Amino acid dipepetide frequency for Tessaracoccus antarcticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.329AlaAla: 16.329 ± 0.172	0.971AlaCys: 0.971 ± 0.034	7.296AlaAsp: 7.296 ± 0.092	6.841AlaGlu: 6.841 ± 0.103	3.568AlaPhe: 3.568 ± 0.063	10.774AlaGly: 10.774 ± 0.108	2.616AlaHis: 2.616 ± 0.052	5.199AlaIle: 5.199 ± 0.076	2.735AlaLys: 2.735 ± 0.065	12.796AlaLeu: 12.796 ± 0.144	2.983AlaMet: 2.983 ± 0.05	2.353AlaAsn: 2.353 ± 0.043	5.557AlaPro: 5.557 ± 0.083	3.597AlaGln: 3.597 ± 0.059	7.881AlaArg: 7.881 ± 0.103	6.901AlaSer: 6.901 ± 0.084	7.801AlaThr: 7.801 ± 0.114	10.384AlaVal: 10.384 ± 0.114	1.938AlaTrp: 1.938 ± 0.051	1.983AlaTyr: 1.983 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	0.812CysAla: 0.812 ± 0.029	0.088CysCys: 0.088 ± 0.009	0.515CysAsp: 0.515 ± 0.023	0.382CysGlu: 0.382 ± 0.018	0.239CysPhe: 0.239 ± 0.013	0.829CysGly: 0.829 ± 0.029	0.206CysHis: 0.206 ± 0.012	0.271CysIle: 0.271 ± 0.015	0.082CysLys: 0.082 ± 0.009	0.658CysLeu: 0.658 ± 0.023	0.144CysMet: 0.144 ± 0.011	0.165CysAsn: 0.165 ± 0.012	0.473CysPro: 0.473 ± 0.025	0.215CysGln: 0.215 ± 0.013	0.569CysArg: 0.569 ± 0.024	0.489CysSer: 0.489 ± 0.021	0.478CysThr: 0.478 ± 0.019	0.602CysVal: 0.602 ± 0.026	0.113CysTrp: 0.113 ± 0.01	0.13CysTyr: 0.13 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.537AspAla: 7.537 ± 0.106	0.377AspCys: 0.377 ± 0.02	4.023AspAsp: 4.023 ± 0.073	3.972AspGlu: 3.972 ± 0.075	1.768AspPhe: 1.768 ± 0.038	6.06AspGly: 6.06 ± 0.084	1.423AspHis: 1.423 ± 0.04	2.561AspIle: 2.561 ± 0.05	1.32AspLys: 1.32 ± 0.037	6.285AspLeu: 6.285 ± 0.074	1.185AspMet: 1.185 ± 0.034	1.187AspAsn: 1.187 ± 0.034	4.093AspPro: 4.093 ± 0.059	1.704AspGln: 1.704 ± 0.033	3.825AspArg: 3.825 ± 0.07	2.828AspSer: 2.828 ± 0.054	3.063AspThr: 3.063 ± 0.055	5.979AspVal: 5.979 ± 0.077	0.955AspTrp: 0.955 ± 0.033	1.21AspTyr: 1.21 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	6.748GluAla: 6.748 ± 0.091	0.39GluCys: 0.39 ± 0.02	2.889GluAsp: 2.889 ± 0.059	2.878GluGlu: 2.878 ± 0.059	1.679GluPhe: 1.679 ± 0.04	4.106GluGly: 4.106 ± 0.062	1.444GluHis: 1.444 ± 0.037	2.328GluIle: 2.328 ± 0.05	1.472GluLys: 1.472 ± 0.043	6.056GluLeu: 6.056 ± 0.092	1.172GluMet: 1.172 ± 0.033	1.204GluAsn: 1.204 ± 0.033	2.842GluPro: 2.842 ± 0.06	2.155GluGln: 2.155 ± 0.051	4.101GluArg: 4.101 ± 0.068	2.769GluSer: 2.769 ± 0.054	2.817GluThr: 2.817 ± 0.051	4.773GluVal: 4.773 ± 0.076	0.786GluTrp: 0.786 ± 0.029	1.034GluTyr: 1.034 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.66PheAla: 3.66 ± 0.059	0.259PheCys: 0.259 ± 0.016	2.315PheAsp: 2.315 ± 0.049	1.613PheGlu: 1.613 ± 0.039	1.041PhePhe: 1.041 ± 0.037	3.228PheGly: 3.228 ± 0.055	0.679PheHis: 0.679 ± 0.027	1.319PheIle: 1.319 ± 0.034	0.613PheLys: 0.613 ± 0.026	2.853PheLeu: 2.853 ± 0.053	0.591PheMet: 0.591 ± 0.027	0.901PheAsn: 0.901 ± 0.034	1.41PhePro: 1.41 ± 0.033	0.864PheGln: 0.864 ± 0.029	1.745PheArg: 1.745 ± 0.039	1.988PheSer: 1.988 ± 0.047	2.287PheThr: 2.287 ± 0.05	2.741PheVal: 2.741 ± 0.055	0.48PheTrp: 0.48 ± 0.024	0.664PheTyr: 0.664 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	9.506GlyAla: 9.506 ± 0.127	0.8GlyCys: 0.8 ± 0.029	5.243GlyAsp: 5.243 ± 0.072	4.604GlyGlu: 4.604 ± 0.074	3.189GlyPhe: 3.189 ± 0.059	7.541GlyGly: 7.541 ± 0.121	2.115GlyHis: 2.115 ± 0.053	4.33GlyIle: 4.33 ± 0.069	2.375GlyLys: 2.375 ± 0.052	9.078GlyLeu: 9.078 ± 0.106	2.297GlyMet: 2.297 ± 0.049	2.086GlyAsn: 2.086 ± 0.043	3.919GlyPro: 3.919 ± 0.066	2.81GlyGln: 2.81 ± 0.055	6.437GlyArg: 6.437 ± 0.086	5.365GlySer: 5.365 ± 0.083	5.674GlyThr: 5.674 ± 0.075	8.048GlyVal: 8.048 ± 0.098	1.862GlyTrp: 1.862 ± 0.042	2.139GlyTyr: 2.139 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.428HisAla: 2.428 ± 0.053	0.189HisCys: 0.189 ± 0.013	1.502HisAsp: 1.502 ± 0.036	1.26HisGlu: 1.26 ± 0.037	0.688HisPhe: 0.688 ± 0.027	2.127HisGly: 2.127 ± 0.042	0.795HisHis: 0.795 ± 0.033	0.866HisIle: 0.866 ± 0.026	0.389HisLys: 0.389 ± 0.021	2.446HisLeu: 2.446 ± 0.051	0.459HisMet: 0.459 ± 0.021	0.477HisAsn: 0.477 ± 0.023	1.576HisPro: 1.576 ± 0.041	0.719HisGln: 0.719 ± 0.027	1.817HisArg: 1.817 ± 0.046	1.116HisSer: 1.116 ± 0.034	1.373HisThr: 1.373 ± 0.032	1.875HisVal: 1.875 ± 0.052	0.338HisTrp: 0.338 ± 0.017	0.454HisTyr: 0.454 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.461IleAla: 5.461 ± 0.071	0.335IleCys: 0.335 ± 0.016	3.143IleAsp: 3.143 ± 0.055	2.353IleGlu: 2.353 ± 0.052	1.233IlePhe: 1.233 ± 0.035	4.079IleGly: 4.079 ± 0.066	0.933IleHis: 0.933 ± 0.03	1.995IleIle: 1.995 ± 0.049	0.867IleLys: 0.867 ± 0.027	3.699IleLeu: 3.699 ± 0.066	0.824IleMet: 0.824 ± 0.029	1.164IleAsn: 1.164 ± 0.036	2.249IlePro: 2.249 ± 0.046	1.003IleGln: 1.003 ± 0.028	2.576IleArg: 2.576 ± 0.051	2.608IleSer: 2.608 ± 0.05	3.161IleThr: 3.161 ± 0.061	3.819IleVal: 3.819 ± 0.067	0.574IleTrp: 0.574 ± 0.023	0.796IleTyr: 0.796 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	2.632LysAla: 2.632 ± 0.058	0.131LysCys: 0.131 ± 0.011	1.36LysAsp: 1.36 ± 0.036	1.218LysGlu: 1.218 ± 0.036	0.664LysPhe: 0.664 ± 0.028	1.871LysGly: 1.871 ± 0.046	0.455LysHis: 0.455 ± 0.02	0.928LysIle: 0.928 ± 0.031	0.807LysLys: 0.807 ± 0.029	2.161LysLeu: 2.161 ± 0.058	0.506LysMet: 0.506 ± 0.023	0.613LysAsn: 0.613 ± 0.028	1.357LysPro: 1.357 ± 0.041	0.775LysGln: 0.775 ± 0.027	1.464LysArg: 1.464 ± 0.037	1.295LysSer: 1.295 ± 0.037	1.328LysThr: 1.328 ± 0.034	2.084LysVal: 2.084 ± 0.049	0.35LysTrp: 0.35 ± 0.02	0.526LysTyr: 0.526 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	13.317LeuAla: 13.317 ± 0.143	0.703LeuCys: 0.703 ± 0.025	6.218LeuAsp: 6.218 ± 0.08	5.288LeuGlu: 5.288 ± 0.077	2.895LeuPhe: 2.895 ± 0.058	9.431LeuGly: 9.431 ± 0.114	2.203LeuHis: 2.203 ± 0.052	3.933LeuIle: 3.933 ± 0.069	2.03LeuLys: 2.03 ± 0.048	10.324LeuLeu: 10.324 ± 0.147	2.161LeuMet: 2.161 ± 0.05	2.173LeuAsn: 2.173 ± 0.043	5.633LeuPro: 5.633 ± 0.078	2.907LeuGln: 2.907 ± 0.05	7.248LeuArg: 7.248 ± 0.096	6.08LeuSer: 6.08 ± 0.08	6.441LeuThr: 6.441 ± 0.073	9.58LeuVal: 9.58 ± 0.12	1.385LeuTrp: 1.385 ± 0.036	1.546LeuTyr: 1.546 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	2.869MetAla: 2.869 ± 0.05	0.145MetCys: 0.145 ± 0.012	1.211MetAsp: 1.211 ± 0.04	1.073MetGlu: 1.073 ± 0.034	0.642MetPhe: 0.642 ± 0.023	2.005MetGly: 2.005 ± 0.045	0.441MetHis: 0.441 ± 0.02	0.914MetIle: 0.914 ± 0.033	0.564MetLys: 0.564 ± 0.027	2.23MetLeu: 2.23 ± 0.046	0.472MetMet: 0.472 ± 0.024	0.582MetAsn: 0.582 ± 0.022	1.244MetPro: 1.244 ± 0.037	0.671MetGln: 0.671 ± 0.024	1.575MetArg: 1.575 ± 0.04	1.619MetSer: 1.619 ± 0.04	1.775MetThr: 1.775 ± 0.035	1.918MetVal: 1.918 ± 0.038	0.292MetTrp: 0.292 ± 0.016	0.329MetTyr: 0.329 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.564AsnAla: 2.564 ± 0.049	0.147AsnCys: 0.147 ± 0.011	1.342AsnAsp: 1.342 ± 0.036	1.016AsnGlu: 1.016 ± 0.032	0.746AsnPhe: 0.746 ± 0.029	2.106AsnGly: 2.106 ± 0.052	0.552AsnHis: 0.552 ± 0.025	0.987AsnIle: 0.987 ± 0.031	0.583AsnLys: 0.583 ± 0.027	2.278AsnLeu: 2.278 ± 0.047	0.482AsnMet: 0.482 ± 0.022	0.78AsnAsn: 0.78 ± 0.032	1.82AsnPro: 1.82 ± 0.037	0.726AsnGln: 0.726 ± 0.028	1.414AsnArg: 1.414 ± 0.041	1.183AsnSer: 1.183 ± 0.034	1.35AsnThr: 1.35 ± 0.04	1.799AsnVal: 1.799 ± 0.052	0.416AsnTrp: 0.416 ± 0.017	0.525AsnTyr: 0.525 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	6.213ProAla: 6.213 ± 0.087	0.315ProCys: 0.315 ± 0.017	3.65ProAsp: 3.65 ± 0.057	3.686ProGlu: 3.686 ± 0.069	1.624ProPhe: 1.624 ± 0.038	5.318ProGly: 5.318 ± 0.079	1.327ProHis: 1.327 ± 0.038	1.917ProIle: 1.917 ± 0.047	1.123ProLys: 1.123 ± 0.038	4.866ProLeu: 4.866 ± 0.076	1.208ProMet: 1.208 ± 0.03	1.16ProAsn: 1.16 ± 0.036	2.683ProPro: 2.683 ± 0.066	1.737ProGln: 1.737 ± 0.046	3.269ProArg: 3.269 ± 0.06	3.63ProSer: 3.63 ± 0.068	3.789ProThr: 3.789 ± 0.073	4.681ProVal: 4.681 ± 0.07	0.947ProTrp: 0.947 ± 0.029	1.067ProTyr: 1.067 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.553GlnAla: 3.553 ± 0.065	0.202GlnCys: 0.202 ± 0.015	1.502GlnAsp: 1.502 ± 0.039	1.437GlnGlu: 1.437 ± 0.038	0.995GlnPhe: 0.995 ± 0.03	2.476GlnGly: 2.476 ± 0.05	0.731GlnHis: 0.731 ± 0.024	1.303GlnIle: 1.303 ± 0.032	0.713GlnLys: 0.713 ± 0.028	3.462GlnLeu: 3.462 ± 0.059	0.686GlnMet: 0.686 ± 0.026	0.664GlnAsn: 0.664 ± 0.026	1.807GlnPro: 1.807 ± 0.042	1.396GlnGln: 1.396 ± 0.045	2.574GlnArg: 2.574 ± 0.056	1.714GlnSer: 1.714 ± 0.037	1.465GlnThr: 1.465 ± 0.038	2.743GlnVal: 2.743 ± 0.049	0.616GlnTrp: 0.616 ± 0.026	0.627GlnTyr: 0.627 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	7.434ArgAla: 7.434 ± 0.099	0.56ArgCys: 0.56 ± 0.023	4.262ArgAsp: 4.262 ± 0.072	3.636ArgGlu: 3.636 ± 0.065	2.222ArgPhe: 2.222 ± 0.044	5.124ArgGly: 5.124 ± 0.078	1.74ArgHis: 1.74 ± 0.045	3.381ArgIle: 3.381 ± 0.059	1.482ArgLys: 1.482 ± 0.04	6.966ArgLeu: 6.966 ± 0.097	1.769ArgMet: 1.769 ± 0.043	1.589ArgAsn: 1.589 ± 0.035	3.582ArgPro: 3.582 ± 0.059	2.29ArgGln: 2.29 ± 0.049	6.165ArgArg: 6.165 ± 0.107	4.113ArgSer: 4.113 ± 0.065	4.267ArgThr: 4.267 ± 0.066	5.468ArgVal: 5.468 ± 0.083	1.26ArgTrp: 1.26 ± 0.035	1.405ArgTyr: 1.405 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.567SerAla: 6.567 ± 0.082	0.418SerCys: 0.418 ± 0.019	3.408SerAsp: 3.408 ± 0.05	2.852SerGlu: 2.852 ± 0.059	1.947SerPhe: 1.947 ± 0.043	5.835SerGly: 5.835 ± 0.071	1.257SerHis: 1.257 ± 0.032	2.527SerIle: 2.527 ± 0.05	1.302SerLys: 1.302 ± 0.04	5.746SerLeu: 5.746 ± 0.079	1.544SerMet: 1.544 ± 0.037	1.369SerAsn: 1.369 ± 0.035	3.418SerPro: 3.418 ± 0.061	1.814SerGln: 1.814 ± 0.043	4.027SerArg: 4.027 ± 0.066	3.724SerSer: 3.724 ± 0.065	3.989SerThr: 3.989 ± 0.071	4.864SerVal: 4.864 ± 0.069	1.016SerTrp: 1.016 ± 0.029	1.267SerTyr: 1.267 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	7.409ThrAla: 7.409 ± 0.11	0.461ThrCys: 0.461 ± 0.021	3.633ThrAsp: 3.633 ± 0.061	2.839ThrGlu: 2.839 ± 0.057	2.046ThrPhe: 2.046 ± 0.048	5.782ThrGly: 5.782 ± 0.083	1.448ThrHis: 1.448 ± 0.037	2.89ThrIle: 2.89 ± 0.053	1.377ThrLys: 1.377 ± 0.038	6.264ThrLeu: 6.264 ± 0.083	1.346ThrMet: 1.346 ± 0.035	1.463ThrAsn: 1.463 ± 0.046	4.233ThrPro: 4.233 ± 0.066	1.865ThrGln: 1.865 ± 0.042	3.827ThrArg: 3.827 ± 0.067	4.123ThrSer: 4.123 ± 0.064	4.613ThrThr: 4.613 ± 0.077	5.68ThrVal: 5.68 ± 0.082	1.154ThrTrp: 1.154 ± 0.039	1.297ThrTyr: 1.297 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	11.637ValAla: 11.637 ± 0.125	0.657ValCys: 0.657 ± 0.023	5.735ValAsp: 5.735 ± 0.075	4.96ValGlu: 4.96 ± 0.073	2.74ValPhe: 2.74 ± 0.059	7.696ValGly: 7.696 ± 0.094	1.777ValHis: 1.777 ± 0.045	3.93ValIle: 3.93 ± 0.07	1.869ValLys: 1.869 ± 0.045	9.28ValLeu: 9.28 ± 0.115	2.025ValMet: 2.025 ± 0.045	1.96ValAsn: 1.96 ± 0.052	4.479ValPro: 4.479 ± 0.068	2.142ValGln: 2.142 ± 0.044	5.484ValArg: 5.484 ± 0.076	5.083ValSer: 5.083 ± 0.07	5.974ValThr: 5.974 ± 0.08	9.403ValVal: 9.403 ± 0.128	1.217ValTrp: 1.217 ± 0.04	1.318ValTyr: 1.318 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.718TrpAla: 1.718 ± 0.043	0.143TrpCys: 0.143 ± 0.011	0.883TrpAsp: 0.883 ± 0.029	0.717TrpGlu: 0.717 ± 0.025	0.645TrpPhe: 0.645 ± 0.028	1.259TrpGly: 1.259 ± 0.034	0.372TrpHis: 0.372 ± 0.021	0.631TrpIle: 0.631 ± 0.026	0.427TrpLys: 0.427 ± 0.02	1.995TrpLeu: 1.995 ± 0.046	0.371TrpMet: 0.371 ± 0.02	0.457TrpAsn: 0.457 ± 0.022	0.8TrpPro: 0.8 ± 0.025	0.655TrpGln: 0.655 ± 0.023	1.323TrpArg: 1.323 ± 0.041	1.101TrpSer: 1.101 ± 0.034	0.925TrpThr: 0.925 ± 0.028	1.331TrpVal: 1.331 ± 0.037	0.443TrpTrp: 0.443 ± 0.024	0.31TrpTyr: 0.31 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.107TyrAla: 2.107 ± 0.049	0.166TyrCys: 0.166 ± 0.012	1.225TyrAsp: 1.225 ± 0.036	1.02TyrGlu: 1.02 ± 0.034	0.679TyrPhe: 0.679 ± 0.027	1.773TyrGly: 1.773 ± 0.043	0.38TyrHis: 0.38 ± 0.022	0.66TyrIle: 0.66 ± 0.026	0.394TyrLys: 0.394 ± 0.022	2.054TyrLeu: 2.054 ± 0.043	0.346TyrMet: 0.346 ± 0.02	0.472TyrAsn: 0.472 ± 0.022	1.036TyrPro: 1.036 ± 0.032	0.619TyrGln: 0.619 ± 0.024	1.395TyrArg: 1.395 ± 0.036	1.163TyrSer: 1.163 ± 0.038	1.177TyrThr: 1.177 ± 0.034	1.594TyrVal: 1.594 ± 0.044	0.366TyrTrp: 0.366 ± 0.02	0.457TyrTyr: 0.457 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3179 proteins (1084951 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---