Amino acid dipepetide frequency for Herbihabitans rhizosphaerae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.578AlaAla: 18.578 ± 0.133
0.979AlaCys: 0.979 ± 0.025
8.216AlaAsp: 8.216 ± 0.064
8.553AlaGlu: 8.553 ± 0.075
3.418AlaPhe: 3.418 ± 0.047
12.291AlaGly: 12.291 ± 0.083
2.556AlaHis: 2.556 ± 0.038
4.784AlaIle: 4.784 ± 0.057
3.253AlaLys: 3.253 ± 0.049
13.071AlaLeu: 13.071 ± 0.1
2.69AlaMet: 2.69 ± 0.036
2.458AlaAsn: 2.458 ± 0.037
6.105AlaPro: 6.105 ± 0.069
3.211AlaGln: 3.211 ± 0.049
9.381AlaArg: 9.381 ± 0.087
5.854AlaSer: 5.854 ± 0.053
7.275AlaThr: 7.275 ± 0.057
11.734AlaVal: 11.734 ± 0.096
1.785AlaTrp: 1.785 ± 0.033
2.221AlaTyr: 2.221 ± 0.036
0.0AlaXaa: 0.0 ± 0.0
Cys
1.034CysAla: 1.034 ± 0.027
0.096CysCys: 0.096 ± 0.008
0.514CysAsp: 0.514 ± 0.017
0.416CysGlu: 0.416 ± 0.015
0.21CysPhe: 0.21 ± 0.01
0.999CysGly: 0.999 ± 0.025
0.188CysHis: 0.188 ± 0.01
0.138CysIle: 0.138 ± 0.007
0.135CysLys: 0.135 ± 0.008
0.672CysLeu: 0.672 ± 0.017
0.122CysMet: 0.122 ± 0.009
0.135CysAsn: 0.135 ± 0.007
0.467CysPro: 0.467 ± 0.015
0.218CysGln: 0.218 ± 0.011
0.595CysArg: 0.595 ± 0.017
0.436CysSer: 0.436 ± 0.013
0.505CysThr: 0.505 ± 0.016
0.77CysVal: 0.77 ± 0.023
0.134CysTrp: 0.134 ± 0.008
0.181CysTyr: 0.181 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
7.724AspAla: 7.724 ± 0.065
0.448AspCys: 0.448 ± 0.016
3.905AspAsp: 3.905 ± 0.047
4.292AspGlu: 4.292 ± 0.05
1.579AspPhe: 1.579 ± 0.024
6.843AspGly: 6.843 ± 0.072
1.406AspHis: 1.406 ± 0.027
1.963AspIle: 1.963 ± 0.032
1.59AspLys: 1.59 ± 0.036
6.215AspLeu: 6.215 ± 0.058
0.941AspMet: 0.941 ± 0.023
1.235AspAsn: 1.235 ± 0.03
4.271AspPro: 4.271 ± 0.05
1.848AspGln: 1.848 ± 0.033
4.72AspArg: 4.72 ± 0.054
2.812AspSer: 2.812 ± 0.039
3.418AspThr: 3.418 ± 0.045
5.419AspVal: 5.419 ± 0.052
1.024AspTrp: 1.024 ± 0.022
1.248AspTyr: 1.248 ± 0.028
0.0AspXaa: 0.0 ± 0.0
Glu
6.034GluAla: 6.034 ± 0.065
0.408GluCys: 0.408 ± 0.014
2.614GluAsp: 2.614 ± 0.037
2.811GluGlu: 2.811 ± 0.043
1.834GluPhe: 1.834 ± 0.03
3.298GluGly: 3.298 ± 0.041
1.835GluHis: 1.835 ± 0.036
2.683GluIle: 2.683 ± 0.043
1.382GluLys: 1.382 ± 0.029
7.088GluLeu: 7.088 ± 0.071
0.982GluMet: 0.982 ± 0.023
1.148GluAsn: 1.148 ± 0.022
3.594GluPro: 3.594 ± 0.042
2.38GluGln: 2.38 ± 0.037
5.409GluArg: 5.409 ± 0.065
2.842GluSer: 2.842 ± 0.041
2.679GluThr: 2.679 ± 0.042
4.859GluVal: 4.859 ± 0.051
0.889GluTrp: 0.889 ± 0.019
1.148GluTyr: 1.148 ± 0.024
0.0GluXaa: 0.0 ± 0.0
Phe
3.899PheAla: 3.899 ± 0.049
0.258PheCys: 0.258 ± 0.01
2.199PheAsp: 2.199 ± 0.038
1.442PheGlu: 1.442 ± 0.028
0.838PhePhe: 0.838 ± 0.023
3.329PheGly: 3.329 ± 0.041
0.614PheHis: 0.614 ± 0.019
0.674PheIle: 0.674 ± 0.019
0.497PheLys: 0.497 ± 0.019
2.473PheLeu: 2.473 ± 0.035
0.385PheMet: 0.385 ± 0.013
0.581PheAsn: 0.581 ± 0.018
1.361PhePro: 1.361 ± 0.027
0.658PheGln: 0.658 ± 0.019
1.786PheArg: 1.786 ± 0.031
1.509PheSer: 1.509 ± 0.031
2.112PheThr: 2.112 ± 0.038
2.485PheVal: 2.485 ± 0.04
0.378PheTrp: 0.378 ± 0.016
0.604PheTyr: 0.604 ± 0.019
0.0PheXaa: 0.0 ± 0.0
Gly
10.058GlyAla: 10.058 ± 0.067
0.876GlyCys: 0.876 ± 0.022
5.279GlyAsp: 5.279 ± 0.051
5.253GlyGlu: 5.253 ± 0.056
2.861GlyPhe: 2.861 ± 0.043
8.561GlyGly: 8.561 ± 0.098
2.023GlyHis: 2.023 ± 0.033
3.529GlyIle: 3.529 ± 0.044
2.836GlyLys: 2.836 ± 0.053
8.77GlyLeu: 8.77 ± 0.078
2.141GlyMet: 2.141 ± 0.034
1.99GlyAsn: 1.99 ± 0.04
4.529GlyPro: 4.529 ± 0.046
2.837GlyGln: 2.837 ± 0.046
6.813GlyArg: 6.813 ± 0.064
5.001GlySer: 5.001 ± 0.065
5.737GlyThr: 5.737 ± 0.061
8.218GlyVal: 8.218 ± 0.066
1.668GlyTrp: 1.668 ± 0.035
2.328GlyTyr: 2.328 ± 0.033
0.0GlyXaa: 0.0 ± 0.0
His
2.591HisAla: 2.591 ± 0.038
0.207HisCys: 0.207 ± 0.009
1.403HisAsp: 1.403 ± 0.027
1.288HisGlu: 1.288 ± 0.025
0.607HisPhe: 0.607 ± 0.017
2.355HisGly: 2.355 ± 0.035
0.619HisHis: 0.619 ± 0.019
0.612HisIle: 0.612 ± 0.019
0.418HisLys: 0.418 ± 0.014
2.28HisLeu: 2.28 ± 0.032
0.335HisMet: 0.335 ± 0.014
0.467HisAsn: 0.467 ± 0.015
1.571HisPro: 1.571 ± 0.031
0.618HisGln: 0.618 ± 0.017
1.901HisArg: 1.901 ± 0.037
1.023HisSer: 1.023 ± 0.023
1.227HisThr: 1.227 ± 0.027
1.843HisVal: 1.843 ± 0.038
0.346HisTrp: 0.346 ± 0.013
0.477HisTyr: 0.477 ± 0.015
0.0HisXaa: 0.0 ± 0.0
Ile
5.891IleAla: 5.891 ± 0.062
0.267IleCys: 0.267 ± 0.012
2.732IleAsp: 2.732 ± 0.039
2.414IleGlu: 2.414 ± 0.039
0.786IlePhe: 0.786 ± 0.027
4.308IleGly: 4.308 ± 0.051
0.575IleHis: 0.575 ± 0.015
1.085IleIle: 1.085 ± 0.026
0.899IleLys: 0.899 ± 0.022
2.416IleLeu: 2.416 ± 0.037
0.602IleMet: 0.602 ± 0.015
0.868IleAsn: 0.868 ± 0.021
1.876IlePro: 1.876 ± 0.037
0.761IleGln: 0.761 ± 0.022
2.375IleArg: 2.375 ± 0.038
1.968IleSer: 1.968 ± 0.031
2.941IleThr: 2.941 ± 0.045
3.511IleVal: 3.511 ± 0.041
0.383IleTrp: 0.383 ± 0.014
0.605IleTyr: 0.605 ± 0.018
0.0IleXaa: 0.0 ± 0.0
Lys
2.892LysAla: 2.892 ± 0.048
0.128LysCys: 0.128 ± 0.009
1.201LysAsp: 1.201 ± 0.027
1.111LysGlu: 1.111 ± 0.027
0.607LysPhe: 0.607 ± 0.018
1.708LysGly: 1.708 ± 0.038
0.551LysHis: 0.551 ± 0.018
1.26LysIle: 1.26 ± 0.025
0.748LysLys: 0.748 ± 0.03
2.434LysLeu: 2.434 ± 0.041
0.444LysMet: 0.444 ± 0.016
0.499LysAsn: 0.499 ± 0.017
1.735LysPro: 1.735 ± 0.038
0.842LysGln: 0.842 ± 0.024
1.727LysArg: 1.727 ± 0.03
1.31LysSer: 1.31 ± 0.033
1.35LysThr: 1.35 ± 0.034
2.114LysVal: 2.114 ± 0.039
0.322LysTrp: 0.322 ± 0.013
0.485LysTyr: 0.485 ± 0.017
0.0LysXaa: 0.0 ± 0.0
Leu
14.873LeuAla: 14.873 ± 0.116
0.844LeuCys: 0.844 ± 0.023
7.006LeuAsp: 7.006 ± 0.066
4.293LeuGlu: 4.293 ± 0.051
2.653LeuPhe: 2.653 ± 0.043
8.83LeuGly: 8.83 ± 0.078
2.056LeuHis: 2.056 ± 0.035
3.949LeuIle: 3.949 ± 0.054
1.622LeuLys: 1.622 ± 0.033
10.327LeuLeu: 10.327 ± 0.092
1.453LeuMet: 1.453 ± 0.029
1.791LeuAsn: 1.791 ± 0.029
5.986LeuPro: 5.986 ± 0.068
1.793LeuGln: 1.793 ± 0.029
8.852LeuArg: 8.852 ± 0.084
5.516LeuSer: 5.516 ± 0.049
6.211LeuThr: 6.211 ± 0.06
9.043LeuVal: 9.043 ± 0.076
1.221LeuTrp: 1.221 ± 0.024
1.667LeuTyr: 1.667 ± 0.026
0.0LeuXaa: 0.0 ± 0.0
Met
2.266MetAla: 2.266 ± 0.034
0.14MetCys: 0.14 ± 0.008
0.939MetAsp: 0.939 ± 0.021
0.674MetGlu: 0.674 ± 0.018
0.584MetPhe: 0.584 ± 0.019
1.24MetGly: 1.24 ± 0.028
0.378MetHis: 0.378 ± 0.015
0.953MetIle: 0.953 ± 0.021
0.405MetLys: 0.405 ± 0.015
1.925MetLeu: 1.925 ± 0.03
0.279MetMet: 0.279 ± 0.011
0.45MetAsn: 0.45 ± 0.015
1.194MetPro: 1.194 ± 0.027
0.384MetGln: 0.384 ± 0.013
1.644MetArg: 1.644 ± 0.027
1.413MetSer: 1.413 ± 0.029
1.61MetThr: 1.61 ± 0.028
1.499MetVal: 1.499 ± 0.027
0.248MetTrp: 0.248 ± 0.01
0.309MetTyr: 0.309 ± 0.012
0.0MetXaa: 0.0 ± 0.0
Asn
2.521AsnAla: 2.521 ± 0.038
0.194AsnCys: 0.194 ± 0.009
1.149AsnAsp: 1.149 ± 0.026
1.01AsnGlu: 1.01 ± 0.024
0.524AsnPhe: 0.524 ± 0.017
2.243AsnGly: 2.243 ± 0.041
0.396AsnHis: 0.396 ± 0.015
0.69AsnIle: 0.69 ± 0.02
0.536AsnLys: 0.536 ± 0.019
1.893AsnLeu: 1.893 ± 0.031
0.331AsnMet: 0.331 ± 0.013
0.492AsnAsn: 0.492 ± 0.018
1.597AsnPro: 1.597 ± 0.033
0.588AsnGln: 0.588 ± 0.019
1.492AsnArg: 1.492 ± 0.03
1.049AsnSer: 1.049 ± 0.022
1.302AsnThr: 1.302 ± 0.027
1.695AsnVal: 1.695 ± 0.032
0.321AsnTrp: 0.321 ± 0.015
0.463AsnTyr: 0.463 ± 0.016
0.0AsnXaa: 0.0 ± 0.0
Pro
7.531ProAla: 7.531 ± 0.073
0.357ProCys: 0.357 ± 0.013
4.603ProAsp: 4.603 ± 0.055
3.942ProGlu: 3.942 ± 0.043
1.545ProPhe: 1.545 ± 0.027
5.817ProGly: 5.817 ± 0.057
1.257ProHis: 1.257 ± 0.023
1.863ProIle: 1.863 ± 0.031
1.401ProLys: 1.401 ± 0.03
4.781ProLeu: 4.781 ± 0.048
1.083ProMet: 1.083 ± 0.022
1.357ProAsn: 1.357 ± 0.027
4.013ProPro: 4.013 ± 0.086
1.538ProGln: 1.538 ± 0.042
3.731ProArg: 3.731 ± 0.054
3.383ProSer: 3.383 ± 0.054
3.453ProThr: 3.453 ± 0.05
5.302ProVal: 5.302 ± 0.061
0.882ProTrp: 0.882 ± 0.023
1.092ProTyr: 1.092 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
3.331GlnAla: 3.331 ± 0.044
0.188GlnCys: 0.188 ± 0.01
1.211GlnAsp: 1.211 ± 0.026
1.184GlnGlu: 1.184 ± 0.027
0.713GlnPhe: 0.713 ± 0.017
2.046GlnGly: 2.046 ± 0.038
0.69GlnHis: 0.69 ± 0.02
1.116GlnIle: 1.116 ± 0.025
0.598GlnLys: 0.598 ± 0.02
2.924GlnLeu: 2.924 ± 0.045
0.504GlnMet: 0.504 ± 0.017
0.567GlnAsn: 0.567 ± 0.02
1.856GlnPro: 1.856 ± 0.039
1.235GlnGln: 1.235 ± 0.042
2.64GlnArg: 2.64 ± 0.036
1.327GlnSer: 1.327 ± 0.031
1.337GlnThr: 1.337 ± 0.026
2.551GlnVal: 2.551 ± 0.031
0.455GlnTrp: 0.455 ± 0.014
0.532GlnTyr: 0.532 ± 0.016
0.0GlnXaa: 0.0 ± 0.0
Arg
9.535ArgAla: 9.535 ± 0.085
0.601ArgCys: 0.601 ± 0.018
4.635ArgAsp: 4.635 ± 0.051
4.649ArgGlu: 4.649 ± 0.053
2.427ArgPhe: 2.427 ± 0.037
5.648ArgGly: 5.648 ± 0.055
1.951ArgHis: 1.951 ± 0.033
3.067ArgIle: 3.067 ± 0.041
2.021ArgLys: 2.021 ± 0.035
8.271ArgLeu: 8.271 ± 0.084
1.942ArgMet: 1.942 ± 0.032
1.548ArgAsn: 1.548 ± 0.03
4.547ArgPro: 4.547 ± 0.055
2.327ArgGln: 2.327 ± 0.039
7.487ArgArg: 7.487 ± 0.07
3.788ArgSer: 3.788 ± 0.049
4.871ArgThr: 4.871 ± 0.052
6.099ArgVal: 6.099 ± 0.061
1.48ArgTrp: 1.48 ± 0.029
1.829ArgTyr: 1.829 ± 0.031
0.0ArgXaa: 0.0 ± 0.0
Ser
6.444SerAla: 6.444 ± 0.056
0.431SerCys: 0.431 ± 0.018
3.037SerAsp: 3.037 ± 0.041
2.561SerGlu: 2.561 ± 0.038
1.522SerPhe: 1.522 ± 0.028
5.725SerGly: 5.725 ± 0.074
0.967SerHis: 0.967 ± 0.023
1.807SerIle: 1.807 ± 0.033
1.197SerLys: 1.197 ± 0.027
4.61SerLeu: 4.61 ± 0.047
1.216SerMet: 1.216 ± 0.024
1.093SerAsn: 1.093 ± 0.027
3.075SerPro: 3.075 ± 0.045
1.249SerGln: 1.249 ± 0.027
3.686SerArg: 3.686 ± 0.043
2.934SerSer: 2.934 ± 0.047
3.892SerThr: 3.892 ± 0.045
4.419SerVal: 4.419 ± 0.049
0.971SerTrp: 0.971 ± 0.021
1.187SerTyr: 1.187 ± 0.024
0.0SerXaa: 0.0 ± 0.0
Thr
7.948ThrAla: 7.948 ± 0.08
0.455ThrCys: 0.455 ± 0.015
3.738ThrAsp: 3.738 ± 0.05
3.43ThrGlu: 3.43 ± 0.042
1.703ThrPhe: 1.703 ± 0.029
6.143ThrGly: 6.143 ± 0.06
1.179ThrHis: 1.179 ± 0.022
2.324ThrIle: 2.324 ± 0.036
1.467ThrLys: 1.467 ± 0.033
5.68ThrLeu: 5.68 ± 0.06
1.212ThrMet: 1.212 ± 0.025
1.182ThrAsn: 1.182 ± 0.026
3.913ThrPro: 3.913 ± 0.054
1.358ThrGln: 1.358 ± 0.028
3.883ThrArg: 3.883 ± 0.044
3.283ThrSer: 3.283 ± 0.038
4.035ThrThr: 4.035 ± 0.056
6.797ThrVal: 6.797 ± 0.068
0.977ThrTrp: 0.977 ± 0.024
1.194ThrTyr: 1.194 ± 0.028
0.0ThrXaa: 0.0 ± 0.0
Val
11.443ValAla: 11.443 ± 0.09
0.748ValCys: 0.748 ± 0.02
6.37ValAsp: 6.37 ± 0.059
4.894ValGlu: 4.894 ± 0.053
2.472ValPhe: 2.472 ± 0.039
6.912ValGly: 6.912 ± 0.06
2.066ValHis: 2.066 ± 0.038
3.629ValIle: 3.629 ± 0.043
1.745ValLys: 1.745 ± 0.032
10.092ValLeu: 10.092 ± 0.096
1.313ValMet: 1.313 ± 0.028
1.857ValAsn: 1.857 ± 0.032
5.246ValPro: 5.246 ± 0.06
1.939ValGln: 1.939 ± 0.032
7.303ValArg: 7.303 ± 0.066
4.644ValSer: 4.644 ± 0.05
5.702ValThr: 5.702 ± 0.054
8.469ValVal: 8.469 ± 0.087
1.139ValTrp: 1.139 ± 0.025
1.608ValTyr: 1.608 ± 0.028
0.0ValXaa: 0.0 ± 0.0
Trp
1.538TrpAla: 1.538 ± 0.027
0.17TrpCys: 0.17 ± 0.009
0.771TrpAsp: 0.771 ± 0.02
0.67TrpGlu: 0.67 ± 0.019
0.536TrpPhe: 0.536 ± 0.016
1.007TrpGly: 1.007 ± 0.027
0.438TrpHis: 0.438 ± 0.014
0.65TrpIle: 0.65 ± 0.019
0.323TrpLys: 0.323 ± 0.011
1.897TrpLeu: 1.897 ± 0.036
0.314TrpMet: 0.314 ± 0.011
0.371TrpAsn: 0.371 ± 0.014
0.835TrpPro: 0.835 ± 0.024
0.595TrpGln: 0.595 ± 0.017
1.495TrpArg: 1.495 ± 0.03
0.892TrpSer: 0.892 ± 0.024
1.082TrpThr: 1.082 ± 0.028
1.105TrpVal: 1.105 ± 0.029
0.373TrpTrp: 0.373 ± 0.015
0.313TrpTyr: 0.313 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.281TyrAla: 2.281 ± 0.035
0.171TyrCys: 0.171 ± 0.009
1.381TyrAsp: 1.381 ± 0.029
1.03TyrGlu: 1.03 ± 0.024
0.66TyrPhe: 0.66 ± 0.015
2.008TyrGly: 2.008 ± 0.037
0.446TyrHis: 0.446 ± 0.016
0.487TyrIle: 0.487 ± 0.015
0.393TyrLys: 0.393 ± 0.014
2.168TyrLeu: 2.168 ± 0.037
0.244TyrMet: 0.244 ± 0.012
0.397TyrAsn: 0.397 ± 0.016
1.161TyrPro: 1.161 ± 0.025
0.622TyrGln: 0.622 ± 0.018
1.801TyrArg: 1.801 ± 0.034
1.039TyrSer: 1.039 ± 0.022
1.162TyrThr: 1.162 ± 0.023
1.659TyrVal: 1.659 ± 0.032
0.377TyrTrp: 0.377 ± 0.015
0.46TyrTyr: 0.46 ± 0.018
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6595 proteins (2000804 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski