.826SerGly: 6.826 ± 0.121	0.836SerHis: 0.836 ± 0.029	2.58SerIle: 2.58 ± 0.057	1.177SerLys: 1.177 ± 0.041	5.002SerLeu: 5.002 ± 0.07	0.99SerMet: 0.99 ± 0.032	1.139SerAsn: 1.139 ± 0.038	3.401SerPro: 3.401 ± 0.06	1.35SerGln: 1.35 ± 0.034	3.924SerArg: 3.924 ± 0.07	3.946SerSer: 3.946 ± 0.087	4.163SerThr: 4.163 ± 0.085	4.649SerVal: 4.649 ± 0.082	0.91SerTrp: 0.91 ± 0.029	1.194SerTyr: 1.194 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	8.9ThrAla: 8.9 ± 0.215	0.21ThrCys: 0.21 ± 0.013	3.235ThrAsp: 3.235 ± 0.065	2.758ThrGlu: 2.758 ± 0.065	1.773ThrPhe: 1.773 ± 0.045	6.292ThrGly: 6.292 ± 0.201	0.98ThrHis: 0.98 ± 0.03	2.91ThrIle: 2.91 ± 0.08	1.283ThrLys: 1.283 ± 0.046	5.79ThrLeu: 5.79 ± 0.1	0.788ThrMet: 0.788 ± 0.026	1.148ThrAsn: 1.148 ± 0.059	4.182ThrPro: 4.182 ± 0.088	1.495ThrGln: 1.495 ± 0.05	3.869ThrArg: 3.869 ± 0.07	3.721ThrSer: 3.721 ± 0.09	4.28ThrThr: 4.28 ± 0.126	5.879ThrVal: 5.879 ± 0.175	0.835ThrTrp: 0.835 ± 0.033	1.037ThrTyr: 1.037 ± 0.063	0.0ThrXaa: 0.0 ± 0.0
Val	12.309ValAla: 12.309 ± 0.118	0.354ValCys: 0.354 ± 0.021	6.236ValAsp: 6.236 ± 0.082	4.716ValGlu: 4.716 ± 0.079	2.653ValPhe: 2.653 ± 0.058	7.515ValGly: 7.515 ± 0.088	1.539ValHis: 1.539 ± 0.042	4.301ValIle: 4.301 ± 0.072	1.754ValLys: 1.754 ± 0.051	9.136ValLeu: 9.136 ± 0.115	1.271ValMet: 1.271 ± 0.04	1.665ValAsn: 1.665 ± 0.042	4.555ValPro: 4.555 ± 0.069	2.118ValGln: 2.118 ± 0.045	5.812ValArg: 5.812 ± 0.081	4.76ValSer: 4.76 ± 0.069	6.054ValThr: 6.054 ± 0.218	8.91ValVal: 8.91 ± 0.109	1.047ValTrp: 1.047 ± 0.031	1.421ValTyr: 1.421 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.568TrpAla: 1.568 ± 0.034	0.076TrpCys: 0.076 ± 0.007	0.75TrpAsp: 0.75 ± 0.027	0.542TrpGlu: 0.542 ± 0.024	0.54TrpPhe: 0.54 ± 0.027	1.053TrpGly: 1.053 ± 0.032	0.301TrpHis: 0.301 ± 0.018	0.79TrpIle: 0.79 ± 0.025	0.286TrpLys: 0.286 ± 0.02	1.554TrpLeu: 1.554 ± 0.042	0.351TrpMet: 0.351 ± 0.018	0.411TrpAsn: 0.411 ± 0.02	0.693TrpPro: 0.693 ± 0.036	0.514TrpGln: 0.514 ± 0.022	1.139TrpArg: 1.139 ± 0.035	0.952TrpSer: 0.952 ± 0.033	0.933TrpThr: 0.933 ± 0.031	1.06TrpVal: 1.06 ± 0.031	0.312TrpTrp: 0.312 ± 0.018	0.259TrpTyr: 0.259 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.252TyrAla: 2.252 ± 0.059	0.104TyrCys: 0.104 ± 0.011	1.249TyrAsp: 1.249 ± 0.039	0.951TyrGlu: 0.951 ± 0.031	0.606TyrPhe: 0.606 ± 0.027	1.79TyrGly: 1.79 ± 0.045	0.253TyrHis: 0.253 ± 0.016	0.575TyrIle: 0.575 ± 0.028	0.338TyrLys: 0.338 ± 0.018	2.058TyrLeu: 2.058 ± 0.052	0.189TyrMet: 0.189 ± 0.013	0.36TyrAsn: 0.36 ± 0.018	0.982TyrPro: 0.982 ± 0.037	0.534TyrGln: 0.534 ± 0.024	1.51TyrArg: 1.51 ± 0.038	1.167TyrSer: 1.167 ± 0.039	1.213TyrThr: 1.213 ± 0.066	1.453TyrVal: 1.453 ± 0.04	0.278TyrTrp: 0.278 ± 0.02	0.45TyrTyr: 0.45 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 3272 proteins (1081973 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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