Amino acid dipepetide frequency for Canis lupus familiaris (Dog) (Canis familiaris)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.947AlaAla: 6.947 ± 0.029	1.404AlaCys: 1.404 ± 0.009	2.877AlaAsp: 2.877 ± 0.01	4.751AlaGlu: 4.751 ± 0.021	2.541AlaPhe: 2.541 ± 0.011	4.934AlaGly: 4.934 ± 0.023	1.545AlaHis: 1.545 ± 0.009	2.768AlaIle: 2.768 ± 0.011	3.421AlaLys: 3.421 ± 0.016	7.101AlaLeu: 7.101 ± 0.022	1.445AlaMet: 1.445 ± 0.008	2.02AlaAsn: 2.02 ± 0.009	4.486AlaPro: 4.486 ± 0.023	3.232AlaGln: 3.232 ± 0.016	3.87AlaArg: 3.87 ± 0.017	5.841AlaSer: 5.841 ± 0.019	3.472AlaThr: 3.472 ± 0.014	4.588AlaVal: 4.588 ± 0.014	0.806AlaTrp: 0.806 ± 0.006	1.457AlaTyr: 1.457 ± 0.009	0.001AlaXaa: 0.001 ± 0.0
Cys	1.277CysAla: 1.277 ± 0.009	0.623CysCys: 0.623 ± 0.007	0.983CysAsp: 0.983 ± 0.008	1.265CysGlu: 1.265 ± 0.009	0.821CysPhe: 0.821 ± 0.006	1.696CysGly: 1.696 ± 0.013	0.665CysHis: 0.665 ± 0.006	0.935CysIle: 0.935 ± 0.006	1.113CysLys: 1.113 ± 0.009	2.127CysLeu: 2.127 ± 0.011	0.404CysMet: 0.404 ± 0.003	0.772CysAsn: 0.772 ± 0.007	1.438CysPro: 1.438 ± 0.012	1.073CysGln: 1.073 ± 0.009	1.298CysArg: 1.298 ± 0.008	2.019CysSer: 2.019 ± 0.011	1.092CysThr: 1.092 ± 0.008	1.289CysVal: 1.289 ± 0.008	0.314CysTrp: 0.314 ± 0.003	0.552CysTyr: 0.552 ± 0.005	0.0CysXaa: 0.0 ± 0.0
Asp	2.846AspAla: 2.846 ± 0.011	1.009AspCys: 1.009 ± 0.007	2.603AspAsp: 2.603 ± 0.012	3.391AspGlu: 3.391 ± 0.015	2.088AspPhe: 2.088 ± 0.01	3.303AspGly: 3.303 ± 0.019	1.147AspHis: 1.147 ± 0.006	2.581AspIle: 2.581 ± 0.01	2.567AspLys: 2.567 ± 0.013	4.973AspLeu: 4.973 ± 0.015	1.106AspMet: 1.106 ± 0.007	1.673AspAsn: 1.673 ± 0.011	2.933AspPro: 2.933 ± 0.013	1.853AspGln: 1.853 ± 0.009	2.392AspArg: 2.392 ± 0.012	4.157AspSer: 4.157 ± 0.016	2.513AspThr: 2.513 ± 0.012	3.009AspVal: 3.009 ± 0.012	0.613AspTrp: 0.613 ± 0.005	1.443AspTyr: 1.443 ± 0.008	0.0AspXaa: 0.0 ± 0.0
Glu	5.251GluAla: 5.251 ± 0.024	1.408GluCys: 1.408 ± 0.015	4.419GluAsp: 4.419 ± 0.015	7.913GluGlu: 7.913 ± 0.036	1.984GluPhe: 1.984 ± 0.01	4.213GluGly: 4.213 ± 0.017	1.508GluHis: 1.508 ± 0.007	3.215GluIle: 3.215 ± 0.015	5.457GluLys: 5.457 ± 0.024	6.544GluLeu: 6.544 ± 0.027	1.651GluMet: 1.651 ± 0.008	3.179GluAsn: 3.179 ± 0.015	3.287GluPro: 3.287 ± 0.015	3.211GluGln: 3.211 ± 0.017	4.086GluArg: 4.086 ± 0.019	4.436GluSer: 4.436 ± 0.017	3.394GluThr: 3.394 ± 0.014	4.169GluVal: 4.169 ± 0.014	0.697GluTrp: 0.697 ± 0.005	1.587GluTyr: 1.587 ± 0.011	0.001GluXaa: 0.001 ± 0.0
Phe	1.929PheAla: 1.929 ± 0.01	0.91PheCys: 0.91 ± 0.006	1.641PheAsp: 1.641 ± 0.008	1.969PheGlu: 1.969 ± 0.01	1.588PhePhe: 1.588 ± 0.009	2.149PheGly: 2.149 ± 0.012	0.992PheHis: 0.992 ± 0.007	1.81PheIle: 1.81 ± 0.01	1.726PheLys: 1.726 ± 0.009	4.013PheLeu: 4.013 ± 0.017	0.745PheMet: 0.745 ± 0.006	1.337PheAsn: 1.337 ± 0.008	2.017PhePro: 2.017 ± 0.012	1.753PheGln: 1.753 ± 0.008	1.932PheArg: 1.932 ± 0.01	3.342PheSer: 3.342 ± 0.014	1.992PheThr: 1.992 ± 0.009	2.056PheVal: 2.056 ± 0.011	0.477PheTrp: 0.477 ± 0.004	1.173PheTyr: 1.173 ± 0.008	0.0PheXaa: 0.0 ± 0.0
Gly	4.745GlyAla: 4.745 ± 0.021	1.307GlyCys: 1.307 ± 0.009	3.138GlyAsp: 3.138 ± 0.016	4.129GlyGlu: 4.129 ± 0.022	2.35GlyPhe: 2.35 ± 0.012	5.249GlyGly: 5.249 ± 0.028	1.725GlyHis: 1.725 ± 0.01	2.784GlyIle: 2.784 ± 0.013	3.729GlyLys: 3.729 ± 0.016	5.864GlyLeu: 5.864 ± 0.022	1.274GlyMet: 1.274 ± 0.008	2.31GlyAsn: 2.31 ± 0.01	4.526GlyPro: 4.526 ± 0.036	2.801GlyGln: 2.801 ± 0.013	4.051GlyArg: 4.051 ± 0.018	5.887GlySer: 5.887 ± 0.022	3.582GlyThr: 3.582 ± 0.013	3.516GlyVal: 3.516 ± 0.015	0.839GlyTrp: 0.839 ± 0.007	1.65GlyTyr: 1.65 ± 0.009	0.001GlyXaa: 0.001 ± 0.0
His	1.308HisAla: 1.308 ± 0.007	0.728HisCys: 0.728 ± 0.006	0.89HisAsp: 0.89 ± 0.006	1.299HisGlu: 1.299 ± 0.008	1.063HisPhe: 1.063 ± 0.007	1.552HisGly: 1.552 ± 0.01	0.897HisHis: 0.897 ± 0.009	1.267HisIle: 1.267 ± 0.007	1.267HisLys: 1.267 ± 0.007	2.918HisLeu: 2.918 ± 0.013	0.58HisMet: 0.58 ± 0.005	0.855HisAsn: 0.855 ± 0.005	1.705HisPro: 1.705 ± 0.01	1.327HisGln: 1.327 ± 0.009	1.566HisArg: 1.566 ± 0.008	2.291HisSer: 2.291 ± 0.011	1.475HisThr: 1.475 ± 0.011	1.474HisVal: 1.474 ± 0.008	0.348HisTrp: 0.348 ± 0.004	0.792HisTyr: 0.792 ± 0.006	0.001HisXaa: 0.001 ± 0.0
Ile	2.531IleAla: 2.531 ± 0.011	1.063IleCys: 1.063 ± 0.007	2.04IleAsp: 2.04 ± 0.01	2.649IleGlu: 2.649 ± 0.015	1.858IlePhe: 1.858 ± 0.012	2.189IleGly: 2.189 ± 0.009	1.344IleHis: 1.344 ± 0.009	2.41IleIle: 2.41 ± 0.012	2.776IleLys: 2.776 ± 0.014	4.664IleLeu: 4.664 ± 0.018	1.001IleMet: 1.001 ± 0.007	1.9IleAsn: 1.9 ± 0.01	2.653IlePro: 2.653 ± 0.012	2.379IleGln: 2.379 ± 0.012	2.37IleArg: 2.37 ± 0.011	3.706IleSer: 3.706 ± 0.013	2.552IleThr: 2.552 ± 0.014	2.455IleVal: 2.455 ± 0.012	0.503IleTrp: 0.503 ± 0.005	1.423IleTyr: 1.423 ± 0.008	0.0IleXaa: 0.0 ± 0.0
Lys	3.979LysAla: 3.979 ± 0.019	1.101LysCys: 1.101 ± 0.008	3.226LysAsp: 3.226 ± 0.016	5.23LysGlu: 5.23 ± 0.024	1.677LysPhe: 1.677 ± 0.009	3.251LysGly: 3.251 ± 0.018	1.398LysHis: 1.398 ± 0.008	2.925LysIle: 2.925 ± 0.016	4.73LysLys: 4.73 ± 0.021	5.207LysLeu: 5.207 ± 0.018	1.435LysMet: 1.435 ± 0.007	2.463LysAsn: 2.463 ± 0.012	3.1LysPro: 3.1 ± 0.017	2.642LysGln: 2.642 ± 0.013	3.277LysArg: 3.277 ± 0.013	3.994LysSer: 3.994 ± 0.018	3.19LysThr: 3.19 ± 0.014	3.39LysVal: 3.39 ± 0.014	0.624LysTrp: 0.624 ± 0.006	1.543LysTyr: 1.543 ± 0.009	0.0LysXaa: 0.0 ± 0.0
Leu	6.734LeuAla: 6.734 ± 0.021	2.148LeuCys: 2.148 ± 0.01	4.669LeuAsp: 4.669 ± 0.016	7.325LeuGlu: 7.325 ± 0.032	3.315LeuPhe: 3.315 ± 0.015	5.877LeuGly: 5.877 ± 0.02	2.705LeuHis: 2.705 ± 0.011	3.874LeuIle: 3.874 ± 0.016	5.887LeuLys: 5.887 ± 0.021	10.617LeuLeu: 10.617 ± 0.032	1.962LeuMet: 1.962 ± 0.009	3.584LeuAsn: 3.584 ± 0.015	6.084LeuPro: 6.084 ± 0.022	5.785LeuGln: 5.785 ± 0.029	6.001LeuArg: 6.001 ± 0.023	7.985LeuSer: 7.985 ± 0.022	5.014LeuThr: 5.014 ± 0.013	5.313LeuVal: 5.313 ± 0.018	1.149LeuTrp: 1.149 ± 0.007	2.506LeuTyr: 2.506 ± 0.012	0.001LeuXaa: 0.001 ± 0.0
Met	1.809MetAla: 1.809 ± 0.008	0.401MetCys: 0.401 ± 0.004	1.249MetAsp: 1.249 ± 0.007	1.841MetGlu: 1.841 ± 0.009	0.73MetPhe: 0.73 ± 0.006	1.262MetGly: 1.262 ± 0.008	0.454MetHis: 0.454 ± 0.004	0.839MetIle: 0.839 ± 0.006	1.476MetLys: 1.476 ± 0.008	1.938MetLeu: 1.938 ± 0.009	0.559MetMet: 0.559 ± 0.005	0.904MetAsn: 0.904 ± 0.006	1.048MetPro: 1.048 ± 0.007	0.913MetGln: 0.913 ± 0.007	1.043MetArg: 1.043 ± 0.006	1.526MetSer: 1.526 ± 0.008	1.098MetThr: 1.098 ± 0.007	1.353MetVal: 1.353 ± 0.006	0.241MetTrp: 0.241 ± 0.003	0.571MetTyr: 0.571 ± 0.004	0.0MetXaa: 0.0 ± 0.0
Asn	2.034AsnAla: 2.034 ± 0.009	0.814AsnCys: 0.814 ± 0.007	1.531AsnAsp: 1.531 ± 0.009	2.271AsnGlu: 2.271 ± 0.012	1.433AsnPhe: 1.433 ± 0.009	2.386AsnGly: 2.386 ± 0.012	0.963AsnHis: 0.963 ± 0.007	2.17AsnIle: 2.17 ± 0.012	2.277AsnLys: 2.277 ± 0.011	3.71AsnLeu: 3.71 ± 0.014	0.911AsnMet: 0.911 ± 0.006	1.515AsnAsn: 1.515 ± 0.01	2.154AsnPro: 2.154 ± 0.01	1.671AsnGln: 1.671 ± 0.009	1.857AsnArg: 1.857 ± 0.008	3.106AsnSer: 3.106 ± 0.015	1.993AsnThr: 1.993 ± 0.01	2.188AsnVal: 2.188 ± 0.008	0.443AsnTrp: 0.443 ± 0.004	1.102AsnTyr: 1.102 ± 0.008	0.0AsnXaa: 0.0 ± 0.0
Pro	5.167ProAla: 5.167 ± 0.023	1.188ProCys: 1.188 ± 0.009	2.797ProAsp: 2.797 ± 0.012	4.49ProGlu: 4.49 ± 0.019	1.92ProPhe: 1.92 ± 0.01	5.661ProGly: 5.661 ± 0.05	1.461ProHis: 1.461 ± 0.009	1.911ProIle: 1.911 ± 0.011	2.811ProLys: 2.811 ± 0.014	5.347ProLeu: 5.347 ± 0.018	1.045ProMet: 1.045 ± 0.007	1.795ProAsn: 1.795 ± 0.009	6.381ProPro: 6.381 ± 0.041	2.867ProGln: 2.867 ± 0.015	3.742ProArg: 3.742 ± 0.016	5.812ProSer: 5.812 ± 0.024	3.14ProThr: 3.14 ± 0.016	3.799ProVal: 3.799 ± 0.017	0.726ProTrp: 0.726 ± 0.005	1.438ProTyr: 1.438 ± 0.01	0.001ProXaa: 0.001 ± 0.0
Gln	3.505GlnAla: 3.505 ± 0.017	0.937GlnCys: 0.937 ± 0.007	2.376GlnAsp: 2.376 ± 0.01	3.976GlnGlu: 3.976 ± 0.02	1.345GlnPhe: 1.345 ± 0.007	2.89GlnGly: 2.89 ± 0.013	1.309GlnHis: 1.309 ± 0.008	2.049GlnIle: 2.049 ± 0.009	3.052GlnLys: 3.052 ± 0.015	4.717GlnLeu: 4.717 ± 0.024	1.116GlnMet: 1.116 ± 0.006	1.86GlnAsn: 1.86 ± 0.01	2.805GlnPro: 2.805 ± 0.016	3.087GlnGln: 3.087 ± 0.027	2.986GlnArg: 2.986 ± 0.013	3.165GlnSer: 3.165 ± 0.015	2.301GlnThr: 2.301 ± 0.01	2.805GlnVal: 2.805 ± 0.01	0.543GlnTrp: 0.543 ± 0.005	1.134GlnTyr: 1.134 ± 0.007	0.0GlnXaa: 0.0 ± 0.0
Arg	4.102ArgAla: 4.102 ± 0.016	1.235ArgCys: 1.235 ± 0.01	2.726ArgAsp: 2.726 ± 0.011	4.101ArgGlu: 4.101 ± 0.018	1.793ArgPhe: 1.793 ± 0.009	3.944ArgGly: 3.944 ± 0.021	1.521ArgHis: 1.521 ± 0.008	2.447ArgIle: 2.447 ± 0.01	3.604ArgLys: 3.604 ± 0.013	5.444ArgLeu: 5.444 ± 0.018	1.177ArgMet: 1.177 ± 0.007	2.093ArgAsn: 2.093 ± 0.009	3.57ArgPro: 3.57 ± 0.019	2.675ArgGln: 2.675 ± 0.014	4.599ArgArg: 4.599 ± 0.022	4.366ArgSer: 4.366 ± 0.02	2.9ArgThr: 2.9 ± 0.011	3.161ArgVal: 3.161 ± 0.012	0.716ArgTrp: 0.716 ± 0.005	1.432ArgTyr: 1.432 ± 0.007	0.002ArgXaa: 0.002 ± 0.0
Ser	5.338SerAla: 5.338 ± 0.018	1.837SerCys: 1.837 ± 0.012	3.849SerAsp: 3.849 ± 0.015	5.217SerGlu: 5.217 ± 0.023	3.0SerPhe: 3.0 ± 0.013	5.694SerGly: 5.694 ± 0.021	2.127SerHis: 2.127 ± 0.01	3.265SerIle: 3.265 ± 0.011	4.119SerLys: 4.119 ± 0.017	8.265SerLeu: 8.265 ± 0.027	1.569SerMet: 1.569 ± 0.007	2.669SerAsn: 2.669 ± 0.013	6.203SerPro: 6.203 ± 0.028	3.881SerGln: 3.881 ± 0.018	4.62SerArg: 4.62 ± 0.019	9.333SerSer: 9.333 ± 0.04	4.462SerThr: 4.462 ± 0.017	4.873SerVal: 4.873 ± 0.017	1.11SerTrp: 1.11 ± 0.007	2.029SerTyr: 2.029 ± 0.011	0.001SerXaa: 0.001 ± 0.0
Thr	3.691ThrAla: 3.691 ± 0.013	1.311ThrCys: 1.311 ± 0.01	2.424ThrAsp: 2.424 ± 0.011	3.514ThrGlu: 3.514 ± 0.012	2.125ThrPhe: 2.125 ± 0.01	3.469ThrGly: 3.469 ± 0.017	1.283ThrHis: 1.283 ± 0.007	2.423ThrIle: 2.423 ± 0.011	2.701ThrLys: 2.701 ± 0.013	5.251ThrLeu: 5.251 ± 0.013	1.116ThrMet: 1.116 ± 0.006	1.738ThrAsn: 1.738 ± 0.008	3.597ThrPro: 3.597 ± 0.017	2.324ThrGln: 2.324 ± 0.01	2.531ThrArg: 2.531 ± 0.009	4.632ThrSer: 4.632 ± 0.02	2.921ThrThr: 2.921 ± 0.018	3.785ThrVal: 3.785 ± 0.016	0.707ThrTrp: 0.707 ± 0.006	1.387ThrTyr: 1.387 ± 0.009	0.001ThrXaa: 0.001 ± 0.0
Val	4.172ValAla: 4.172 ± 0.014	1.427ValCys: 1.427 ± 0.01	2.854ValAsp: 2.854 ± 0.012	3.77ValGlu: 3.77 ± 0.015	2.295ValPhe: 2.295 ± 0.011	3.362ValGly: 3.362 ± 0.014	1.513ValHis: 1.513 ± 0.008	2.845ValIle: 2.845 ± 0.014	3.364ValLys: 3.364 ± 0.013	6.088ValLeu: 6.088 ± 0.019	1.253ValMet: 1.253 ± 0.007	2.249ValAsn: 2.249 ± 0.012	3.685ValPro: 3.685 ± 0.016	2.7ValGln: 2.7 ± 0.01	3.052ValArg: 3.052 ± 0.011	4.864ValSer: 4.864 ± 0.018	3.673ValThr: 3.673 ± 0.018	3.829ValVal: 3.829 ± 0.015	0.728ValTrp: 0.728 ± 0.005	1.534ValTyr: 1.534 ± 0.009	0.0ValXaa: 0.0 ± 0.0
Trp	0.796TrpAla: 0.796 ± 0.006	0.251TrpCys: 0.251 ± 0.003	0.656TrpAsp: 0.656 ± 0.005	0.817TrpGlu: 0.817 ± 0.006	0.444TrpPhe: 0.444 ± 0.004	0.785TrpGly: 0.785 ± 0.007	0.309TrpHis: 0.309 ± 0.003	0.564TrpIle: 0.564 ± 0.005	0.827TrpLys: 0.827 ± 0.007	1.183TrpLeu: 1.183 ± 0.008	0.327TrpMet: 0.327 ± 0.004	0.548TrpAsn: 0.548 ± 0.005	0.562TrpPro: 0.562 ± 0.004	0.531TrpGln: 0.531 ± 0.004	0.778TrpArg: 0.778 ± 0.006	0.87TrpSer: 0.87 ± 0.007	0.694TrpThr: 0.694 ± 0.006	0.679TrpVal: 0.679 ± 0.004	0.197TrpTrp: 0.197 ± 0.003	0.331TrpTyr: 0.331 ± 0.004	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.346TyrAla: 1.346 ± 0.008	0.653TyrCys: 0.653 ± 0.005	1.253TyrAsp: 1.253 ± 0.008	1.693TyrGlu: 1.693 ± 0.01	1.181TyrPhe: 1.181 ± 0.007	1.592TyrGly: 1.592 ± 0.009	0.738TyrHis: 0.738 ± 0.006	1.382TyrIle: 1.382 ± 0.008	1.475TyrLys: 1.475 ± 0.011	2.562TyrLeu: 2.562 ± 0.014	0.578TyrMet: 0.578 ± 0.005	1.068TyrAsn: 1.068 ± 0.008	1.264TyrPro: 1.264 ± 0.008	1.251TyrGln: 1.251 ± 0.007	1.558TyrArg: 1.558 ± 0.008	2.13TyrSer: 2.13 ± 0.011	1.469TyrThr: 1.469 ± 0.009	1.525TyrVal: 1.525 ± 0.007	0.366TyrTrp: 0.366 ± 0.004	0.923TyrTyr: 0.923 ± 0.007	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.0	0.002XaaGly: 0.002 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.0	0.001XaaSer: 0.001 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.254XaaXaa: 0.254 ± 0.033

Statistics based on 45399 proteins (29901829 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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