Amino acid dipepetide frequency for Salmonella phage Munch

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.581AlaAla: 3.581 ± 0.257
0.581AlaCys: 0.581 ± 0.071
2.999AlaAsp: 2.999 ± 0.182
3.894AlaGlu: 3.894 ± 0.217
2.372AlaPhe: 2.372 ± 0.153
3.267AlaGly: 3.267 ± 0.237
0.969AlaHis: 0.969 ± 0.104
3.701AlaIle: 3.701 ± 0.181
4.051AlaLys: 4.051 ± 0.24
4.347AlaLeu: 4.347 ± 0.201
1.578AlaMet: 1.578 ± 0.107
2.962AlaAsn: 2.962 ± 0.176
1.615AlaPro: 1.615 ± 0.111
1.966AlaGln: 1.966 ± 0.134
2.095AlaArg: 2.095 ± 0.123
3.562AlaSer: 3.562 ± 0.262
2.861AlaThr: 2.861 ± 0.271
3.461AlaVal: 3.461 ± 0.17
0.664AlaTrp: 0.664 ± 0.085
2.252AlaTyr: 2.252 ± 0.139
0.0AlaXaa: 0.0 ± 0.0
Cys
0.637CysAla: 0.637 ± 0.088
0.185CysCys: 0.185 ± 0.039
0.738CysAsp: 0.738 ± 0.091
0.674CysGlu: 0.674 ± 0.07
0.48CysPhe: 0.48 ± 0.066
0.877CysGly: 0.877 ± 0.103
0.268CysHis: 0.268 ± 0.051
0.932CysIle: 0.932 ± 0.099
0.628CysLys: 0.628 ± 0.072
0.821CysLeu: 0.821 ± 0.078
0.277CysMet: 0.277 ± 0.054
0.683CysAsn: 0.683 ± 0.09
0.443CysPro: 0.443 ± 0.069
0.378CysGln: 0.378 ± 0.059
0.452CysArg: 0.452 ± 0.075
0.923CysSer: 0.923 ± 0.087
0.978CysThr: 0.978 ± 0.09
0.895CysVal: 0.895 ± 0.105
0.157CysTrp: 0.157 ± 0.036
0.526CysTyr: 0.526 ± 0.066
0.0CysXaa: 0.0 ± 0.0
Asp
3.682AspAla: 3.682 ± 0.187
0.886AspCys: 0.886 ± 0.089
4.836AspAsp: 4.836 ± 0.256
5.445AspGlu: 5.445 ± 0.246
3.424AspPhe: 3.424 ± 0.196
5.029AspGly: 5.029 ± 0.252
1.089AspHis: 1.089 ± 0.092
5.269AspIle: 5.269 ± 0.205
3.848AspLys: 3.848 ± 0.189
4.983AspLeu: 4.983 ± 0.271
2.261AspMet: 2.261 ± 0.162
3.451AspAsn: 3.451 ± 0.193
1.984AspPro: 1.984 ± 0.144
1.458AspGln: 1.458 ± 0.12
2.261AspArg: 2.261 ± 0.152
4.153AspSer: 4.153 ± 0.211
3.599AspThr: 3.599 ± 0.173
4.79AspVal: 4.79 ± 0.226
0.895AspTrp: 0.895 ± 0.082
3.414AspTyr: 3.414 ± 0.172
0.0AspXaa: 0.0 ± 0.0
Glu
3.673GluAla: 3.673 ± 0.211
0.932GluCys: 0.932 ± 0.107
4.393GluAsp: 4.393 ± 0.216
6.34GluGlu: 6.34 ± 0.395
3.285GluPhe: 3.285 ± 0.177
3.091GluGly: 3.091 ± 0.167
1.772GluHis: 1.772 ± 0.12
5.454GluIle: 5.454 ± 0.239
4.882GluLys: 4.882 ± 0.28
6.534GluLeu: 6.534 ± 0.301
2.409GluMet: 2.409 ± 0.173
3.885GluAsn: 3.885 ± 0.267
1.975GluPro: 1.975 ± 0.138
2.667GluGln: 2.667 ± 0.161
2.972GluArg: 2.972 ± 0.181
4.079GluSer: 4.079 ± 0.213
3.414GluThr: 3.414 ± 0.163
5.196GluVal: 5.196 ± 0.235
0.997GluTrp: 0.997 ± 0.095
4.107GluTyr: 4.107 ± 0.241
0.0GluXaa: 0.0 ± 0.0
Phe
2.15PheAla: 2.15 ± 0.159
0.674PheCys: 0.674 ± 0.091
3.581PheAsp: 3.581 ± 0.171
2.888PheGlu: 2.888 ± 0.15
1.975PhePhe: 1.975 ± 0.159
2.953PheGly: 2.953 ± 0.183
0.747PheHis: 0.747 ± 0.078
3.156PheIle: 3.156 ± 0.164
3.414PheLys: 3.414 ± 0.175
2.722PheLeu: 2.722 ± 0.145
1.32PheMet: 1.32 ± 0.106
3.331PheAsn: 3.331 ± 0.184
1.2PhePro: 1.2 ± 0.105
1.79PheGln: 1.79 ± 0.136
1.578PheArg: 1.578 ± 0.132
3.128PheSer: 3.128 ± 0.176
2.925PheThr: 2.925 ± 0.153
2.944PheVal: 2.944 ± 0.172
0.683PheTrp: 0.683 ± 0.089
2.086PheTyr: 2.086 ± 0.159
0.0PheXaa: 0.0 ± 0.0
Gly
2.888GlyAla: 2.888 ± 0.209
0.784GlyCys: 0.784 ± 0.087
3.931GlyAsp: 3.931 ± 0.264
3.765GlyGlu: 3.765 ± 0.187
2.649GlyPhe: 2.649 ± 0.165
3.451GlyGly: 3.451 ± 0.443
0.923GlyHis: 0.923 ± 0.095
4.107GlyIle: 4.107 ± 0.2
4.319GlyLys: 4.319 ± 0.227
4.586GlyLeu: 4.586 ± 0.216
1.578GlyMet: 1.578 ± 0.117
4.31GlyAsn: 4.31 ± 0.264
0.683GlyPro: 0.683 ± 0.079
2.049GlyGln: 2.049 ± 0.16
2.584GlyArg: 2.584 ± 0.147
4.559GlySer: 4.559 ± 0.29
4.78GlyThr: 4.78 ± 0.371
3.922GlyVal: 3.922 ± 0.214
0.738GlyTrp: 0.738 ± 0.083
3.258GlyTyr: 3.258 ± 0.177
0.0GlyXaa: 0.0 ± 0.0
His
1.052HisAla: 1.052 ± 0.102
0.249HisCys: 0.249 ± 0.04
1.357HisAsp: 1.357 ± 0.126
1.347HisGlu: 1.347 ± 0.12
1.089HisPhe: 1.089 ± 0.105
1.237HisGly: 1.237 ± 0.106
0.388HisHis: 0.388 ± 0.06
1.523HisIle: 1.523 ± 0.126
1.393HisLys: 1.393 ± 0.125
1.458HisLeu: 1.458 ± 0.117
0.443HisMet: 0.443 ± 0.067
1.255HisAsn: 1.255 ± 0.127
0.803HisPro: 0.803 ± 0.087
0.581HisGln: 0.581 ± 0.076
0.997HisArg: 0.997 ± 0.102
1.19HisSer: 1.19 ± 0.114
1.024HisThr: 1.024 ± 0.108
1.32HisVal: 1.32 ± 0.109
0.194HisTrp: 0.194 ± 0.041
0.969HisTyr: 0.969 ± 0.096
0.0HisXaa: 0.0 ± 0.0
Ile
4.171IleAla: 4.171 ± 0.223
0.849IleCys: 0.849 ± 0.095
5.602IleAsp: 5.602 ± 0.195
5.482IleGlu: 5.482 ± 0.266
2.482IlePhe: 2.482 ± 0.146
3.987IleGly: 3.987 ± 0.202
1.716IleHis: 1.716 ± 0.152
4.568IleIle: 4.568 ± 0.272
4.753IleLys: 4.753 ± 0.183
5.112IleLeu: 5.112 ± 0.227
1.929IleMet: 1.929 ± 0.163
4.217IleAsn: 4.217 ± 0.261
2.704IlePro: 2.704 ± 0.171
2.602IleGln: 2.602 ± 0.157
3.322IleArg: 3.322 ± 0.176
4.863IleSer: 4.863 ± 0.223
4.725IleThr: 4.725 ± 0.224
4.374IleVal: 4.374 ± 0.186
0.72IleTrp: 0.72 ± 0.079
3.027IleTyr: 3.027 ± 0.189
0.0IleXaa: 0.0 ± 0.0
Lys
3.59LysAla: 3.59 ± 0.202
0.858LysCys: 0.858 ± 0.085
4.134LysAsp: 4.134 ± 0.265
5.389LysGlu: 5.389 ± 0.256
3.064LysPhe: 3.064 ± 0.164
3.341LysGly: 3.341 ± 0.179
1.716LysHis: 1.716 ± 0.133
4.79LysIle: 4.79 ± 0.206
5.029LysLys: 5.029 ± 0.301
5.731LysLeu: 5.731 ± 0.239
2.704LysMet: 2.704 ± 0.181
3.913LysAsn: 3.913 ± 0.204
2.206LysPro: 2.206 ± 0.139
2.436LysGln: 2.436 ± 0.153
3.064LysArg: 3.064 ± 0.167
4.393LysSer: 4.393 ± 0.219
3.811LysThr: 3.811 ± 0.197
4.439LysVal: 4.439 ± 0.181
0.637LysTrp: 0.637 ± 0.064
3.811LysTyr: 3.811 ± 0.215
0.0LysXaa: 0.0 ± 0.0
Leu
4.088LeuAla: 4.088 ± 0.191
0.867LeuCys: 0.867 ± 0.079
5.223LeuAsp: 5.223 ± 0.218
5.768LeuGlu: 5.768 ± 0.265
3.055LeuPhe: 3.055 ± 0.167
4.365LeuGly: 4.365 ± 0.226
1.513LeuHis: 1.513 ± 0.136
4.263LeuIle: 4.263 ± 0.208
5.639LeuLys: 5.639 ± 0.236
5.546LeuLeu: 5.546 ± 0.236
2.381LeuMet: 2.381 ± 0.16
4.956LeuAsn: 4.956 ± 0.218
3.498LeuPro: 3.498 ± 0.189
2.953LeuGln: 2.953 ± 0.162
3.211LeuArg: 3.211 ± 0.193
5.795LeuSer: 5.795 ± 0.23
4.55LeuThr: 4.55 ± 0.263
4.762LeuVal: 4.762 ± 0.214
0.757LeuTrp: 0.757 ± 0.08
3.737LeuTyr: 3.737 ± 0.202
0.0LeuXaa: 0.0 ± 0.0
Met
1.698MetAla: 1.698 ± 0.123
0.406MetCys: 0.406 ± 0.061
1.827MetAsp: 1.827 ± 0.143
1.753MetGlu: 1.753 ± 0.137
1.449MetPhe: 1.449 ± 0.124
1.403MetGly: 1.403 ± 0.122
0.618MetHis: 0.618 ± 0.079
2.399MetIle: 2.399 ± 0.15
2.51MetLys: 2.51 ± 0.154
1.956MetLeu: 1.956 ± 0.142
0.803MetMet: 0.803 ± 0.101
2.067MetAsn: 2.067 ± 0.125
0.858MetPro: 0.858 ± 0.095
0.941MetGln: 0.941 ± 0.089
1.44MetArg: 1.44 ± 0.105
2.196MetSer: 2.196 ± 0.149
1.67MetThr: 1.67 ± 0.115
1.523MetVal: 1.523 ± 0.129
0.323MetTrp: 0.323 ± 0.054
1.449MetTyr: 1.449 ± 0.12
0.0MetXaa: 0.0 ± 0.0
Asn
3.193AsnAla: 3.193 ± 0.165
0.646AsnCys: 0.646 ± 0.077
3.756AsnAsp: 3.756 ± 0.201
4.153AsnGlu: 4.153 ± 0.215
2.649AsnPhe: 2.649 ± 0.18
4.845AsnGly: 4.845 ± 0.259
1.117AsnHis: 1.117 ± 0.096
4.577AsnIle: 4.577 ± 0.208
3.876AsnLys: 3.876 ± 0.22
4.144AsnLeu: 4.144 ± 0.206
1.772AsnMet: 1.772 ± 0.119
3.959AsnAsn: 3.959 ± 0.216
2.556AsnPro: 2.556 ± 0.189
1.883AsnGln: 1.883 ± 0.132
2.261AsnArg: 2.261 ± 0.136
3.876AsnSer: 3.876 ± 0.253
4.42AsnThr: 4.42 ± 0.22
4.005AsnVal: 4.005 ± 0.218
0.628AsnTrp: 0.628 ± 0.079
2.722AsnTyr: 2.722 ± 0.16
0.0AsnXaa: 0.0 ± 0.0
Pro
1.68ProAla: 1.68 ± 0.123
0.286ProCys: 0.286 ± 0.053
2.556ProAsp: 2.556 ± 0.168
3.082ProGlu: 3.082 ± 0.182
1.661ProPhe: 1.661 ± 0.111
1.449ProGly: 1.449 ± 0.128
0.618ProHis: 0.618 ± 0.069
2.206ProIle: 2.206 ± 0.154
2.15ProLys: 2.15 ± 0.171
2.206ProLeu: 2.206 ± 0.15
0.729ProMet: 0.729 ± 0.075
1.984ProAsn: 1.984 ± 0.144
0.886ProPro: 0.886 ± 0.092
1.209ProGln: 1.209 ± 0.099
1.117ProArg: 1.117 ± 0.105
2.233ProSer: 2.233 ± 0.164
1.938ProThr: 1.938 ± 0.113
2.261ProVal: 2.261 ± 0.15
0.277ProTrp: 0.277 ± 0.056
1.578ProTyr: 1.578 ± 0.116
0.0ProXaa: 0.0 ± 0.0
Gln
1.901GlnAla: 1.901 ± 0.131
0.36GlnCys: 0.36 ± 0.064
1.966GlnAsp: 1.966 ± 0.156
2.621GlnGlu: 2.621 ± 0.149
1.67GlnPhe: 1.67 ± 0.141
1.818GlnGly: 1.818 ± 0.123
0.747GlnHis: 0.747 ± 0.062
2.538GlnIle: 2.538 ± 0.14
2.538GlnLys: 2.538 ± 0.173
2.833GlnLeu: 2.833 ± 0.197
1.246GlnMet: 1.246 ± 0.107
2.021GlnAsn: 2.021 ± 0.141
0.951GlnPro: 0.951 ± 0.107
1.578GlnGln: 1.578 ± 0.16
1.43GlnArg: 1.43 ± 0.115
2.159GlnSer: 2.159 ± 0.166
1.836GlnThr: 1.836 ± 0.136
2.003GlnVal: 2.003 ± 0.126
0.369GlnTrp: 0.369 ± 0.048
2.178GlnTyr: 2.178 ± 0.164
0.0GlnXaa: 0.0 ± 0.0
Arg
1.975ArgAla: 1.975 ± 0.15
0.471ArgCys: 0.471 ± 0.066
2.519ArgAsp: 2.519 ± 0.144
2.962ArgGlu: 2.962 ± 0.184
1.984ArgPhe: 1.984 ± 0.144
2.206ArgGly: 2.206 ± 0.136
0.747ArgHis: 0.747 ± 0.097
3.184ArgIle: 3.184 ± 0.187
3.073ArgLys: 3.073 ± 0.194
2.916ArgLeu: 2.916 ± 0.174
1.283ArgMet: 1.283 ± 0.107
2.556ArgAsn: 2.556 ± 0.142
1.089ArgPro: 1.089 ± 0.098
1.384ArgGln: 1.384 ± 0.103
1.827ArgArg: 1.827 ± 0.162
2.621ArgSer: 2.621 ± 0.148
2.492ArgThr: 2.492 ± 0.153
2.732ArgVal: 2.732 ± 0.187
0.572ArgTrp: 0.572 ± 0.059
1.956ArgTyr: 1.956 ± 0.121
0.0ArgXaa: 0.0 ± 0.0
Ser
3.378SerAla: 3.378 ± 0.228
0.683SerCys: 0.683 ± 0.096
4.217SerAsp: 4.217 ± 0.202
4.033SerGlu: 4.033 ± 0.183
3.331SerPhe: 3.331 ± 0.168
4.762SerGly: 4.762 ± 0.288
1.043SerHis: 1.043 ± 0.108
4.946SerIle: 4.946 ± 0.216
4.679SerLys: 4.679 ± 0.237
5.38SerLeu: 5.38 ± 0.256
1.513SerMet: 1.513 ± 0.128
3.95SerAsn: 3.95 ± 0.218
1.929SerPro: 1.929 ± 0.144
2.03SerGln: 2.03 ± 0.14
2.427SerArg: 2.427 ± 0.151
4.836SerSer: 4.836 ± 0.252
5.842SerThr: 5.842 ± 0.289
4.494SerVal: 4.494 ± 0.265
0.812SerTrp: 0.812 ± 0.097
3.008SerTyr: 3.008 ± 0.186
0.0SerXaa: 0.0 ± 0.0
Thr
3.424ThrAla: 3.424 ± 0.253
0.498ThrCys: 0.498 ± 0.073
3.95ThrAsp: 3.95 ± 0.178
4.162ThrGlu: 4.162 ± 0.183
2.935ThrPhe: 2.935 ± 0.147
4.347ThrGly: 4.347 ± 0.431
1.107ThrHis: 1.107 ± 0.104
5.057ThrIle: 5.057 ± 0.264
3.94ThrLys: 3.94 ± 0.186
5.251ThrLeu: 5.251 ± 0.332
1.532ThrMet: 1.532 ± 0.12
3.645ThrAsn: 3.645 ± 0.231
2.399ThrPro: 2.399 ± 0.163
1.947ThrGln: 1.947 ± 0.138
2.159ThrArg: 2.159 ± 0.165
4.171ThrSer: 4.171 ± 0.196
3.71ThrThr: 3.71 ± 0.376
4.485ThrVal: 4.485 ± 0.331
0.757ThrTrp: 0.757 ± 0.092
3.082ThrTyr: 3.082 ± 0.179
0.0ThrXaa: 0.0 ± 0.0
Val
2.907ValAla: 2.907 ± 0.193
0.701ValCys: 0.701 ± 0.07
4.347ValAsp: 4.347 ± 0.213
4.116ValGlu: 4.116 ± 0.228
2.787ValPhe: 2.787 ± 0.177
3.71ValGly: 3.71 ± 0.236
1.31ValHis: 1.31 ± 0.122
4.402ValIle: 4.402 ± 0.2
4.153ValLys: 4.153 ± 0.2
6.903ValLeu: 6.903 ± 0.273
1.643ValMet: 1.643 ± 0.132
3.636ValAsn: 3.636 ± 0.184
2.75ValPro: 2.75 ± 0.19
3.027ValGln: 3.027 ± 0.159
2.695ValArg: 2.695 ± 0.181
4.54ValSer: 4.54 ± 0.234
3.867ValThr: 3.867 ± 0.404
4.227ValVal: 4.227 ± 0.234
0.628ValTrp: 0.628 ± 0.086
3.331ValTyr: 3.331 ± 0.197
0.0ValXaa: 0.0 ± 0.0
Trp
0.563TrpAla: 0.563 ± 0.065
0.175TrpCys: 0.175 ± 0.037
0.904TrpAsp: 0.904 ± 0.087
0.664TrpGlu: 0.664 ± 0.08
0.461TrpPhe: 0.461 ± 0.066
0.664TrpGly: 0.664 ± 0.088
0.323TrpHis: 0.323 ± 0.06
0.784TrpIle: 0.784 ± 0.094
0.849TrpLys: 0.849 ± 0.093
0.628TrpLeu: 0.628 ± 0.069
0.508TrpMet: 0.508 ± 0.066
0.831TrpAsn: 0.831 ± 0.098
0.166TrpPro: 0.166 ± 0.042
0.277TrpGln: 0.277 ± 0.058
0.425TrpArg: 0.425 ± 0.061
0.701TrpSer: 0.701 ± 0.079
0.877TrpThr: 0.877 ± 0.078
0.812TrpVal: 0.812 ± 0.097
0.166TrpTrp: 0.166 ± 0.04
0.72TrpTyr: 0.72 ± 0.083
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.547TyrAla: 2.547 ± 0.147
0.858TyrCys: 0.858 ± 0.09
3.922TyrAsp: 3.922 ± 0.274
3.516TyrGlu: 3.516 ± 0.183
2.446TyrPhe: 2.446 ± 0.162
3.064TyrGly: 3.064 ± 0.206
1.135TyrHis: 1.135 ± 0.129
3.35TyrIle: 3.35 ± 0.204
3.341TyrLys: 3.341 ± 0.2
2.87TyrLeu: 2.87 ± 0.131
1.375TyrMet: 1.375 ± 0.109
3.424TyrAsn: 3.424 ± 0.202
1.412TyrPro: 1.412 ± 0.108
1.606TyrGln: 1.606 ± 0.135
2.233TyrArg: 2.233 ± 0.162
3.313TyrSer: 3.313 ± 0.179
3.239TyrThr: 3.239 ± 0.174
3.036TyrVal: 3.036 ± 0.187
0.526TyrTrp: 0.526 ± 0.071
2.307TyrTyr: 2.307 ± 0.167
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 538 proteins (108363 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski