Amino acid dipepetide frequency for Saccharibacter sp. 17.LH.SD

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.561AlaAla: 9.561 ± 0.14
1.088AlaCys: 1.088 ± 0.048
4.684AlaAsp: 4.684 ± 0.094
5.556AlaGlu: 5.556 ± 0.11
3.476AlaPhe: 3.476 ± 0.079
7.418AlaGly: 7.418 ± 0.134
2.792AlaHis: 2.792 ± 0.069
5.159AlaIle: 5.159 ± 0.098
2.959AlaLys: 2.959 ± 0.084
12.049AlaLeu: 12.049 ± 0.174
2.45AlaMet: 2.45 ± 0.062
2.406AlaAsn: 2.406 ± 0.062
4.461AlaPro: 4.461 ± 0.09
4.506AlaGln: 4.506 ± 0.11
6.729AlaArg: 6.729 ± 0.116
6.194AlaSer: 6.194 ± 0.11
4.898AlaThr: 4.898 ± 0.092
6.351AlaVal: 6.351 ± 0.132
1.196AlaTrp: 1.196 ± 0.047
2.361AlaTyr: 2.361 ± 0.071
0.0AlaXaa: 0.0 ± 0.0
Cys
1.08CysAla: 1.08 ± 0.045
0.163CysCys: 0.163 ± 0.016
0.555CysAsp: 0.555 ± 0.03
0.428CysGlu: 0.428 ± 0.027
0.377CysPhe: 0.377 ± 0.023
0.931CysGly: 0.931 ± 0.042
0.348CysHis: 0.348 ± 0.023
0.462CysIle: 0.462 ± 0.027
0.197CysLys: 0.197 ± 0.018
1.103CysLeu: 1.103 ± 0.042
0.158CysMet: 0.158 ± 0.017
0.236CysAsn: 0.236 ± 0.019
0.511CysPro: 0.511 ± 0.03
0.374CysGln: 0.374 ± 0.026
0.681CysArg: 0.681 ± 0.034
0.618CysSer: 0.618 ± 0.033
0.477CysThr: 0.477 ± 0.031
0.847CysVal: 0.847 ± 0.04
0.136CysTrp: 0.136 ± 0.014
0.249CysTyr: 0.249 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
4.784AspAla: 4.784 ± 0.108
0.459AspCys: 0.459 ± 0.03
2.93AspAsp: 2.93 ± 0.081
3.21AspGlu: 3.21 ± 0.082
1.942AspPhe: 1.942 ± 0.066
4.362AspGly: 4.362 ± 0.085
1.604AspHis: 1.604 ± 0.048
3.514AspIle: 3.514 ± 0.075
1.636AspLys: 1.636 ± 0.056
5.203AspLeu: 5.203 ± 0.097
1.31AspMet: 1.31 ± 0.055
1.58AspAsn: 1.58 ± 0.05
2.993AspPro: 2.993 ± 0.071
1.926AspGln: 1.926 ± 0.06
3.266AspArg: 3.266 ± 0.073
2.471AspSer: 2.471 ± 0.062
2.796AspThr: 2.796 ± 0.073
4.125AspVal: 4.125 ± 0.091
0.783AspTrp: 0.783 ± 0.035
1.576AspTyr: 1.576 ± 0.056
0.0AspXaa: 0.0 ± 0.0
Glu
6.605GluAla: 6.605 ± 0.137
0.456GluCys: 0.456 ± 0.027
2.708GluAsp: 2.708 ± 0.076
4.201GluGlu: 4.201 ± 0.117
1.504GluPhe: 1.504 ± 0.052
4.464GluGly: 4.464 ± 0.09
1.597GluHis: 1.597 ± 0.05
3.229GluIle: 3.229 ± 0.079
3.134GluLys: 3.134 ± 0.08
4.767GluLeu: 4.767 ± 0.108
1.42GluMet: 1.42 ± 0.053
2.086GluAsn: 2.086 ± 0.065
1.944GluPro: 1.944 ± 0.063
2.513GluGln: 2.513 ± 0.081
4.576GluArg: 4.576 ± 0.114
2.77GluSer: 2.77 ± 0.066
3.449GluThr: 3.449 ± 0.084
3.3GluVal: 3.3 ± 0.075
0.7GluTrp: 0.7 ± 0.033
1.007GluTyr: 1.007 ± 0.042
0.0GluXaa: 0.0 ± 0.0
Phe
3.192PheAla: 3.192 ± 0.065
0.574PheCys: 0.574 ± 0.031
2.147PheAsp: 2.147 ± 0.065
1.769PheGlu: 1.769 ± 0.058
1.651PhePhe: 1.651 ± 0.062
3.166PheGly: 3.166 ± 0.069
1.056PheHis: 1.056 ± 0.044
1.96PheIle: 1.96 ± 0.065
1.08PheLys: 1.08 ± 0.041
4.037PheLeu: 4.037 ± 0.101
0.899PheMet: 0.899 ± 0.038
1.229PheAsn: 1.229 ± 0.051
1.811PhePro: 1.811 ± 0.061
1.361PheGln: 1.361 ± 0.049
2.181PheArg: 2.181 ± 0.064
3.041PheSer: 3.041 ± 0.078
1.982PheThr: 1.982 ± 0.059
2.535PheVal: 2.535 ± 0.07
0.558PheTrp: 0.558 ± 0.032
1.072PheTyr: 1.072 ± 0.047
0.0PheXaa: 0.0 ± 0.0
Gly
6.946GlyAla: 6.946 ± 0.112
0.91GlyCys: 0.91 ± 0.04
3.953GlyAsp: 3.953 ± 0.093
4.181GlyGlu: 4.181 ± 0.082
3.292GlyPhe: 3.292 ± 0.081
6.734GlyGly: 6.734 ± 0.15
2.357GlyHis: 2.357 ± 0.062
4.705GlyIle: 4.705 ± 0.101
3.384GlyLys: 3.384 ± 0.071
7.879GlyLeu: 7.879 ± 0.122
2.26GlyMet: 2.26 ± 0.062
2.5GlyAsn: 2.5 ± 0.083
2.812GlyPro: 2.812 ± 0.076
3.242GlyGln: 3.242 ± 0.085
5.468GlyArg: 5.468 ± 0.1
4.733GlySer: 4.733 ± 0.095
4.335GlyThr: 4.335 ± 0.112
5.745GlyVal: 5.745 ± 0.11
1.308GlyTrp: 1.308 ± 0.048
2.217GlyTyr: 2.217 ± 0.069
0.0GlyXaa: 0.0 ± 0.0
His
2.749HisAla: 2.749 ± 0.066
0.281HisCys: 0.281 ± 0.023
1.78HisAsp: 1.78 ± 0.052
1.505HisGlu: 1.505 ± 0.063
1.211HisPhe: 1.211 ± 0.044
2.196HisGly: 2.196 ± 0.052
1.357HisHis: 1.357 ± 0.057
1.804HisIle: 1.804 ± 0.054
0.807HisLys: 0.807 ± 0.037
2.817HisLeu: 2.817 ± 0.076
0.671HisMet: 0.671 ± 0.031
0.951HisAsn: 0.951 ± 0.045
1.876HisPro: 1.876 ± 0.055
1.104HisGln: 1.104 ± 0.041
1.706HisArg: 1.706 ± 0.051
1.607HisSer: 1.607 ± 0.055
1.355HisThr: 1.355 ± 0.054
2.039HisVal: 2.039 ± 0.053
0.458HisTrp: 0.458 ± 0.028
1.03HisTyr: 1.03 ± 0.04
0.0HisXaa: 0.0 ± 0.0
Ile
5.868IleAla: 5.868 ± 0.11
0.627IleCys: 0.627 ± 0.035
3.255IleAsp: 3.255 ± 0.074
3.261IleGlu: 3.261 ± 0.084
1.913IlePhe: 1.913 ± 0.062
4.661IleGly: 4.661 ± 0.096
1.357IleHis: 1.357 ± 0.042
3.289IleIle: 3.289 ± 0.101
1.829IleLys: 1.829 ± 0.066
5.546IleLeu: 5.546 ± 0.114
1.161IleMet: 1.161 ± 0.046
1.879IleAsn: 1.879 ± 0.055
3.098IlePro: 3.098 ± 0.071
1.762IleGln: 1.762 ± 0.054
3.383IleArg: 3.383 ± 0.07
3.772IleSer: 3.772 ± 0.091
3.578IleThr: 3.578 ± 0.081
4.026IleVal: 4.026 ± 0.09
0.658IleTrp: 0.658 ± 0.034
1.253IleTyr: 1.253 ± 0.051
0.0IleXaa: 0.0 ± 0.0
Lys
4.1LysAla: 4.1 ± 0.096
0.192LysCys: 0.192 ± 0.018
1.924LysAsp: 1.924 ± 0.063
2.574LysGlu: 2.574 ± 0.083
0.836LysPhe: 0.836 ± 0.044
2.922LysGly: 2.922 ± 0.08
0.896LysHis: 0.896 ± 0.041
2.186LysIle: 2.186 ± 0.067
2.173LysLys: 2.173 ± 0.072
3.277LysLeu: 3.277 ± 0.076
0.897LysMet: 0.897 ± 0.039
1.536LysAsn: 1.536 ± 0.06
1.798LysPro: 1.798 ± 0.06
1.458LysGln: 1.458 ± 0.05
2.729LysArg: 2.729 ± 0.072
1.937LysSer: 1.937 ± 0.054
2.37LysThr: 2.37 ± 0.063
2.079LysVal: 2.079 ± 0.06
0.38LysTrp: 0.38 ± 0.025
0.681LysTyr: 0.681 ± 0.034
0.0LysXaa: 0.0 ± 0.0
Leu
10.096LeuAla: 10.096 ± 0.169
1.357LeuCys: 1.357 ± 0.051
5.362LeuAsp: 5.362 ± 0.099
5.606LeuGlu: 5.606 ± 0.132
4.07LeuPhe: 4.07 ± 0.093
7.574LeuGly: 7.574 ± 0.152
2.891LeuHis: 2.891 ± 0.075
5.341LeuIle: 5.341 ± 0.11
4.324LeuLys: 4.324 ± 0.102
10.382LeuLeu: 10.382 ± 0.206
2.391LeuMet: 2.391 ± 0.06
3.279LeuAsn: 3.279 ± 0.071
6.395LeuPro: 6.395 ± 0.106
3.709LeuGln: 3.709 ± 0.098
6.957LeuArg: 6.957 ± 0.12
8.212LeuSer: 8.212 ± 0.152
6.149LeuThr: 6.149 ± 0.11
6.202LeuVal: 6.202 ± 0.127
1.412LeuTrp: 1.412 ± 0.057
2.508LeuTyr: 2.508 ± 0.071
0.0LeuXaa: 0.0 ± 0.0
Met
2.708MetAla: 2.708 ± 0.068
0.157MetCys: 0.157 ± 0.014
1.093MetAsp: 1.093 ± 0.045
1.248MetGlu: 1.248 ± 0.045
0.702MetPhe: 0.702 ± 0.034
1.914MetGly: 1.914 ± 0.057
0.568MetHis: 0.568 ± 0.028
1.363MetIle: 1.363 ± 0.046
0.998MetLys: 0.998 ± 0.041
2.235MetLeu: 2.235 ± 0.06
0.702MetMet: 0.702 ± 0.034
0.82MetAsn: 0.82 ± 0.036
1.374MetPro: 1.374 ± 0.055
0.859MetGln: 0.859 ± 0.036
1.596MetArg: 1.596 ± 0.053
1.827MetSer: 1.827 ± 0.052
1.782MetThr: 1.782 ± 0.05
1.62MetVal: 1.62 ± 0.051
0.209MetTrp: 0.209 ± 0.018
0.317MetTyr: 0.317 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
3.192AsnAla: 3.192 ± 0.086
0.207AsnCys: 0.207 ± 0.019
1.738AsnAsp: 1.738 ± 0.056
1.51AsnGlu: 1.51 ± 0.056
1.164AsnPhe: 1.164 ± 0.043
2.781AsnGly: 2.781 ± 0.084
0.875AsnHis: 0.875 ± 0.038
1.982AsnIle: 1.982 ± 0.067
1.104AsnLys: 1.104 ± 0.047
2.875AsnLeu: 2.875 ± 0.073
0.71AsnMet: 0.71 ± 0.033
1.214AsnAsn: 1.214 ± 0.061
2.032AsnPro: 2.032 ± 0.066
1.18AsnGln: 1.18 ± 0.054
1.931AsnArg: 1.931 ± 0.062
1.78AsnSer: 1.78 ± 0.063
1.889AsnThr: 1.889 ± 0.07
2.344AsnVal: 2.344 ± 0.062
0.488AsnTrp: 0.488 ± 0.031
0.939AsnTyr: 0.939 ± 0.052
0.0AsnXaa: 0.0 ± 0.0
Pro
4.364ProAla: 4.364 ± 0.092
0.43ProCys: 0.43 ± 0.026
3.172ProAsp: 3.172 ± 0.064
3.594ProGlu: 3.594 ± 0.078
2.091ProPhe: 2.091 ± 0.061
3.761ProGly: 3.761 ± 0.087
1.682ProHis: 1.682 ± 0.057
2.576ProIle: 2.576 ± 0.056
1.804ProLys: 1.804 ± 0.061
5.3ProLeu: 5.3 ± 0.091
1.175ProMet: 1.175 ± 0.038
1.622ProAsn: 1.622 ± 0.057
2.86ProPro: 2.86 ± 0.101
2.238ProGln: 2.238 ± 0.062
2.687ProArg: 2.687 ± 0.066
4.026ProSer: 4.026 ± 0.103
2.87ProThr: 2.87 ± 0.065
3.908ProVal: 3.908 ± 0.088
0.807ProTrp: 0.807 ± 0.037
1.436ProTyr: 1.436 ± 0.051
0.0ProXaa: 0.0 ± 0.0
Gln
4.379GlnAla: 4.379 ± 0.1
0.298GlnCys: 0.298 ± 0.022
1.939GlnAsp: 1.939 ± 0.054
2.539GlnGlu: 2.539 ± 0.084
1.221GlnPhe: 1.221 ± 0.046
3.163GlnGly: 3.163 ± 0.075
1.209GlnHis: 1.209 ± 0.054
2.138GlnIle: 2.138 ± 0.064
1.998GlnLys: 1.998 ± 0.076
3.57GlnLeu: 3.57 ± 0.078
0.878GlnMet: 0.878 ± 0.042
1.651GlnAsn: 1.651 ± 0.062
2.016GlnPro: 2.016 ± 0.061
2.005GlnGln: 2.005 ± 0.072
2.914GlnArg: 2.914 ± 0.073
2.353GlnSer: 2.353 ± 0.064
2.252GlnThr: 2.252 ± 0.058
2.252GlnVal: 2.252 ± 0.071
0.55GlnTrp: 0.55 ± 0.03
0.839GlnTyr: 0.839 ± 0.04
0.0GlnXaa: 0.0 ± 0.0
Arg
5.995ArgAla: 5.995 ± 0.12
0.537ArgCys: 0.537 ± 0.032
3.653ArgAsp: 3.653 ± 0.071
3.745ArgGlu: 3.745 ± 0.091
2.813ArgPhe: 2.813 ± 0.068
4.346ArgGly: 4.346 ± 0.091
2.377ArgHis: 2.377 ± 0.069
3.62ArgIle: 3.62 ± 0.074
2.322ArgLys: 2.322 ± 0.066
7.701ArgLeu: 7.701 ± 0.139
1.53ArgMet: 1.53 ± 0.048
2.031ArgAsn: 2.031 ± 0.056
3.211ArgPro: 3.211 ± 0.066
2.988ArgGln: 2.988 ± 0.078
5.041ArgArg: 5.041 ± 0.109
3.903ArgSer: 3.903 ± 0.07
2.839ArgThr: 2.839 ± 0.067
4.448ArgVal: 4.448 ± 0.089
0.935ArgTrp: 0.935 ± 0.039
2.062ArgTyr: 2.062 ± 0.064
0.0ArgXaa: 0.0 ± 0.0
Ser
5.683SerAla: 5.683 ± 0.097
0.6SerCys: 0.6 ± 0.034
3.373SerAsp: 3.373 ± 0.076
3.145SerGlu: 3.145 ± 0.075
2.98SerPhe: 2.98 ± 0.074
5.407SerGly: 5.407 ± 0.105
1.989SerHis: 1.989 ± 0.058
3.402SerIle: 3.402 ± 0.073
1.783SerLys: 1.783 ± 0.054
7.622SerLeu: 7.622 ± 0.12
1.478SerMet: 1.478 ± 0.049
1.804SerAsn: 1.804 ± 0.063
3.708SerPro: 3.708 ± 0.083
2.411SerGln: 2.411 ± 0.065
3.957SerArg: 3.957 ± 0.083
4.831SerSer: 4.831 ± 0.119
3.365SerThr: 3.365 ± 0.073
4.597SerVal: 4.597 ± 0.091
0.96SerTrp: 0.96 ± 0.04
1.727SerTyr: 1.727 ± 0.061
0.0SerXaa: 0.0 ± 0.0
Thr
5.138ThrAla: 5.138 ± 0.094
0.409ThrCys: 0.409 ± 0.026
2.537ThrAsp: 2.537 ± 0.06
2.593ThrGlu: 2.593 ± 0.071
2.021ThrPhe: 2.021 ± 0.063
4.59ThrGly: 4.59 ± 0.114
1.549ThrHis: 1.549 ± 0.053
3.394ThrIle: 3.394 ± 0.076
1.568ThrLys: 1.568 ± 0.049
7.079ThrLeu: 7.079 ± 0.132
1.263ThrMet: 1.263 ± 0.047
1.638ThrAsn: 1.638 ± 0.057
3.895ThrPro: 3.895 ± 0.099
2.171ThrGln: 2.171 ± 0.071
3.227ThrArg: 3.227 ± 0.082
3.627ThrSer: 3.627 ± 0.093
3.185ThrThr: 3.185 ± 0.089
3.864ThrVal: 3.864 ± 0.089
0.682ThrTrp: 0.682 ± 0.033
1.381ThrTyr: 1.381 ± 0.057
0.0ThrXaa: 0.0 ± 0.0
Val
6.401ValAla: 6.401 ± 0.124
0.695ValCys: 0.695 ± 0.033
3.457ValAsp: 3.457 ± 0.08
3.874ValGlu: 3.874 ± 0.086
2.577ValPhe: 2.577 ± 0.083
5.106ValGly: 5.106 ± 0.106
1.583ValHis: 1.583 ± 0.046
4.099ValIle: 4.099 ± 0.093
2.459ValLys: 2.459 ± 0.065
6.948ValLeu: 6.948 ± 0.102
1.96ValMet: 1.96 ± 0.058
2.057ValAsn: 2.057 ± 0.065
3.693ValPro: 3.693 ± 0.08
2.469ValGln: 2.469 ± 0.072
4.142ValArg: 4.142 ± 0.089
4.823ValSer: 4.823 ± 0.088
4.286ValThr: 4.286 ± 0.092
5.111ValVal: 5.111 ± 0.123
0.791ValTrp: 0.791 ± 0.037
1.394ValTyr: 1.394 ± 0.053
0.0ValXaa: 0.0 ± 0.0
Trp
1.027TrpAla: 1.027 ± 0.047
0.196TrpCys: 0.196 ± 0.017
0.644TrpAsp: 0.644 ± 0.037
0.559TrpGlu: 0.559 ± 0.029
0.55TrpPhe: 0.55 ± 0.034
1.057TrpGly: 1.057 ± 0.049
0.458TrpHis: 0.458 ± 0.027
0.736TrpIle: 0.736 ± 0.038
0.564TrpLys: 0.564 ± 0.03
1.612TrpLeu: 1.612 ± 0.052
0.314TrpMet: 0.314 ± 0.023
0.529TrpAsn: 0.529 ± 0.034
0.665TrpPro: 0.665 ± 0.036
0.713TrpGln: 0.713 ± 0.032
1.104TrpArg: 1.104 ± 0.049
0.867TrpSer: 0.867 ± 0.042
0.626TrpThr: 0.626 ± 0.031
0.825TrpVal: 0.825 ± 0.036
0.222TrpTrp: 0.222 ± 0.019
0.351TrpTyr: 0.351 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.429TyrAla: 2.429 ± 0.068
0.294TyrCys: 0.294 ± 0.021
1.565TyrAsp: 1.565 ± 0.051
1.329TyrGlu: 1.329 ± 0.047
0.912TyrPhe: 0.912 ± 0.041
2.408TyrGly: 2.408 ± 0.069
0.76TyrHis: 0.76 ± 0.038
1.218TyrIle: 1.218 ± 0.044
0.823TyrLys: 0.823 ± 0.039
2.214TyrLeu: 2.214 ± 0.063
0.462TyrMet: 0.462 ± 0.032
0.891TyrAsn: 0.891 ± 0.048
1.251TyrPro: 1.251 ± 0.047
1.172TyrGln: 1.172 ± 0.053
1.821TyrArg: 1.821 ± 0.059
1.429TyrSer: 1.429 ± 0.058
1.331TyrThr: 1.331 ± 0.052
1.706TyrVal: 1.706 ± 0.053
0.385TyrTrp: 0.385 ± 0.026
0.708TyrTyr: 0.708 ± 0.038
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1859 proteins (618472 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski