Amino acid dipepetide frequency for Desulfofundulus salinum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.986AlaAla: 10.986 ± 0.161
1.279AlaCys: 1.279 ± 0.042
3.824AlaAsp: 3.824 ± 0.072
5.832AlaGlu: 5.832 ± 0.101
3.081AlaPhe: 3.081 ± 0.062
9.863AlaGly: 9.863 ± 0.141
1.542AlaHis: 1.542 ± 0.049
5.091AlaIle: 5.091 ± 0.089
3.077AlaLys: 3.077 ± 0.067
10.784AlaLeu: 10.784 ± 0.139
2.364AlaMet: 2.364 ± 0.063
2.145AlaAsn: 2.145 ± 0.05
3.365AlaPro: 3.365 ± 0.07
2.877AlaGln: 2.877 ± 0.067
8.442AlaArg: 8.442 ± 0.126
4.128AlaSer: 4.128 ± 0.075
4.082AlaThr: 4.082 ± 0.09
8.697AlaVal: 8.697 ± 0.132
0.921AlaTrp: 0.921 ± 0.034
2.342AlaTyr: 2.342 ± 0.056
0.0AlaXaa: 0.0 ± 0.0
Cys
1.032CysAla: 1.032 ± 0.044
0.258CysCys: 0.258 ± 0.021
0.537CysAsp: 0.537 ± 0.026
0.54CysGlu: 0.54 ± 0.026
0.43CysPhe: 0.43 ± 0.021
1.481CysGly: 1.481 ± 0.051
0.325CysHis: 0.325 ± 0.021
0.557CysIle: 0.557 ± 0.03
0.373CysLys: 0.373 ± 0.022
1.287CysLeu: 1.287 ± 0.038
0.253CysMet: 0.253 ± 0.018
0.38CysAsn: 0.38 ± 0.021
0.937CysPro: 0.937 ± 0.042
0.386CysGln: 0.386 ± 0.023
1.164CysArg: 1.164 ± 0.045
0.66CysSer: 0.66 ± 0.035
0.62CysThr: 0.62 ± 0.03
0.751CysVal: 0.751 ± 0.034
0.135CysTrp: 0.135 ± 0.013
0.417CysTyr: 0.417 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
3.518AspAla: 3.518 ± 0.078
0.513AspCys: 0.513 ± 0.029
1.739AspAsp: 1.739 ± 0.052
3.289AspGlu: 3.289 ± 0.07
1.929AspPhe: 1.929 ± 0.04
3.544AspGly: 3.544 ± 0.072
0.806AspHis: 0.806 ± 0.033
3.064AspIle: 3.064 ± 0.069
1.834AspLys: 1.834 ± 0.054
5.35AspLeu: 5.35 ± 0.077
1.135AspMet: 1.135 ± 0.034
1.245AspAsn: 1.245 ± 0.042
3.048AspPro: 3.048 ± 0.066
1.411AspGln: 1.411 ± 0.042
3.321AspArg: 3.321 ± 0.081
1.729AspSer: 1.729 ± 0.05
1.97AspThr: 1.97 ± 0.052
3.645AspVal: 3.645 ± 0.076
0.571AspTrp: 0.571 ± 0.029
1.659AspTyr: 1.659 ± 0.042
0.0AspXaa: 0.0 ± 0.0
Glu
6.494GluAla: 6.494 ± 0.089
0.585GluCys: 0.585 ± 0.028
2.993GluAsp: 2.993 ± 0.07
6.501GluGlu: 6.501 ± 0.118
1.996GluPhe: 1.996 ± 0.048
4.764GluGly: 4.764 ± 0.09
1.267GluHis: 1.267 ± 0.04
5.126GluIle: 5.126 ± 0.079
4.997GluLys: 4.997 ± 0.078
7.7GluLeu: 7.7 ± 0.127
2.087GluMet: 2.087 ± 0.054
2.327GluAsn: 2.327 ± 0.053
2.527GluPro: 2.527 ± 0.062
2.79GluGln: 2.79 ± 0.069
4.807GluArg: 4.807 ± 0.096
2.419GluSer: 2.419 ± 0.053
2.828GluThr: 2.828 ± 0.069
6.089GluVal: 6.089 ± 0.093
0.625GluTrp: 0.625 ± 0.03
1.88GluTyr: 1.88 ± 0.052
0.0GluXaa: 0.0 ± 0.0
Phe
3.046PheAla: 3.046 ± 0.062
0.558PheCys: 0.558 ± 0.027
1.7PheAsp: 1.7 ± 0.047
1.847PheGlu: 1.847 ± 0.048
1.598PhePhe: 1.598 ± 0.05
2.905PheGly: 2.905 ± 0.065
0.787PheHis: 0.787 ± 0.03
2.277PheIle: 2.277 ± 0.056
1.545PheLys: 1.545 ± 0.045
4.097PheLeu: 4.097 ± 0.09
0.843PheMet: 0.843 ± 0.032
1.231PheAsn: 1.231 ± 0.04
1.774PhePro: 1.774 ± 0.054
1.046PheGln: 1.046 ± 0.036
2.079PheArg: 2.079 ± 0.046
2.086PheSer: 2.086 ± 0.049
2.139PheThr: 2.139 ± 0.052
2.397PheVal: 2.397 ± 0.059
0.465PheTrp: 0.465 ± 0.03
1.242PheTyr: 1.242 ± 0.039
0.0PheXaa: 0.0 ± 0.0
Gly
7.039GlyAla: 7.039 ± 0.118
1.276GlyCys: 1.276 ± 0.047
3.661GlyAsp: 3.661 ± 0.07
5.824GlyGlu: 5.824 ± 0.099
3.026GlyPhe: 3.026 ± 0.054
7.018GlyGly: 7.018 ± 0.129
1.573GlyHis: 1.573 ± 0.046
5.357GlyIle: 5.357 ± 0.091
4.501GlyLys: 4.501 ± 0.077
9.066GlyLeu: 9.066 ± 0.133
2.32GlyMet: 2.32 ± 0.06
2.35GlyAsn: 2.35 ± 0.05
3.07GlyPro: 3.07 ± 0.065
3.097GlyGln: 3.097 ± 0.072
6.154GlyArg: 6.154 ± 0.106
3.975GlySer: 3.975 ± 0.081
4.349GlyThr: 4.349 ± 0.076
6.852GlyVal: 6.852 ± 0.094
0.946GlyTrp: 0.946 ± 0.037
2.919GlyTyr: 2.919 ± 0.065
0.0GlyXaa: 0.0 ± 0.0
His
1.376HisAla: 1.376 ± 0.04
0.319HisCys: 0.319 ± 0.02
0.789HisAsp: 0.789 ± 0.035
0.91HisGlu: 0.91 ± 0.037
0.783HisPhe: 0.783 ± 0.035
1.565HisGly: 1.565 ± 0.04
0.533HisHis: 0.533 ± 0.033
1.114HisIle: 1.114 ± 0.036
0.634HisLys: 0.634 ± 0.026
2.321HisLeu: 2.321 ± 0.058
0.449HisMet: 0.449 ± 0.027
0.62HisAsn: 0.62 ± 0.028
1.349HisPro: 1.349 ± 0.045
0.699HisGln: 0.699 ± 0.028
1.47HisArg: 1.47 ± 0.047
0.834HisSer: 0.834 ± 0.034
0.962HisThr: 0.962 ± 0.036
1.262HisVal: 1.262 ± 0.041
0.242HisTrp: 0.242 ± 0.018
0.649HisTyr: 0.649 ± 0.027
0.0HisXaa: 0.0 ± 0.0
Ile
5.281IleAla: 5.281 ± 0.084
0.778IleCys: 0.778 ± 0.035
2.859IleAsp: 2.859 ± 0.057
3.442IleGlu: 3.442 ± 0.064
2.274IlePhe: 2.274 ± 0.057
4.18IleGly: 4.18 ± 0.079
1.103IleHis: 1.103 ± 0.034
3.947IleIle: 3.947 ± 0.083
3.104IleLys: 3.104 ± 0.072
6.014IleLeu: 6.014 ± 0.102
1.474IleMet: 1.474 ± 0.041
2.197IleAsn: 2.197 ± 0.053
3.247IlePro: 3.247 ± 0.065
1.692IleGln: 1.692 ± 0.042
3.728IleArg: 3.728 ± 0.065
3.256IleSer: 3.256 ± 0.064
3.543IleThr: 3.543 ± 0.069
4.033IleVal: 4.033 ± 0.071
0.535IleTrp: 0.535 ± 0.028
1.816IleTyr: 1.816 ± 0.051
0.0IleXaa: 0.0 ± 0.0
Lys
4.054LysAla: 4.054 ± 0.082
0.453LysCys: 0.453 ± 0.031
2.244LysAsp: 2.244 ± 0.047
4.269LysGlu: 4.269 ± 0.085
1.309LysPhe: 1.309 ± 0.041
3.4LysGly: 3.4 ± 0.072
0.821LysHis: 0.821 ± 0.027
3.028LysIle: 3.028 ± 0.061
3.114LysLys: 3.114 ± 0.072
4.131LysLeu: 4.131 ± 0.07
1.276LysMet: 1.276 ± 0.045
1.681LysAsn: 1.681 ± 0.045
2.078LysPro: 2.078 ± 0.047
1.583LysGln: 1.583 ± 0.048
2.6LysArg: 2.6 ± 0.059
1.961LysSer: 1.961 ± 0.055
2.361LysThr: 2.361 ± 0.063
3.91LysVal: 3.91 ± 0.069
0.392LysTrp: 0.392 ± 0.023
1.42LysTyr: 1.42 ± 0.053
0.0LysXaa: 0.0 ± 0.0
Leu
12.589LeuAla: 12.589 ± 0.159
1.202LeuCys: 1.202 ± 0.044
5.164LeuAsp: 5.164 ± 0.087
7.694LeuGlu: 7.694 ± 0.126
3.736LeuPhe: 3.736 ± 0.092
8.754LeuGly: 8.754 ± 0.113
1.906LeuHis: 1.906 ± 0.047
5.393LeuIle: 5.393 ± 0.084
5.467LeuLys: 5.467 ± 0.095
11.085LeuLeu: 11.085 ± 0.181
2.326LeuMet: 2.326 ± 0.054
3.214LeuAsn: 3.214 ± 0.052
5.59LeuPro: 5.59 ± 0.096
3.467LeuGln: 3.467 ± 0.075
6.163LeuArg: 6.163 ± 0.096
5.548LeuSer: 5.548 ± 0.09
5.457LeuThr: 5.457 ± 0.081
9.374LeuVal: 9.374 ± 0.122
1.057LeuTrp: 1.057 ± 0.039
2.744LeuTyr: 2.744 ± 0.065
0.0LeuXaa: 0.0 ± 0.0
Met
2.828MetAla: 2.828 ± 0.07
0.222MetCys: 0.222 ± 0.019
1.235MetAsp: 1.235 ± 0.037
1.867MetGlu: 1.867 ± 0.053
0.744MetPhe: 0.744 ± 0.03
2.042MetGly: 2.042 ± 0.05
0.427MetHis: 0.427 ± 0.025
1.364MetIle: 1.364 ± 0.044
1.253MetLys: 1.253 ± 0.037
2.393MetLeu: 2.393 ± 0.058
0.549MetMet: 0.549 ± 0.029
0.738MetAsn: 0.738 ± 0.03
1.167MetPro: 1.167 ± 0.04
0.81MetGln: 0.81 ± 0.032
1.41MetArg: 1.41 ± 0.046
1.217MetSer: 1.217 ± 0.041
1.147MetThr: 1.147 ± 0.036
2.165MetVal: 2.165 ± 0.049
0.19MetTrp: 0.19 ± 0.017
0.496MetTyr: 0.496 ± 0.024
0.0MetXaa: 0.0 ± 0.0
Asn
2.357AsnAla: 2.357 ± 0.056
0.425AsnCys: 0.425 ± 0.025
1.144AsnAsp: 1.144 ± 0.04
1.491AsnGlu: 1.491 ± 0.045
1.22AsnPhe: 1.22 ± 0.041
2.203AsnGly: 2.203 ± 0.058
0.566AsnHis: 0.566 ± 0.028
2.031AsnIle: 2.031 ± 0.053
1.285AsnLys: 1.285 ± 0.035
3.573AsnLeu: 3.573 ± 0.064
0.772AsnMet: 0.772 ± 0.03
0.997AsnAsn: 0.997 ± 0.039
2.152AsnPro: 2.152 ± 0.054
1.041AsnGln: 1.041 ± 0.035
2.149AsnArg: 2.149 ± 0.05
1.262AsnSer: 1.262 ± 0.038
1.509AsnThr: 1.509 ± 0.046
2.149AsnVal: 2.149 ± 0.052
0.331AsnTrp: 0.331 ± 0.02
0.963AsnTyr: 0.963 ± 0.036
0.0AsnXaa: 0.0 ± 0.0
Pro
5.07ProAla: 5.07 ± 0.104
0.548ProCys: 0.548 ± 0.027
2.684ProAsp: 2.684 ± 0.06
4.204ProGlu: 4.204 ± 0.078
1.774ProPhe: 1.774 ± 0.049
5.563ProGly: 5.563 ± 0.091
0.975ProHis: 0.975 ± 0.033
1.735ProIle: 1.735 ± 0.047
1.435ProLys: 1.435 ± 0.046
4.689ProLeu: 4.689 ± 0.077
0.879ProMet: 0.879 ± 0.035
1.167ProAsn: 1.167 ± 0.041
2.588ProPro: 2.588 ± 0.079
1.648ProGln: 1.648 ± 0.051
3.125ProArg: 3.125 ± 0.072
1.995ProSer: 1.995 ± 0.051
1.862ProThr: 1.862 ± 0.05
5.214ProVal: 5.214 ± 0.085
0.603ProTrp: 0.603 ± 0.031
1.371ProTyr: 1.371 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
3.478GlnAla: 3.478 ± 0.073
0.306GlnCys: 0.306 ± 0.022
1.453GlnAsp: 1.453 ± 0.038
2.962GlnGlu: 2.962 ± 0.065
1.046GlnPhe: 1.046 ± 0.035
2.553GlnGly: 2.553 ± 0.053
0.548GlnHis: 0.548 ± 0.024
1.936GlnIle: 1.936 ± 0.051
2.08GlnLys: 2.08 ± 0.053
3.359GlnLeu: 3.359 ± 0.067
0.921GlnMet: 0.921 ± 0.031
1.032GlnAsn: 1.032 ± 0.038
1.488GlnPro: 1.488 ± 0.045
1.438GlnGln: 1.438 ± 0.063
2.026GlnArg: 2.026 ± 0.057
1.253GlnSer: 1.253 ± 0.041
1.403GlnThr: 1.403 ± 0.043
3.45GlnVal: 3.45 ± 0.073
0.345GlnTrp: 0.345 ± 0.02
0.846GlnTyr: 0.846 ± 0.032
0.0GlnXaa: 0.0 ± 0.0
Arg
6.083ArgAla: 6.083 ± 0.111
0.876ArgCys: 0.876 ± 0.039
3.258ArgAsp: 3.258 ± 0.068
6.579ArgGlu: 6.579 ± 0.095
2.388ArgPhe: 2.388 ± 0.049
5.071ArgGly: 5.071 ± 0.084
1.453ArgHis: 1.453 ± 0.045
3.654ArgIle: 3.654 ± 0.078
2.926ArgLys: 2.926 ± 0.077
7.814ArgLeu: 7.814 ± 0.121
1.623ArgMet: 1.623 ± 0.044
1.826ArgAsn: 1.826 ± 0.048
3.148ArgPro: 3.148 ± 0.065
3.09ArgGln: 3.09 ± 0.062
5.408ArgArg: 5.408 ± 0.118
2.67ArgSer: 2.67 ± 0.055
2.901ArgThr: 2.901 ± 0.06
6.198ArgVal: 6.198 ± 0.104
0.805ArgTrp: 0.805 ± 0.036
2.229ArgTyr: 2.229 ± 0.052
0.0ArgXaa: 0.0 ± 0.0
Ser
3.511SerAla: 3.511 ± 0.075
0.738SerCys: 0.738 ± 0.033
1.771SerAsp: 1.771 ± 0.049
2.366SerGlu: 2.366 ± 0.053
1.989SerPhe: 1.989 ± 0.051
4.561SerGly: 4.561 ± 0.078
0.906SerHis: 0.906 ± 0.035
2.578SerIle: 2.578 ± 0.062
1.699SerLys: 1.699 ± 0.053
5.518SerLeu: 5.518 ± 0.096
1.185SerMet: 1.185 ± 0.038
1.127SerAsn: 1.127 ± 0.041
2.633SerPro: 2.633 ± 0.051
1.38SerGln: 1.38 ± 0.042
3.84SerArg: 3.84 ± 0.073
2.493SerSer: 2.493 ± 0.069
2.324SerThr: 2.324 ± 0.059
3.003SerVal: 3.003 ± 0.067
0.553SerTrp: 0.553 ± 0.029
1.41SerTyr: 1.41 ± 0.042
0.0SerXaa: 0.0 ± 0.0
Thr
4.709ThrAla: 4.709 ± 0.076
0.656ThrCys: 0.656 ± 0.029
1.994ThrAsp: 1.994 ± 0.055
2.512ThrGlu: 2.512 ± 0.063
1.806ThrPhe: 1.806 ± 0.058
5.604ThrGly: 5.604 ± 0.088
0.904ThrHis: 0.904 ± 0.031
2.896ThrIle: 2.896 ± 0.063
1.37ThrLys: 1.37 ± 0.046
4.994ThrLeu: 4.994 ± 0.076
1.095ThrMet: 1.095 ± 0.033
1.313ThrAsn: 1.313 ± 0.044
2.857ThrPro: 2.857 ± 0.063
1.106ThrGln: 1.106 ± 0.034
3.492ThrArg: 3.492 ± 0.069
2.297ThrSer: 2.297 ± 0.057
2.582ThrThr: 2.582 ± 0.072
4.525ThrVal: 4.525 ± 0.079
0.519ThrTrp: 0.519 ± 0.031
1.357ThrTyr: 1.357 ± 0.042
0.0ThrXaa: 0.0 ± 0.0
Val
8.234ValAla: 8.234 ± 0.112
0.967ValCys: 0.967 ± 0.037
4.338ValAsp: 4.338 ± 0.071
6.277ValGlu: 6.277 ± 0.097
2.935ValPhe: 2.935 ± 0.06
5.925ValGly: 5.925 ± 0.084
1.465ValHis: 1.465 ± 0.045
5.251ValIle: 5.251 ± 0.092
3.928ValLys: 3.928 ± 0.074
8.911ValLeu: 8.911 ± 0.101
1.957ValMet: 1.957 ± 0.058
2.729ValAsn: 2.729 ± 0.06
4.004ValPro: 4.004 ± 0.07
2.671ValGln: 2.671 ± 0.058
5.266ValArg: 5.266 ± 0.082
4.063ValSer: 4.063 ± 0.081
4.613ValThr: 4.613 ± 0.087
7.95ValVal: 7.95 ± 0.129
0.688ValTrp: 0.688 ± 0.029
2.213ValTyr: 2.213 ± 0.058
0.0ValXaa: 0.0 ± 0.0
Trp
0.796TrpAla: 0.796 ± 0.032
0.125TrpCys: 0.125 ± 0.015
0.475TrpAsp: 0.475 ± 0.026
0.814TrpGlu: 0.814 ± 0.03
0.412TrpPhe: 0.412 ± 0.023
0.839TrpGly: 0.839 ± 0.033
0.251TrpHis: 0.251 ± 0.017
0.471TrpIle: 0.471 ± 0.029
0.446TrpLys: 0.446 ± 0.027
1.307TrpLeu: 1.307 ± 0.046
0.25TrpMet: 0.25 ± 0.019
0.322TrpAsn: 0.322 ± 0.021
0.524TrpPro: 0.524 ± 0.025
0.548TrpGln: 0.548 ± 0.026
0.731TrpArg: 0.731 ± 0.038
0.474TrpSer: 0.474 ± 0.025
0.42TrpThr: 0.42 ± 0.023
0.732TrpVal: 0.732 ± 0.034
0.152TrpTrp: 0.152 ± 0.014
0.303TrpTyr: 0.303 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.241TyrAla: 2.241 ± 0.056
0.438TyrCys: 0.438 ± 0.023
1.46TyrAsp: 1.46 ± 0.041
1.583TyrGlu: 1.583 ± 0.043
1.185TyrPhe: 1.185 ± 0.044
2.539TyrGly: 2.539 ± 0.055
0.723TyrHis: 0.723 ± 0.032
1.631TyrIle: 1.631 ± 0.053
1.017TyrLys: 1.017 ± 0.04
3.538TyrLeu: 3.538 ± 0.074
0.504TyrMet: 0.504 ± 0.027
0.983TyrAsn: 0.983 ± 0.034
1.583TyrPro: 1.583 ± 0.049
1.144TyrGln: 1.144 ± 0.036
2.623TyrArg: 2.623 ± 0.061
1.264TyrSer: 1.264 ± 0.045
1.516TyrThr: 1.516 ± 0.046
1.988TyrVal: 1.988 ± 0.053
0.315TyrTrp: 0.315 ± 0.022
1.041TyrTyr: 1.041 ± 0.035
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2755 proteins (821128 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski