Amino acid dipepetide frequency for Vitrella brassicaformis (strain CCMP3155)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.738AlaAla: 14.738 ± 0.071	1.338AlaCys: 1.338 ± 0.013	5.607AlaAsp: 5.607 ± 0.024	5.488AlaGlu: 5.488 ± 0.024	3.188AlaPhe: 3.188 ± 0.017	6.491AlaGly: 6.491 ± 0.029	2.286AlaHis: 2.286 ± 0.015	3.73AlaIle: 3.73 ± 0.021	3.893AlaLys: 3.893 ± 0.025	8.211AlaLeu: 8.211 ± 0.035	2.352AlaMet: 2.352 ± 0.015	2.402AlaAsn: 2.402 ± 0.016	5.904AlaPro: 5.904 ± 0.035	3.213AlaGln: 3.213 ± 0.02	5.18AlaArg: 5.18 ± 0.023	7.567AlaSer: 7.567 ± 0.035	5.212AlaThr: 5.212 ± 0.027	6.44AlaVal: 6.44 ± 0.031	0.948AlaTrp: 0.948 ± 0.009	1.835AlaTyr: 1.835 ± 0.013	0.001AlaXaa: 0.001 ± 0.0
Cys	1.248CysAla: 1.248 ± 0.011	0.478CysCys: 0.478 ± 0.008	0.918CysAsp: 0.918 ± 0.011	0.99CysGlu: 0.99 ± 0.009	0.634CysPhe: 0.634 ± 0.007	1.427CysGly: 1.427 ± 0.015	0.466CysHis: 0.466 ± 0.006	0.697CysIle: 0.697 ± 0.009	0.588CysLys: 0.588 ± 0.008	1.656CysLeu: 1.656 ± 0.013	0.337CysMet: 0.337 ± 0.006	0.422CysAsn: 0.422 ± 0.007	1.123CysPro: 1.123 ± 0.021	0.632CysGln: 0.632 ± 0.008	1.353CysArg: 1.353 ± 0.013	1.144CysSer: 1.144 ± 0.011	0.819CysThr: 0.819 ± 0.01	1.415CysVal: 1.415 ± 0.012	0.276CysTrp: 0.276 ± 0.005	0.391CysTyr: 0.391 ± 0.006	0.0CysXaa: 0.0 ± 0.0
Asp	5.296AspAla: 5.296 ± 0.021	0.819AspCys: 0.819 ± 0.01	4.919AspAsp: 4.919 ± 0.033	4.979AspGlu: 4.979 ± 0.027	1.875AspPhe: 1.875 ± 0.015	5.508AspGly: 5.508 ± 0.031	1.412AspHis: 1.412 ± 0.011	2.499AspIle: 2.499 ± 0.016	2.69AspLys: 2.69 ± 0.019	4.616AspLeu: 4.616 ± 0.024	1.425AspMet: 1.425 ± 0.012	1.636AspAsn: 1.636 ± 0.012	3.08AspPro: 3.08 ± 0.018	1.971AspGln: 1.971 ± 0.012	3.772AspArg: 3.772 ± 0.022	3.617AspSer: 3.617 ± 0.016	3.273AspThr: 3.273 ± 0.019	4.072AspVal: 4.072 ± 0.02	0.758AspTrp: 0.758 ± 0.009	1.205AspTyr: 1.205 ± 0.011	0.0AspXaa: 0.0 ± 0.0
Glu	6.449GluAla: 6.449 ± 0.029	1.024GluCys: 1.024 ± 0.011	4.046GluAsp: 4.046 ± 0.022	6.135GluGlu: 6.135 ± 0.038	1.448GluPhe: 1.448 ± 0.012	6.215GluGly: 6.215 ± 0.028	1.405GluHis: 1.405 ± 0.012	2.123GluIle: 2.123 ± 0.017	2.932GluLys: 2.932 ± 0.023	5.05GluLeu: 5.05 ± 0.028	1.669GluMet: 1.669 ± 0.013	1.369GluAsn: 1.369 ± 0.012	2.807GluPro: 2.807 ± 0.018	2.788GluGln: 2.788 ± 0.019	5.021GluArg: 5.021 ± 0.027	3.744GluSer: 3.744 ± 0.019	2.957GluThr: 2.957 ± 0.02	3.957GluVal: 3.957 ± 0.021	1.055GluTrp: 1.055 ± 0.009	1.341GluTyr: 1.341 ± 0.012	0.0GluXaa: 0.0 ± 0.0
Phe	2.695PheAla: 2.695 ± 0.015	0.629PheCys: 0.629 ± 0.007	2.176PheAsp: 2.176 ± 0.015	1.773PheGlu: 1.773 ± 0.014	1.356PhePhe: 1.356 ± 0.013	2.338PheGly: 2.338 ± 0.014	0.86PheHis: 0.86 ± 0.008	1.478PheIle: 1.478 ± 0.012	1.157PheLys: 1.157 ± 0.01	3.027PheLeu: 3.027 ± 0.017	0.683PheMet: 0.683 ± 0.008	0.944PheAsn: 0.944 ± 0.009	1.874PhePro: 1.874 ± 0.016	1.066PheGln: 1.066 ± 0.01	1.972PheArg: 1.972 ± 0.014	2.268PheSer: 2.268 ± 0.016	1.72PheThr: 1.72 ± 0.012	2.364PheVal: 2.364 ± 0.015	0.472PheTrp: 0.472 ± 0.007	0.874PheTyr: 0.874 ± 0.009	0.0PheXaa: 0.0 ± 0.0
Gly	6.432GlyAla: 6.432 ± 0.029	1.284GlyCys: 1.284 ± 0.01	4.712GlyAsp: 4.712 ± 0.02	5.244GlyGlu: 5.244 ± 0.025	2.221GlyPhe: 2.221 ± 0.017	9.952GlyGly: 9.952 ± 0.065	2.003GlyHis: 2.003 ± 0.014	2.492GlyIle: 2.492 ± 0.017	3.133GlyLys: 3.133 ± 0.022	5.654GlyLeu: 5.654 ± 0.023	1.787GlyMet: 1.787 ± 0.014	1.928GlyAsn: 1.928 ± 0.015	3.743GlyPro: 3.743 ± 0.023	2.96GlyGln: 2.96 ± 0.017	5.732GlyArg: 5.732 ± 0.03	5.464GlySer: 5.464 ± 0.029	3.566GlyThr: 3.566 ± 0.022	5.273GlyVal: 5.273 ± 0.025	1.207GlyTrp: 1.207 ± 0.012	1.701GlyTyr: 1.701 ± 0.014	0.001GlyXaa: 0.001 ± 0.0
His	1.995HisAla: 1.995 ± 0.013	0.438HisCys: 0.438 ± 0.006	1.468HisAsp: 1.468 ± 0.012	1.484HisGlu: 1.484 ± 0.012	1.004HisPhe: 1.004 ± 0.009	1.965HisGly: 1.965 ± 0.015	1.383HisHis: 1.383 ± 0.017	1.109HisIle: 1.109 ± 0.011	1.025HisLys: 1.025 ± 0.011	2.575HisLeu: 2.575 ± 0.016	0.641HisMet: 0.641 ± 0.007	0.75HisAsn: 0.75 ± 0.008	2.259HisPro: 2.259 ± 0.018	1.488HisGln: 1.488 ± 0.013	2.151HisArg: 2.151 ± 0.018	1.852HisSer: 1.852 ± 0.014	1.792HisThr: 1.792 ± 0.014	1.635HisVal: 1.635 ± 0.011	0.372HisTrp: 0.372 ± 0.006	0.669HisTyr: 0.669 ± 0.008	0.0HisXaa: 0.0 ± 0.0
Ile	3.348IleAla: 3.348 ± 0.017	0.707IleCys: 0.707 ± 0.008	2.84IleAsp: 2.84 ± 0.019	2.484IleGlu: 2.484 ± 0.016	1.251IlePhe: 1.251 ± 0.01	2.512IleGly: 2.512 ± 0.017	1.046IleHis: 1.046 ± 0.011	1.481IleIle: 1.481 ± 0.014	1.749IleLys: 1.749 ± 0.014	3.035IleLeu: 3.035 ± 0.018	0.752IleMet: 0.752 ± 0.008	1.211IleAsn: 1.211 ± 0.01	2.189IlePro: 2.189 ± 0.015	1.447IleGln: 1.447 ± 0.012	2.54IleArg: 2.54 ± 0.015	2.474IleSer: 2.474 ± 0.016	1.974IleThr: 1.974 ± 0.013	2.451IleVal: 2.451 ± 0.014	0.462IleTrp: 0.462 ± 0.006	0.876IleTyr: 0.876 ± 0.009	0.0IleXaa: 0.0 ± 0.0
Lys	4.24LysAla: 4.24 ± 0.025	0.668LysCys: 0.668 ± 0.01	2.534LysAsp: 2.534 ± 0.021	3.234LysGlu: 3.234 ± 0.022	0.899LysPhe: 0.899 ± 0.01	3.314LysGly: 3.314 ± 0.023	1.019LysHis: 1.019 ± 0.01	1.449LysIle: 1.449 ± 0.015	2.927LysLys: 2.927 ± 0.03	3.188LysLeu: 3.188 ± 0.019	1.059LysMet: 1.059 ± 0.011	1.043LysAsn: 1.043 ± 0.01	2.07LysPro: 2.07 ± 0.016	1.827LysGln: 1.827 ± 0.013	3.465LysArg: 3.465 ± 0.02	2.329LysSer: 2.329 ± 0.017	2.426LysThr: 2.426 ± 0.016	2.39LysVal: 2.39 ± 0.015	0.627LysTrp: 0.627 ± 0.007	0.985LysTyr: 0.985 ± 0.011	0.0LysXaa: 0.0 ± 0.0
Leu	7.596LeuAla: 7.596 ± 0.028	1.707LeuCys: 1.707 ± 0.013	4.62LeuAsp: 4.62 ± 0.022	4.921LeuGlu: 4.921 ± 0.028	3.141LeuPhe: 3.141 ± 0.019	5.088LeuGly: 5.088 ± 0.022	2.509LeuHis: 2.509 ± 0.015	3.265LeuIle: 3.265 ± 0.02	3.854LeuLys: 3.854 ± 0.024	9.162LeuLeu: 9.162 ± 0.043	2.098LeuMet: 2.098 ± 0.011	2.282LeuAsn: 2.282 ± 0.015	6.522LeuPro: 6.522 ± 0.03	4.127LeuGln: 4.127 ± 0.022	6.464LeuArg: 6.464 ± 0.033	7.082LeuSer: 7.082 ± 0.031	5.359LeuThr: 5.359 ± 0.026	5.539LeuVal: 5.539 ± 0.023	1.219LeuTrp: 1.219 ± 0.011	2.005LeuTyr: 2.005 ± 0.015	0.0LeuXaa: 0.0 ± 0.0
Met	2.627MetAla: 2.627 ± 0.017	0.393MetCys: 0.393 ± 0.006	1.448MetAsp: 1.448 ± 0.012	1.49MetGlu: 1.49 ± 0.011	0.559MetPhe: 0.559 ± 0.007	1.686MetGly: 1.686 ± 0.015	0.556MetHis: 0.556 ± 0.008	0.719MetIle: 0.719 ± 0.007	0.97MetLys: 0.97 ± 0.01	1.89MetLeu: 1.89 ± 0.013	0.705MetMet: 0.705 ± 0.009	0.544MetAsn: 0.544 ± 0.007	1.502MetPro: 1.502 ± 0.014	1.058MetGln: 1.058 ± 0.009	1.715MetArg: 1.715 ± 0.011	1.706MetSer: 1.706 ± 0.011	1.346MetThr: 1.346 ± 0.011	1.425MetVal: 1.425 ± 0.011	0.328MetTrp: 0.328 ± 0.006	0.461MetTyr: 0.461 ± 0.007	0.0MetXaa: 0.0 ± 0.0
Asn	2.265AsnAla: 2.265 ± 0.014	0.403AsnCys: 0.403 ± 0.005	1.585AsnAsp: 1.585 ± 0.013	1.669AsnGlu: 1.669 ± 0.013	0.794AsnPhe: 0.794 ± 0.009	2.317AsnGly: 2.317 ± 0.018	0.657AsnHis: 0.657 ± 0.008	1.089AsnIle: 1.089 ± 0.01	1.214AsnLys: 1.214 ± 0.011	2.116AsnLeu: 2.116 ± 0.015	0.583AsnMet: 0.583 ± 0.007	0.972AsnAsn: 0.972 ± 0.012	1.504AsnPro: 1.504 ± 0.011	0.983AsnGln: 0.983 ± 0.009	1.706AsnArg: 1.706 ± 0.013	1.467AsnSer: 1.467 ± 0.012	1.565AsnThr: 1.565 ± 0.013	1.721AsnVal: 1.721 ± 0.014	0.317AsnTrp: 0.317 ± 0.005	0.588AsnTyr: 0.588 ± 0.008	0.0AsnXaa: 0.0 ± 0.0
Pro	6.584ProAla: 6.584 ± 0.036	0.905ProCys: 0.905 ± 0.013	3.231ProAsp: 3.231 ± 0.02	3.081ProGlu: 3.081 ± 0.019	2.302ProPhe: 2.302 ± 0.018	3.416ProGly: 3.416 ± 0.026	2.169ProHis: 2.169 ± 0.017	2.164ProIle: 2.164 ± 0.016	2.147ProLys: 2.147 ± 0.017	5.997ProLeu: 5.997 ± 0.027	1.282ProMet: 1.282 ± 0.013	1.557ProAsn: 1.557 ± 0.012	9.306ProPro: 9.306 ± 0.076	2.832ProGln: 2.832 ± 0.022	3.656ProArg: 3.656 ± 0.024	7.361ProSer: 7.361 ± 0.036	4.063ProThr: 4.063 ± 0.023	3.72ProVal: 3.72 ± 0.023	0.665ProTrp: 0.665 ± 0.008	1.324ProTyr: 1.324 ± 0.011	0.001ProXaa: 0.001 ± 0.0
Gln	3.428GlnAla: 3.428 ± 0.019	0.655GlnCys: 0.655 ± 0.008	1.937GlnAsp: 1.937 ± 0.013	2.797GlnGlu: 2.797 ± 0.018	0.96GlnPhe: 0.96 ± 0.011	2.662GlnGly: 2.662 ± 0.015	1.655GlnHis: 1.655 ± 0.013	1.314GlnIle: 1.314 ± 0.01	1.678GlnLys: 1.678 ± 0.015	4.4GlnLeu: 4.4 ± 0.026	1.06GlnMet: 1.06 ± 0.01	0.862GlnAsn: 0.862 ± 0.009	3.458GlnPro: 3.458 ± 0.024	4.981GlnGln: 4.981 ± 0.05	3.468GlnArg: 3.468 ± 0.019	2.458GlnSer: 2.458 ± 0.016	2.148GlnThr: 2.148 ± 0.014	2.132GlnVal: 2.132 ± 0.014	0.69GlnTrp: 0.69 ± 0.009	0.876GlnTyr: 0.876 ± 0.009	0.0GlnXaa: 0.0 ± 0.0
Arg	5.554ArgAla: 5.554 ± 0.026	1.209ArgCys: 1.209 ± 0.011	3.924ArgAsp: 3.924 ± 0.025	4.934ArgGlu: 4.934 ± 0.029	2.153ArgPhe: 2.153 ± 0.014	5.077ArgGly: 5.077 ± 0.027	2.291ArgHis: 2.291 ± 0.015	2.451ArgIle: 2.451 ± 0.014	2.988ArgLys: 2.988 ± 0.02	6.934ArgLeu: 6.934 ± 0.032	1.578ArgMet: 1.578 ± 0.011	1.62ArgAsn: 1.62 ± 0.012	4.514ArgPro: 4.514 ± 0.026	3.682ArgGln: 3.682 ± 0.023	7.042ArgArg: 7.042 ± 0.046	4.649ArgSer: 4.649 ± 0.029	3.193ArgThr: 3.193 ± 0.018	4.378ArgVal: 4.378 ± 0.021	1.04ArgTrp: 1.04 ± 0.01	1.525ArgTyr: 1.525 ± 0.012	0.0ArgXaa: 0.0 ± 0.0
Ser	7.05SerAla: 7.05 ± 0.03	1.273SerCys: 1.273 ± 0.013	3.993SerAsp: 3.993 ± 0.02	3.672SerGlu: 3.672 ± 0.019	2.582SerPhe: 2.582 ± 0.016	5.504SerGly: 5.504 ± 0.025	2.015SerHis: 2.015 ± 0.015	2.764SerIle: 2.764 ± 0.017	2.48SerLys: 2.48 ± 0.016	6.959SerLeu: 6.959 ± 0.032	1.531SerMet: 1.531 ± 0.011	1.751SerAsn: 1.751 ± 0.012	6.083SerPro: 6.083 ± 0.042	2.612SerGln: 2.612 ± 0.016	4.973SerArg: 4.973 ± 0.027	7.988SerSer: 7.988 ± 0.044	4.164SerThr: 4.164 ± 0.025	4.809SerVal: 4.809 ± 0.024	0.882SerTrp: 0.882 ± 0.009	1.462SerTyr: 1.462 ± 0.012	0.0SerXaa: 0.0 ± 0.0
Thr	5.796ThrAla: 5.796 ± 0.03	0.894ThrCys: 0.894 ± 0.011	3.259ThrAsp: 3.259 ± 0.017	2.99ThrGlu: 2.99 ± 0.016	1.822ThrPhe: 1.822 ± 0.013	3.574ThrGly: 3.574 ± 0.023	1.754ThrHis: 1.754 ± 0.013	2.268ThrIle: 2.268 ± 0.015	2.117ThrLys: 2.117 ± 0.016	4.741ThrLeu: 4.741 ± 0.02	1.162ThrMet: 1.162 ± 0.01	1.585ThrAsn: 1.585 ± 0.013	4.085ThrPro: 4.085 ± 0.024	2.176ThrGln: 2.176 ± 0.014	3.171ThrArg: 3.171 ± 0.018	4.323ThrSer: 4.323 ± 0.023	3.87ThrThr: 3.87 ± 0.035	3.556ThrVal: 3.556 ± 0.021	0.63ThrTrp: 0.63 ± 0.007	1.25ThrTyr: 1.25 ± 0.011	0.0ThrXaa: 0.0 ± 0.0
Val	5.977ValAla: 5.977 ± 0.026	1.429ValCys: 1.429 ± 0.012	4.098ValAsp: 4.098 ± 0.02	3.973ValGlu: 3.973 ± 0.02	2.255ValPhe: 2.255 ± 0.015	4.69ValGly: 4.69 ± 0.021	1.538ValHis: 1.538 ± 0.012	2.401ValIle: 2.401 ± 0.016	2.715ValLys: 2.715 ± 0.017	5.903ValLeu: 5.903 ± 0.022	1.562ValMet: 1.562 ± 0.012	1.645ValAsn: 1.645 ± 0.011	3.934ValPro: 3.934 ± 0.023	2.284ValGln: 2.284 ± 0.014	4.385ValArg: 4.385 ± 0.02	4.747ValSer: 4.747 ± 0.025	3.665ValThr: 3.665 ± 0.022	4.861ValVal: 4.861 ± 0.022	1.011ValTrp: 1.011 ± 0.01	1.514ValTyr: 1.514 ± 0.013	0.0ValXaa: 0.0 ± 0.0
Trp	1.018TrpAla: 1.018 ± 0.008	0.307TrpCys: 0.307 ± 0.005	0.737TrpAsp: 0.737 ± 0.008	0.795TrpGlu: 0.795 ± 0.009	0.412TrpPhe: 0.412 ± 0.006	1.0TrpGly: 1.0 ± 0.011	0.366TrpHis: 0.366 ± 0.006	0.487TrpIle: 0.487 ± 0.007	0.58TrpLys: 0.58 ± 0.008	1.409TrpLeu: 1.409 ± 0.011	0.394TrpMet: 0.394 ± 0.006	0.37TrpAsn: 0.37 ± 0.007	0.654TrpPro: 0.654 ± 0.007	0.605TrpGln: 0.605 ± 0.007	1.27TrpArg: 1.27 ± 0.012	0.951TrpSer: 0.951 ± 0.009	0.769TrpThr: 0.769 ± 0.009	0.888TrpVal: 0.888 ± 0.009	0.275TrpTrp: 0.275 ± 0.005	0.307TrpTyr: 0.307 ± 0.005	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.685TyrAla: 1.685 ± 0.013	0.454TyrCys: 0.454 ± 0.01	1.371TyrAsp: 1.371 ± 0.013	1.401TyrGlu: 1.401 ± 0.011	0.867TyrPhe: 0.867 ± 0.009	1.751TyrGly: 1.751 ± 0.014	0.665TyrHis: 0.665 ± 0.009	0.85TyrIle: 0.85 ± 0.008	0.858TyrLys: 0.858 ± 0.011	2.038TyrLeu: 2.038 ± 0.016	0.468TyrMet: 0.468 ± 0.006	0.623TyrAsn: 0.623 ± 0.008	1.15TyrPro: 1.15 ± 0.011	0.89TyrGln: 0.89 ± 0.008	1.698TyrArg: 1.698 ± 0.014	1.358TyrSer: 1.358 ± 0.011	1.141TyrThr: 1.141 ± 0.012	1.561TyrVal: 1.561 ± 0.011	0.358TyrTrp: 0.358 ± 0.006	0.641TyrTyr: 0.641 ± 0.009	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.312XaaXaa: 0.312 ± 0.049

Statistics based on 23030 proteins (11959242 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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