Amino acid dipepetide frequency for Limnohabitans sp. 103DPR2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.914AlaAla: 12.914 ± 0.242
1.276AlaCys: 1.276 ± 0.036
5.484AlaAsp: 5.484 ± 0.088
5.716AlaGlu: 5.716 ± 0.109
3.861AlaPhe: 3.861 ± 0.069
8.429AlaGly: 8.429 ± 0.114
2.585AlaHis: 2.585 ± 0.059
5.484AlaIle: 5.484 ± 0.093
5.751AlaLys: 5.751 ± 0.112
12.931AlaLeu: 12.931 ± 0.164
3.787AlaMet: 3.787 ± 0.065
3.6AlaAsn: 3.6 ± 0.082
4.822AlaPro: 4.822 ± 0.086
6.125AlaGln: 6.125 ± 0.103
5.347AlaArg: 5.347 ± 0.085
6.834AlaSer: 6.834 ± 0.101
5.496AlaThr: 5.496 ± 0.101
7.73AlaVal: 7.73 ± 0.102
1.844AlaTrp: 1.844 ± 0.062
2.489AlaTyr: 2.489 ± 0.054
0.0AlaXaa: 0.0 ± 0.0
Cys
1.023CysAla: 1.023 ± 0.035
0.117CysCys: 0.117 ± 0.012
0.543CysAsp: 0.543 ± 0.022
0.54CysGlu: 0.54 ± 0.024
0.35CysPhe: 0.35 ± 0.019
0.983CysGly: 0.983 ± 0.034
0.297CysHis: 0.297 ± 0.021
0.507CysIle: 0.507 ± 0.024
0.337CysLys: 0.337 ± 0.02
0.914CysLeu: 0.914 ± 0.034
0.274CysMet: 0.274 ± 0.017
0.305CysAsn: 0.305 ± 0.017
0.505CysPro: 0.505 ± 0.022
0.373CysGln: 0.373 ± 0.02
0.397CysArg: 0.397 ± 0.023
0.495CysSer: 0.495 ± 0.022
0.533CysThr: 0.533 ± 0.026
0.821CysVal: 0.821 ± 0.032
0.128CysTrp: 0.128 ± 0.011
0.198CysTyr: 0.198 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
6.13AspAla: 6.13 ± 0.079
0.443AspCys: 0.443 ± 0.023
2.234AspAsp: 2.234 ± 0.051
2.78AspGlu: 2.78 ± 0.067
2.155AspPhe: 2.155 ± 0.054
3.808AspGly: 3.808 ± 0.07
1.165AspHis: 1.165 ± 0.041
2.631AspIle: 2.631 ± 0.05
2.244AspLys: 2.244 ± 0.056
5.355AspLeu: 5.355 ± 0.078
1.481AspMet: 1.481 ± 0.038
1.4AspAsn: 1.4 ± 0.041
2.57AspPro: 2.57 ± 0.053
1.839AspGln: 1.839 ± 0.041
2.598AspArg: 2.598 ± 0.071
2.244AspSer: 2.244 ± 0.055
2.483AspThr: 2.483 ± 0.07
4.132AspVal: 4.132 ± 0.069
0.926AspTrp: 0.926 ± 0.036
1.287AspTyr: 1.287 ± 0.04
0.0AspXaa: 0.0 ± 0.0
Glu
6.279GluAla: 6.279 ± 0.106
0.424GluCys: 0.424 ± 0.024
2.327GluAsp: 2.327 ± 0.055
2.667GluGlu: 2.667 ± 0.071
2.009GluPhe: 2.009 ± 0.053
3.889GluGly: 3.889 ± 0.073
1.196GluHis: 1.196 ± 0.04
2.911GluIle: 2.911 ± 0.058
2.797GluLys: 2.797 ± 0.06
5.303GluLeu: 5.303 ± 0.088
1.469GluMet: 1.469 ± 0.041
1.657GluAsn: 1.657 ± 0.04
2.152GluPro: 2.152 ± 0.046
2.251GluGln: 2.251 ± 0.057
3.355GluArg: 3.355 ± 0.065
2.707GluSer: 2.707 ± 0.057
2.697GluThr: 2.697 ± 0.059
4.173GluVal: 4.173 ± 0.075
0.829GluTrp: 0.829 ± 0.033
1.042GluTyr: 1.042 ± 0.034
0.0GluXaa: 0.0 ± 0.0
Phe
4.04PheAla: 4.04 ± 0.066
0.435PheCys: 0.435 ± 0.022
2.419PheAsp: 2.419 ± 0.049
2.371PheGlu: 2.371 ± 0.053
1.499PhePhe: 1.499 ± 0.049
3.234PheGly: 3.234 ± 0.059
0.786PheHis: 0.786 ± 0.028
1.709PheIle: 1.709 ± 0.043
2.024PheLys: 2.024 ± 0.048
3.167PheLeu: 3.167 ± 0.068
1.025PheMet: 1.025 ± 0.039
1.5PheAsn: 1.5 ± 0.041
1.609PhePro: 1.609 ± 0.044
1.411PheGln: 1.411 ± 0.038
1.52PheArg: 1.52 ± 0.037
2.461PheSer: 2.461 ± 0.058
2.028PheThr: 2.028 ± 0.059
2.862PheVal: 2.862 ± 0.061
0.56PheTrp: 0.56 ± 0.027
0.909PheTyr: 0.909 ± 0.033
0.0PheXaa: 0.0 ± 0.0
Gly
7.757GlyAla: 7.757 ± 0.107
0.875GlyCys: 0.875 ± 0.036
3.491GlyAsp: 3.491 ± 0.065
3.911GlyGlu: 3.911 ± 0.063
3.252GlyPhe: 3.252 ± 0.06
6.38GlyGly: 6.38 ± 0.117
2.038GlyHis: 2.038 ± 0.051
4.312GlyIle: 4.312 ± 0.066
4.066GlyLys: 4.066 ± 0.076
8.553GlyLeu: 8.553 ± 0.103
2.456GlyMet: 2.456 ± 0.052
2.491GlyAsn: 2.491 ± 0.07
2.881GlyPro: 2.881 ± 0.059
3.844GlyGln: 3.844 ± 0.069
3.929GlyArg: 3.929 ± 0.082
4.554GlySer: 4.554 ± 0.092
4.336GlyThr: 4.336 ± 0.106
6.289GlyVal: 6.289 ± 0.088
1.241GlyTrp: 1.241 ± 0.042
2.245GlyTyr: 2.245 ± 0.052
0.0GlyXaa: 0.0 ± 0.0
His
2.638HisAla: 2.638 ± 0.052
0.296HisCys: 0.296 ± 0.017
1.151HisAsp: 1.151 ± 0.038
1.155HisGlu: 1.155 ± 0.037
0.978HisPhe: 0.978 ± 0.033
2.003HisGly: 2.003 ± 0.048
0.681HisHis: 0.681 ± 0.032
1.208HisIle: 1.208 ± 0.038
0.818HisLys: 0.818 ± 0.034
2.437HisLeu: 2.437 ± 0.056
0.624HisMet: 0.624 ± 0.028
0.686HisAsn: 0.686 ± 0.03
1.431HisPro: 1.431 ± 0.044
1.015HisGln: 1.015 ± 0.034
1.225HisArg: 1.225 ± 0.04
1.187HisSer: 1.187 ± 0.041
1.131HisThr: 1.131 ± 0.034
1.777HisVal: 1.777 ± 0.05
0.461HisTrp: 0.461 ± 0.02
0.616HisTyr: 0.616 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
5.711IleAla: 5.711 ± 0.088
0.487IleCys: 0.487 ± 0.021
3.217IleAsp: 3.217 ± 0.064
3.486IleGlu: 3.486 ± 0.067
1.686IlePhe: 1.686 ± 0.044
4.107IleGly: 4.107 ± 0.078
1.038IleHis: 1.038 ± 0.037
1.865IleIle: 1.865 ± 0.048
2.183IleLys: 2.183 ± 0.062
4.011IleLeu: 4.011 ± 0.068
1.094IleMet: 1.094 ± 0.038
1.678IleAsn: 1.678 ± 0.045
2.259IlePro: 2.259 ± 0.054
2.295IleGln: 2.295 ± 0.053
2.521IleArg: 2.521 ± 0.056
3.087IleSer: 3.087 ± 0.072
2.894IleThr: 2.894 ± 0.073
3.406IleVal: 3.406 ± 0.063
0.638IleTrp: 0.638 ± 0.029
1.193IleTyr: 1.193 ± 0.038
0.0IleXaa: 0.0 ± 0.0
Lys
5.739LysAla: 5.739 ± 0.103
0.259LysCys: 0.259 ± 0.018
2.496LysAsp: 2.496 ± 0.05
2.323LysGlu: 2.323 ± 0.059
1.516LysPhe: 1.516 ± 0.044
3.443LysGly: 3.443 ± 0.07
1.057LysHis: 1.057 ± 0.033
2.252LysIle: 2.252 ± 0.051
2.228LysLys: 2.228 ± 0.065
4.775LysLeu: 4.775 ± 0.078
1.306LysMet: 1.306 ± 0.038
1.54LysAsn: 1.54 ± 0.048
2.756LysPro: 2.756 ± 0.074
1.881LysGln: 1.881 ± 0.046
2.637LysArg: 2.637 ± 0.053
2.835LysSer: 2.835 ± 0.054
2.694LysThr: 2.694 ± 0.063
3.666LysVal: 3.666 ± 0.075
0.583LysTrp: 0.583 ± 0.027
0.972LysTyr: 0.972 ± 0.037
0.0LysXaa: 0.0 ± 0.0
Leu
12.079LeuAla: 12.079 ± 0.156
1.05LeuCys: 1.05 ± 0.03
5.074LeuAsp: 5.074 ± 0.088
4.982LeuGlu: 4.982 ± 0.085
3.47LeuPhe: 3.47 ± 0.076
7.916LeuGly: 7.916 ± 0.086
2.293LeuHis: 2.293 ± 0.054
5.044LeuIle: 5.044 ± 0.086
5.587LeuLys: 5.587 ± 0.088
10.094LeuLeu: 10.094 ± 0.158
3.16LeuMet: 3.16 ± 0.068
4.073LeuAsn: 4.073 ± 0.097
5.693LeuPro: 5.693 ± 0.09
4.842LeuGln: 4.842 ± 0.093
5.496LeuArg: 5.496 ± 0.086
7.088LeuSer: 7.088 ± 0.107
5.663LeuThr: 5.663 ± 0.078
6.961LeuVal: 6.961 ± 0.105
1.341LeuTrp: 1.341 ± 0.039
1.94LeuTyr: 1.94 ± 0.048
0.0LeuXaa: 0.0 ± 0.0
Met
3.634MetAla: 3.634 ± 0.059
0.242MetCys: 0.242 ± 0.018
1.313MetAsp: 1.313 ± 0.042
1.144MetGlu: 1.144 ± 0.038
0.888MetPhe: 0.888 ± 0.03
2.612MetGly: 2.612 ± 0.056
0.632MetHis: 0.632 ± 0.024
1.223MetIle: 1.223 ± 0.037
1.482MetLys: 1.482 ± 0.045
2.802MetLeu: 2.802 ± 0.064
0.821MetMet: 0.821 ± 0.033
1.195MetAsn: 1.195 ± 0.032
1.645MetPro: 1.645 ± 0.038
1.348MetGln: 1.348 ± 0.04
1.638MetArg: 1.638 ± 0.051
2.001MetSer: 2.001 ± 0.045
1.907MetThr: 1.907 ± 0.042
2.053MetVal: 2.053 ± 0.046
0.283MetTrp: 0.283 ± 0.018
0.475MetTyr: 0.475 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
4.002AsnAla: 4.002 ± 0.086
0.312AsnCys: 0.312 ± 0.02
1.673AsnAsp: 1.673 ± 0.048
1.58AsnGlu: 1.58 ± 0.043
1.431AsnPhe: 1.431 ± 0.045
2.578AsnGly: 2.578 ± 0.07
0.666AsnHis: 0.666 ± 0.025
1.715AsnIle: 1.715 ± 0.04
1.356AsnLys: 1.356 ± 0.042
3.373AsnLeu: 3.373 ± 0.065
0.989AsnMet: 0.989 ± 0.033
1.128AsnAsn: 1.128 ± 0.047
2.262AsnPro: 2.262 ± 0.06
1.218AsnGln: 1.218 ± 0.04
1.576AsnArg: 1.576 ± 0.043
1.783AsnSer: 1.783 ± 0.053
1.983AsnThr: 1.983 ± 0.063
2.469AsnVal: 2.469 ± 0.052
0.525AsnTrp: 0.525 ± 0.027
0.852AsnTyr: 0.852 ± 0.036
0.0AsnXaa: 0.0 ± 0.0
Pro
5.218ProAla: 5.218 ± 0.092
0.388ProCys: 0.388 ± 0.025
2.75ProAsp: 2.75 ± 0.06
3.4ProGlu: 3.4 ± 0.069
1.85ProPhe: 1.85 ± 0.048
3.891ProGly: 3.891 ± 0.07
1.206ProHis: 1.206 ± 0.042
2.127ProIle: 2.127 ± 0.049
2.135ProLys: 2.135 ± 0.056
4.765ProLeu: 4.765 ± 0.08
1.444ProMet: 1.444 ± 0.037
1.692ProAsn: 1.692 ± 0.045
1.818ProPro: 1.818 ± 0.05
2.241ProGln: 2.241 ± 0.054
1.981ProArg: 1.981 ± 0.048
2.932ProSer: 2.932 ± 0.057
2.688ProThr: 2.688 ± 0.073
3.99ProVal: 3.99 ± 0.068
0.727ProTrp: 0.727 ± 0.029
1.263ProTyr: 1.263 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
6.016GlnAla: 6.016 ± 0.098
0.354GlnCys: 0.354 ± 0.021
2.035GlnAsp: 2.035 ± 0.049
1.989GlnGlu: 1.989 ± 0.045
1.611GlnPhe: 1.611 ± 0.037
3.525GlnGly: 3.525 ± 0.071
1.183GlnHis: 1.183 ± 0.036
2.259GlnIle: 2.259 ± 0.045
2.052GlnLys: 2.052 ± 0.055
4.662GlnLeu: 4.662 ± 0.087
1.24GlnMet: 1.24 ± 0.041
1.434GlnAsn: 1.434 ± 0.039
1.837GlnPro: 1.837 ± 0.05
2.136GlnGln: 2.136 ± 0.06
2.87GlnArg: 2.87 ± 0.055
2.854GlnSer: 2.854 ± 0.061
2.583GlnThr: 2.583 ± 0.06
3.478GlnVal: 3.478 ± 0.069
0.863GlnTrp: 0.863 ± 0.034
0.929GlnTyr: 0.929 ± 0.032
0.0GlnXaa: 0.0 ± 0.0
Arg
5.031ArgAla: 5.031 ± 0.071
0.44ArgCys: 0.44 ± 0.026
2.667ArgAsp: 2.667 ± 0.058
3.13ArgGlu: 3.13 ± 0.06
2.115ArgPhe: 2.115 ± 0.051
3.355ArgGly: 3.355 ± 0.065
1.312ArgHis: 1.312 ± 0.04
2.977ArgIle: 2.977 ± 0.059
2.3ArgLys: 2.3 ± 0.059
5.625ArgLeu: 5.625 ± 0.089
1.794ArgMet: 1.794 ± 0.042
1.784ArgAsn: 1.784 ± 0.047
2.232ArgPro: 2.232 ± 0.055
2.516ArgGln: 2.516 ± 0.051
2.756ArgArg: 2.756 ± 0.06
2.835ArgSer: 2.835 ± 0.064
2.468ArgThr: 2.468 ± 0.052
3.91ArgVal: 3.91 ± 0.067
0.885ArgTrp: 0.885 ± 0.032
1.482ArgTyr: 1.482 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
6.477SerAla: 6.477 ± 0.11
0.503SerCys: 0.503 ± 0.024
2.818SerAsp: 2.818 ± 0.062
2.942SerGlu: 2.942 ± 0.056
2.399SerPhe: 2.399 ± 0.048
5.245SerGly: 5.245 ± 0.104
1.396SerHis: 1.396 ± 0.041
2.869SerIle: 2.869 ± 0.068
2.521SerLys: 2.521 ± 0.052
6.609SerLeu: 6.609 ± 0.107
1.715SerMet: 1.715 ± 0.045
1.952SerAsn: 1.952 ± 0.056
2.917SerPro: 2.917 ± 0.064
2.708SerGln: 2.708 ± 0.058
2.88SerArg: 2.88 ± 0.056
3.683SerSer: 3.683 ± 0.081
3.332SerThr: 3.332 ± 0.072
4.343SerVal: 4.343 ± 0.075
0.871SerTrp: 0.871 ± 0.032
1.382SerTyr: 1.382 ± 0.043
0.0SerXaa: 0.0 ± 0.0
Thr
5.709ThrAla: 5.709 ± 0.13
0.498ThrCys: 0.498 ± 0.025
2.649ThrAsp: 2.649 ± 0.059
2.584ThrGlu: 2.584 ± 0.045
1.984ThrPhe: 1.984 ± 0.053
4.763ThrGly: 4.763 ± 0.103
1.372ThrHis: 1.372 ± 0.043
2.179ThrIle: 2.179 ± 0.063
1.77ThrLys: 1.77 ± 0.044
6.363ThrLeu: 6.363 ± 0.099
1.16ThrMet: 1.16 ± 0.041
1.476ThrAsn: 1.476 ± 0.047
3.559ThrPro: 3.559 ± 0.063
2.682ThrGln: 2.682 ± 0.055
2.698ThrArg: 2.698 ± 0.056
3.319ThrSer: 3.319 ± 0.073
2.846ThrThr: 2.846 ± 0.082
4.226ThrVal: 4.226 ± 0.08
0.842ThrTrp: 0.842 ± 0.032
1.293ThrTyr: 1.293 ± 0.044
0.0ThrXaa: 0.0 ± 0.0
Val
8.311ValAla: 8.311 ± 0.093
0.779ValCys: 0.779 ± 0.03
3.696ValAsp: 3.696 ± 0.071
3.642ValGlu: 3.642 ± 0.067
2.924ValPhe: 2.924 ± 0.058
5.611ValGly: 5.611 ± 0.081
1.728ValHis: 1.728 ± 0.045
3.949ValIle: 3.949 ± 0.06
3.657ValLys: 3.657 ± 0.079
7.705ValLeu: 7.705 ± 0.111
2.482ValMet: 2.482 ± 0.057
2.62ValAsn: 2.62 ± 0.068
3.72ValPro: 3.72 ± 0.066
3.244ValGln: 3.244 ± 0.058
3.832ValArg: 3.832 ± 0.073
4.538ValSer: 4.538 ± 0.075
4.052ValThr: 4.052 ± 0.083
6.242ValVal: 6.242 ± 0.102
1.131ValTrp: 1.131 ± 0.038
1.602ValTyr: 1.602 ± 0.042
0.0ValXaa: 0.0 ± 0.0
Trp
1.342TrpAla: 1.342 ± 0.043
0.183TrpCys: 0.183 ± 0.014
0.656TrpAsp: 0.656 ± 0.024
0.529TrpGlu: 0.529 ± 0.026
0.554TrpPhe: 0.554 ± 0.026
1.128TrpGly: 1.128 ± 0.04
0.419TrpHis: 0.419 ± 0.025
0.708TrpIle: 0.708 ± 0.032
0.514TrpLys: 0.514 ± 0.026
2.073TrpLeu: 2.073 ± 0.062
0.49TrpMet: 0.49 ± 0.023
0.5TrpAsn: 0.5 ± 0.023
0.713TrpPro: 0.713 ± 0.029
0.952TrpGln: 0.952 ± 0.036
1.092TrpArg: 1.092 ± 0.038
0.809TrpSer: 0.809 ± 0.03
0.855TrpThr: 0.855 ± 0.03
1.262TrpVal: 1.262 ± 0.041
0.261TrpTrp: 0.261 ± 0.019
0.294TrpTyr: 0.294 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.454TyrAla: 2.454 ± 0.046
0.28TyrCys: 0.28 ± 0.016
1.212TyrAsp: 1.212 ± 0.038
1.262TyrGlu: 1.262 ± 0.037
1.04TyrPhe: 1.04 ± 0.031
2.0TyrGly: 2.0 ± 0.046
0.467TyrHis: 0.467 ± 0.023
0.929TyrIle: 0.929 ± 0.033
1.137TyrLys: 1.137 ± 0.037
2.329TyrLeu: 2.329 ± 0.059
0.525TyrMet: 0.525 ± 0.023
0.758TyrAsn: 0.758 ± 0.03
1.126TyrPro: 1.126 ± 0.04
0.99TyrGln: 0.99 ± 0.037
1.263TyrArg: 1.263 ± 0.036
1.318TyrSer: 1.318 ± 0.038
1.305TyrThr: 1.305 ± 0.039
1.676TyrVal: 1.676 ± 0.046
0.393TyrTrp: 0.393 ± 0.022
0.541TyrTyr: 0.541 ± 0.028
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2804 proteins (922556 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski