Amino acid dipepetide frequency for Candidatus Izimaplasma sp. HR2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.001AlaAla: 3.001 ± 0.106	0.51AlaCys: 0.51 ± 0.032	2.448AlaAsp: 2.448 ± 0.067	2.834AlaGlu: 2.834 ± 0.102	2.551AlaPhe: 2.551 ± 0.068	3.381AlaGly: 3.381 ± 0.102	0.838AlaHis: 0.838 ± 0.04	5.301AlaIle: 5.301 ± 0.108	3.82AlaLys: 3.82 ± 0.097	5.43AlaLeu: 5.43 ± 0.112	1.363AlaMet: 1.363 ± 0.057	2.44AlaAsn: 2.44 ± 0.074	1.257AlaPro: 1.257 ± 0.046	1.291AlaGln: 1.291 ± 0.048	1.826AlaArg: 1.826 ± 0.057	3.29AlaSer: 3.29 ± 0.081	2.826AlaThr: 2.826 ± 0.08	3.455AlaVal: 3.455 ± 0.087	0.361AlaTrp: 0.361 ± 0.025	2.166AlaTyr: 2.166 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	0.41CysAla: 0.41 ± 0.029	0.098CysCys: 0.098 ± 0.013	0.636CysAsp: 0.636 ± 0.041	0.596CysGlu: 0.596 ± 0.033	0.325CysPhe: 0.325 ± 0.025	0.71CysGly: 0.71 ± 0.037	0.183CysHis: 0.183 ± 0.018	0.648CysIle: 0.648 ± 0.035	0.614CysLys: 0.614 ± 0.032	0.572CysLeu: 0.572 ± 0.033	0.156CysMet: 0.156 ± 0.016	0.568CysAsn: 0.568 ± 0.038	0.542CysPro: 0.542 ± 0.057	0.188CysGln: 0.188 ± 0.023	0.271CysArg: 0.271 ± 0.02	0.553CysSer: 0.553 ± 0.036	0.492CysThr: 0.492 ± 0.037	0.465CysVal: 0.465 ± 0.033	0.056CysTrp: 0.056 ± 0.009	0.29CysTyr: 0.29 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	3.003AspAla: 3.003 ± 0.084	0.51AspCys: 0.51 ± 0.04	3.517AspAsp: 3.517 ± 0.089	4.575AspGlu: 4.575 ± 0.086	3.376AspPhe: 3.376 ± 0.084	3.628AspGly: 3.628 ± 0.102	0.893AspHis: 0.893 ± 0.032	6.751AspIle: 6.751 ± 0.124	4.747AspLys: 4.747 ± 0.096	5.972AspLeu: 5.972 ± 0.109	1.502AspMet: 1.502 ± 0.052	3.54AspAsn: 3.54 ± 0.081	1.545AspPro: 1.545 ± 0.056	1.212AspGln: 1.212 ± 0.044	1.813AspArg: 1.813 ± 0.053	3.716AspSer: 3.716 ± 0.091	3.192AspThr: 3.192 ± 0.092	4.051AspVal: 4.051 ± 0.09	0.491AspTrp: 0.491 ± 0.034	3.448AspTyr: 3.448 ± 0.082	0.002AspXaa: 0.002 ± 0.002
Glu	3.645GluAla: 3.645 ± 0.089	0.523GluCys: 0.523 ± 0.031	4.322GluAsp: 4.322 ± 0.089	5.725GluGlu: 5.725 ± 0.107	3.644GluPhe: 3.644 ± 0.086	3.695GluGly: 3.695 ± 0.085	0.981GluHis: 0.981 ± 0.042	7.092GluIle: 7.092 ± 0.117	5.71GluLys: 5.71 ± 0.113	7.309GluLeu: 7.309 ± 0.116	2.137GluMet: 2.137 ± 0.058	4.136GluAsn: 4.136 ± 0.088	1.335GluPro: 1.335 ± 0.054	1.736GluGln: 1.736 ± 0.055	2.443GluArg: 2.443 ± 0.067	3.649GluSer: 3.649 ± 0.074	3.623GluThr: 3.623 ± 0.081	5.165GluVal: 5.165 ± 0.094	0.489GluTrp: 0.489 ± 0.028	3.822GluTyr: 3.822 ± 0.084	0.002GluXaa: 0.002 ± 0.002
Phe	2.316PheAla: 2.316 ± 0.071	0.353PheCys: 0.353 ± 0.026	3.501PheAsp: 3.501 ± 0.073	3.484PheGlu: 3.484 ± 0.086	2.167PhePhe: 2.167 ± 0.08	3.11PheGly: 3.11 ± 0.083	0.67PheHis: 0.67 ± 0.028	4.862PheIle: 4.862 ± 0.099	3.74PheLys: 3.74 ± 0.091	4.319PheLeu: 4.319 ± 0.105	1.276PheMet: 1.276 ± 0.045	3.203PheAsn: 3.203 ± 0.081	1.268PhePro: 1.268 ± 0.045	0.963PheGln: 0.963 ± 0.044	1.526PheArg: 1.526 ± 0.057	3.435PheSer: 3.435 ± 0.078	3.006PheThr: 3.006 ± 0.08	3.182PheVal: 3.182 ± 0.082	0.329PheTrp: 0.329 ± 0.024	2.188PheTyr: 2.188 ± 0.068	0.002PheXaa: 0.002 ± 0.002
Gly	3.463GlyAla: 3.463 ± 0.103	0.652GlyCys: 0.652 ± 0.036	3.527GlyAsp: 3.527 ± 0.092	3.678GlyGlu: 3.678 ± 0.074	3.245GlyPhe: 3.245 ± 0.085	3.899GlyGly: 3.899 ± 0.106	1.154GlyHis: 1.154 ± 0.047	6.278GlyIle: 6.278 ± 0.107	4.534GlyLys: 4.534 ± 0.095	5.665GlyLeu: 5.665 ± 0.12	1.723GlyMet: 1.723 ± 0.056	3.11GlyAsn: 3.11 ± 0.079	1.212GlyPro: 1.212 ± 0.055	1.292GlyGln: 1.292 ± 0.046	2.023GlyArg: 2.023 ± 0.08	3.604GlySer: 3.604 ± 0.08	3.629GlyThr: 3.629 ± 0.108	4.603GlyVal: 4.603 ± 0.115	0.5GlyTrp: 0.5 ± 0.034	3.272GlyTyr: 3.272 ± 0.093	0.003GlyXaa: 0.003 ± 0.002
His	0.786HisAla: 0.786 ± 0.037	0.188HisCys: 0.188 ± 0.016	0.891HisAsp: 0.891 ± 0.039	1.092HisGlu: 1.092 ± 0.044	0.778HisPhe: 0.778 ± 0.036	1.015HisGly: 1.015 ± 0.043	0.374HisHis: 0.374 ± 0.028	1.552HisIle: 1.552 ± 0.046	1.258HisLys: 1.258 ± 0.05	1.573HisLeu: 1.573 ± 0.054	0.404HisMet: 0.404 ± 0.026	1.034HisAsn: 1.034 ± 0.041	0.696HisPro: 0.696 ± 0.032	0.433HisGln: 0.433 ± 0.023	0.572HisArg: 0.572 ± 0.029	1.063HisSer: 1.063 ± 0.041	0.827HisThr: 0.827 ± 0.045	0.988HisVal: 0.988 ± 0.038	0.083HisTrp: 0.083 ± 0.01	0.757HisTyr: 0.757 ± 0.035	0.0HisXaa: 0.0 ± 0.0
Ile	5.266IleAla: 5.266 ± 0.12	0.758IleCys: 0.758 ± 0.042	6.651IleAsp: 6.651 ± 0.126	7.2IleGlu: 7.2 ± 0.129	4.546IlePhe: 4.546 ± 0.098	6.143IleGly: 6.143 ± 0.135	1.505IleHis: 1.505 ± 0.058	9.713IleIle: 9.713 ± 0.158	7.878IleLys: 7.878 ± 0.14	8.727IleLeu: 8.727 ± 0.148	2.275IleMet: 2.275 ± 0.065	6.259IleAsn: 6.259 ± 0.12	3.115IlePro: 3.115 ± 0.07	2.217IleGln: 2.217 ± 0.054	2.838IleArg: 2.838 ± 0.076	6.658IleSer: 6.658 ± 0.136	5.545IleThr: 5.545 ± 0.126	6.376IleVal: 6.376 ± 0.111	0.518IleTrp: 0.518 ± 0.024	4.223IleTyr: 4.223 ± 0.093	0.002IleXaa: 0.002 ± 0.002
Lys	3.742LysAla: 3.742 ± 0.09	0.699LysCys: 0.699 ± 0.054	5.245LysAsp: 5.245 ± 0.108	7.671LysGlu: 7.671 ± 0.132	3.16LysPhe: 3.16 ± 0.08	4.131LysGly: 4.131 ± 0.09	1.43LysHis: 1.43 ± 0.058	7.11LysIle: 7.11 ± 0.13	7.313LysLys: 7.313 ± 0.143	7.094LysLeu: 7.094 ± 0.113	2.475LysMet: 2.475 ± 0.072	4.792LysAsn: 4.792 ± 0.098	1.815LysPro: 1.815 ± 0.057	2.227LysGln: 2.227 ± 0.066	3.325LysArg: 3.325 ± 0.081	4.465LysSer: 4.465 ± 0.101	4.053LysThr: 4.053 ± 0.081	5.258LysVal: 5.258 ± 0.109	0.561LysTrp: 0.561 ± 0.034	4.208LysTyr: 4.208 ± 0.088	0.0LysXaa: 0.0 ± 0.0
Leu	4.771LeuAla: 4.771 ± 0.112	0.633LeuCys: 0.633 ± 0.035	6.055LeuAsp: 6.055 ± 0.118	6.756LeuGlu: 6.756 ± 0.13	4.817LeuPhe: 4.817 ± 0.114	6.101LeuGly: 6.101 ± 0.104	1.416LeuHis: 1.416 ± 0.047	8.687LeuIle: 8.687 ± 0.159	7.403LeuLys: 7.403 ± 0.14	9.021LeuLeu: 9.021 ± 0.185	2.228LeuMet: 2.228 ± 0.066	5.619LeuAsn: 5.619 ± 0.131	2.696LeuPro: 2.696 ± 0.073	1.937LeuGln: 1.937 ± 0.058	3.245LeuArg: 3.245 ± 0.077	6.752LeuSer: 6.752 ± 0.109	5.114LeuThr: 5.114 ± 0.106	6.321LeuVal: 6.321 ± 0.103	0.572LeuTrp: 0.572 ± 0.032	3.843LeuTyr: 3.843 ± 0.082	0.002LeuXaa: 0.002 ± 0.002
Met	1.484MetAla: 1.484 ± 0.053	0.184MetCys: 0.184 ± 0.018	1.473MetAsp: 1.473 ± 0.051	1.555MetGlu: 1.555 ± 0.054	1.358MetPhe: 1.358 ± 0.053	1.542MetGly: 1.542 ± 0.057	0.39MetHis: 0.39 ± 0.03	2.552MetIle: 2.552 ± 0.068	2.464MetLys: 2.464 ± 0.055	2.113MetLeu: 2.113 ± 0.061	0.71MetMet: 0.71 ± 0.037	1.627MetAsn: 1.627 ± 0.049	0.786MetPro: 0.786 ± 0.035	0.508MetGln: 0.508 ± 0.032	0.914MetArg: 0.914 ± 0.034	1.768MetSer: 1.768 ± 0.051	1.351MetThr: 1.351 ± 0.054	1.488MetVal: 1.488 ± 0.046	0.141MetTrp: 0.141 ± 0.015	1.064MetTyr: 1.064 ± 0.043	0.002MetXaa: 0.002 ± 0.001
Asn	2.663AsnAla: 2.663 ± 0.08	0.455AsnCys: 0.455 ± 0.026	3.548AsnAsp: 3.548 ± 0.074	4.261AsnGlu: 4.261 ± 0.099	2.475AsnPhe: 2.475 ± 0.069	3.355AsnGly: 3.355 ± 0.091	1.037AsnHis: 1.037 ± 0.048	6.161AsnIle: 6.161 ± 0.121	5.324AsnLys: 5.324 ± 0.099	5.257AsnLeu: 5.257 ± 0.121	1.416AsnMet: 1.416 ± 0.042	4.13AsnAsn: 4.13 ± 0.115	2.001AsnPro: 2.001 ± 0.055	1.632AsnGln: 1.632 ± 0.062	2.068AsnArg: 2.068 ± 0.065	3.653AsnSer: 3.653 ± 0.083	3.15AsnThr: 3.15 ± 0.082	3.673AsnVal: 3.673 ± 0.082	0.452AsnTrp: 0.452 ± 0.027	2.85AsnTyr: 2.85 ± 0.071	0.0AsnXaa: 0.0 ± 0.0
Pro	1.198ProAla: 1.198 ± 0.054	0.199ProCys: 0.199 ± 0.018	1.454ProAsp: 1.454 ± 0.047	1.994ProGlu: 1.994 ± 0.06	1.446ProPhe: 1.446 ± 0.046	1.616ProGly: 1.616 ± 0.057	0.537ProHis: 0.537 ± 0.026	2.611ProIle: 2.611 ± 0.07	2.116ProLys: 2.116 ± 0.067	2.543ProLeu: 2.543 ± 0.07	0.612ProMet: 0.612 ± 0.029	1.592ProAsn: 1.592 ± 0.05	0.548ProPro: 0.548 ± 0.028	0.603ProGln: 0.603 ± 0.032	0.874ProArg: 0.874 ± 0.041	1.858ProSer: 1.858 ± 0.062	1.669ProThr: 1.669 ± 0.057	1.887ProVal: 1.887 ± 0.058	0.194ProTrp: 0.194 ± 0.019	1.34ProTyr: 1.34 ± 0.048	0.003ProXaa: 0.003 ± 0.002
Gln	1.427GlnAla: 1.427 ± 0.056	0.186GlnCys: 0.186 ± 0.021	1.295GlnAsp: 1.295 ± 0.046	1.711GlnGlu: 1.711 ± 0.06	1.143GlnPhe: 1.143 ± 0.041	1.374GlnGly: 1.374 ± 0.055	0.34GlnHis: 0.34 ± 0.023	2.23GlnIle: 2.23 ± 0.059	1.797GlnLys: 1.797 ± 0.059	2.159GlnLeu: 2.159 ± 0.06	0.608GlnMet: 0.608 ± 0.036	1.323GlnAsn: 1.323 ± 0.044	0.484GlnPro: 0.484 ± 0.027	0.616GlnGln: 0.616 ± 0.041	0.935GlnArg: 0.935 ± 0.046	1.356GlnSer: 1.356 ± 0.045	1.17GlnThr: 1.17 ± 0.048	1.675GlnVal: 1.675 ± 0.056	0.181GlnTrp: 0.181 ± 0.016	1.116GlnTyr: 1.116 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	1.576ArgAla: 1.576 ± 0.05	0.369ArgCys: 0.369 ± 0.042	2.11ArgAsp: 2.11 ± 0.064	2.432ArgGlu: 2.432 ± 0.071	1.642ArgPhe: 1.642 ± 0.053	1.937ArgGly: 1.937 ± 0.054	0.616ArgHis: 0.616 ± 0.029	3.245ArgIle: 3.245 ± 0.075	3.08ArgLys: 3.08 ± 0.082	3.129ArgLeu: 3.129 ± 0.073	0.939ArgMet: 0.939 ± 0.044	2.063ArgAsn: 2.063 ± 0.062	0.858ArgPro: 0.858 ± 0.041	0.882ArgGln: 0.882 ± 0.043	1.478ArgArg: 1.478 ± 0.057	1.787ArgSer: 1.787 ± 0.058	1.834ArgThr: 1.834 ± 0.062	2.297ArgVal: 2.297 ± 0.057	0.256ArgTrp: 0.256 ± 0.019	1.616ArgTyr: 1.616 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	2.868SerAla: 2.868 ± 0.084	0.515SerCys: 0.515 ± 0.033	3.649SerAsp: 3.649 ± 0.075	4.082SerGlu: 4.082 ± 0.082	3.365SerPhe: 3.365 ± 0.084	4.292SerGly: 4.292 ± 0.098	1.077SerHis: 1.077 ± 0.043	6.295SerIle: 6.295 ± 0.123	5.268SerLys: 5.268 ± 0.1	6.145SerLeu: 6.145 ± 0.12	1.528SerMet: 1.528 ± 0.053	3.932SerAsn: 3.932 ± 0.095	1.48SerPro: 1.48 ± 0.045	1.385SerGln: 1.385 ± 0.043	2.27SerArg: 2.27 ± 0.067	4.203SerSer: 4.203 ± 0.115	3.439SerThr: 3.439 ± 0.098	4.192SerVal: 4.192 ± 0.078	0.483SerTrp: 0.483 ± 0.028	2.839SerTyr: 2.839 ± 0.061	0.002SerXaa: 0.002 ± 0.002
Thr	2.77ThrAla: 2.77 ± 0.072	0.491ThrCys: 0.491 ± 0.058	3.142ThrAsp: 3.142 ± 0.087	3.359ThrGlu: 3.359 ± 0.067	2.666ThrPhe: 2.666 ± 0.069	3.785ThrGly: 3.785 ± 0.102	1.01ThrHis: 1.01 ± 0.041	5.388ThrIle: 5.388 ± 0.115	4.351ThrLys: 4.351 ± 0.102	5.326ThrLeu: 5.326 ± 0.122	1.212ThrMet: 1.212 ± 0.037	3.064ThrAsn: 3.064 ± 0.092	1.908ThrPro: 1.908 ± 0.06	1.207ThrGln: 1.207 ± 0.047	1.72ThrArg: 1.72 ± 0.054	3.49ThrSer: 3.49 ± 0.115	3.185ThrThr: 3.185 ± 0.111	4.013ThrVal: 4.013 ± 0.114	0.399ThrTrp: 0.399 ± 0.029	2.578ThrTyr: 2.578 ± 0.077	0.002ThrXaa: 0.002 ± 0.001
Val	3.66ValAla: 3.66 ± 0.09	0.609ValCys: 0.609 ± 0.036	4.235ValAsp: 4.235 ± 0.097	4.474ValGlu: 4.474 ± 0.091	3.448ValPhe: 3.448 ± 0.099	4.09ValGly: 4.09 ± 0.104	0.981ValHis: 0.981 ± 0.049	6.884ValIle: 6.884 ± 0.11	5.116ValLys: 5.116 ± 0.097	6.395ValLeu: 6.395 ± 0.121	1.672ValMet: 1.672 ± 0.052	3.711ValAsn: 3.711 ± 0.089	1.824ValPro: 1.824 ± 0.054	1.302ValGln: 1.302 ± 0.046	2.142ValArg: 2.142 ± 0.069	4.388ValSer: 4.388 ± 0.09	4.059ValThr: 4.059 ± 0.099	5.018ValVal: 5.018 ± 0.115	0.447ValTrp: 0.447 ± 0.028	2.85ValTyr: 2.85 ± 0.075	0.006ValXaa: 0.006 ± 0.003
Trp	0.343TrpAla: 0.343 ± 0.026	0.067TrpCys: 0.067 ± 0.01	0.527TrpAsp: 0.527 ± 0.039	0.447TrpGlu: 0.447 ± 0.022	0.335TrpPhe: 0.335 ± 0.026	0.5TrpGly: 0.5 ± 0.039	0.138TrpHis: 0.138 ± 0.017	0.667TrpIle: 0.667 ± 0.032	0.438TrpLys: 0.438 ± 0.026	0.561TrpLeu: 0.561 ± 0.027	0.22TrpMet: 0.22 ± 0.02	0.457TrpAsn: 0.457 ± 0.029	0.183TrpPro: 0.183 ± 0.018	0.191TrpGln: 0.191 ± 0.017	0.231TrpArg: 0.231 ± 0.017	0.382TrpSer: 0.382 ± 0.023	0.372TrpThr: 0.372 ± 0.028	0.438TrpVal: 0.438 ± 0.025	0.106TrpTrp: 0.106 ± 0.015	0.325TrpTyr: 0.325 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.993TyrAla: 1.993 ± 0.068	0.375TyrCys: 0.375 ± 0.026	3.253TyrAsp: 3.253 ± 0.102	3.259TyrGlu: 3.259 ± 0.083	2.413TyrPhe: 2.413 ± 0.066	2.761TyrGly: 2.761 ± 0.071	0.792TyrHis: 0.792 ± 0.039	4.386TyrIle: 4.386 ± 0.1	3.799TyrLys: 3.799 ± 0.092	4.676TyrLeu: 4.676 ± 0.089	1.016TyrMet: 1.016 ± 0.04	2.961TyrAsn: 2.961 ± 0.072	1.342TyrPro: 1.342 ± 0.045	1.303TyrGln: 1.303 ± 0.046	1.632TyrArg: 1.632 ± 0.055	3.233TyrSer: 3.233 ± 0.067	2.527TyrThr: 2.527 ± 0.068	2.769TyrVal: 2.769 ± 0.066	0.308TyrTrp: 0.308 ± 0.023	2.361TyrTyr: 2.361 ± 0.072	0.002TyrXaa: 0.002 ± 0.002
Xaa	0.003XaaAla: 0.003 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.002XaaAsp: 0.002 ± 0.002	0.0XaaGlu: 0.0 ± 0.0	0.002XaaPhe: 0.002 ± 0.001	0.002XaaGly: 0.002 ± 0.002	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.003XaaLys: 0.003 ± 0.002	0.005XaaLeu: 0.005 ± 0.003	0.002XaaMet: 0.002 ± 0.002	0.002XaaAsn: 0.002 ± 0.001	0.0XaaPro: 0.0 ± 0.0	0.002XaaGln: 0.002 ± 0.002	0.0XaaArg: 0.0 ± 0.0	0.003XaaSer: 0.003 ± 0.002	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.003XaaTyr: 0.003 ± 0.002	0.077XaaXaa: 0.077 ± 0.032

Statistics based on 2222 proteins (623788 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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