Amino acid dipepetide frequency for [Ruminococcus] lactaris ATCC 29176

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.008AlaAla: 7.008 ± 0.132	0.917AlaCys: 0.917 ± 0.036	4.593AlaAsp: 4.593 ± 0.092	6.144AlaGlu: 6.144 ± 0.103	2.86AlaPhe: 2.86 ± 0.065	6.41AlaGly: 6.41 ± 0.106	1.081AlaHis: 1.081 ± 0.036	4.608AlaIle: 4.608 ± 0.087	4.965AlaLys: 4.965 ± 0.089	6.23AlaLeu: 6.23 ± 0.113	2.254AlaMet: 2.254 ± 0.053	2.486AlaAsn: 2.486 ± 0.064	1.859AlaPro: 1.859 ± 0.053	2.11AlaGln: 2.11 ± 0.053	2.83AlaArg: 2.83 ± 0.065	3.635AlaSer: 3.635 ± 0.073	3.419AlaThr: 3.419 ± 0.1	6.48AlaVal: 6.48 ± 0.1	0.588AlaTrp: 0.588 ± 0.031	2.772AlaTyr: 2.772 ± 0.062	0.0AlaXaa: 0.0 ± 0.0
Cys	0.933CysAla: 0.933 ± 0.035	0.244CysCys: 0.244 ± 0.018	0.724CysAsp: 0.724 ± 0.028	0.925CysGlu: 0.925 ± 0.035	0.579CysPhe: 0.579 ± 0.028	1.386CysGly: 1.386 ± 0.05	0.273CysHis: 0.273 ± 0.017	1.078CysIle: 1.078 ± 0.039	0.792CysLys: 0.792 ± 0.03	1.1CysLeu: 1.1 ± 0.037	0.436CysMet: 0.436 ± 0.023	0.532CysAsn: 0.532 ± 0.027	0.562CysPro: 0.562 ± 0.034	0.413CysGln: 0.413 ± 0.022	0.708CysArg: 0.708 ± 0.032	0.845CysSer: 0.845 ± 0.032	0.78CysThr: 0.78 ± 0.032	0.905CysVal: 0.905 ± 0.031	0.099CysTrp: 0.099 ± 0.011	0.544CysTyr: 0.544 ± 0.027	0.0CysXaa: 0.0 ± 0.0
Asp	4.344AspAla: 4.344 ± 0.11	0.727AspCys: 0.727 ± 0.029	2.891AspAsp: 2.891 ± 0.077	4.963AspGlu: 4.963 ± 0.095	2.596AspPhe: 2.596 ± 0.064	4.471AspGly: 4.471 ± 0.111	0.997AspHis: 0.997 ± 0.038	3.892AspIle: 3.892 ± 0.069	3.453AspLys: 3.453 ± 0.081	4.835AspLeu: 4.835 ± 0.079	1.682AspMet: 1.682 ± 0.05	2.018AspAsn: 2.018 ± 0.065	1.857AspPro: 1.857 ± 0.049	1.656AspGln: 1.656 ± 0.044	2.488AspArg: 2.488 ± 0.056	3.244AspSer: 3.244 ± 0.079	3.204AspThr: 3.204 ± 0.081	3.78AspVal: 3.78 ± 0.077	0.598AspTrp: 0.598 ± 0.033	2.642AspTyr: 2.642 ± 0.061	0.0AspXaa: 0.0 ± 0.0
Glu	5.481GluAla: 5.481 ± 0.095	0.893GluCys: 0.893 ± 0.038	4.527GluAsp: 4.527 ± 0.095	8.229GluGlu: 8.229 ± 0.176	2.6GluPhe: 2.6 ± 0.059	4.416GluGly: 4.416 ± 0.07	1.374GluHis: 1.374 ± 0.047	5.877GluIle: 5.877 ± 0.108	8.176GluLys: 8.176 ± 0.134	7.079GluLeu: 7.079 ± 0.12	2.604GluMet: 2.604 ± 0.057	4.377GluAsn: 4.377 ± 0.075	1.952GluPro: 1.952 ± 0.06	3.231GluGln: 3.231 ± 0.076	3.638GluArg: 3.638 ± 0.08	3.61GluSer: 3.61 ± 0.077	3.849GluThr: 3.849 ± 0.077	4.961GluVal: 4.961 ± 0.089	0.706GluTrp: 0.706 ± 0.033	3.34GluTyr: 3.34 ± 0.068	0.0GluXaa: 0.0 ± 0.0
Phe	2.808PheAla: 2.808 ± 0.056	0.775PheCys: 0.775 ± 0.034	2.49PheAsp: 2.49 ± 0.056	2.595PheGlu: 2.595 ± 0.064	1.768PhePhe: 1.768 ± 0.061	2.872PheGly: 2.872 ± 0.07	0.837PheHis: 0.837 ± 0.034	2.589PheIle: 2.589 ± 0.072	1.899PheLys: 1.899 ± 0.045	3.85PheLeu: 3.85 ± 0.091	1.156PheMet: 1.156 ± 0.039	1.424PheAsn: 1.424 ± 0.041	1.411PhePro: 1.411 ± 0.04	1.269PheGln: 1.269 ± 0.039	1.76PheArg: 1.76 ± 0.054	2.7PheSer: 2.7 ± 0.063	2.265PheThr: 2.265 ± 0.066	2.695PheVal: 2.695 ± 0.069	0.452PheTrp: 0.452 ± 0.025	1.665PheTyr: 1.665 ± 0.048	0.0PheXaa: 0.0 ± 0.0
Gly	4.87GlyAla: 4.87 ± 0.089	1.125GlyCys: 1.125 ± 0.042	3.434GlyAsp: 3.434 ± 0.083	4.86GlyGlu: 4.86 ± 0.085	2.887GlyPhe: 2.887 ± 0.065	4.851GlyGly: 4.851 ± 0.12	1.236GlyHis: 1.236 ± 0.045	6.23GlyIle: 6.23 ± 0.099	6.013GlyLys: 6.013 ± 0.099	5.653GlyLeu: 5.653 ± 0.095	2.59GlyMet: 2.59 ± 0.067	3.424GlyAsn: 3.424 ± 0.114	1.205GlyPro: 1.205 ± 0.04	2.239GlyGln: 2.239 ± 0.057	3.236GlyArg: 3.236 ± 0.068	4.277GlySer: 4.277 ± 0.082	4.783GlyThr: 4.783 ± 0.104	4.839GlyVal: 4.839 ± 0.092	0.676GlyTrp: 0.676 ± 0.034	3.232GlyTyr: 3.232 ± 0.072	0.0GlyXaa: 0.0 ± 0.0
His	1.151HisAla: 1.151 ± 0.043	0.303HisCys: 0.303 ± 0.017	0.84HisAsp: 0.84 ± 0.036	1.094HisGlu: 1.094 ± 0.041	0.868HisPhe: 0.868 ± 0.032	1.225HisGly: 1.225 ± 0.039	0.415HisHis: 0.415 ± 0.031	1.401HisIle: 1.401 ± 0.046	0.929HisLys: 0.929 ± 0.034	1.523HisLeu: 1.523 ± 0.048	0.537HisMet: 0.537 ± 0.027	0.649HisAsn: 0.649 ± 0.027	0.923HisPro: 0.923 ± 0.04	0.583HisGln: 0.583 ± 0.027	0.795HisArg: 0.795 ± 0.035	1.021HisSer: 1.021 ± 0.033	1.069HisThr: 1.069 ± 0.039	1.007HisVal: 1.007 ± 0.034	0.175HisTrp: 0.175 ± 0.017	0.77HisTyr: 0.77 ± 0.035	0.0HisXaa: 0.0 ± 0.0
Ile	5.33IleAla: 5.33 ± 0.097	1.285IleCys: 1.285 ± 0.042	3.861IleAsp: 3.861 ± 0.075	5.036IleGlu: 5.036 ± 0.093	2.903IlePhe: 2.903 ± 0.066	5.04IleGly: 5.04 ± 0.101	1.39IleHis: 1.39 ± 0.046	4.497IleIle: 4.497 ± 0.089	3.881IleLys: 3.881 ± 0.073	7.018IleLeu: 7.018 ± 0.117	1.794IleMet: 1.794 ± 0.047	2.71IleAsn: 2.71 ± 0.061	3.016IlePro: 3.016 ± 0.059	2.474IleGln: 2.474 ± 0.06	4.041IleArg: 4.041 ± 0.089	4.75IleSer: 4.75 ± 0.081	3.856IleThr: 3.856 ± 0.08	4.883IleVal: 4.883 ± 0.084	0.621IleTrp: 0.621 ± 0.031	2.687IleTyr: 2.687 ± 0.062	0.0IleXaa: 0.0 ± 0.0
Lys	5.393LysAla: 5.393 ± 0.104	0.749LysCys: 0.749 ± 0.029	4.158LysAsp: 4.158 ± 0.075	7.661LysGlu: 7.661 ± 0.132	2.03LysPhe: 2.03 ± 0.059	4.298LysGly: 4.298 ± 0.079	0.932LysHis: 0.932 ± 0.036	5.352LysIle: 5.352 ± 0.094	7.451LysLys: 7.451 ± 0.131	5.548LysLeu: 5.548 ± 0.09	2.597LysMet: 2.597 ± 0.054	3.874LysAsn: 3.874 ± 0.082	1.896LysPro: 1.896 ± 0.051	2.058LysGln: 2.058 ± 0.05	3.279LysArg: 3.279 ± 0.072	3.633LysSer: 3.633 ± 0.068	3.671LysThr: 3.671 ± 0.068	4.68LysVal: 4.68 ± 0.078	0.661LysTrp: 0.661 ± 0.033	3.027LysTyr: 3.027 ± 0.072	0.0LysXaa: 0.0 ± 0.0
Leu	6.481LeuAla: 6.481 ± 0.089	1.389LeuCys: 1.389 ± 0.05	4.941LeuAsp: 4.941 ± 0.083	6.434LeuGlu: 6.434 ± 0.104	3.537LeuPhe: 3.537 ± 0.087	5.783LeuGly: 5.783 ± 0.102	1.521LeuHis: 1.521 ± 0.044	5.889LeuIle: 5.889 ± 0.095	6.57LeuLys: 6.57 ± 0.108	8.504LeuLeu: 8.504 ± 0.144	2.64LeuMet: 2.64 ± 0.063	3.753LeuAsn: 3.753 ± 0.072	3.318LeuPro: 3.318 ± 0.071	2.97LeuGln: 2.97 ± 0.063	3.784LeuArg: 3.784 ± 0.086	5.749LeuSer: 5.749 ± 0.096	5.051LeuThr: 5.051 ± 0.087	5.347LeuVal: 5.347 ± 0.096	0.783LeuTrp: 0.783 ± 0.03	3.367LeuTyr: 3.367 ± 0.071	0.0LeuXaa: 0.0 ± 0.0
Met	2.293MetAla: 2.293 ± 0.059	0.33MetCys: 0.33 ± 0.021	1.797MetAsp: 1.797 ± 0.055	2.619MetGlu: 2.619 ± 0.061	0.979MetPhe: 0.979 ± 0.034	2.028MetGly: 2.028 ± 0.049	0.511MetHis: 0.511 ± 0.025	2.375MetIle: 2.375 ± 0.062	2.886MetLys: 2.886 ± 0.068	2.562MetLeu: 2.562 ± 0.057	0.954MetMet: 0.954 ± 0.036	1.593MetAsn: 1.593 ± 0.045	1.012MetPro: 1.012 ± 0.035	1.139MetGln: 1.139 ± 0.033	1.297MetArg: 1.297 ± 0.04	1.807MetSer: 1.807 ± 0.048	1.809MetThr: 1.809 ± 0.046	1.76MetVal: 1.76 ± 0.05	0.271MetTrp: 0.271 ± 0.017	0.965MetTyr: 0.965 ± 0.033	0.0MetXaa: 0.0 ± 0.0
Asn	3.228AsnAla: 3.228 ± 0.074	0.572AsnCys: 0.572 ± 0.027	2.054AsnAsp: 2.054 ± 0.058	2.926AsnGlu: 2.926 ± 0.064	1.461AsnPhe: 1.461 ± 0.043	3.857AsnGly: 3.857 ± 0.1	0.827AsnHis: 0.827 ± 0.034	3.049AsnIle: 3.049 ± 0.067	2.562AsnLys: 2.562 ± 0.067	3.703AsnLeu: 3.703 ± 0.076	1.29AsnMet: 1.29 ± 0.04	1.67AsnAsn: 1.67 ± 0.069	2.013AsnPro: 2.013 ± 0.051	1.475AsnGln: 1.475 ± 0.052	2.192AsnArg: 2.192 ± 0.053	2.198AsnSer: 2.198 ± 0.061	2.345AsnThr: 2.345 ± 0.061	2.966AsnVal: 2.966 ± 0.069	0.441AsnTrp: 0.441 ± 0.025	1.771AsnTyr: 1.771 ± 0.049	0.0AsnXaa: 0.0 ± 0.0
Pro	2.413ProAla: 2.413 ± 0.076	0.39ProCys: 0.39 ± 0.021	2.262ProAsp: 2.262 ± 0.054	3.286ProGlu: 3.286 ± 0.063	1.44ProPhe: 1.44 ± 0.046	2.379ProGly: 2.379 ± 0.066	0.529ProHis: 0.529 ± 0.027	1.799ProIle: 1.799 ± 0.05	1.926ProLys: 1.926 ± 0.044	2.6ProLeu: 2.6 ± 0.07	0.853ProMet: 0.853 ± 0.029	1.084ProAsn: 1.084 ± 0.039	0.657ProPro: 0.657 ± 0.031	0.988ProGln: 0.988 ± 0.031	0.948ProArg: 0.948 ± 0.034	1.726ProSer: 1.726 ± 0.047	1.561ProThr: 1.561 ± 0.052	3.073ProVal: 3.073 ± 0.071	0.268ProTrp: 0.268 ± 0.021	1.394ProTyr: 1.394 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	2.369GlnAla: 2.369 ± 0.058	0.377GlnCys: 0.377 ± 0.021	1.556GlnAsp: 1.556 ± 0.047	2.803GlnGlu: 2.803 ± 0.07	1.22GlnPhe: 1.22 ± 0.038	1.996GlnGly: 1.996 ± 0.047	0.456GlnHis: 0.456 ± 0.023	2.807GlnIle: 2.807 ± 0.056	2.932GlnLys: 2.932 ± 0.067	2.742GlnLeu: 2.742 ± 0.069	1.284GlnMet: 1.284 ± 0.042	1.688GlnAsn: 1.688 ± 0.05	0.88GlnPro: 0.88 ± 0.036	1.234GlnGln: 1.234 ± 0.045	1.511GlnArg: 1.511 ± 0.053	1.738GlnSer: 1.738 ± 0.045	1.779GlnThr: 1.779 ± 0.061	2.042GlnVal: 2.042 ± 0.056	0.303GlnTrp: 0.303 ± 0.023	1.352GlnTyr: 1.352 ± 0.044	0.0GlnXaa: 0.0 ± 0.0
Arg	2.534ArgAla: 2.534 ± 0.063	0.564ArgCys: 0.564 ± 0.028	2.132ArgAsp: 2.132 ± 0.063	3.926ArgGlu: 3.926 ± 0.093	1.884ArgPhe: 1.884 ± 0.047	2.509ArgGly: 2.509 ± 0.063	0.82ArgHis: 0.82 ± 0.035	3.608ArgIle: 3.608 ± 0.071	3.949ArgLys: 3.949 ± 0.076	4.067ArgLeu: 4.067 ± 0.08	1.672ArgMet: 1.672 ± 0.049	2.083ArgAsn: 2.083 ± 0.051	1.334ArgPro: 1.334 ± 0.049	1.882ArgGln: 1.882 ± 0.052	2.499ArgArg: 2.499 ± 0.07	2.274ArgSer: 2.274 ± 0.06	2.468ArgThr: 2.468 ± 0.059	2.695ArgVal: 2.695 ± 0.061	0.395ArgTrp: 0.395 ± 0.023	1.941ArgTyr: 1.941 ± 0.053	0.0ArgXaa: 0.0 ± 0.0
Ser	4.171SerAla: 4.171 ± 0.081	0.727SerCys: 0.727 ± 0.033	3.453SerAsp: 3.453 ± 0.086	4.296SerGlu: 4.296 ± 0.075	2.428SerPhe: 2.428 ± 0.056	5.274SerGly: 5.274 ± 0.091	1.07SerHis: 1.07 ± 0.039	3.756SerIle: 3.756 ± 0.079	3.359SerLys: 3.359 ± 0.072	4.909SerLeu: 4.909 ± 0.086	1.728SerMet: 1.728 ± 0.054	2.147SerAsn: 2.147 ± 0.063	1.667SerPro: 1.667 ± 0.045	1.763SerGln: 1.763 ± 0.048	2.704SerArg: 2.704 ± 0.067	3.596SerSer: 3.596 ± 0.094	2.8SerThr: 2.8 ± 0.076	4.478SerVal: 4.478 ± 0.083	0.584SerTrp: 0.584 ± 0.028	2.439SerTyr: 2.439 ± 0.071	0.0SerXaa: 0.0 ± 0.0
Thr	4.506ThrAla: 4.506 ± 0.112	0.558ThrCys: 0.558 ± 0.027	3.463ThrAsp: 3.463 ± 0.095	4.457ThrGlu: 4.457 ± 0.085	2.133ThrPhe: 2.133 ± 0.059	4.921ThrGly: 4.921 ± 0.098	0.889ThrHis: 0.889 ± 0.037	3.689ThrIle: 3.689 ± 0.072	3.322ThrLys: 3.322 ± 0.069	4.714ThrLeu: 4.714 ± 0.094	1.485ThrMet: 1.485 ± 0.036	1.997ThrAsn: 1.997 ± 0.066	1.944ThrPro: 1.944 ± 0.053	1.494ThrGln: 1.494 ± 0.048	1.981ThrArg: 1.981 ± 0.059	3.013ThrSer: 3.013 ± 0.085	2.991ThrThr: 2.991 ± 0.096	4.692ThrVal: 4.692 ± 0.106	0.487ThrTrp: 0.487 ± 0.032	2.321ThrTyr: 2.321 ± 0.102	0.0ThrXaa: 0.0 ± 0.0
Val	4.723ValAla: 4.723 ± 0.087	1.18ValCys: 1.18 ± 0.043	3.887ValAsp: 3.887 ± 0.079	4.809ValGlu: 4.809 ± 0.086	2.871ValPhe: 2.871 ± 0.065	4.295ValGly: 4.295 ± 0.093	1.099ValHis: 1.099 ± 0.029	5.157ValIle: 5.157 ± 0.089	4.713ValLys: 4.713 ± 0.081	6.657ValLeu: 6.657 ± 0.103	2.019ValMet: 2.019 ± 0.057	2.838ValAsn: 2.838 ± 0.066	2.523ValPro: 2.523 ± 0.058	2.069ValGln: 2.069 ± 0.051	3.108ValArg: 3.108 ± 0.07	4.658ValSer: 4.658 ± 0.087	4.447ValThr: 4.447 ± 0.11	4.819ValVal: 4.819 ± 0.087	0.649ValTrp: 0.649 ± 0.03	2.704ValTyr: 2.704 ± 0.062	0.0ValXaa: 0.0 ± 0.0
Trp	0.503TrpAla: 0.503 ± 0.028	0.15TrpCys: 0.15 ± 0.015	0.529TrpAsp: 0.529 ± 0.032	0.613TrpGlu: 0.613 ± 0.027	0.406TrpPhe: 0.406 ± 0.025	0.631TrpGly: 0.631 ± 0.029	0.181TrpHis: 0.181 ± 0.015	0.738TrpIle: 0.738 ± 0.032	0.825TrpLys: 0.825 ± 0.036	0.823TrpLeu: 0.823 ± 0.036	0.357TrpMet: 0.357 ± 0.023	0.541TrpAsn: 0.541 ± 0.033	0.165TrpPro: 0.165 ± 0.017	0.411TrpGln: 0.411 ± 0.021	0.352TrpArg: 0.352 ± 0.022	0.518TrpSer: 0.518 ± 0.032	0.437TrpThr: 0.437 ± 0.026	0.498TrpVal: 0.498 ± 0.023	0.091TrpTrp: 0.091 ± 0.011	0.432TrpTyr: 0.432 ± 0.032	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.711TyrAla: 2.711 ± 0.061	0.606TyrCys: 0.606 ± 0.028	2.745TyrAsp: 2.745 ± 0.125	3.242TyrGlu: 3.242 ± 0.073	1.829TyrPhe: 1.829 ± 0.049	3.02TyrGly: 3.02 ± 0.068	0.843TyrHis: 0.843 ± 0.031	2.681TyrIle: 2.681 ± 0.067	2.348TyrLys: 2.348 ± 0.061	3.69TyrLeu: 3.69 ± 0.082	1.053TyrMet: 1.053 ± 0.038	1.712TyrAsn: 1.712 ± 0.055	1.381TyrPro: 1.381 ± 0.047	1.615TyrGln: 1.615 ± 0.054	2.085TyrArg: 2.085 ± 0.051	2.355TyrSer: 2.355 ± 0.061	2.47TyrThr: 2.47 ± 0.087	2.626TyrVal: 2.626 ± 0.06	0.355TyrTrp: 0.355 ± 0.023	1.917TyrTyr: 1.917 ± 0.078	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2706 proteins (800791 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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