Amino acid dipepetide frequency for Rhodovastum atsumiense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.745AlaAla: 23.745 ± 0.188	1.471AlaCys: 1.471 ± 0.03	6.759AlaAsp: 6.759 ± 0.058	8.733AlaGlu: 8.733 ± 0.092	4.221AlaPhe: 4.221 ± 0.05	13.481AlaGly: 13.481 ± 0.115	2.541AlaHis: 2.541 ± 0.037	5.881AlaIle: 5.881 ± 0.062	2.434AlaLys: 2.434 ± 0.042	16.051AlaLeu: 16.051 ± 0.115	3.727AlaMet: 3.727 ± 0.045	2.477AlaAsn: 2.477 ± 0.035	7.335AlaPro: 7.335 ± 0.086	4.451AlaGln: 4.451 ± 0.051	12.138AlaArg: 12.138 ± 0.089	6.216AlaSer: 6.216 ± 0.057	7.563AlaThr: 7.563 ± 0.069	10.497AlaVal: 10.497 ± 0.083	2.086AlaTrp: 2.086 ± 0.037	2.217AlaTyr: 2.217 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	1.227CysAla: 1.227 ± 0.025	0.143CysCys: 0.143 ± 0.007	0.557CysAsp: 0.557 ± 0.017	0.459CysGlu: 0.459 ± 0.015	0.347CysPhe: 0.347 ± 0.013	1.136CysGly: 1.136 ± 0.025	0.299CysHis: 0.299 ± 0.014	0.391CysIle: 0.391 ± 0.015	0.145CysLys: 0.145 ± 0.009	0.97CysLeu: 0.97 ± 0.024	0.176CysMet: 0.176 ± 0.011	0.204CysAsn: 0.204 ± 0.008	0.608CysPro: 0.608 ± 0.018	0.261CysGln: 0.261 ± 0.012	0.881CysArg: 0.881 ± 0.023	0.452CysSer: 0.452 ± 0.015	0.516CysThr: 0.516 ± 0.016	0.686CysVal: 0.686 ± 0.018	0.154CysTrp: 0.154 ± 0.008	0.187CysTyr: 0.187 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.247AspAla: 7.247 ± 0.074	0.469AspCys: 0.469 ± 0.016	2.474AspAsp: 2.474 ± 0.037	2.552AspGlu: 2.552 ± 0.039	1.811AspPhe: 1.811 ± 0.033	5.066AspGly: 5.066 ± 0.061	1.093AspHis: 1.093 ± 0.026	2.523AspIle: 2.523 ± 0.033	0.815AspLys: 0.815 ± 0.023	5.867AspLeu: 5.867 ± 0.057	1.061AspMet: 1.061 ± 0.026	0.876AspAsn: 0.876 ± 0.021	3.987AspPro: 3.987 ± 0.05	1.34AspGln: 1.34 ± 0.03	4.475AspArg: 4.475 ± 0.047	1.908AspSer: 1.908 ± 0.026	2.443AspThr: 2.443 ± 0.037	3.751AspVal: 3.751 ± 0.046	0.974AspTrp: 0.974 ± 0.025	1.049AspTyr: 1.049 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	8.596GluAla: 8.596 ± 0.09	0.339GluCys: 0.339 ± 0.013	2.458GluAsp: 2.458 ± 0.037	2.705GluGlu: 2.705 ± 0.05	1.381GluPhe: 1.381 ± 0.027	3.91GluGly: 3.91 ± 0.046	1.071GluHis: 1.071 ± 0.024	2.832GluIle: 2.832 ± 0.04	1.263GluLys: 1.263 ± 0.028	5.08GluLeu: 5.08 ± 0.055	1.278GluMet: 1.278 ± 0.026	0.977GluAsn: 0.977 ± 0.02	2.672GluPro: 2.672 ± 0.045	2.106GluGln: 2.106 ± 0.036	5.045GluArg: 5.045 ± 0.056	1.978GluSer: 1.978 ± 0.03	3.05GluThr: 3.05 ± 0.041	3.909GluVal: 3.909 ± 0.05	0.673GluTrp: 0.673 ± 0.018	0.815GluTyr: 0.815 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	4.516PheAla: 4.516 ± 0.046	0.402PheCys: 0.402 ± 0.015	2.073PheAsp: 2.073 ± 0.038	1.587PheGlu: 1.587 ± 0.03	1.141PhePhe: 1.141 ± 0.028	3.279PheGly: 3.279 ± 0.043	0.733PheHis: 0.733 ± 0.021	1.274PheIle: 1.274 ± 0.029	0.509PheLys: 0.509 ± 0.015	3.349PheLeu: 3.349 ± 0.049	0.574PheMet: 0.574 ± 0.015	0.82PheAsn: 0.82 ± 0.021	1.665PhePro: 1.665 ± 0.03	0.865PheGln: 0.865 ± 0.021	2.453PheArg: 2.453 ± 0.039	1.673PheSer: 1.673 ± 0.032	1.834PheThr: 1.834 ± 0.033	2.441PheVal: 2.441 ± 0.035	0.499PheTrp: 0.499 ± 0.018	0.695PheTyr: 0.695 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	10.48GlyAla: 10.48 ± 0.1	1.121GlyCys: 1.121 ± 0.027	4.02GlyAsp: 4.02 ± 0.048	4.607GlyGlu: 4.607 ± 0.053	3.529GlyPhe: 3.529 ± 0.047	8.331GlyGly: 8.331 ± 0.082	2.122GlyHis: 2.122 ± 0.033	4.42GlyIle: 4.42 ± 0.047	2.16GlyLys: 2.16 ± 0.041	9.973GlyLeu: 9.973 ± 0.087	2.363GlyMet: 2.363 ± 0.037	1.976GlyAsn: 1.976 ± 0.035	4.312GlyPro: 4.312 ± 0.047	3.167GlyGln: 3.167 ± 0.046	7.944GlyArg: 7.944 ± 0.069	4.408GlySer: 4.408 ± 0.05	5.486GlyThr: 5.486 ± 0.071	6.524GlyVal: 6.524 ± 0.061	1.628GlyTrp: 1.628 ± 0.028	1.998GlyTyr: 1.998 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	2.933HisAla: 2.933 ± 0.045	0.239HisCys: 0.239 ± 0.011	1.284HisAsp: 1.284 ± 0.025	1.014HisGlu: 1.014 ± 0.022	0.757HisPhe: 0.757 ± 0.02	2.2HisGly: 2.2 ± 0.039	0.607HisHis: 0.607 ± 0.021	0.757HisIle: 0.757 ± 0.022	0.299HisLys: 0.299 ± 0.012	2.192HisLeu: 2.192 ± 0.032	0.447HisMet: 0.447 ± 0.015	0.389HisAsn: 0.389 ± 0.012	1.659HisPro: 1.659 ± 0.028	0.552HisGln: 0.552 ± 0.016	1.756HisArg: 1.756 ± 0.034	0.803HisSer: 0.803 ± 0.02	0.837HisThr: 0.837 ± 0.022	1.57HisVal: 1.57 ± 0.029	0.388HisTrp: 0.388 ± 0.013	0.432HisTyr: 0.432 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	6.871IleAla: 6.871 ± 0.063	0.475IleCys: 0.475 ± 0.016	2.751IleAsp: 2.751 ± 0.039	2.747IleGlu: 2.747 ± 0.038	1.094IlePhe: 1.094 ± 0.024	4.713IleGly: 4.713 ± 0.054	0.777IleHis: 0.777 ± 0.018	1.512IleIle: 1.512 ± 0.032	0.72IleLys: 0.72 ± 0.024	3.786IleLeu: 3.786 ± 0.051	0.693IleMet: 0.693 ± 0.02	0.971IleAsn: 0.971 ± 0.022	2.241IlePro: 2.241 ± 0.037	0.963IleGln: 0.963 ± 0.023	3.194IleArg: 3.194 ± 0.039	2.193IleSer: 2.193 ± 0.038	2.549IleThr: 2.549 ± 0.036	3.353IleVal: 3.353 ± 0.047	0.544IleTrp: 0.544 ± 0.016	0.811IleTyr: 0.811 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	2.57LysAla: 2.57 ± 0.046	0.121LysCys: 0.121 ± 0.009	0.954LysAsp: 0.954 ± 0.024	0.907LysGlu: 0.907 ± 0.022	0.505LysPhe: 0.505 ± 0.015	1.634LysGly: 1.634 ± 0.028	0.325LysHis: 0.325 ± 0.016	0.855LysIle: 0.855 ± 0.026	0.529LysLys: 0.529 ± 0.02	2.193LysLeu: 2.193 ± 0.041	0.417LysMet: 0.417 ± 0.015	0.399LysAsn: 0.399 ± 0.015	1.288LysPro: 1.288 ± 0.027	0.62LysGln: 0.62 ± 0.02	1.443LysArg: 1.443 ± 0.027	0.934LysSer: 0.934 ± 0.024	1.076LysThr: 1.076 ± 0.023	1.557LysVal: 1.557 ± 0.029	0.229LysTrp: 0.229 ± 0.011	0.406LysTyr: 0.406 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	17.403LeuAla: 17.403 ± 0.106	1.097LeuCys: 1.097 ± 0.026	5.981LeuAsp: 5.981 ± 0.064	4.854LeuGlu: 4.854 ± 0.054	3.251LeuPhe: 3.251 ± 0.049	9.447LeuGly: 9.447 ± 0.092	2.346LeuHis: 2.346 ± 0.037	3.875LeuIle: 3.875 ± 0.055	2.029LeuLys: 2.029 ± 0.036	12.001LeuLeu: 12.001 ± 0.124	1.945LeuMet: 1.945 ± 0.03	2.032LeuAsn: 2.032 ± 0.038	7.145LeuPro: 7.145 ± 0.068	3.475LeuGln: 3.475 ± 0.047	9.903LeuArg: 9.903 ± 0.084	5.403LeuSer: 5.403 ± 0.053	5.425LeuThr: 5.425 ± 0.055	8.365LeuVal: 8.365 ± 0.075	1.378LeuTrp: 1.378 ± 0.029	1.724LeuTyr: 1.724 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	3.127MetAla: 3.127 ± 0.038	0.152MetCys: 0.152 ± 0.009	1.02MetAsp: 1.02 ± 0.023	0.928MetGlu: 0.928 ± 0.023	0.56MetPhe: 0.56 ± 0.017	1.492MetGly: 1.492 ± 0.03	0.424MetHis: 0.424 ± 0.015	0.981MetIle: 0.981 ± 0.022	0.53MetLys: 0.53 ± 0.018	2.555MetLeu: 2.555 ± 0.038	0.512MetMet: 0.512 ± 0.02	0.515MetAsn: 0.515 ± 0.018	1.626MetPro: 1.626 ± 0.029	0.823MetGln: 0.823 ± 0.02	1.803MetArg: 1.803 ± 0.03	1.305MetSer: 1.305 ± 0.024	1.569MetThr: 1.569 ± 0.024	1.667MetVal: 1.667 ± 0.03	0.189MetTrp: 0.189 ± 0.01	0.248MetTyr: 0.248 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.692AsnAla: 2.692 ± 0.042	0.206AsnCys: 0.206 ± 0.009	1.058AsnAsp: 1.058 ± 0.023	0.914AsnGlu: 0.914 ± 0.023	0.67AsnPhe: 0.67 ± 0.015	1.943AsnGly: 1.943 ± 0.038	0.394AsnHis: 0.394 ± 0.016	0.916AsnIle: 0.916 ± 0.024	0.378AsnLys: 0.378 ± 0.015	2.192AsnLeu: 2.192 ± 0.038	0.384AsnMet: 0.384 ± 0.014	0.571AsnAsn: 0.571 ± 0.021	1.585AsnPro: 1.585 ± 0.031	0.562AsnGln: 0.562 ± 0.018	1.597AsnArg: 1.597 ± 0.026	0.796AsnSer: 0.796 ± 0.022	1.022AsnThr: 1.022 ± 0.026	1.525AsnVal: 1.525 ± 0.028	0.335AsnTrp: 0.335 ± 0.012	0.449AsnTyr: 0.449 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	9.07ProAla: 9.07 ± 0.098	0.512ProCys: 0.512 ± 0.014	4.124ProAsp: 4.124 ± 0.05	3.858ProGlu: 3.858 ± 0.05	1.918ProPhe: 1.918 ± 0.035	6.328ProGly: 6.328 ± 0.07	1.179ProHis: 1.179 ± 0.024	1.9ProIle: 1.9 ± 0.033	1.044ProLys: 1.044 ± 0.027	5.502ProLeu: 5.502 ± 0.048	1.195ProMet: 1.195 ± 0.025	1.087ProAsn: 1.087 ± 0.025	4.5ProPro: 4.5 ± 0.077	1.797ProGln: 1.797 ± 0.032	4.129ProArg: 4.129 ± 0.053	2.725ProSer: 2.725 ± 0.04	2.665ProThr: 2.665 ± 0.038	5.16ProVal: 5.16 ± 0.053	0.909ProTrp: 0.909 ± 0.024	1.029ProTyr: 1.029 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	5.303GlnAla: 5.303 ± 0.055	0.218GlnCys: 0.218 ± 0.01	1.629GlnAsp: 1.629 ± 0.031	1.621GlnGlu: 1.621 ± 0.028	0.917GlnPhe: 0.917 ± 0.021	2.649GlnGly: 2.649 ± 0.036	0.654GlnHis: 0.654 ± 0.019	1.462GlnIle: 1.462 ± 0.027	0.702GlnLys: 0.702 ± 0.019	2.816GlnLeu: 2.816 ± 0.039	0.736GlnMet: 0.736 ± 0.022	0.607GlnAsn: 0.607 ± 0.019	1.914GlnPro: 1.914 ± 0.037	1.334GlnGln: 1.334 ± 0.032	2.754GlnArg: 2.754 ± 0.04	1.441GlnSer: 1.441 ± 0.029	1.584GlnThr: 1.584 ± 0.032	2.65GlnVal: 2.65 ± 0.039	0.393GlnTrp: 0.393 ± 0.013	0.508GlnTyr: 0.508 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	10.785ArgAla: 10.785 ± 0.085	0.751ArgCys: 0.751 ± 0.021	4.396ArgAsp: 4.396 ± 0.049	4.354ArgGlu: 4.354 ± 0.052	3.141ArgPhe: 3.141 ± 0.044	5.985ArgGly: 5.985 ± 0.057	2.295ArgHis: 2.295 ± 0.039	4.235ArgIle: 4.235 ± 0.049	1.567ArgLys: 1.567 ± 0.029	10.217ArgLeu: 10.217 ± 0.085	1.981ArgMet: 1.981 ± 0.029	1.75ArgAsn: 1.75 ± 0.034	5.139ArgPro: 5.139 ± 0.059	3.202ArgGln: 3.202 ± 0.043	8.348ArgArg: 8.348 ± 0.086	3.695ArgSer: 3.695 ± 0.046	3.908ArgThr: 3.908 ± 0.044	5.728ArgVal: 5.728 ± 0.06	1.251ArgTrp: 1.251 ± 0.027	1.527ArgTyr: 1.527 ± 0.027	0.0ArgXaa: 0.0 ± 0.0
Ser	5.64SerAla: 5.64 ± 0.058	0.48SerCys: 0.48 ± 0.016	2.236SerAsp: 2.236 ± 0.034	2.028SerGlu: 2.028 ± 0.035	1.892SerPhe: 1.892 ± 0.031	5.131SerGly: 5.131 ± 0.063	0.932SerHis: 0.932 ± 0.024	1.95SerIle: 1.95 ± 0.029	0.817SerLys: 0.817 ± 0.021	5.06SerLeu: 5.06 ± 0.055	1.051SerMet: 1.051 ± 0.021	0.957SerAsn: 0.957 ± 0.021	2.894SerPro: 2.894 ± 0.039	1.279SerGln: 1.279 ± 0.03	3.457SerArg: 3.457 ± 0.039	2.169SerSer: 2.169 ± 0.039	2.294SerThr: 2.294 ± 0.038	3.6SerVal: 3.6 ± 0.038	0.837SerTrp: 0.837 ± 0.021	1.079SerTyr: 1.079 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	7.206ThrAla: 7.206 ± 0.062	0.494ThrCys: 0.494 ± 0.017	2.679ThrAsp: 2.679 ± 0.037	2.767ThrGlu: 2.767 ± 0.039	1.598ThrPhe: 1.598 ± 0.031	5.403ThrGly: 5.403 ± 0.06	1.033ThrHis: 1.033 ± 0.025	2.476ThrIle: 2.476 ± 0.039	0.913ThrLys: 0.913 ± 0.02	6.363ThrLeu: 6.363 ± 0.071	1.082ThrMet: 1.082 ± 0.024	1.028ThrAsn: 1.028 ± 0.024	3.548ThrPro: 3.548 ± 0.044	1.435ThrGln: 1.435 ± 0.03	3.825ThrArg: 3.825 ± 0.039	2.329ThrSer: 2.329 ± 0.038	2.959ThrThr: 2.959 ± 0.046	4.305ThrVal: 4.305 ± 0.044	0.761ThrTrp: 0.761 ± 0.023	1.021ThrTyr: 1.021 ± 0.024	0.0ThrXaa: 0.0 ± 0.0
Val	10.829ValAla: 10.829 ± 0.089	0.717ValCys: 0.717 ± 0.02	3.531ValAsp: 3.531 ± 0.042	3.988ValGlu: 3.988 ± 0.046	2.476ValPhe: 2.476 ± 0.036	5.704ValGly: 5.704 ± 0.056	1.463ValHis: 1.463 ± 0.026	3.458ValIle: 3.458 ± 0.048	1.443ValLys: 1.443 ± 0.029	9.038ValLeu: 9.038 ± 0.072	1.747ValMet: 1.747 ± 0.032	1.699ValAsn: 1.699 ± 0.031	4.668ValPro: 4.668 ± 0.048	2.339ValGln: 2.339 ± 0.035	5.896ValArg: 5.896 ± 0.052	3.786ValSer: 3.786 ± 0.05	4.701ValThr: 4.701 ± 0.05	6.729ValVal: 6.729 ± 0.069	0.946ValTrp: 0.946 ± 0.024	1.21ValTyr: 1.21 ± 0.027	0.0ValXaa: 0.0 ± 0.0
Trp	1.454TrpAla: 1.454 ± 0.029	0.178TrpCys: 0.178 ± 0.008	0.69TrpAsp: 0.69 ± 0.021	0.589TrpGlu: 0.589 ± 0.018	0.527TrpPhe: 0.527 ± 0.017	1.019TrpGly: 1.019 ± 0.022	0.427TrpHis: 0.427 ± 0.015	0.647TrpIle: 0.647 ± 0.018	0.354TrpLys: 0.354 ± 0.012	1.918TrpLeu: 1.918 ± 0.037	0.348TrpMet: 0.348 ± 0.014	0.422TrpAsn: 0.422 ± 0.013	0.882TrpPro: 0.882 ± 0.021	0.701TrpGln: 0.701 ± 0.018	1.518TrpArg: 1.518 ± 0.027	0.764TrpSer: 0.764 ± 0.02	0.827TrpThr: 0.827 ± 0.02	0.926TrpVal: 0.926 ± 0.022	0.264TrpTrp: 0.264 ± 0.011	0.272TrpTyr: 0.272 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.326TyrAla: 2.326 ± 0.034	0.213TyrCys: 0.213 ± 0.01	1.109TyrAsp: 1.109 ± 0.023	0.924TyrGlu: 0.924 ± 0.023	0.647TyrPhe: 0.647 ± 0.019	1.722TyrGly: 1.722 ± 0.029	0.398TyrHis: 0.398 ± 0.014	0.617TyrIle: 0.617 ± 0.018	0.311TyrLys: 0.311 ± 0.013	1.956TyrLeu: 1.956 ± 0.034	0.308TyrMet: 0.308 ± 0.011	0.43TyrAsn: 0.43 ± 0.015	0.966TyrPro: 0.966 ± 0.023	0.621TyrGln: 0.621 ± 0.018	1.695TyrArg: 1.695 ± 0.031	0.805TyrSer: 0.805 ± 0.023	0.916TyrThr: 0.916 ± 0.025	1.422TyrVal: 1.422 ± 0.023	0.29TyrTrp: 0.29 ± 0.013	0.43TyrTyr: 0.43 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6206 proteins (2055468 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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