Amino acid dipepetide frequency for Amaricoccus sp. HB172011

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
21.763AlaAla: 21.763 ± 0.193
1.128AlaCys: 1.128 ± 0.028
6.939AlaAsp: 6.939 ± 0.087
10.32AlaGlu: 10.32 ± 0.114
4.583AlaPhe: 4.583 ± 0.066
13.126AlaGly: 13.126 ± 0.119
2.411AlaHis: 2.411 ± 0.048
6.255AlaIle: 6.255 ± 0.076
3.208AlaLys: 3.208 ± 0.06
15.833AlaLeu: 15.833 ± 0.136
3.667AlaMet: 3.667 ± 0.047
2.554AlaAsn: 2.554 ± 0.049
7.827AlaPro: 7.827 ± 0.101
3.225AlaGln: 3.225 ± 0.055
13.19AlaArg: 13.19 ± 0.14
5.756AlaSer: 5.756 ± 0.073
6.428AlaThr: 6.428 ± 0.075
8.774AlaVal: 8.774 ± 0.095
1.736AlaTrp: 1.736 ± 0.04
2.446AlaTyr: 2.446 ± 0.043
0.0AlaXaa: 0.0 ± 0.0
Cys
1.254CysAla: 1.254 ± 0.034
0.123CysCys: 0.123 ± 0.01
0.596CysAsp: 0.596 ± 0.022
0.461CysGlu: 0.461 ± 0.019
0.302CysPhe: 0.302 ± 0.013
0.858CysGly: 0.858 ± 0.026
0.251CysHis: 0.251 ± 0.014
0.185CysIle: 0.185 ± 0.011
0.146CysLys: 0.146 ± 0.01
0.868CysLeu: 0.868 ± 0.027
0.128CysMet: 0.128 ± 0.01
0.167CysAsn: 0.167 ± 0.011
0.509CysPro: 0.509 ± 0.023
0.184CysGln: 0.184 ± 0.01
0.609CysArg: 0.609 ± 0.02
0.388CysSer: 0.388 ± 0.017
0.247CysThr: 0.247 ± 0.015
0.726CysVal: 0.726 ± 0.024
0.128CysTrp: 0.128 ± 0.01
0.177CysTyr: 0.177 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
7.163AspAla: 7.163 ± 0.074
0.471AspCys: 0.471 ± 0.02
2.682AspAsp: 2.682 ± 0.064
3.128AspGlu: 3.128 ± 0.051
2.375AspPhe: 2.375 ± 0.043
5.206AspGly: 5.206 ± 0.071
1.196AspHis: 1.196 ± 0.032
2.434AspIle: 2.434 ± 0.041
1.135AspLys: 1.135 ± 0.033
6.463AspLeu: 6.463 ± 0.075
1.252AspMet: 1.252 ± 0.028
0.96AspAsn: 0.96 ± 0.028
4.462AspPro: 4.462 ± 0.061
1.501AspGln: 1.501 ± 0.035
4.722AspArg: 4.722 ± 0.063
1.831AspSer: 1.831 ± 0.043
2.515AspThr: 2.515 ± 0.057
3.667AspVal: 3.667 ± 0.056
1.222AspTrp: 1.222 ± 0.027
1.518AspTyr: 1.518 ± 0.034
0.0AspXaa: 0.0 ± 0.0
Glu
9.548GluAla: 9.548 ± 0.107
0.344GluCys: 0.344 ± 0.015
2.94GluAsp: 2.94 ± 0.044
3.625GluGlu: 3.625 ± 0.063
1.742GluPhe: 1.742 ± 0.034
5.357GluGly: 5.357 ± 0.062
1.156GluHis: 1.156 ± 0.028
3.789GluIle: 3.789 ± 0.047
1.908GluLys: 1.908 ± 0.046
5.302GluLeu: 5.302 ± 0.07
1.669GluMet: 1.669 ± 0.033
1.474GluAsn: 1.474 ± 0.038
3.108GluPro: 3.108 ± 0.058
1.725GluGln: 1.725 ± 0.042
5.205GluArg: 5.205 ± 0.068
2.328GluSer: 2.328 ± 0.038
3.939GluThr: 3.939 ± 0.058
4.229GluVal: 4.229 ± 0.057
0.706GluTrp: 0.706 ± 0.024
0.98GluTyr: 0.98 ± 0.027
0.0GluXaa: 0.0 ± 0.0
Phe
4.802PheAla: 4.802 ± 0.062
0.366PheCys: 0.366 ± 0.016
2.657PheAsp: 2.657 ± 0.05
2.098PheGlu: 2.098 ± 0.043
1.31PhePhe: 1.31 ± 0.039
3.636PheGly: 3.636 ± 0.052
0.785PheHis: 0.785 ± 0.028
1.427PheIle: 1.427 ± 0.027
0.656PheLys: 0.656 ± 0.023
3.525PheLeu: 3.525 ± 0.06
0.733PheMet: 0.733 ± 0.024
0.845PheAsn: 0.845 ± 0.027
1.656PhePro: 1.656 ± 0.034
0.888PheGln: 0.888 ± 0.025
2.489PheArg: 2.489 ± 0.043
1.797PheSer: 1.797 ± 0.035
1.809PheThr: 1.809 ± 0.032
2.667PheVal: 2.667 ± 0.049
0.568PheTrp: 0.568 ± 0.019
0.777PheTyr: 0.777 ± 0.023
0.0PheXaa: 0.0 ± 0.0
Gly
12.712GlyAla: 12.712 ± 0.118
0.855GlyCys: 0.855 ± 0.029
4.775GlyAsp: 4.775 ± 0.078
5.463GlyGlu: 5.463 ± 0.076
3.778GlyPhe: 3.778 ± 0.047
8.772GlyGly: 8.772 ± 0.148
1.896GlyHis: 1.896 ± 0.038
4.482GlyIle: 4.482 ± 0.068
2.586GlyLys: 2.586 ± 0.051
10.094GlyLeu: 10.094 ± 0.102
2.427GlyMet: 2.427 ± 0.042
1.848GlyAsn: 1.848 ± 0.05
4.535GlyPro: 4.535 ± 0.062
2.658GlyGln: 2.658 ± 0.047
7.455GlyArg: 7.455 ± 0.084
4.178GlySer: 4.178 ± 0.063
4.614GlyThr: 4.614 ± 0.064
6.738GlyVal: 6.738 ± 0.077
1.64GlyTrp: 1.64 ± 0.036
2.295GlyTyr: 2.295 ± 0.043
0.0GlyXaa: 0.0 ± 0.0
His
2.347HisAla: 2.347 ± 0.047
0.225HisCys: 0.225 ± 0.014
1.186HisAsp: 1.186 ± 0.03
0.968HisGlu: 0.968 ± 0.025
0.76HisPhe: 0.76 ± 0.022
1.988HisGly: 1.988 ± 0.039
0.512HisHis: 0.512 ± 0.018
0.72HisIle: 0.72 ± 0.019
0.302HisLys: 0.302 ± 0.013
2.014HisLeu: 2.014 ± 0.036
0.471HisMet: 0.471 ± 0.021
0.374HisAsn: 0.374 ± 0.017
1.48HisPro: 1.48 ± 0.036
0.477HisGln: 0.477 ± 0.016
1.49HisArg: 1.49 ± 0.032
0.787HisSer: 0.787 ± 0.027
0.713HisThr: 0.713 ± 0.024
1.515HisVal: 1.515 ± 0.033
0.319HisTrp: 0.319 ± 0.014
0.469HisTyr: 0.469 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
7.084IleAla: 7.084 ± 0.069
0.486IleCys: 0.486 ± 0.019
3.31IleAsp: 3.31 ± 0.048
3.235IleGlu: 3.235 ± 0.047
1.552IlePhe: 1.552 ± 0.036
5.001IleGly: 5.001 ± 0.07
0.871IleHis: 0.871 ± 0.024
1.663IleIle: 1.663 ± 0.037
0.904IleLys: 0.904 ± 0.03
4.612IleLeu: 4.612 ± 0.071
0.845IleMet: 0.845 ± 0.027
1.054IleAsn: 1.054 ± 0.027
2.264IlePro: 2.264 ± 0.041
0.961IleGln: 0.961 ± 0.029
3.568IleArg: 3.568 ± 0.052
2.321IleSer: 2.321 ± 0.046
2.338IleThr: 2.338 ± 0.041
3.532IleVal: 3.532 ± 0.053
0.612IleTrp: 0.612 ± 0.021
1.008IleTyr: 1.008 ± 0.031
0.0IleXaa: 0.0 ± 0.0
Lys
3.229LysAla: 3.229 ± 0.051
0.153LysCys: 0.153 ± 0.01
1.232LysAsp: 1.232 ± 0.032
1.191LysGlu: 1.191 ± 0.036
0.672LysPhe: 0.672 ± 0.026
2.253LysGly: 2.253 ± 0.047
0.441LysHis: 0.441 ± 0.018
1.18LysIle: 1.18 ± 0.036
0.738LysLys: 0.738 ± 0.03
2.391LysLeu: 2.391 ± 0.053
0.566LysMet: 0.566 ± 0.021
0.52LysAsn: 0.52 ± 0.021
1.48LysPro: 1.48 ± 0.035
0.599LysGln: 0.599 ± 0.021
1.619LysArg: 1.619 ± 0.033
1.288LysSer: 1.288 ± 0.036
1.329LysThr: 1.329 ± 0.034
1.907LysVal: 1.907 ± 0.042
0.3LysTrp: 0.3 ± 0.015
0.52LysTyr: 0.52 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
15.976LeuAla: 15.976 ± 0.153
0.908LeuCys: 0.908 ± 0.029
6.403LeuAsp: 6.403 ± 0.071
5.167LeuGlu: 5.167 ± 0.068
3.344LeuPhe: 3.344 ± 0.057
10.103LeuGly: 10.103 ± 0.105
1.6LeuHis: 1.6 ± 0.036
4.794LeuIle: 4.794 ± 0.063
2.073LeuLys: 2.073 ± 0.045
9.631LeuLeu: 9.631 ± 0.101
2.308LeuMet: 2.308 ± 0.043
2.194LeuAsn: 2.194 ± 0.043
5.785LeuPro: 5.785 ± 0.071
1.717LeuGln: 1.717 ± 0.037
9.011LeuArg: 9.011 ± 0.091
5.806LeuSer: 5.806 ± 0.062
5.655LeuThr: 5.655 ± 0.064
7.563LeuVal: 7.563 ± 0.077
1.308LeuTrp: 1.308 ± 0.032
1.993LeuTyr: 1.993 ± 0.036
0.0LeuXaa: 0.0 ± 0.0
Met
3.209MetAla: 3.209 ± 0.05
0.135MetCys: 0.135 ± 0.009
1.098MetAsp: 1.098 ± 0.026
1.225MetGlu: 1.225 ± 0.031
0.659MetPhe: 0.659 ± 0.022
1.835MetGly: 1.835 ± 0.036
0.37MetHis: 0.37 ± 0.017
1.361MetIle: 1.361 ± 0.031
0.872MetLys: 0.872 ± 0.022
2.489MetLeu: 2.489 ± 0.044
0.595MetMet: 0.595 ± 0.023
0.749MetAsn: 0.749 ± 0.023
1.473MetPro: 1.473 ± 0.034
0.49MetGln: 0.49 ± 0.018
1.973MetArg: 1.973 ± 0.038
1.477MetSer: 1.477 ± 0.032
1.77MetThr: 1.77 ± 0.038
1.672MetVal: 1.672 ± 0.036
0.195MetTrp: 0.195 ± 0.013
0.304MetTyr: 0.304 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
2.755AsnAla: 2.755 ± 0.041
0.204AsnCys: 0.204 ± 0.013
1.112AsnAsp: 1.112 ± 0.034
1.005AsnGlu: 1.005 ± 0.029
0.78AsnPhe: 0.78 ± 0.023
1.895AsnGly: 1.895 ± 0.046
0.43AsnHis: 0.43 ± 0.019
1.093AsnIle: 1.093 ± 0.029
0.42AsnLys: 0.42 ± 0.018
2.217AsnLeu: 2.217 ± 0.041
0.522AsnMet: 0.522 ± 0.021
0.515AsnAsn: 0.515 ± 0.021
1.626AsnPro: 1.626 ± 0.036
0.586AsnGln: 0.586 ± 0.02
1.579AsnArg: 1.579 ± 0.033
0.944AsnSer: 0.944 ± 0.03
1.061AsnThr: 1.061 ± 0.032
1.595AsnVal: 1.595 ± 0.034
0.395AsnTrp: 0.395 ± 0.018
0.568AsnTyr: 0.568 ± 0.023
0.0AsnXaa: 0.0 ± 0.0
Pro
8.1ProAla: 8.1 ± 0.101
0.4ProCys: 0.4 ± 0.016
3.936ProAsp: 3.936 ± 0.053
5.072ProGlu: 5.072 ± 0.067
1.983ProPhe: 1.983 ± 0.036
6.046ProGly: 6.046 ± 0.064
0.939ProHis: 0.939 ± 0.026
2.096ProIle: 2.096 ± 0.036
1.368ProLys: 1.368 ± 0.03
5.038ProLeu: 5.038 ± 0.066
1.285ProMet: 1.285 ± 0.03
1.165ProAsn: 1.165 ± 0.028
3.312ProPro: 3.312 ± 0.065
0.911ProGln: 0.911 ± 0.024
4.424ProArg: 4.424 ± 0.057
2.52ProSer: 2.52 ± 0.041
2.285ProThr: 2.285 ± 0.042
4.46ProVal: 4.46 ± 0.05
0.811ProTrp: 0.811 ± 0.024
1.102ProTyr: 1.102 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
3.137GlnAla: 3.137 ± 0.045
0.15GlnCys: 0.15 ± 0.01
1.07GlnAsp: 1.07 ± 0.027
1.212GlnGlu: 1.212 ± 0.034
0.817GlnPhe: 0.817 ± 0.026
2.101GlnGly: 2.101 ± 0.038
0.392GlnHis: 0.392 ± 0.017
1.395GlnIle: 1.395 ± 0.039
0.709GlnLys: 0.709 ± 0.024
2.171GlnLeu: 2.171 ± 0.041
0.695GlnMet: 0.695 ± 0.02
0.578GlnAsn: 0.578 ± 0.022
1.362GlnPro: 1.362 ± 0.033
0.721GlnGln: 0.721 ± 0.029
1.833GlnArg: 1.833 ± 0.038
1.252GlnSer: 1.252 ± 0.033
1.218GlnThr: 1.218 ± 0.035
1.886GlnVal: 1.886 ± 0.038
0.303GlnTrp: 0.303 ± 0.015
0.47GlnTyr: 0.47 ± 0.018
0.0GlnXaa: 0.0 ± 0.0
Arg
11.973ArgAla: 11.973 ± 0.132
0.523ArgCys: 0.523 ± 0.023
4.923ArgAsp: 4.923 ± 0.063
4.975ArgGlu: 4.975 ± 0.071
3.045ArgPhe: 3.045 ± 0.05
6.591ArgGly: 6.591 ± 0.082
1.801ArgHis: 1.801 ± 0.039
4.249ArgIle: 4.249 ± 0.048
1.833ArgLys: 1.833 ± 0.034
9.109ArgLeu: 9.109 ± 0.109
2.075ArgMet: 2.075 ± 0.04
1.577ArgAsn: 1.577 ± 0.035
4.575ArgPro: 4.575 ± 0.052
1.976ArgGln: 1.976 ± 0.045
7.401ArgArg: 7.401 ± 0.093
3.446ArgSer: 3.446 ± 0.057
3.156ArgThr: 3.156 ± 0.045
5.781ArgVal: 5.781 ± 0.071
1.096ArgTrp: 1.096 ± 0.03
1.692ArgTyr: 1.692 ± 0.033
0.0ArgXaa: 0.0 ± 0.0
Ser
5.707SerAla: 5.707 ± 0.077
0.388SerCys: 0.388 ± 0.016
2.657SerAsp: 2.657 ± 0.051
2.58SerGlu: 2.58 ± 0.044
1.977SerPhe: 1.977 ± 0.041
5.21SerGly: 5.21 ± 0.076
0.948SerHis: 0.948 ± 0.025
2.123SerIle: 2.123 ± 0.042
1.067SerLys: 1.067 ± 0.033
4.553SerLeu: 4.553 ± 0.062
1.083SerMet: 1.083 ± 0.023
1.043SerAsn: 1.043 ± 0.031
2.616SerPro: 2.616 ± 0.049
1.215SerGln: 1.215 ± 0.035
3.489SerArg: 3.489 ± 0.052
2.105SerSer: 2.105 ± 0.054
2.115SerThr: 2.115 ± 0.041
3.419SerVal: 3.419 ± 0.053
0.763SerTrp: 0.763 ± 0.026
1.192SerTyr: 1.192 ± 0.033
0.0SerXaa: 0.0 ± 0.0
Thr
6.107ThrAla: 6.107 ± 0.075
0.433ThrCys: 0.433 ± 0.017
2.581ThrAsp: 2.581 ± 0.041
2.815ThrGlu: 2.815 ± 0.048
1.771ThrPhe: 1.771 ± 0.038
5.32ThrGly: 5.32 ± 0.063
0.99ThrHis: 0.99 ± 0.029
2.43ThrIle: 2.43 ± 0.046
1.023ThrLys: 1.023 ± 0.027
5.815ThrLeu: 5.815 ± 0.071
1.03ThrMet: 1.03 ± 0.028
1.022ThrAsn: 1.022 ± 0.026
3.452ThrPro: 3.452 ± 0.049
1.116ThrGln: 1.116 ± 0.033
3.917ThrArg: 3.917 ± 0.053
2.287ThrSer: 2.287 ± 0.044
2.416ThrThr: 2.416 ± 0.045
3.758ThrVal: 3.758 ± 0.059
0.629ThrTrp: 0.629 ± 0.023
1.05ThrTyr: 1.05 ± 0.029
0.0ThrXaa: 0.0 ± 0.0
Val
10.247ValAla: 10.247 ± 0.101
0.67ValCys: 0.67 ± 0.023
3.69ValAsp: 3.69 ± 0.05
4.633ValGlu: 4.633 ± 0.065
2.709ValPhe: 2.709 ± 0.048
5.506ValGly: 5.506 ± 0.058
1.301ValHis: 1.301 ± 0.033
4.027ValIle: 4.027 ± 0.055
1.768ValLys: 1.768 ± 0.042
7.21ValLeu: 7.21 ± 0.08
1.793ValMet: 1.793 ± 0.039
1.733ValAsn: 1.733 ± 0.038
3.825ValPro: 3.825 ± 0.049
1.422ValGln: 1.422 ± 0.036
4.697ValArg: 4.697 ± 0.056
3.912ValSer: 3.912 ± 0.051
4.596ValThr: 4.596 ± 0.064
5.53ValVal: 5.53 ± 0.066
0.98ValTrp: 0.98 ± 0.028
1.503ValTyr: 1.503 ± 0.031
0.0ValXaa: 0.0 ± 0.0
Trp
1.382TrpAla: 1.382 ± 0.033
0.14TrpCys: 0.14 ± 0.01
0.679TrpAsp: 0.679 ± 0.021
0.702TrpGlu: 0.702 ± 0.021
0.54TrpPhe: 0.54 ± 0.021
1.023TrpGly: 1.023 ± 0.028
0.331TrpHis: 0.331 ± 0.016
0.764TrpIle: 0.764 ± 0.027
0.435TrpLys: 0.435 ± 0.019
1.767TrpLeu: 1.767 ± 0.042
0.377TrpMet: 0.377 ± 0.017
0.416TrpAsn: 0.416 ± 0.015
0.812TrpPro: 0.812 ± 0.026
0.501TrpGln: 0.501 ± 0.018
1.409TrpArg: 1.409 ± 0.033
0.823TrpSer: 0.823 ± 0.024
0.826TrpThr: 0.826 ± 0.024
0.825TrpVal: 0.825 ± 0.025
0.238TrpTrp: 0.238 ± 0.014
0.289TrpTyr: 0.289 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.673TyrAla: 2.673 ± 0.043
0.204TyrCys: 0.204 ± 0.011
1.44TyrAsp: 1.44 ± 0.035
1.2TyrGlu: 1.2 ± 0.03
0.791TyrPhe: 0.791 ± 0.024
1.974TyrGly: 1.974 ± 0.039
0.495TyrHis: 0.495 ± 0.019
0.755TyrIle: 0.755 ± 0.024
0.459TyrLys: 0.459 ± 0.019
2.239TyrLeu: 2.239 ± 0.039
0.427TyrMet: 0.427 ± 0.017
0.513TyrAsn: 0.513 ± 0.02
1.095TyrPro: 1.095 ± 0.03
0.598TyrGln: 0.598 ± 0.021
1.716TyrArg: 1.716 ± 0.038
1.005TyrSer: 1.005 ± 0.029
0.932TyrThr: 0.932 ± 0.026
1.509TyrVal: 1.509 ± 0.035
0.331TyrTrp: 0.331 ± 0.016
0.591TyrTyr: 0.591 ± 0.026
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4522 proteins (1433990 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski