Amino acid dipepetide frequency for Sphingomonas sp. YZ-8

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.22AlaAla: 17.22 ± 0.202	1.001AlaCys: 1.001 ± 0.039	7.309AlaAsp: 7.309 ± 0.085	6.696AlaGlu: 6.696 ± 0.107	4.256AlaPhe: 4.256 ± 0.07	10.69AlaGly: 10.69 ± 0.12	2.327AlaHis: 2.327 ± 0.054	7.347AlaIle: 7.347 ± 0.085	4.471AlaLys: 4.471 ± 0.078	13.119AlaLeu: 13.119 ± 0.136	3.755AlaMet: 3.755 ± 0.06	3.512AlaAsn: 3.512 ± 0.056	5.683AlaPro: 5.683 ± 0.085	4.183AlaGln: 4.183 ± 0.065	8.85AlaArg: 8.85 ± 0.096	6.98AlaSer: 6.98 ± 0.084	7.36AlaThr: 7.36 ± 0.099	8.665AlaVal: 8.665 ± 0.096	1.475AlaTrp: 1.475 ± 0.043	2.519AlaTyr: 2.519 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	1.016CysAla: 1.016 ± 0.033	0.099CysCys: 0.099 ± 0.011	0.575CysAsp: 0.575 ± 0.022	0.436CysGlu: 0.436 ± 0.023	0.316CysPhe: 0.316 ± 0.017	0.87CysGly: 0.87 ± 0.035	0.224CysHis: 0.224 ± 0.021	0.399CysIle: 0.399 ± 0.02	0.197CysLys: 0.197 ± 0.014	0.694CysLeu: 0.694 ± 0.026	0.153CysMet: 0.153 ± 0.012	0.219CysAsn: 0.219 ± 0.015	0.453CysPro: 0.453 ± 0.021	0.2CysGln: 0.2 ± 0.012	0.575CysArg: 0.575 ± 0.024	0.491CysSer: 0.491 ± 0.021	0.426CysThr: 0.426 ± 0.022	0.552CysVal: 0.552 ± 0.022	0.119CysTrp: 0.119 ± 0.012	0.177CysTyr: 0.177 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.527AspAla: 7.527 ± 0.094	0.508AspCys: 0.508 ± 0.022	3.311AspAsp: 3.311 ± 0.063	3.098AspGlu: 3.098 ± 0.065	2.132AspPhe: 2.132 ± 0.044	5.535AspGly: 5.535 ± 0.074	1.276AspHis: 1.276 ± 0.034	3.092AspIle: 3.092 ± 0.053	1.722AspLys: 1.722 ± 0.041	5.523AspLeu: 5.523 ± 0.078	1.33AspMet: 1.33 ± 0.036	1.483AspAsn: 1.483 ± 0.035	3.402AspPro: 3.402 ± 0.059	1.776AspGln: 1.776 ± 0.042	4.515AspArg: 4.515 ± 0.066	2.439AspSer: 2.439 ± 0.047	2.974AspThr: 2.974 ± 0.055	4.3AspVal: 4.3 ± 0.065	1.067AspTrp: 1.067 ± 0.031	1.584AspTyr: 1.584 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	6.726GluAla: 6.726 ± 0.101	0.323GluCys: 0.323 ± 0.017	2.465GluAsp: 2.465 ± 0.052	2.35GluGlu: 2.35 ± 0.062	1.569GluPhe: 1.569 ± 0.038	3.862GluGly: 3.862 ± 0.062	1.16GluHis: 1.16 ± 0.034	3.074GluIle: 3.074 ± 0.056	1.871GluLys: 1.871 ± 0.044	4.722GluLeu: 4.722 ± 0.075	1.395GluMet: 1.395 ± 0.038	1.527GluAsn: 1.527 ± 0.038	2.285GluPro: 2.285 ± 0.05	1.808GluGln: 1.808 ± 0.045	4.361GluArg: 4.361 ± 0.073	2.359GluSer: 2.359 ± 0.05	3.205GluThr: 3.205 ± 0.058	3.355GluVal: 3.355 ± 0.054	0.67GluTrp: 0.67 ± 0.026	1.011GluTyr: 1.011 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.729PheAla: 4.729 ± 0.076	0.347PheCys: 0.347 ± 0.02	2.658PheAsp: 2.658 ± 0.05	2.005PheGlu: 2.005 ± 0.039	1.253PhePhe: 1.253 ± 0.035	3.714PheGly: 3.714 ± 0.07	0.749PheHis: 0.749 ± 0.027	1.608PheIle: 1.608 ± 0.041	0.967PheLys: 0.967 ± 0.03	2.962PheLeu: 2.962 ± 0.066	0.754PheMet: 0.754 ± 0.03	1.168PheAsn: 1.168 ± 0.034	1.486PhePro: 1.486 ± 0.036	0.953PheGln: 0.953 ± 0.026	2.232PheArg: 2.232 ± 0.047	2.235PheSer: 2.235 ± 0.043	2.074PheThr: 2.074 ± 0.05	2.744PheVal: 2.744 ± 0.055	0.516PheTrp: 0.516 ± 0.024	0.885PheTyr: 0.885 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	9.64GlyAla: 9.64 ± 0.12	0.858GlyCys: 0.858 ± 0.027	4.608GlyAsp: 4.608 ± 0.076	4.243GlyGlu: 4.243 ± 0.061	3.663GlyPhe: 3.663 ± 0.067	8.191GlyGly: 8.191 ± 0.143	1.851GlyHis: 1.851 ± 0.043	4.922GlyIle: 4.922 ± 0.069	3.369GlyLys: 3.369 ± 0.054	8.333GlyLeu: 8.333 ± 0.091	2.216GlyMet: 2.216 ± 0.051	2.58GlyAsn: 2.58 ± 0.055	3.489GlyPro: 3.489 ± 0.062	2.968GlyGln: 2.968 ± 0.055	6.056GlyArg: 6.056 ± 0.072	5.298GlySer: 5.298 ± 0.084	5.249GlyThr: 5.249 ± 0.088	6.387GlyVal: 6.387 ± 0.084	1.528GlyTrp: 1.528 ± 0.04	2.411GlyTyr: 2.411 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	2.239HisAla: 2.239 ± 0.054	0.247HisCys: 0.247 ± 0.016	1.261HisAsp: 1.261 ± 0.035	0.993HisGlu: 0.993 ± 0.029	0.819HisPhe: 0.819 ± 0.03	1.963HisGly: 1.963 ± 0.044	0.58HisHis: 0.58 ± 0.024	1.048HisIle: 1.048 ± 0.031	0.505HisLys: 0.505 ± 0.023	1.902HisLeu: 1.902 ± 0.049	0.478HisMet: 0.478 ± 0.022	0.518HisAsn: 0.518 ± 0.021	1.25HisPro: 1.25 ± 0.034	0.579HisGln: 0.579 ± 0.02	1.483HisArg: 1.483 ± 0.037	1.027HisSer: 1.027 ± 0.032	0.831HisThr: 0.831 ± 0.031	1.503HisVal: 1.503 ± 0.038	0.347HisTrp: 0.347 ± 0.018	0.584HisTyr: 0.584 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	8.414IleAla: 8.414 ± 0.097	0.485IleCys: 0.485 ± 0.023	4.27IleAsp: 4.27 ± 0.068	3.706IleGlu: 3.706 ± 0.063	1.698IlePhe: 1.698 ± 0.041	5.493IleGly: 5.493 ± 0.081	0.955IleHis: 0.955 ± 0.03	2.598IleIle: 2.598 ± 0.055	1.435IleLys: 1.435 ± 0.036	4.296IleLeu: 4.296 ± 0.059	1.064IleMet: 1.064 ± 0.03	1.553IleAsn: 1.553 ± 0.041	2.471IlePro: 2.471 ± 0.048	1.297IleGln: 1.297 ± 0.038	3.197IleArg: 3.197 ± 0.048	3.166IleSer: 3.166 ± 0.058	3.024IleThr: 3.024 ± 0.063	4.859IleVal: 4.859 ± 0.068	0.632IleTrp: 0.632 ± 0.026	1.17IleTyr: 1.17 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	4.152LysAla: 4.152 ± 0.066	0.199LysCys: 0.199 ± 0.014	1.496LysAsp: 1.496 ± 0.039	1.133LysGlu: 1.133 ± 0.038	1.002LysPhe: 1.002 ± 0.031	2.64LysGly: 2.64 ± 0.057	0.623LysHis: 0.623 ± 0.024	1.854LysIle: 1.854 ± 0.041	1.091LysLys: 1.091 ± 0.041	3.494LysLeu: 3.494 ± 0.055	0.918LysMet: 0.918 ± 0.035	0.896LysAsn: 0.896 ± 0.032	2.068LysPro: 2.068 ± 0.047	0.921LysGln: 0.921 ± 0.028	2.368LysArg: 2.368 ± 0.049	1.939LysSer: 1.939 ± 0.051	2.078LysThr: 2.078 ± 0.045	2.233LysVal: 2.233 ± 0.051	0.426LysTrp: 0.426 ± 0.018	0.683LysTyr: 0.683 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	12.673LeuAla: 12.673 ± 0.133	0.771LeuCys: 0.771 ± 0.027	5.843LeuAsp: 5.843 ± 0.07	4.232LeuGlu: 4.232 ± 0.067	3.469LeuPhe: 3.469 ± 0.065	8.006LeuGly: 8.006 ± 0.095	1.789LeuHis: 1.789 ± 0.043	5.354LeuIle: 5.354 ± 0.08	3.264LeuLys: 3.264 ± 0.06	8.727LeuLeu: 8.727 ± 0.119	2.126LeuMet: 2.126 ± 0.049	2.791LeuAsn: 2.791 ± 0.052	5.197LeuPro: 5.197 ± 0.071	2.506LeuGln: 2.506 ± 0.054	6.3LeuArg: 6.3 ± 0.074	6.412LeuSer: 6.412 ± 0.08	6.198LeuThr: 6.198 ± 0.082	6.784LeuVal: 6.784 ± 0.08	1.139LeuTrp: 1.139 ± 0.033	1.907LeuTyr: 1.907 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	3.22MetAla: 3.22 ± 0.057	0.162MetCys: 0.162 ± 0.013	1.064MetAsp: 1.064 ± 0.029	1.001MetGlu: 1.001 ± 0.028	0.765MetPhe: 0.765 ± 0.028	1.908MetGly: 1.908 ± 0.04	0.427MetHis: 0.427 ± 0.019	1.569MetIle: 1.569 ± 0.039	1.033MetLys: 1.033 ± 0.031	2.581MetLeu: 2.581 ± 0.055	0.685MetMet: 0.685 ± 0.028	0.773MetAsn: 0.773 ± 0.027	1.413MetPro: 1.413 ± 0.04	0.694MetGln: 0.694 ± 0.025	1.728MetArg: 1.728 ± 0.042	1.579MetSer: 1.579 ± 0.038	1.864MetThr: 1.864 ± 0.041	1.722MetVal: 1.722 ± 0.039	0.199MetTrp: 0.199 ± 0.013	0.281MetTyr: 0.281 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.762AsnAla: 3.762 ± 0.065	0.263AsnCys: 0.263 ± 0.017	1.636AsnAsp: 1.636 ± 0.037	1.224AsnGlu: 1.224 ± 0.033	1.035AsnPhe: 1.035 ± 0.034	2.828AsnGly: 2.828 ± 0.069	0.548AsnHis: 0.548 ± 0.021	1.61AsnIle: 1.61 ± 0.048	0.794AsnLys: 0.794 ± 0.025	2.748AsnLeu: 2.748 ± 0.053	0.608AsnMet: 0.608 ± 0.025	0.882AsnAsn: 0.882 ± 0.03	1.806AsnPro: 1.806 ± 0.039	0.841AsnGln: 0.841 ± 0.031	1.97AsnArg: 1.97 ± 0.045	1.456AsnSer: 1.456 ± 0.037	1.447AsnThr: 1.447 ± 0.046	2.13AsnVal: 2.13 ± 0.044	0.461AsnTrp: 0.461 ± 0.021	0.803AsnTyr: 0.803 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	6.048ProAla: 6.048 ± 0.089	0.333ProCys: 0.333 ± 0.018	3.414ProAsp: 3.414 ± 0.061	3.125ProGlu: 3.125 ± 0.054	1.877ProPhe: 1.877 ± 0.04	4.348ProGly: 4.348 ± 0.068	1.041ProHis: 1.041 ± 0.031	2.713ProIle: 2.713 ± 0.051	1.671ProLys: 1.671 ± 0.038	4.472ProLeu: 4.472 ± 0.068	1.264ProMet: 1.264 ± 0.031	1.441ProAsn: 1.441 ± 0.038	2.287ProPro: 2.287 ± 0.057	1.523ProGln: 1.523 ± 0.04	2.733ProArg: 2.733 ± 0.054	2.816ProSer: 2.816 ± 0.055	2.923ProThr: 2.923 ± 0.058	4.341ProVal: 4.341 ± 0.071	0.619ProTrp: 0.619 ± 0.026	1.073ProTyr: 1.073 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	3.844GlnAla: 3.844 ± 0.059	0.237GlnCys: 0.237 ± 0.015	1.275GlnAsp: 1.275 ± 0.033	1.099GlnGlu: 1.099 ± 0.028	1.128GlnPhe: 1.128 ± 0.033	2.321GlnGly: 2.321 ± 0.047	0.626GlnHis: 0.626 ± 0.024	1.939GlnIle: 1.939 ± 0.041	0.958GlnLys: 0.958 ± 0.033	2.872GlnLeu: 2.872 ± 0.056	0.839GlnMet: 0.839 ± 0.027	0.897GlnAsn: 0.897 ± 0.028	1.55GlnPro: 1.55 ± 0.037	1.141GlnGln: 1.141 ± 0.041	2.388GlnArg: 2.388 ± 0.05	1.986GlnSer: 1.986 ± 0.042	1.811GlnThr: 1.811 ± 0.042	2.178GlnVal: 2.178 ± 0.052	0.381GlnTrp: 0.381 ± 0.02	0.656GlnTyr: 0.656 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	8.317ArgAla: 8.317 ± 0.111	0.513ArgCys: 0.513 ± 0.021	4.042ArgAsp: 4.042 ± 0.061	3.539ArgGlu: 3.539 ± 0.064	2.885ArgPhe: 2.885 ± 0.052	4.808ArgGly: 4.808 ± 0.067	1.561ArgHis: 1.561 ± 0.041	4.227ArgIle: 4.227 ± 0.065	2.056ArgLys: 2.056 ± 0.046	7.255ArgLeu: 7.255 ± 0.098	1.871ArgMet: 1.871 ± 0.041	1.935ArgAsn: 1.935 ± 0.049	3.33ArgPro: 3.33 ± 0.058	2.181ArgGln: 2.181 ± 0.045	4.973ArgArg: 4.973 ± 0.076	3.875ArgSer: 3.875 ± 0.062	3.656ArgThr: 3.656 ± 0.055	4.819ArgVal: 4.819 ± 0.065	1.104ArgTrp: 1.104 ± 0.037	1.863ArgTyr: 1.863 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	6.875SerAla: 6.875 ± 0.082	0.464SerCys: 0.464 ± 0.024	3.429SerAsp: 3.429 ± 0.059	2.772SerGlu: 2.772 ± 0.054	2.395SerPhe: 2.395 ± 0.051	6.037SerGly: 6.037 ± 0.1	1.067SerHis: 1.067 ± 0.035	3.234SerIle: 3.234 ± 0.057	1.721SerLys: 1.721 ± 0.042	5.381SerLeu: 5.381 ± 0.075	1.33SerMet: 1.33 ± 0.037	1.729SerAsn: 1.729 ± 0.047	2.885SerPro: 2.885 ± 0.048	1.606SerGln: 1.606 ± 0.043	3.56SerArg: 3.56 ± 0.061	3.308SerSer: 3.308 ± 0.069	3.089SerThr: 3.089 ± 0.066	4.29SerVal: 4.29 ± 0.068	0.815SerTrp: 0.815 ± 0.027	1.516SerTyr: 1.516 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	7.164ThrAla: 7.164 ± 0.111	0.411ThrCys: 0.411 ± 0.019	3.184ThrAsp: 3.184 ± 0.055	2.542ThrGlu: 2.542 ± 0.056	1.972ThrPhe: 1.972 ± 0.044	5.816ThrGly: 5.816 ± 0.091	1.085ThrHis: 1.085 ± 0.03	3.523ThrIle: 3.523 ± 0.067	1.695ThrLys: 1.695 ± 0.044	6.205ThrLeu: 6.205 ± 0.083	1.415ThrMet: 1.415 ± 0.036	1.673ThrAsn: 1.673 ± 0.046	3.538ThrPro: 3.538 ± 0.067	1.652ThrGln: 1.652 ± 0.045	3.493ThrArg: 3.493 ± 0.057	3.159ThrSer: 3.159 ± 0.061	3.525ThrThr: 3.525 ± 0.08	4.649ThrVal: 4.649 ± 0.082	0.631ThrTrp: 0.631 ± 0.023	1.286ThrTyr: 1.286 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	9.884ValAla: 9.884 ± 0.116	0.596ValCys: 0.596 ± 0.025	4.515ValAsp: 4.515 ± 0.067	4.19ValGlu: 4.19 ± 0.064	2.381ValPhe: 2.381 ± 0.047	5.799ValGly: 5.799 ± 0.074	1.389ValHis: 1.389 ± 0.039	4.05ValIle: 4.05 ± 0.065	2.273ValLys: 2.273 ± 0.046	6.499ValLeu: 6.499 ± 0.084	1.679ValMet: 1.679 ± 0.037	2.124ValAsn: 2.124 ± 0.048	3.744ValPro: 3.744 ± 0.064	2.013ValGln: 2.013 ± 0.046	5.048ValArg: 5.048 ± 0.076	4.702ValSer: 4.702 ± 0.068	4.894ValThr: 4.894 ± 0.066	5.424ValVal: 5.424 ± 0.076	0.831ValTrp: 0.831 ± 0.025	1.328ValTyr: 1.328 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.302TrpAla: 1.302 ± 0.041	0.132TrpCys: 0.132 ± 0.011	0.699TrpAsp: 0.699 ± 0.026	0.57TrpGlu: 0.57 ± 0.022	0.531TrpPhe: 0.531 ± 0.021	0.89TrpGly: 0.89 ± 0.032	0.357TrpHis: 0.357 ± 0.018	0.685TrpIle: 0.685 ± 0.026	0.48TrpLys: 0.48 ± 0.021	1.596TrpLeu: 1.596 ± 0.039	0.36TrpMet: 0.36 ± 0.018	0.457TrpAsn: 0.457 ± 0.019	0.679TrpPro: 0.679 ± 0.026	0.562TrpGln: 0.562 ± 0.02	1.15TrpArg: 1.15 ± 0.037	0.909TrpSer: 0.909 ± 0.03	0.827TrpThr: 0.827 ± 0.031	0.826TrpVal: 0.826 ± 0.028	0.235TrpTrp: 0.235 ± 0.017	0.272TrpTyr: 0.272 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.666TyrAla: 2.666 ± 0.055	0.243TyrCys: 0.243 ± 0.016	1.538TyrAsp: 1.538 ± 0.044	1.145TyrGlu: 1.145 ± 0.036	0.892TyrPhe: 0.892 ± 0.03	2.139TyrGly: 2.139 ± 0.055	0.521TyrHis: 0.521 ± 0.023	0.939TyrIle: 0.939 ± 0.031	0.64TyrLys: 0.64 ± 0.023	2.108TyrLeu: 2.108 ± 0.051	0.428TyrMet: 0.428 ± 0.021	0.694TyrAsn: 0.694 ± 0.025	1.044TyrPro: 1.044 ± 0.034	0.721TyrGln: 0.721 ± 0.028	1.829TyrArg: 1.829 ± 0.043	1.37TyrSer: 1.37 ± 0.04	1.164TyrThr: 1.164 ± 0.044	1.603TyrVal: 1.603 ± 0.042	0.325TyrTrp: 0.325 ± 0.019	0.639TyrTyr: 0.639 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3584 proteins (1076289 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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