Amino acid dipepetide frequency for Beggiatoa sp. PS

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.575AlaAla: 4.575 ± 0.067	0.806AlaCys: 0.806 ± 0.026	3.452AlaAsp: 3.452 ± 0.06	4.415AlaGlu: 4.415 ± 0.057	2.934AlaPhe: 2.934 ± 0.051	4.209AlaGly: 4.209 ± 0.061	1.496AlaHis: 1.496 ± 0.035	5.565AlaIle: 5.565 ± 0.065	4.395AlaLys: 4.395 ± 0.062	7.919AlaLeu: 7.919 ± 0.097	1.697AlaMet: 1.697 ± 0.033	3.315AlaAsn: 3.315 ± 0.053	2.215AlaPro: 2.215 ± 0.044	3.553AlaGln: 3.553 ± 0.056	2.843AlaArg: 2.843 ± 0.05	3.716AlaSer: 3.716 ± 0.052	3.878AlaThr: 3.878 ± 0.054	3.97AlaVal: 3.97 ± 0.057	0.871AlaTrp: 0.871 ± 0.027	2.192AlaTyr: 2.192 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.627CysAla: 0.627 ± 0.022	0.169CysCys: 0.169 ± 0.01	0.53CysAsp: 0.53 ± 0.019	0.611CysGlu: 0.611 ± 0.022	0.504CysPhe: 0.504 ± 0.022	0.799CysGly: 0.799 ± 0.033	0.421CysHis: 0.421 ± 0.024	0.623CysIle: 0.623 ± 0.022	0.414CysLys: 0.414 ± 0.016	1.105CysLeu: 1.105 ± 0.031	0.217CysMet: 0.217 ± 0.012	0.379CysAsn: 0.379 ± 0.016	0.525CysPro: 0.525 ± 0.023	0.679CysGln: 0.679 ± 0.023	0.502CysArg: 0.502 ± 0.019	0.664CysSer: 0.664 ± 0.024	0.507CysThr: 0.507 ± 0.021	0.626CysVal: 0.626 ± 0.023	0.155CysTrp: 0.155 ± 0.012	0.437CysTyr: 0.437 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.138AspAla: 3.138 ± 0.053	0.639AspCys: 0.639 ± 0.027	2.936AspAsp: 2.936 ± 0.061	3.797AspGlu: 3.797 ± 0.06	2.653AspPhe: 2.653 ± 0.043	3.322AspGly: 3.322 ± 0.064	0.806AspHis: 0.806 ± 0.024	4.34AspIle: 4.34 ± 0.063	3.62AspLys: 3.62 ± 0.05	4.74AspLeu: 4.74 ± 0.072	1.199AspMet: 1.199 ± 0.032	3.03AspAsn: 3.03 ± 0.048	1.741AspPro: 1.741 ± 0.041	1.476AspGln: 1.476 ± 0.034	1.812AspArg: 1.812 ± 0.037	3.1AspSer: 3.1 ± 0.053	2.747AspThr: 2.747 ± 0.054	2.875AspVal: 2.875 ± 0.044	0.838AspTrp: 0.838 ± 0.025	2.138AspTyr: 2.138 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	4.698GluAla: 4.698 ± 0.064	0.51GluCys: 0.51 ± 0.019	2.828GluAsp: 2.828 ± 0.047	4.772GluGlu: 4.772 ± 0.09	2.451GluPhe: 2.451 ± 0.045	3.525GluGly: 3.525 ± 0.054	1.448GluHis: 1.448 ± 0.035	5.284GluIle: 5.284 ± 0.067	4.941GluLys: 4.941 ± 0.074	6.694GluLeu: 6.694 ± 0.088	1.838GluMet: 1.838 ± 0.04	3.596GluAsn: 3.596 ± 0.065	2.396GluPro: 2.396 ± 0.045	4.042GluGln: 4.042 ± 0.066	3.144GluArg: 3.144 ± 0.055	3.39GluSer: 3.39 ± 0.053	3.945GluThr: 3.945 ± 0.061	3.852GluVal: 3.852 ± 0.058	0.867GluTrp: 0.867 ± 0.024	1.946GluTyr: 1.946 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	2.816PheAla: 2.816 ± 0.049	0.563PheCys: 0.563 ± 0.024	2.641PheAsp: 2.641 ± 0.045	2.948PheGlu: 2.948 ± 0.047	2.396PhePhe: 2.396 ± 0.048	2.797PheGly: 2.797 ± 0.05	0.97PheHis: 0.97 ± 0.025	3.254PheIle: 3.254 ± 0.06	2.543PheLys: 2.543 ± 0.043	4.692PheLeu: 4.692 ± 0.061	1.147PheMet: 1.147 ± 0.03	2.132PheAsn: 2.132 ± 0.046	1.606PhePro: 1.606 ± 0.033	1.889PheGln: 1.889 ± 0.034	1.7PheArg: 1.7 ± 0.035	3.335PheSer: 3.335 ± 0.052	2.412PheThr: 2.412 ± 0.042	2.653PheVal: 2.653 ± 0.049	0.627PheTrp: 0.627 ± 0.025	1.638PheTyr: 1.638 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	3.26GlyAla: 3.26 ± 0.06	0.736GlyCys: 0.736 ± 0.022	3.006GlyAsp: 3.006 ± 0.065	3.773GlyGlu: 3.773 ± 0.055	2.773GlyPhe: 2.773 ± 0.048	3.88GlyGly: 3.88 ± 0.09	1.482GlyHis: 1.482 ± 0.032	5.06GlyIle: 5.06 ± 0.06	4.184GlyLys: 4.184 ± 0.053	6.062GlyLeu: 6.062 ± 0.072	1.543GlyMet: 1.543 ± 0.036	3.013GlyAsn: 3.013 ± 0.069	1.61GlyPro: 1.61 ± 0.044	2.893GlyGln: 2.893 ± 0.043	2.433GlyArg: 2.433 ± 0.046	3.187GlySer: 3.187 ± 0.06	3.475GlyThr: 3.475 ± 0.069	3.394GlyVal: 3.394 ± 0.059	0.99GlyTrp: 0.99 ± 0.028	2.356GlyTyr: 2.356 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	1.367HisAla: 1.367 ± 0.033	0.335HisCys: 0.335 ± 0.016	1.123HisAsp: 1.123 ± 0.029	1.236HisGlu: 1.236 ± 0.031	1.35HisPhe: 1.35 ± 0.024	1.244HisGly: 1.244 ± 0.031	0.858HisHis: 0.858 ± 0.027	1.639HisIle: 1.639 ± 0.035	1.221HisLys: 1.221 ± 0.03	2.858HisLeu: 2.858 ± 0.044	0.232HisMet: 0.232 ± 0.012	0.97HisAsn: 0.97 ± 0.025	1.29HisPro: 1.29 ± 0.031	1.419HisGln: 1.419 ± 0.033	1.106HisArg: 1.106 ± 0.029	1.403HisSer: 1.403 ± 0.032	1.097HisThr: 1.097 ± 0.028	1.045HisVal: 1.045 ± 0.027	0.414HisTrp: 0.414 ± 0.017	1.094HisTyr: 1.094 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.798IleAla: 5.798 ± 0.073	0.757IleCys: 0.757 ± 0.023	4.232IleAsp: 4.232 ± 0.052	5.632IleGlu: 5.632 ± 0.069	3.276IlePhe: 3.276 ± 0.057	4.425IleGly: 4.425 ± 0.067	1.68IleHis: 1.68 ± 0.034	5.317IleIle: 5.317 ± 0.086	4.551IleLys: 4.551 ± 0.052	7.473IleLeu: 7.473 ± 0.075	1.445IleMet: 1.445 ± 0.034	3.73IleAsn: 3.73 ± 0.059	3.539IlePro: 3.539 ± 0.059	3.124IleGln: 3.124 ± 0.045	3.191IleArg: 3.191 ± 0.047	4.864IleSer: 4.864 ± 0.062	4.551IleThr: 4.551 ± 0.072	4.477IleVal: 4.477 ± 0.06	0.811IleTrp: 0.811 ± 0.025	2.405IleTyr: 2.405 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	4.458LysAla: 4.458 ± 0.064	0.472LysCys: 0.472 ± 0.019	2.617LysAsp: 2.617 ± 0.04	4.038LysGlu: 4.038 ± 0.064	2.095LysPhe: 2.095 ± 0.039	3.294LysGly: 3.294 ± 0.05	1.397LysHis: 1.397 ± 0.035	5.014LysIle: 5.014 ± 0.064	4.642LysLys: 4.642 ± 0.076	5.858LysLeu: 5.858 ± 0.061	1.905LysMet: 1.905 ± 0.035	3.656LysAsn: 3.656 ± 0.056	2.831LysPro: 2.831 ± 0.056	3.337LysGln: 3.337 ± 0.046	3.146LysArg: 3.146 ± 0.054	3.467LysSer: 3.467 ± 0.054	4.033LysThr: 4.033 ± 0.058	3.533LysVal: 3.533 ± 0.054	0.747LysTrp: 0.747 ± 0.022	1.861LysTyr: 1.861 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	8.008LeuAla: 8.008 ± 0.095	1.067LeuCys: 1.067 ± 0.03	5.157LeuAsp: 5.157 ± 0.067	7.193LeuGlu: 7.193 ± 0.099	4.733LeuPhe: 4.733 ± 0.064	6.022LeuGly: 6.022 ± 0.081	2.141LeuHis: 2.141 ± 0.042	7.316LeuIle: 7.316 ± 0.083	6.915LeuLys: 6.915 ± 0.077	10.975LeuLeu: 10.975 ± 0.12	2.548LeuMet: 2.548 ± 0.044	5.154LeuAsn: 5.154 ± 0.059	5.034LeuPro: 5.034 ± 0.061	4.558LeuGln: 4.558 ± 0.064	4.639LeuArg: 4.639 ± 0.058	7.747LeuSer: 7.747 ± 0.087	6.483LeuThr: 6.483 ± 0.088	6.052LeuVal: 6.052 ± 0.073	1.423LeuTrp: 1.423 ± 0.041	3.014LeuTyr: 3.014 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	1.898MetAla: 1.898 ± 0.038	0.158MetCys: 0.158 ± 0.01	1.22MetAsp: 1.22 ± 0.028	1.387MetGlu: 1.387 ± 0.03	0.715MetPhe: 0.715 ± 0.024	1.484MetGly: 1.484 ± 0.035	0.339MetHis: 0.339 ± 0.016	1.692MetIle: 1.692 ± 0.034	1.547MetLys: 1.547 ± 0.037	2.35MetLeu: 2.35 ± 0.044	0.707MetMet: 0.707 ± 0.024	1.181MetAsn: 1.181 ± 0.032	1.362MetPro: 1.362 ± 0.033	0.992MetGln: 0.992 ± 0.026	1.146MetArg: 1.146 ± 0.025	1.473MetSer: 1.473 ± 0.037	1.621MetThr: 1.621 ± 0.033	1.541MetVal: 1.541 ± 0.034	0.19MetTrp: 0.19 ± 0.01	0.489MetTyr: 0.489 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.152AsnAla: 3.152 ± 0.047	0.524AsnCys: 0.524 ± 0.023	2.589AsnAsp: 2.589 ± 0.048	2.956AsnGlu: 2.956 ± 0.052	2.061AsnPhe: 2.061 ± 0.043	2.995AsnGly: 2.995 ± 0.049	1.288AsnHis: 1.288 ± 0.032	3.527AsnIle: 3.527 ± 0.053	2.669AsnLys: 2.669 ± 0.043	5.173AsnLeu: 5.173 ± 0.063	1.044AsnMet: 1.044 ± 0.022	2.663AsnAsn: 2.663 ± 0.048	2.535AsnPro: 2.535 ± 0.051	2.991AsnGln: 2.991 ± 0.055	2.287AsnArg: 2.287 ± 0.041	2.894AsnSer: 2.894 ± 0.058	2.803AsnThr: 2.803 ± 0.044	2.582AsnVal: 2.582 ± 0.039	0.739AsnTrp: 0.739 ± 0.023	1.836AsnTyr: 1.836 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	2.465ProAla: 2.465 ± 0.041	0.342ProCys: 0.342 ± 0.017	2.616ProAsp: 2.616 ± 0.052	3.104ProGlu: 3.104 ± 0.056	1.956ProPhe: 1.956 ± 0.043	2.011ProGly: 2.011 ± 0.047	0.915ProHis: 0.915 ± 0.026	3.4ProIle: 3.4 ± 0.055	2.65ProLys: 2.65 ± 0.045	4.409ProLeu: 4.409 ± 0.068	0.877ProMet: 0.877 ± 0.027	2.345ProAsn: 2.345 ± 0.046	2.0ProPro: 2.0 ± 0.048	1.816ProGln: 1.816 ± 0.041	1.451ProArg: 1.451 ± 0.038	2.496ProSer: 2.496 ± 0.05	2.597ProThr: 2.597 ± 0.05	2.682ProVal: 2.682 ± 0.049	0.48ProTrp: 0.48 ± 0.019	1.416ProTyr: 1.416 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.953GlnAla: 3.953 ± 0.06	0.431GlnCys: 0.431 ± 0.019	1.933GlnAsp: 1.933 ± 0.038	3.056GlnGlu: 3.056 ± 0.054	2.056GlnPhe: 2.056 ± 0.041	2.66GlnGly: 2.66 ± 0.049	1.24GlnHis: 1.24 ± 0.028	3.759GlnIle: 3.759 ± 0.051	3.369GlnLys: 3.369 ± 0.055	5.621GlnLeu: 5.621 ± 0.076	1.149GlnMet: 1.149 ± 0.03	2.419GlnAsn: 2.419 ± 0.042	2.067GlnPro: 2.067 ± 0.043	3.359GlnGln: 3.359 ± 0.066	2.559GlnArg: 2.559 ± 0.046	2.831GlnSer: 2.831 ± 0.044	2.998GlnThr: 2.998 ± 0.045	2.963GlnVal: 2.963 ± 0.052	0.722GlnTrp: 0.722 ± 0.022	1.417GlnTyr: 1.417 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	2.725ArgAla: 2.725 ± 0.044	0.501ArgCys: 0.501 ± 0.019	2.097ArgAsp: 2.097 ± 0.032	2.882ArgGlu: 2.882 ± 0.045	2.374ArgPhe: 2.374 ± 0.036	2.333ArgGly: 2.333 ± 0.041	1.216ArgHis: 1.216 ± 0.033	3.285ArgIle: 3.285 ± 0.049	2.526ArgLys: 2.526 ± 0.051	5.268ArgLeu: 5.268 ± 0.073	1.106ArgMet: 1.106 ± 0.027	1.829ArgAsn: 1.829 ± 0.032	1.4ArgPro: 1.4 ± 0.037	2.555ArgGln: 2.555 ± 0.049	2.248ArgArg: 2.248 ± 0.041	2.171ArgSer: 2.171 ± 0.044	2.224ArgThr: 2.224 ± 0.043	2.519ArgVal: 2.519 ± 0.045	0.685ArgTrp: 0.685 ± 0.022	1.863ArgTyr: 1.863 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	3.7SerAla: 3.7 ± 0.06	0.652SerCys: 0.652 ± 0.021	3.188SerAsp: 3.188 ± 0.058	3.875SerGlu: 3.875 ± 0.057	2.843SerPhe: 2.843 ± 0.046	3.957SerGly: 3.957 ± 0.071	1.566SerHis: 1.566 ± 0.035	4.27SerIle: 4.27 ± 0.059	3.492SerLys: 3.492 ± 0.051	6.668SerLeu: 6.668 ± 0.071	1.329SerMet: 1.329 ± 0.032	2.737SerAsn: 2.737 ± 0.049	2.785SerPro: 2.785 ± 0.051	3.17SerGln: 3.17 ± 0.048	2.402SerArg: 2.402 ± 0.047	3.973SerSer: 3.973 ± 0.072	3.313SerThr: 3.313 ± 0.052	3.704SerVal: 3.704 ± 0.055	0.752SerTrp: 0.752 ± 0.023	1.939SerTyr: 1.939 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	4.018ThrAla: 4.018 ± 0.065	0.559ThrCys: 0.559 ± 0.024	3.093ThrAsp: 3.093 ± 0.055	3.72ThrGlu: 3.72 ± 0.059	2.495ThrPhe: 2.495 ± 0.044	3.943ThrGly: 3.943 ± 0.078	1.487ThrHis: 1.487 ± 0.031	4.367ThrIle: 4.367 ± 0.063	2.898ThrLys: 2.898 ± 0.047	6.842ThrLeu: 6.842 ± 0.082	1.115ThrMet: 1.115 ± 0.031	2.448ThrAsn: 2.448 ± 0.056	2.825ThrPro: 2.825 ± 0.051	3.077ThrGln: 3.077 ± 0.053	2.258ThrArg: 2.258 ± 0.039	3.199ThrSer: 3.199 ± 0.05	3.662ThrThr: 3.662 ± 0.062	3.901ThrVal: 3.901 ± 0.061	0.625ThrTrp: 0.625 ± 0.019	1.753ThrTyr: 1.753 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	4.286ValAla: 4.286 ± 0.07	0.67ValCys: 0.67 ± 0.021	3.256ValAsp: 3.256 ± 0.051	3.92ValGlu: 3.92 ± 0.062	2.609ValPhe: 2.609 ± 0.045	3.549ValGly: 3.549 ± 0.058	1.123ValHis: 1.123 ± 0.028	4.745ValIle: 4.745 ± 0.061	3.525ValLys: 3.525 ± 0.055	5.914ValLeu: 5.914 ± 0.072	1.46ValMet: 1.46 ± 0.032	2.739ValAsn: 2.739 ± 0.045	2.389ValPro: 2.389 ± 0.048	2.349ValGln: 2.349 ± 0.045	2.469ValArg: 2.469 ± 0.044	3.692ValSer: 3.692 ± 0.051	3.549ValThr: 3.549 ± 0.06	3.814ValVal: 3.814 ± 0.057	0.847ValTrp: 0.847 ± 0.024	1.775ValTyr: 1.775 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	0.811TrpAla: 0.811 ± 0.022	0.169TrpCys: 0.169 ± 0.011	0.644TrpAsp: 0.644 ± 0.025	0.858TrpGlu: 0.858 ± 0.027	0.67TrpPhe: 0.67 ± 0.024	0.704TrpGly: 0.704 ± 0.024	0.413TrpHis: 0.413 ± 0.016	0.933TrpIle: 0.933 ± 0.026	0.731TrpLys: 0.731 ± 0.022	1.773TrpLeu: 1.773 ± 0.042	0.328TrpMet: 0.328 ± 0.015	0.594TrpAsn: 0.594 ± 0.021	0.398TrpPro: 0.398 ± 0.018	0.984TrpGln: 0.984 ± 0.029	0.663TrpArg: 0.663 ± 0.026	0.642TrpSer: 0.642 ± 0.023	0.69TrpThr: 0.69 ± 0.024	0.826TrpVal: 0.826 ± 0.024	0.248TrpTrp: 0.248 ± 0.016	0.457TrpTyr: 0.457 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.263TyrAla: 2.263 ± 0.042	0.432TyrCys: 0.432 ± 0.017	1.791TyrAsp: 1.791 ± 0.045	1.992TyrGlu: 1.992 ± 0.044	1.817TyrPhe: 1.817 ± 0.042	1.954TyrGly: 1.954 ± 0.038	1.015TyrHis: 1.015 ± 0.03	1.888TyrIle: 1.888 ± 0.041	1.568TyrLys: 1.568 ± 0.038	3.784TyrLeu: 3.784 ± 0.045	0.604TyrMet: 0.604 ± 0.022	1.382TyrAsn: 1.382 ± 0.029	1.48TyrPro: 1.48 ± 0.035	2.299TyrGln: 2.299 ± 0.044	1.807TyrArg: 1.807 ± 0.04	2.07TyrSer: 2.07 ± 0.04	1.7TyrThr: 1.7 ± 0.039	1.673TyrVal: 1.673 ± 0.034	0.507TyrTrp: 0.507 ± 0.019	1.321TyrTyr: 1.321 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6644 proteins (1440897 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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