Amino acid dipepetide frequency for Salmonella phage St162

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.642AlaAla: 11.642 ± 1.487
1.328AlaCys: 1.328 ± 0.37
7.423AlaAsp: 7.423 ± 0.87
6.642AlaGlu: 6.642 ± 0.693
3.751AlaPhe: 3.751 ± 0.595
8.517AlaGly: 8.517 ± 0.809
1.563AlaHis: 1.563 ± 0.329
4.766AlaIle: 4.766 ± 0.728
6.485AlaLys: 6.485 ± 0.933
7.814AlaLeu: 7.814 ± 0.824
1.719AlaMet: 1.719 ± 0.447
3.985AlaAsn: 3.985 ± 0.627
3.204AlaPro: 3.204 ± 0.48
3.985AlaGln: 3.985 ± 0.751
5.001AlaArg: 5.001 ± 0.57
5.391AlaSer: 5.391 ± 0.734
5.782AlaThr: 5.782 ± 0.946
7.657AlaVal: 7.657 ± 0.774
1.328AlaTrp: 1.328 ± 0.287
2.969AlaTyr: 2.969 ± 0.431
0.0AlaXaa: 0.0 ± 0.0
Cys
0.86CysAla: 0.86 ± 0.274
0.156CysCys: 0.156 ± 0.095
0.547CysAsp: 0.547 ± 0.183
0.938CysGlu: 0.938 ± 0.395
0.078CysPhe: 0.078 ± 0.075
1.172CysGly: 1.172 ± 0.301
0.234CysHis: 0.234 ± 0.116
0.234CysIle: 0.234 ± 0.139
0.547CysLys: 0.547 ± 0.224
0.781CysLeu: 0.781 ± 0.323
0.078CysMet: 0.078 ± 0.071
0.625CysAsn: 0.625 ± 0.219
0.469CysPro: 0.469 ± 0.209
0.625CysGln: 0.625 ± 0.256
1.094CysArg: 1.094 ± 0.311
0.313CysSer: 0.313 ± 0.149
0.625CysThr: 0.625 ± 0.176
0.703CysVal: 0.703 ± 0.289
0.234CysTrp: 0.234 ± 0.124
0.703CysTyr: 0.703 ± 0.278
0.0CysXaa: 0.0 ± 0.0
Asp
7.579AspAla: 7.579 ± 0.593
0.547AspCys: 0.547 ± 0.17
4.141AspAsp: 4.141 ± 0.7
4.923AspGlu: 4.923 ± 0.913
2.579AspPhe: 2.579 ± 0.342
5.938AspGly: 5.938 ± 0.558
1.094AspHis: 1.094 ± 0.341
3.672AspIle: 3.672 ± 0.464
3.672AspLys: 3.672 ± 0.557
5.86AspLeu: 5.86 ± 0.918
1.797AspMet: 1.797 ± 0.427
2.657AspAsn: 2.657 ± 0.487
1.563AspPro: 1.563 ± 0.365
1.016AspGln: 1.016 ± 0.277
2.422AspArg: 2.422 ± 0.463
3.516AspSer: 3.516 ± 0.458
4.219AspThr: 4.219 ± 0.615
4.063AspVal: 4.063 ± 0.609
1.25AspTrp: 1.25 ± 0.379
2.266AspTyr: 2.266 ± 0.423
0.0AspXaa: 0.0 ± 0.0
Glu
5.782GluAla: 5.782 ± 0.883
0.391GluCys: 0.391 ± 0.155
4.141GluAsp: 4.141 ± 0.498
3.907GluGlu: 3.907 ± 0.69
2.032GluPhe: 2.032 ± 0.371
4.298GluGly: 4.298 ± 0.654
1.016GluHis: 1.016 ± 0.4
3.438GluIle: 3.438 ± 0.468
3.985GluLys: 3.985 ± 0.639
5.548GluLeu: 5.548 ± 0.847
2.5GluMet: 2.5 ± 0.451
3.125GluAsn: 3.125 ± 0.462
2.032GluPro: 2.032 ± 0.469
2.969GluGln: 2.969 ± 0.541
2.891GluArg: 2.891 ± 0.56
3.672GluSer: 3.672 ± 0.435
3.36GluThr: 3.36 ± 0.504
4.298GluVal: 4.298 ± 0.462
0.86GluTrp: 0.86 ± 0.225
2.5GluTyr: 2.5 ± 0.379
0.0GluXaa: 0.0 ± 0.0
Phe
2.735PheAla: 2.735 ± 0.444
0.547PheCys: 0.547 ± 0.201
2.735PheAsp: 2.735 ± 0.488
2.735PheGlu: 2.735 ± 0.425
0.86PhePhe: 0.86 ± 0.26
2.579PheGly: 2.579 ± 0.438
0.781PheHis: 0.781 ± 0.233
1.953PheIle: 1.953 ± 0.373
1.485PheLys: 1.485 ± 0.34
2.266PheLeu: 2.266 ± 0.395
0.391PheMet: 0.391 ± 0.162
1.797PheAsn: 1.797 ± 0.456
1.25PhePro: 1.25 ± 0.372
0.781PheGln: 0.781 ± 0.223
2.188PheArg: 2.188 ± 0.335
2.657PheSer: 2.657 ± 0.507
2.813PheThr: 2.813 ± 0.686
2.579PheVal: 2.579 ± 0.379
1.016PheTrp: 1.016 ± 0.297
0.86PheTyr: 0.86 ± 0.22
0.0PheXaa: 0.0 ± 0.0
Gly
7.579GlyAla: 7.579 ± 0.793
1.094GlyCys: 1.094 ± 0.33
5.548GlyAsp: 5.548 ± 0.688
4.219GlyGlu: 4.219 ± 0.516
2.891GlyPhe: 2.891 ± 0.404
5.782GlyGly: 5.782 ± 0.791
1.172GlyHis: 1.172 ± 0.313
3.829GlyIle: 3.829 ± 0.514
4.532GlyLys: 4.532 ± 0.599
6.251GlyLeu: 6.251 ± 0.763
1.953GlyMet: 1.953 ± 0.342
4.141GlyAsn: 4.141 ± 0.583
1.641GlyPro: 1.641 ± 0.33
2.969GlyGln: 2.969 ± 0.442
4.298GlyArg: 4.298 ± 0.47
5.548GlySer: 5.548 ± 0.826
4.063GlyThr: 4.063 ± 0.567
6.251GlyVal: 6.251 ± 0.573
1.172GlyTrp: 1.172 ± 0.308
2.891GlyTyr: 2.891 ± 0.487
0.0GlyXaa: 0.0 ± 0.0
His
1.172HisAla: 1.172 ± 0.272
0.313HisCys: 0.313 ± 0.149
0.938HisAsp: 0.938 ± 0.337
0.938HisGlu: 0.938 ± 0.298
0.547HisPhe: 0.547 ± 0.202
1.094HisGly: 1.094 ± 0.324
0.625HisHis: 0.625 ± 0.182
1.485HisIle: 1.485 ± 0.407
1.485HisLys: 1.485 ± 0.376
1.328HisLeu: 1.328 ± 0.426
0.469HisMet: 0.469 ± 0.193
0.938HisAsn: 0.938 ± 0.306
1.328HisPro: 1.328 ± 0.231
0.86HisGln: 0.86 ± 0.233
0.781HisArg: 0.781 ± 0.196
1.094HisSer: 1.094 ± 0.289
0.313HisThr: 0.313 ± 0.138
1.016HisVal: 1.016 ± 0.273
0.156HisTrp: 0.156 ± 0.1
0.391HisTyr: 0.391 ± 0.156
0.0HisXaa: 0.0 ± 0.0
Ile
5.157IleAla: 5.157 ± 0.789
1.094IleCys: 1.094 ± 0.314
3.282IleAsp: 3.282 ± 0.563
3.594IleGlu: 3.594 ± 0.512
1.016IlePhe: 1.016 ± 0.338
3.751IleGly: 3.751 ± 0.54
0.469IleHis: 0.469 ± 0.154
2.422IleIle: 2.422 ± 0.433
3.204IleLys: 3.204 ± 0.477
2.735IleLeu: 2.735 ± 0.458
1.25IleMet: 1.25 ± 0.247
2.422IleAsn: 2.422 ± 0.404
2.813IlePro: 2.813 ± 0.451
1.641IleGln: 1.641 ± 0.341
2.5IleArg: 2.5 ± 0.327
3.516IleSer: 3.516 ± 0.553
4.219IleThr: 4.219 ± 0.655
2.579IleVal: 2.579 ± 0.334
0.938IleTrp: 0.938 ± 0.32
1.953IleTyr: 1.953 ± 0.405
0.0IleXaa: 0.0 ± 0.0
Lys
6.72LysAla: 6.72 ± 0.861
1.016LysCys: 1.016 ± 0.334
2.813LysAsp: 2.813 ± 0.455
2.969LysGlu: 2.969 ± 0.517
2.188LysPhe: 2.188 ± 0.368
4.219LysGly: 4.219 ± 0.662
1.797LysHis: 1.797 ± 0.443
2.735LysIle: 2.735 ± 0.537
3.36LysLys: 3.36 ± 0.547
5.626LysLeu: 5.626 ± 0.799
2.032LysMet: 2.032 ± 0.491
2.5LysAsn: 2.5 ± 0.52
3.282LysPro: 3.282 ± 0.556
2.657LysGln: 2.657 ± 0.438
3.438LysArg: 3.438 ± 0.503
3.282LysSer: 3.282 ± 0.57
3.594LysThr: 3.594 ± 0.548
2.813LysVal: 2.813 ± 0.372
0.938LysTrp: 0.938 ± 0.31
2.891LysTyr: 2.891 ± 0.512
0.0LysXaa: 0.0 ± 0.0
Leu
8.439LeuAla: 8.439 ± 0.801
0.625LeuCys: 0.625 ± 0.229
4.532LeuAsp: 4.532 ± 0.604
5.079LeuGlu: 5.079 ± 0.552
2.266LeuPhe: 2.266 ± 0.436
5.079LeuGly: 5.079 ± 0.587
0.938LeuHis: 0.938 ± 0.294
3.36LeuIle: 3.36 ± 0.399
5.47LeuLys: 5.47 ± 0.696
7.032LeuLeu: 7.032 ± 0.715
1.953LeuMet: 1.953 ± 0.332
4.688LeuAsn: 4.688 ± 0.605
3.829LeuPro: 3.829 ± 0.564
3.672LeuGln: 3.672 ± 0.644
4.376LeuArg: 4.376 ± 0.57
4.298LeuSer: 4.298 ± 0.598
3.829LeuThr: 3.829 ± 0.596
5.47LeuVal: 5.47 ± 0.72
0.625LeuTrp: 0.625 ± 0.214
2.579LeuTyr: 2.579 ± 0.412
0.0LeuXaa: 0.0 ± 0.0
Met
2.969MetAla: 2.969 ± 0.458
0.313MetCys: 0.313 ± 0.157
1.25MetAsp: 1.25 ± 0.302
1.953MetGlu: 1.953 ± 0.376
1.25MetPhe: 1.25 ± 0.27
1.328MetGly: 1.328 ± 0.283
0.313MetHis: 0.313 ± 0.137
1.094MetIle: 1.094 ± 0.345
1.25MetLys: 1.25 ± 0.3
1.485MetLeu: 1.485 ± 0.321
1.172MetMet: 1.172 ± 0.284
0.86MetAsn: 0.86 ± 0.29
1.016MetPro: 1.016 ± 0.286
0.86MetGln: 0.86 ± 0.228
1.719MetArg: 1.719 ± 0.39
1.406MetSer: 1.406 ± 0.353
1.485MetThr: 1.485 ± 0.366
1.563MetVal: 1.563 ± 0.315
0.234MetTrp: 0.234 ± 0.124
0.781MetTyr: 0.781 ± 0.226
0.0MetXaa: 0.0 ± 0.0
Asn
3.672AsnAla: 3.672 ± 0.555
0.313AsnCys: 0.313 ± 0.146
3.516AsnAsp: 3.516 ± 0.575
2.422AsnGlu: 2.422 ± 0.404
1.25AsnPhe: 1.25 ± 0.29
4.219AsnGly: 4.219 ± 0.602
1.016AsnHis: 1.016 ± 0.303
3.204AsnIle: 3.204 ± 0.473
2.5AsnLys: 2.5 ± 0.445
3.047AsnLeu: 3.047 ± 0.5
0.86AsnMet: 0.86 ± 0.239
2.579AsnAsn: 2.579 ± 0.453
2.032AsnPro: 2.032 ± 0.387
1.328AsnGln: 1.328 ± 0.358
2.735AsnArg: 2.735 ± 0.491
2.188AsnSer: 2.188 ± 0.485
3.438AsnThr: 3.438 ± 0.557
2.891AsnVal: 2.891 ± 0.392
0.938AsnTrp: 0.938 ± 0.307
1.485AsnTyr: 1.485 ± 0.352
0.0AsnXaa: 0.0 ± 0.0
Pro
4.063ProAla: 4.063 ± 0.581
0.391ProCys: 0.391 ± 0.181
3.282ProAsp: 3.282 ± 0.438
3.829ProGlu: 3.829 ± 0.393
1.641ProPhe: 1.641 ± 0.325
2.422ProGly: 2.422 ± 0.587
0.156ProHis: 0.156 ± 0.092
1.328ProIle: 1.328 ± 0.296
1.953ProLys: 1.953 ± 0.408
2.891ProLeu: 2.891 ± 0.473
0.86ProMet: 0.86 ± 0.287
1.719ProAsn: 1.719 ± 0.461
0.86ProPro: 0.86 ± 0.228
1.485ProGln: 1.485 ± 0.391
1.406ProArg: 1.406 ± 0.311
2.422ProSer: 2.422 ± 0.401
2.032ProThr: 2.032 ± 0.38
3.751ProVal: 3.751 ± 0.592
0.234ProTrp: 0.234 ± 0.152
1.563ProTyr: 1.563 ± 0.361
0.0ProXaa: 0.0 ± 0.0
Gln
4.298GlnAla: 4.298 ± 0.739
0.313GlnCys: 0.313 ± 0.166
2.188GlnAsp: 2.188 ± 0.497
2.032GlnGlu: 2.032 ± 0.428
1.406GlnPhe: 1.406 ± 0.431
2.11GlnGly: 2.11 ± 0.401
0.86GlnHis: 0.86 ± 0.278
2.579GlnIle: 2.579 ± 0.507
2.11GlnLys: 2.11 ± 0.401
2.891GlnLeu: 2.891 ± 0.506
1.25GlnMet: 1.25 ± 0.262
1.797GlnAsn: 1.797 ± 0.442
2.188GlnPro: 2.188 ± 0.449
2.657GlnGln: 2.657 ± 0.707
2.735GlnArg: 2.735 ± 0.545
1.641GlnSer: 1.641 ± 0.297
1.953GlnThr: 1.953 ± 0.441
2.735GlnVal: 2.735 ± 0.426
0.625GlnTrp: 0.625 ± 0.21
1.563GlnTyr: 1.563 ± 0.297
0.0GlnXaa: 0.0 ± 0.0
Arg
5.235ArgAla: 5.235 ± 0.615
0.469ArgCys: 0.469 ± 0.167
3.516ArgAsp: 3.516 ± 0.455
2.813ArgGlu: 2.813 ± 0.46
1.719ArgPhe: 1.719 ± 0.321
4.61ArgGly: 4.61 ± 0.312
1.172ArgHis: 1.172 ± 0.277
2.813ArgIle: 2.813 ± 0.353
4.063ArgLys: 4.063 ± 0.681
3.438ArgLeu: 3.438 ± 0.431
1.094ArgMet: 1.094 ± 0.261
3.125ArgAsn: 3.125 ± 0.479
1.563ArgPro: 1.563 ± 0.49
3.204ArgGln: 3.204 ± 0.522
3.36ArgArg: 3.36 ± 0.596
1.953ArgSer: 1.953 ± 0.316
3.125ArgThr: 3.125 ± 0.489
4.298ArgVal: 4.298 ± 0.431
0.938ArgTrp: 0.938 ± 0.258
1.406ArgTyr: 1.406 ± 0.327
0.0ArgXaa: 0.0 ± 0.0
Ser
6.329SerAla: 6.329 ± 1.069
0.078SerCys: 0.078 ± 0.081
3.282SerAsp: 3.282 ± 0.421
2.657SerGlu: 2.657 ± 0.537
2.969SerPhe: 2.969 ± 0.508
5.313SerGly: 5.313 ± 0.981
1.485SerHis: 1.485 ± 0.29
2.344SerIle: 2.344 ± 0.456
2.969SerLys: 2.969 ± 0.336
4.845SerLeu: 4.845 ± 0.635
1.328SerMet: 1.328 ± 0.311
1.875SerAsn: 1.875 ± 0.313
2.032SerPro: 2.032 ± 0.428
2.11SerGln: 2.11 ± 0.572
3.047SerArg: 3.047 ± 0.392
2.579SerSer: 2.579 ± 0.477
4.141SerThr: 4.141 ± 0.589
4.454SerVal: 4.454 ± 0.821
1.016SerTrp: 1.016 ± 0.24
1.875SerTyr: 1.875 ± 0.429
0.0SerXaa: 0.0 ± 0.0
Thr
6.329ThrAla: 6.329 ± 0.776
0.547ThrCys: 0.547 ± 0.206
2.891ThrAsp: 2.891 ± 0.363
3.516ThrGlu: 3.516 ± 0.602
2.657ThrPhe: 2.657 ± 0.504
6.72ThrGly: 6.72 ± 0.977
0.547ThrHis: 0.547 ± 0.19
3.125ThrIle: 3.125 ± 0.469
2.969ThrLys: 2.969 ± 0.45
4.923ThrLeu: 4.923 ± 0.685
0.938ThrMet: 0.938 ± 0.237
1.641ThrAsn: 1.641 ± 0.29
3.751ThrPro: 3.751 ± 0.561
2.11ThrGln: 2.11 ± 0.471
2.735ThrArg: 2.735 ± 0.385
4.376ThrSer: 4.376 ± 0.678
4.063ThrThr: 4.063 ± 0.646
4.923ThrVal: 4.923 ± 0.687
0.781ThrTrp: 0.781 ± 0.257
2.188ThrTyr: 2.188 ± 0.468
0.0ThrXaa: 0.0 ± 0.0
Val
6.095ValAla: 6.095 ± 0.562
0.781ValCys: 0.781 ± 0.23
4.376ValAsp: 4.376 ± 0.475
4.219ValGlu: 4.219 ± 0.744
1.875ValPhe: 1.875 ± 0.43
4.688ValGly: 4.688 ± 0.566
1.094ValHis: 1.094 ± 0.269
4.454ValIle: 4.454 ± 0.619
5.548ValLys: 5.548 ± 0.629
5.235ValLeu: 5.235 ± 0.609
1.328ValMet: 1.328 ± 0.296
3.438ValAsn: 3.438 ± 0.591
2.032ValPro: 2.032 ± 0.511
2.5ValGln: 2.5 ± 0.42
3.985ValArg: 3.985 ± 0.552
4.376ValSer: 4.376 ± 0.624
5.548ValThr: 5.548 ± 0.816
5.079ValVal: 5.079 ± 0.856
0.781ValTrp: 0.781 ± 0.278
2.735ValTyr: 2.735 ± 0.397
0.0ValXaa: 0.0 ± 0.0
Trp
1.094TrpAla: 1.094 ± 0.328
0.156TrpCys: 0.156 ± 0.116
1.328TrpAsp: 1.328 ± 0.298
0.547TrpGlu: 0.547 ± 0.201
0.625TrpPhe: 0.625 ± 0.235
0.86TrpGly: 0.86 ± 0.296
0.547TrpHis: 0.547 ± 0.196
0.469TrpIle: 0.469 ± 0.171
0.781TrpLys: 0.781 ± 0.211
1.875TrpLeu: 1.875 ± 0.497
0.391TrpMet: 0.391 ± 0.188
0.469TrpAsn: 0.469 ± 0.181
0.313TrpPro: 0.313 ± 0.233
0.781TrpGln: 0.781 ± 0.273
1.172TrpArg: 1.172 ± 0.315
0.781TrpSer: 0.781 ± 0.308
0.86TrpThr: 0.86 ± 0.247
1.25TrpVal: 1.25 ± 0.281
0.234TrpTrp: 0.234 ± 0.101
0.469TrpTyr: 0.469 ± 0.195
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.204TyrAla: 3.204 ± 0.552
0.547TyrCys: 0.547 ± 0.2
3.047TyrAsp: 3.047 ± 0.47
2.813TyrGlu: 2.813 ± 0.465
1.406TyrPhe: 1.406 ± 0.354
3.125TyrGly: 3.125 ± 0.496
0.391TyrHis: 0.391 ± 0.137
1.25TyrIle: 1.25 ± 0.3
2.5TyrLys: 2.5 ± 0.394
2.266TyrLeu: 2.266 ± 0.441
0.86TyrMet: 0.86 ± 0.211
1.25TyrAsn: 1.25 ± 0.277
1.094TyrPro: 1.094 ± 0.367
1.719TyrGln: 1.719 ± 0.418
2.032TyrArg: 2.032 ± 0.383
1.797TyrSer: 1.797 ± 0.384
2.266TyrThr: 2.266 ± 0.412
1.797TyrVal: 1.797 ± 0.422
0.703TyrTrp: 0.703 ± 0.238
1.094TyrTyr: 1.094 ± 0.254
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 62 proteins (12799 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski