Amino acid dipepetide frequency for Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.531AlaAla: 4.531 ± 1.071
1.133AlaCys: 1.133 ± 0.507
3.021AlaAsp: 3.021 ± 0.687
3.587AlaGlu: 3.587 ± 0.637
1.322AlaPhe: 1.322 ± 0.63
4.153AlaGly: 4.153 ± 0.992
0.566AlaHis: 0.566 ± 0.401
4.72AlaIle: 4.72 ± 0.743
2.265AlaLys: 2.265 ± 0.586
4.72AlaLeu: 4.72 ± 0.646
2.832AlaMet: 2.832 ± 0.687
3.021AlaAsn: 3.021 ± 0.45
2.077AlaPro: 2.077 ± 0.487
1.51AlaGln: 1.51 ± 0.486
2.643AlaArg: 2.643 ± 0.582
5.475AlaSer: 5.475 ± 1.281
3.587AlaThr: 3.587 ± 0.73
3.965AlaVal: 3.965 ± 0.823
0.755AlaTrp: 0.755 ± 0.324
1.133AlaTyr: 1.133 ± 0.254
0.0AlaXaa: 0.0 ± 0.0
Cys
0.944CysAla: 0.944 ± 0.347
0.189CysCys: 0.189 ± 0.148
0.378CysAsp: 0.378 ± 0.371
0.566CysGlu: 0.566 ± 0.227
1.51CysPhe: 1.51 ± 0.549
0.378CysGly: 0.378 ± 0.383
0.944CysHis: 0.944 ± 0.275
0.944CysIle: 0.944 ± 0.463
1.133CysLys: 1.133 ± 0.469
1.133CysLeu: 1.133 ± 0.377
1.133CysMet: 1.133 ± 0.285
1.699CysAsn: 1.699 ± 0.45
0.755CysPro: 0.755 ± 0.44
0.378CysGln: 0.378 ± 0.276
1.51CysArg: 1.51 ± 0.592
1.699CysSer: 1.699 ± 0.575
0.566CysThr: 0.566 ± 0.311
0.944CysVal: 0.944 ± 0.401
0.378CysTrp: 0.378 ± 0.235
0.378CysTyr: 0.378 ± 0.254
0.0CysXaa: 0.0 ± 0.0
Asp
2.832AspAla: 2.832 ± 0.48
1.51AspCys: 1.51 ± 0.445
1.51AspAsp: 1.51 ± 0.339
2.643AspGlu: 2.643 ± 0.585
2.265AspPhe: 2.265 ± 0.729
3.021AspGly: 3.021 ± 1.146
0.378AspHis: 0.378 ± 0.235
1.888AspIle: 1.888 ± 0.678
1.699AspLys: 1.699 ± 0.452
3.398AspLeu: 3.398 ± 0.659
1.51AspMet: 1.51 ± 0.429
2.643AspAsn: 2.643 ± 0.721
3.398AspPro: 3.398 ± 0.617
2.077AspGln: 2.077 ± 0.614
2.265AspArg: 2.265 ± 0.529
2.454AspSer: 2.454 ± 0.547
2.454AspThr: 2.454 ± 0.777
3.021AspVal: 3.021 ± 0.633
0.755AspTrp: 0.755 ± 0.44
1.888AspTyr: 1.888 ± 0.516
0.0AspXaa: 0.0 ± 0.0
Glu
2.454GluAla: 2.454 ± 0.418
1.699GluCys: 1.699 ± 0.86
3.776GluAsp: 3.776 ± 0.584
6.985GluGlu: 6.985 ± 0.955
2.077GluPhe: 2.077 ± 0.449
3.965GluGly: 3.965 ± 0.971
0.566GluHis: 0.566 ± 0.33
4.72GluIle: 4.72 ± 0.838
6.608GluLys: 6.608 ± 1.245
6.041GluLeu: 6.041 ± 0.772
3.398GluMet: 3.398 ± 0.716
3.587GluAsn: 3.587 ± 1.012
2.265GluPro: 2.265 ± 0.904
4.908GluGln: 4.908 ± 1.042
4.72GluArg: 4.72 ± 1.115
6.041GluSer: 6.041 ± 0.894
3.587GluThr: 3.587 ± 0.64
5.475GluVal: 5.475 ± 1.172
0.755GluTrp: 0.755 ± 0.314
1.51GluTyr: 1.51 ± 0.394
0.0GluXaa: 0.0 ± 0.0
Phe
1.322PheAla: 1.322 ± 0.305
0.189PheCys: 0.189 ± 0.192
1.51PheAsp: 1.51 ± 0.645
5.097PheGlu: 5.097 ± 0.822
1.322PhePhe: 1.322 ± 0.41
2.077PheGly: 2.077 ± 0.345
0.755PheHis: 0.755 ± 0.335
1.888PheIle: 1.888 ± 0.564
1.133PheLys: 1.133 ± 0.489
3.776PheLeu: 3.776 ± 0.727
0.566PheMet: 0.566 ± 0.291
1.888PheAsn: 1.888 ± 0.614
0.944PhePro: 0.944 ± 0.334
2.454PheGln: 2.454 ± 0.653
1.322PheArg: 1.322 ± 0.393
3.587PheSer: 3.587 ± 0.625
3.398PheThr: 3.398 ± 0.458
3.021PheVal: 3.021 ± 0.626
0.566PheTrp: 0.566 ± 0.301
0.944PheTyr: 0.944 ± 0.416
0.0PheXaa: 0.0 ± 0.0
Gly
3.398GlyAla: 3.398 ± 0.922
0.378GlyCys: 0.378 ± 0.299
3.776GlyAsp: 3.776 ± 0.396
3.776GlyGlu: 3.776 ± 1.166
2.832GlyPhe: 2.832 ± 0.545
3.209GlyGly: 3.209 ± 0.757
1.133GlyHis: 1.133 ± 0.58
4.908GlyIle: 4.908 ± 0.907
3.965GlyLys: 3.965 ± 0.97
4.342GlyLeu: 4.342 ± 0.841
2.077GlyMet: 2.077 ± 0.352
2.832GlyAsn: 2.832 ± 0.711
3.587GlyPro: 3.587 ± 0.696
1.888GlyGln: 1.888 ± 0.564
4.72GlyArg: 4.72 ± 0.798
4.153GlySer: 4.153 ± 1.392
4.72GlyThr: 4.72 ± 0.903
5.286GlyVal: 5.286 ± 0.489
1.322GlyTrp: 1.322 ± 0.716
2.454GlyTyr: 2.454 ± 0.512
0.0GlyXaa: 0.0 ± 0.0
His
0.755HisAla: 0.755 ± 0.254
0.378HisCys: 0.378 ± 0.261
0.378HisAsp: 0.378 ± 0.254
1.699HisGlu: 1.699 ± 0.407
1.51HisPhe: 1.51 ± 0.464
1.322HisGly: 1.322 ± 0.479
0.378HisHis: 0.378 ± 0.371
1.699HisIle: 1.699 ± 0.821
1.133HisLys: 1.133 ± 0.407
1.699HisLeu: 1.699 ± 0.484
0.566HisMet: 0.566 ± 0.246
0.378HisAsn: 0.378 ± 0.371
1.133HisPro: 1.133 ± 0.443
0.944HisGln: 0.944 ± 0.405
1.133HisArg: 1.133 ± 0.444
1.888HisSer: 1.888 ± 0.595
0.378HisThr: 0.378 ± 0.282
0.189HisVal: 0.189 ± 0.201
0.0HisTrp: 0.0 ± 0.0
0.566HisTyr: 0.566 ± 0.278
0.0HisXaa: 0.0 ± 0.0
Ile
3.209IleAla: 3.209 ± 0.855
2.643IleCys: 2.643 ± 0.615
2.265IleAsp: 2.265 ± 0.656
6.419IleGlu: 6.419 ± 1.708
1.322IlePhe: 1.322 ± 0.421
5.286IleGly: 5.286 ± 0.856
0.755IleHis: 0.755 ± 0.411
4.342IleIle: 4.342 ± 0.772
3.965IleLys: 3.965 ± 0.879
6.419IleLeu: 6.419 ± 1.378
1.888IleMet: 1.888 ± 0.281
3.209IleAsn: 3.209 ± 0.759
2.077IlePro: 2.077 ± 0.485
2.265IleGln: 2.265 ± 0.442
6.041IleArg: 6.041 ± 1.028
3.776IleSer: 3.776 ± 1.066
4.342IleThr: 4.342 ± 1.07
3.209IleVal: 3.209 ± 0.651
1.133IleTrp: 1.133 ± 0.677
1.888IleTyr: 1.888 ± 0.466
0.0IleXaa: 0.0 ± 0.0
Lys
4.342LysAla: 4.342 ± 0.814
1.322LysCys: 1.322 ± 0.667
2.265LysAsp: 2.265 ± 0.628
6.041LysGlu: 6.041 ± 0.967
1.699LysPhe: 1.699 ± 0.56
3.398LysGly: 3.398 ± 0.721
1.133LysHis: 1.133 ± 0.323
4.531LysIle: 4.531 ± 1.019
3.965LysLys: 3.965 ± 1.283
4.908LysLeu: 4.908 ± 1.156
3.209LysMet: 3.209 ± 0.459
2.643LysAsn: 2.643 ± 0.77
0.755LysPro: 0.755 ± 0.362
1.699LysGln: 1.699 ± 0.773
4.908LysArg: 4.908 ± 1.182
3.209LysSer: 3.209 ± 0.793
4.342LysThr: 4.342 ± 1.072
3.021LysVal: 3.021 ± 0.794
1.699LysTrp: 1.699 ± 0.474
2.077LysTyr: 2.077 ± 0.378
0.0LysXaa: 0.0 ± 0.0
Leu
4.342LeuAla: 4.342 ± 0.651
0.944LeuCys: 0.944 ± 0.432
1.888LeuAsp: 1.888 ± 0.683
6.796LeuGlu: 6.796 ± 1.16
2.077LeuPhe: 2.077 ± 0.463
3.965LeuGly: 3.965 ± 0.889
1.322LeuHis: 1.322 ± 0.534
6.041LeuIle: 6.041 ± 0.699
7.551LeuLys: 7.551 ± 1.488
7.551LeuLeu: 7.551 ± 1.711
1.888LeuMet: 1.888 ± 0.512
3.776LeuAsn: 3.776 ± 0.809
4.153LeuPro: 4.153 ± 0.601
3.209LeuGln: 3.209 ± 0.385
6.23LeuArg: 6.23 ± 1.07
4.72LeuSer: 4.72 ± 0.973
6.419LeuThr: 6.419 ± 1.184
3.587LeuVal: 3.587 ± 0.935
1.699LeuTrp: 1.699 ± 0.43
2.643LeuTyr: 2.643 ± 0.873
0.0LeuXaa: 0.0 ± 0.0
Met
3.965MetAla: 3.965 ± 0.806
1.322MetCys: 1.322 ± 0.545
2.454MetAsp: 2.454 ± 0.776
4.342MetGlu: 4.342 ± 0.804
0.944MetPhe: 0.944 ± 0.597
3.021MetGly: 3.021 ± 0.833
0.566MetHis: 0.566 ± 0.259
3.587MetIle: 3.587 ± 0.479
2.643MetLys: 2.643 ± 0.729
1.322MetLeu: 1.322 ± 0.424
1.888MetMet: 1.888 ± 0.722
1.322MetAsn: 1.322 ± 0.4
0.378MetPro: 0.378 ± 0.25
1.133MetGln: 1.133 ± 0.402
2.643MetArg: 2.643 ± 0.711
2.454MetSer: 2.454 ± 0.376
2.077MetThr: 2.077 ± 0.663
3.398MetVal: 3.398 ± 1.027
0.378MetTrp: 0.378 ± 0.221
1.133MetTyr: 1.133 ± 0.251
0.0MetXaa: 0.0 ± 0.0
Asn
3.587AsnAla: 3.587 ± 0.949
0.0AsnCys: 0.0 ± 0.0
2.454AsnAsp: 2.454 ± 0.383
4.531AsnGlu: 4.531 ± 0.608
1.51AsnPhe: 1.51 ± 0.463
5.852AsnGly: 5.852 ± 1.679
0.566AsnHis: 0.566 ± 0.263
2.265AsnIle: 2.265 ± 0.749
2.832AsnLys: 2.832 ± 0.747
4.153AsnLeu: 4.153 ± 0.956
2.077AsnMet: 2.077 ± 0.751
1.322AsnAsn: 1.322 ± 0.515
4.531AsnPro: 4.531 ± 0.767
2.077AsnGln: 2.077 ± 0.605
3.209AsnArg: 3.209 ± 0.661
4.153AsnSer: 4.153 ± 1.162
3.776AsnThr: 3.776 ± 0.605
1.888AsnVal: 1.888 ± 0.625
0.755AsnTrp: 0.755 ± 0.377
0.944AsnTyr: 0.944 ± 0.407
0.0AsnXaa: 0.0 ± 0.0
Pro
2.643ProAla: 2.643 ± 0.903
0.378ProCys: 0.378 ± 0.215
1.51ProAsp: 1.51 ± 0.561
2.643ProGlu: 2.643 ± 0.443
1.699ProPhe: 1.699 ± 0.52
2.265ProGly: 2.265 ± 0.418
0.566ProHis: 0.566 ± 0.335
3.021ProIle: 3.021 ± 0.563
4.153ProLys: 4.153 ± 0.892
4.153ProLeu: 4.153 ± 0.926
1.51ProMet: 1.51 ± 0.522
3.965ProAsn: 3.965 ± 0.738
1.133ProPro: 1.133 ± 0.334
0.378ProGln: 0.378 ± 0.207
1.51ProArg: 1.51 ± 0.652
3.021ProSer: 3.021 ± 0.549
1.133ProThr: 1.133 ± 0.349
2.077ProVal: 2.077 ± 0.603
0.566ProTrp: 0.566 ± 0.294
0.944ProTyr: 0.944 ± 0.46
0.0ProXaa: 0.0 ± 0.0
Gln
2.265GlnAla: 2.265 ± 0.67
0.755GlnCys: 0.755 ± 0.427
1.888GlnAsp: 1.888 ± 0.559
2.077GlnGlu: 2.077 ± 0.569
0.566GlnPhe: 0.566 ± 0.283
2.832GlnGly: 2.832 ± 0.557
0.378GlnHis: 0.378 ± 0.257
3.021GlnIle: 3.021 ± 0.423
2.643GlnLys: 2.643 ± 0.809
3.587GlnLeu: 3.587 ± 0.744
2.265GlnMet: 2.265 ± 0.65
3.965GlnAsn: 3.965 ± 0.791
0.566GlnPro: 0.566 ± 0.326
1.322GlnGln: 1.322 ± 0.37
3.021GlnArg: 3.021 ± 0.765
3.021GlnSer: 3.021 ± 0.994
2.643GlnThr: 2.643 ± 0.734
1.51GlnVal: 1.51 ± 0.517
0.566GlnTrp: 0.566 ± 0.37
0.566GlnTyr: 0.566 ± 0.269
0.0GlnXaa: 0.0 ± 0.0
Arg
3.776ArgAla: 3.776 ± 0.667
0.755ArgCys: 0.755 ± 0.321
2.643ArgAsp: 2.643 ± 0.59
3.587ArgGlu: 3.587 ± 0.756
3.209ArgPhe: 3.209 ± 0.52
5.475ArgGly: 5.475 ± 0.985
0.944ArgHis: 0.944 ± 0.365
4.531ArgIle: 4.531 ± 1.155
3.021ArgLys: 3.021 ± 0.522
4.531ArgLeu: 4.531 ± 0.7
3.965ArgMet: 3.965 ± 1.027
5.852ArgAsn: 5.852 ± 1.121
2.454ArgPro: 2.454 ± 0.768
3.398ArgGln: 3.398 ± 0.647
5.664ArgArg: 5.664 ± 0.855
3.965ArgSer: 3.965 ± 1.114
5.664ArgThr: 5.664 ± 1.001
3.209ArgVal: 3.209 ± 1.067
0.566ArgTrp: 0.566 ± 0.29
1.322ArgTyr: 1.322 ± 0.467
0.0ArgXaa: 0.0 ± 0.0
Ser
3.965SerAla: 3.965 ± 1.022
1.888SerCys: 1.888 ± 0.931
2.643SerAsp: 2.643 ± 0.6
3.021SerGlu: 3.021 ± 0.569
5.097SerPhe: 5.097 ± 0.579
4.531SerGly: 4.531 ± 0.913
2.454SerHis: 2.454 ± 0.799
5.664SerIle: 5.664 ± 1.176
3.587SerLys: 3.587 ± 0.695
6.041SerLeu: 6.041 ± 1.035
3.021SerMet: 3.021 ± 0.741
2.643SerAsn: 2.643 ± 0.831
3.209SerPro: 3.209 ± 0.619
3.965SerGln: 3.965 ± 0.639
3.587SerArg: 3.587 ± 0.656
7.929SerSer: 7.929 ± 1.351
3.965SerThr: 3.965 ± 0.882
3.587SerVal: 3.587 ± 0.764
1.699SerTrp: 1.699 ± 0.624
2.077SerTyr: 2.077 ± 0.721
0.0SerXaa: 0.0 ± 0.0
Thr
3.776ThrAla: 3.776 ± 0.624
0.755ThrCys: 0.755 ± 0.277
2.265ThrAsp: 2.265 ± 0.55
4.72ThrGlu: 4.72 ± 0.735
2.832ThrPhe: 2.832 ± 0.478
4.531ThrGly: 4.531 ± 1.103
2.077ThrHis: 2.077 ± 0.627
4.153ThrIle: 4.153 ± 0.775
4.153ThrLys: 4.153 ± 0.58
4.342ThrLeu: 4.342 ± 0.734
2.832ThrMet: 2.832 ± 0.654
2.265ThrAsn: 2.265 ± 0.413
2.454ThrPro: 2.454 ± 0.71
2.643ThrGln: 2.643 ± 0.717
4.342ThrArg: 4.342 ± 0.924
3.587ThrSer: 3.587 ± 0.624
3.021ThrThr: 3.021 ± 0.789
4.342ThrVal: 4.342 ± 0.87
0.755ThrTrp: 0.755 ± 0.271
2.454ThrTyr: 2.454 ± 0.573
0.0ThrXaa: 0.0 ± 0.0
Val
3.587ValAla: 3.587 ± 0.642
1.133ValCys: 1.133 ± 0.359
4.342ValAsp: 4.342 ± 1.171
3.587ValGlu: 3.587 ± 0.577
2.454ValPhe: 2.454 ± 0.555
2.832ValGly: 2.832 ± 0.564
1.51ValHis: 1.51 ± 0.666
1.322ValIle: 1.322 ± 0.428
3.021ValLys: 3.021 ± 0.601
6.608ValLeu: 6.608 ± 1.148
2.265ValMet: 2.265 ± 0.54
3.209ValAsn: 3.209 ± 0.409
1.322ValPro: 1.322 ± 0.336
1.51ValGln: 1.51 ± 0.579
5.475ValArg: 5.475 ± 0.984
5.097ValSer: 5.097 ± 0.592
2.643ValThr: 2.643 ± 1.09
3.021ValVal: 3.021 ± 0.612
0.378ValTrp: 0.378 ± 0.268
1.51ValTyr: 1.51 ± 0.402
0.0ValXaa: 0.0 ± 0.0
Trp
0.566TrpAla: 0.566 ± 0.274
0.0TrpCys: 0.0 ± 0.0
0.755TrpAsp: 0.755 ± 0.271
1.322TrpGlu: 1.322 ± 0.579
0.378TrpPhe: 0.378 ± 0.207
0.944TrpGly: 0.944 ± 0.337
0.566TrpHis: 0.566 ± 0.345
1.51TrpIle: 1.51 ± 0.479
0.566TrpLys: 0.566 ± 0.378
1.133TrpLeu: 1.133 ± 0.572
1.133TrpMet: 1.133 ± 0.418
0.755TrpAsn: 0.755 ± 0.286
0.566TrpPro: 0.566 ± 0.243
0.0TrpGln: 0.0 ± 0.0
1.133TrpArg: 1.133 ± 0.581
1.51TrpSer: 1.51 ± 0.611
1.699TrpThr: 1.699 ± 0.599
0.755TrpVal: 0.755 ± 0.553
0.566TrpTrp: 0.566 ± 0.262
0.189TrpTyr: 0.189 ± 0.186
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.755TyrAla: 0.755 ± 0.353
0.189TyrCys: 0.189 ± 0.161
1.888TyrAsp: 1.888 ± 0.706
1.699TyrGlu: 1.699 ± 0.54
1.133TyrPhe: 1.133 ± 0.325
1.699TyrGly: 1.699 ± 0.351
0.566TyrHis: 0.566 ± 0.557
1.699TyrIle: 1.699 ± 0.354
1.133TyrLys: 1.133 ± 0.378
1.133TyrLeu: 1.133 ± 0.417
0.755TyrMet: 0.755 ± 0.354
1.51TyrAsn: 1.51 ± 0.503
1.51TyrPro: 1.51 ± 0.62
1.699TyrGln: 1.699 ± 0.525
2.454TyrArg: 2.454 ± 0.725
2.832TyrSer: 2.832 ± 0.364
1.888TyrThr: 1.888 ± 0.664
1.322TyrVal: 1.322 ± 0.59
0.755TyrTrp: 0.755 ± 0.329
0.566TyrTyr: 0.566 ± 0.277
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 13 proteins (5298 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski