Amino acid dipepetide frequency for Burkholderia virus phiE202

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
23.909AlaAla: 23.909 ± 2.253
0.837AlaCys: 0.837 ± 0.3
8.931AlaAsp: 8.931 ± 0.936
5.582AlaGlu: 5.582 ± 0.628
3.721AlaPhe: 3.721 ± 0.57
10.699AlaGly: 10.699 ± 0.773
2.419AlaHis: 2.419 ± 0.383
5.303AlaIle: 5.303 ± 0.758
4.931AlaLys: 4.931 ± 0.712
14.234AlaLeu: 14.234 ± 1.845
3.628AlaMet: 3.628 ± 0.458
3.442AlaAsn: 3.442 ± 0.489
7.536AlaPro: 7.536 ± 0.927
4.0AlaGln: 4.0 ± 0.754
10.42AlaArg: 10.42 ± 1.014
7.35AlaSer: 7.35 ± 0.633
8.094AlaThr: 8.094 ± 0.94
6.419AlaVal: 6.419 ± 0.775
2.791AlaTrp: 2.791 ± 0.666
2.884AlaTyr: 2.884 ± 0.522
0.0AlaXaa: 0.0 ± 0.0
Cys
1.023CysAla: 1.023 ± 0.583
0.0CysCys: 0.0 ± 0.0
0.093CysAsp: 0.093 ± 0.094
0.837CysGlu: 0.837 ± 0.293
0.093CysPhe: 0.093 ± 0.088
0.465CysGly: 0.465 ± 0.236
0.372CysHis: 0.372 ± 0.209
0.372CysIle: 0.372 ± 0.204
0.093CysLys: 0.093 ± 0.104
0.837CysLeu: 0.837 ± 0.297
0.279CysMet: 0.279 ± 0.166
0.372CysAsn: 0.372 ± 0.169
0.372CysPro: 0.372 ± 0.209
0.279CysGln: 0.279 ± 0.216
0.558CysArg: 0.558 ± 0.248
0.558CysSer: 0.558 ± 0.273
0.465CysThr: 0.465 ± 0.305
0.465CysVal: 0.465 ± 0.166
0.465CysTrp: 0.465 ± 0.191
0.279CysTyr: 0.279 ± 0.139
0.0CysXaa: 0.0 ± 0.0
Asp
10.327AspAla: 10.327 ± 0.944
0.465AspCys: 0.465 ± 0.192
4.186AspAsp: 4.186 ± 0.728
4.279AspGlu: 4.279 ± 0.625
2.512AspPhe: 2.512 ± 0.46
5.768AspGly: 5.768 ± 1.092
1.209AspHis: 1.209 ± 0.435
2.512AspIle: 2.512 ± 0.7
2.233AspLys: 2.233 ± 0.725
4.931AspLeu: 4.931 ± 0.674
2.14AspMet: 2.14 ± 0.448
1.395AspAsn: 1.395 ± 0.345
2.977AspPro: 2.977 ± 0.528
2.14AspGln: 2.14 ± 0.367
4.0AspArg: 4.0 ± 0.601
1.861AspSer: 1.861 ± 0.546
3.07AspThr: 3.07 ± 0.582
4.559AspVal: 4.559 ± 0.8
0.558AspTrp: 0.558 ± 0.213
2.326AspTyr: 2.326 ± 0.528
0.0AspXaa: 0.0 ± 0.0
Glu
5.024GluAla: 5.024 ± 0.768
0.651GluCys: 0.651 ± 0.231
1.582GluAsp: 1.582 ± 0.373
1.675GluGlu: 1.675 ± 0.465
2.14GluPhe: 2.14 ± 0.384
2.884GluGly: 2.884 ± 0.596
1.675GluHis: 1.675 ± 0.36
2.605GluIle: 2.605 ± 0.492
2.977GluLys: 2.977 ± 0.705
6.326GluLeu: 6.326 ± 0.705
1.116GluMet: 1.116 ± 0.397
1.861GluAsn: 1.861 ± 0.464
2.791GluPro: 2.791 ± 0.549
2.14GluGln: 2.14 ± 0.393
6.326GluArg: 6.326 ± 0.54
2.512GluSer: 2.512 ± 0.494
2.605GluThr: 2.605 ± 0.462
3.256GluVal: 3.256 ± 0.56
1.395GluTrp: 1.395 ± 0.39
1.675GluTyr: 1.675 ± 0.379
0.0GluXaa: 0.0 ± 0.0
Phe
5.861PheAla: 5.861 ± 0.684
0.186PheCys: 0.186 ± 0.132
2.512PheAsp: 2.512 ± 0.436
1.954PheGlu: 1.954 ± 0.382
1.489PhePhe: 1.489 ± 0.415
2.791PheGly: 2.791 ± 0.688
0.651PheHis: 0.651 ± 0.303
1.023PheIle: 1.023 ± 0.291
1.489PheLys: 1.489 ± 0.341
1.954PheLeu: 1.954 ± 0.417
0.558PheMet: 0.558 ± 0.179
0.837PheAsn: 0.837 ± 0.265
1.489PhePro: 1.489 ± 0.335
0.837PheGln: 0.837 ± 0.302
2.698PheArg: 2.698 ± 0.498
2.326PheSer: 2.326 ± 0.424
1.768PheThr: 1.768 ± 0.345
2.14PheVal: 2.14 ± 0.441
0.651PheTrp: 0.651 ± 0.281
0.651PheTyr: 0.651 ± 0.275
0.0PheXaa: 0.0 ± 0.0
Gly
9.396GlyAla: 9.396 ± 1.26
0.651GlyCys: 0.651 ± 0.26
3.907GlyAsp: 3.907 ± 0.531
3.721GlyGlu: 3.721 ± 0.535
2.791GlyPhe: 2.791 ± 0.432
7.256GlyGly: 7.256 ± 1.319
2.047GlyHis: 2.047 ± 0.528
2.698GlyIle: 2.698 ± 0.526
3.535GlyLys: 3.535 ± 0.661
6.605GlyLeu: 6.605 ± 0.976
2.419GlyMet: 2.419 ± 0.402
2.14GlyAsn: 2.14 ± 0.563
2.512GlyPro: 2.512 ± 0.488
2.14GlyGln: 2.14 ± 0.411
5.954GlyArg: 5.954 ± 0.665
3.163GlySer: 3.163 ± 0.592
5.396GlyThr: 5.396 ± 0.774
5.675GlyVal: 5.675 ± 0.852
2.512GlyTrp: 2.512 ± 0.437
2.047GlyTyr: 2.047 ± 0.51
0.0GlyXaa: 0.0 ± 0.0
His
4.466HisAla: 4.466 ± 0.714
0.372HisCys: 0.372 ± 0.172
1.395HisAsp: 1.395 ± 0.388
1.395HisGlu: 1.395 ± 0.229
0.372HisPhe: 0.372 ± 0.18
1.395HisGly: 1.395 ± 0.38
0.744HisHis: 0.744 ± 0.226
0.93HisIle: 0.93 ± 0.263
0.837HisLys: 0.837 ± 0.3
1.861HisLeu: 1.861 ± 0.486
0.372HisMet: 0.372 ± 0.178
0.744HisAsn: 0.744 ± 0.287
0.93HisPro: 0.93 ± 0.323
0.837HisGln: 0.837 ± 0.243
1.209HisArg: 1.209 ± 0.398
0.744HisSer: 0.744 ± 0.274
1.582HisThr: 1.582 ± 0.465
2.047HisVal: 2.047 ± 0.418
0.372HisTrp: 0.372 ± 0.164
0.558HisTyr: 0.558 ± 0.219
0.0HisXaa: 0.0 ± 0.0
Ile
5.489IleAla: 5.489 ± 0.753
0.186IleCys: 0.186 ± 0.118
5.396IleAsp: 5.396 ± 0.733
3.07IleGlu: 3.07 ± 0.671
0.744IlePhe: 0.744 ± 0.221
3.907IleGly: 3.907 ± 0.733
1.116IleHis: 1.116 ± 0.296
0.651IleIle: 0.651 ± 0.272
1.489IleLys: 1.489 ± 0.314
2.512IleLeu: 2.512 ± 0.343
0.558IleMet: 0.558 ± 0.229
1.395IleAsn: 1.395 ± 0.311
1.675IlePro: 1.675 ± 0.419
1.582IleGln: 1.582 ± 0.444
2.326IleArg: 2.326 ± 0.482
2.233IleSer: 2.233 ± 0.402
1.675IleThr: 1.675 ± 0.329
3.256IleVal: 3.256 ± 0.678
0.186IleTrp: 0.186 ± 0.118
0.651IleTyr: 0.651 ± 0.229
0.0IleXaa: 0.0 ± 0.0
Lys
4.931LysAla: 4.931 ± 0.565
0.093LysCys: 0.093 ± 0.081
1.954LysAsp: 1.954 ± 0.449
1.395LysGlu: 1.395 ± 0.351
1.302LysPhe: 1.302 ± 0.34
2.884LysGly: 2.884 ± 0.512
0.744LysHis: 0.744 ± 0.256
1.023LysIle: 1.023 ± 0.321
1.768LysLys: 1.768 ± 0.353
3.535LysLeu: 3.535 ± 0.738
1.023LysMet: 1.023 ± 0.278
1.209LysAsn: 1.209 ± 0.393
1.954LysPro: 1.954 ± 0.426
2.419LysGln: 2.419 ± 0.54
5.21LysArg: 5.21 ± 0.68
1.582LysSer: 1.582 ± 0.428
2.419LysThr: 2.419 ± 0.396
2.326LysVal: 2.326 ± 0.523
0.372LysTrp: 0.372 ± 0.176
1.209LysTyr: 1.209 ± 0.356
0.0LysXaa: 0.0 ± 0.0
Leu
12.094LeuAla: 12.094 ± 1.336
0.837LeuCys: 0.837 ± 0.358
5.861LeuAsp: 5.861 ± 0.605
4.838LeuGlu: 4.838 ± 0.708
3.256LeuPhe: 3.256 ± 0.64
7.35LeuGly: 7.35 ± 1.583
2.14LeuHis: 2.14 ± 0.654
3.256LeuIle: 3.256 ± 0.466
2.884LeuLys: 2.884 ± 0.513
6.326LeuLeu: 6.326 ± 0.731
1.675LeuMet: 1.675 ± 0.419
3.163LeuAsn: 3.163 ± 0.569
3.814LeuPro: 3.814 ± 0.621
2.605LeuGln: 2.605 ± 0.311
7.536LeuArg: 7.536 ± 1.078
6.14LeuSer: 6.14 ± 0.751
5.303LeuThr: 5.303 ± 0.605
6.605LeuVal: 6.605 ± 0.671
0.279LeuTrp: 0.279 ± 0.132
2.419LeuTyr: 2.419 ± 0.52
0.0LeuXaa: 0.0 ± 0.0
Met
2.977MetAla: 2.977 ± 0.568
0.186MetCys: 0.186 ± 0.111
1.489MetAsp: 1.489 ± 0.314
0.837MetGlu: 0.837 ± 0.252
0.651MetPhe: 0.651 ± 0.368
1.209MetGly: 1.209 ± 0.453
0.465MetHis: 0.465 ± 0.18
0.837MetIle: 0.837 ± 0.388
0.93MetLys: 0.93 ± 0.354
1.489MetLeu: 1.489 ± 0.281
0.372MetMet: 0.372 ± 0.185
0.93MetAsn: 0.93 ± 0.279
1.954MetPro: 1.954 ± 0.47
0.837MetGln: 0.837 ± 0.339
2.698MetArg: 2.698 ± 0.499
0.837MetSer: 0.837 ± 0.298
2.512MetThr: 2.512 ± 0.475
1.768MetVal: 1.768 ± 0.299
0.093MetTrp: 0.093 ± 0.087
0.465MetTyr: 0.465 ± 0.209
0.0MetXaa: 0.0 ± 0.0
Asn
2.605AsnAla: 2.605 ± 0.433
0.0AsnCys: 0.0 ± 0.0
2.791AsnAsp: 2.791 ± 0.572
2.512AsnGlu: 2.512 ± 0.498
0.744AsnPhe: 0.744 ± 0.205
4.186AsnGly: 4.186 ± 0.651
0.651AsnHis: 0.651 ± 0.354
1.209AsnIle: 1.209 ± 0.313
1.209AsnLys: 1.209 ± 0.36
1.954AsnLeu: 1.954 ± 0.394
0.837AsnMet: 0.837 ± 0.368
0.837AsnAsn: 0.837 ± 0.364
1.582AsnPro: 1.582 ± 0.401
0.837AsnGln: 0.837 ± 0.295
1.954AsnArg: 1.954 ± 0.342
0.93AsnSer: 0.93 ± 0.261
1.209AsnThr: 1.209 ± 0.304
2.698AsnVal: 2.698 ± 0.449
0.279AsnTrp: 0.279 ± 0.153
0.837AsnTyr: 0.837 ± 0.312
0.0AsnXaa: 0.0 ± 0.0
Pro
6.419ProAla: 6.419 ± 0.975
0.372ProCys: 0.372 ± 0.296
4.093ProAsp: 4.093 ± 0.706
2.884ProGlu: 2.884 ± 0.602
1.395ProPhe: 1.395 ± 0.323
1.954ProGly: 1.954 ± 0.366
1.023ProHis: 1.023 ± 0.322
2.14ProIle: 2.14 ± 0.434
2.419ProLys: 2.419 ± 0.505
4.466ProLeu: 4.466 ± 0.705
0.465ProMet: 0.465 ± 0.213
1.116ProAsn: 1.116 ± 0.282
3.163ProPro: 3.163 ± 0.824
1.395ProGln: 1.395 ± 0.308
3.163ProArg: 3.163 ± 0.527
2.419ProSer: 2.419 ± 0.347
2.605ProThr: 2.605 ± 0.513
4.093ProVal: 4.093 ± 0.736
1.023ProTrp: 1.023 ± 0.289
0.744ProTyr: 0.744 ± 0.324
0.0ProXaa: 0.0 ± 0.0
Gln
4.652GlnAla: 4.652 ± 0.661
0.279GlnCys: 0.279 ± 0.145
1.302GlnAsp: 1.302 ± 0.302
1.116GlnGlu: 1.116 ± 0.337
1.116GlnPhe: 1.116 ± 0.395
1.768GlnGly: 1.768 ± 0.336
0.93GlnHis: 0.93 ± 0.263
1.768GlnIle: 1.768 ± 0.462
1.489GlnLys: 1.489 ± 0.365
3.256GlnLeu: 3.256 ± 0.53
1.302GlnMet: 1.302 ± 0.459
0.744GlnAsn: 0.744 ± 0.196
1.209GlnPro: 1.209 ± 0.252
2.047GlnGln: 2.047 ± 0.455
3.721GlnArg: 3.721 ± 0.787
1.954GlnSer: 1.954 ± 0.516
2.326GlnThr: 2.326 ± 0.483
1.861GlnVal: 1.861 ± 0.351
0.372GlnTrp: 0.372 ± 0.215
0.93GlnTyr: 0.93 ± 0.293
0.0GlnXaa: 0.0 ± 0.0
Arg
10.234ArgAla: 10.234 ± 1.295
0.93ArgCys: 0.93 ± 0.299
3.628ArgAsp: 3.628 ± 0.424
6.326ArgGlu: 6.326 ± 0.905
2.233ArgPhe: 2.233 ± 0.385
5.675ArgGly: 5.675 ± 0.921
1.954ArgHis: 1.954 ± 0.403
4.745ArgIle: 4.745 ± 0.689
3.442ArgLys: 3.442 ± 0.656
7.163ArgLeu: 7.163 ± 0.818
1.675ArgMet: 1.675 ± 0.365
2.605ArgAsn: 2.605 ± 0.582
2.698ArgPro: 2.698 ± 0.503
4.186ArgGln: 4.186 ± 0.66
7.256ArgArg: 7.256 ± 1.044
3.628ArgSer: 3.628 ± 0.639
3.907ArgThr: 3.907 ± 0.62
6.14ArgVal: 6.14 ± 0.676
1.116ArgTrp: 1.116 ± 0.283
2.698ArgTyr: 2.698 ± 0.637
0.0ArgXaa: 0.0 ± 0.0
Ser
6.605SerAla: 6.605 ± 0.731
0.465SerCys: 0.465 ± 0.216
3.535SerAsp: 3.535 ± 0.501
2.419SerGlu: 2.419 ± 0.641
1.489SerPhe: 1.489 ± 0.331
4.559SerGly: 4.559 ± 0.632
1.209SerHis: 1.209 ± 0.419
2.233SerIle: 2.233 ± 0.403
1.861SerLys: 1.861 ± 0.352
4.745SerLeu: 4.745 ± 0.634
1.116SerMet: 1.116 ± 0.319
1.954SerAsn: 1.954 ± 0.53
2.977SerPro: 2.977 ± 0.731
0.744SerGln: 0.744 ± 0.228
3.256SerArg: 3.256 ± 0.551
2.884SerSer: 2.884 ± 0.534
4.372SerThr: 4.372 ± 0.647
2.512SerVal: 2.512 ± 0.498
0.651SerTrp: 0.651 ± 0.215
0.93SerTyr: 0.93 ± 0.221
0.0SerXaa: 0.0 ± 0.0
Thr
6.326ThrAla: 6.326 ± 0.872
0.837ThrCys: 0.837 ± 0.3
4.093ThrAsp: 4.093 ± 0.637
2.512ThrGlu: 2.512 ± 0.46
2.977ThrPhe: 2.977 ± 0.693
5.117ThrGly: 5.117 ± 0.619
1.302ThrHis: 1.302 ± 0.385
2.605ThrIle: 2.605 ± 0.578
2.14ThrLys: 2.14 ± 0.477
5.21ThrLeu: 5.21 ± 0.705
1.209ThrMet: 1.209 ± 0.302
1.768ThrAsn: 1.768 ± 0.352
4.0ThrPro: 4.0 ± 0.487
1.675ThrGln: 1.675 ± 0.389
4.0ThrArg: 4.0 ± 0.416
2.977ThrSer: 2.977 ± 0.562
3.814ThrThr: 3.814 ± 0.536
4.838ThrVal: 4.838 ± 0.656
1.116ThrTrp: 1.116 ± 0.3
0.837ThrTyr: 0.837 ± 0.308
0.0ThrXaa: 0.0 ± 0.0
Val
9.303ValAla: 9.303 ± 0.962
0.558ValCys: 0.558 ± 0.229
4.652ValAsp: 4.652 ± 0.82
4.186ValGlu: 4.186 ± 0.56
2.791ValPhe: 2.791 ± 0.496
4.372ValGly: 4.372 ± 0.605
0.744ValHis: 0.744 ± 0.259
2.698ValIle: 2.698 ± 0.543
2.605ValLys: 2.605 ± 0.513
6.047ValLeu: 6.047 ± 0.74
1.954ValMet: 1.954 ± 0.4
2.419ValAsn: 2.419 ± 0.464
2.512ValPro: 2.512 ± 0.417
1.489ValGln: 1.489 ± 0.365
5.954ValArg: 5.954 ± 0.623
4.652ValSer: 4.652 ± 0.931
4.0ValThr: 4.0 ± 0.638
5.117ValVal: 5.117 ± 0.684
0.93ValTrp: 0.93 ± 0.357
1.954ValTyr: 1.954 ± 0.4
0.0ValXaa: 0.0 ± 0.0
Trp
2.419TrpAla: 2.419 ± 0.495
0.186TrpCys: 0.186 ± 0.135
0.465TrpAsp: 0.465 ± 0.285
0.279TrpGlu: 0.279 ± 0.15
0.651TrpPhe: 0.651 ± 0.228
1.023TrpGly: 1.023 ± 0.446
0.651TrpHis: 0.651 ± 0.242
0.651TrpIle: 0.651 ± 0.252
0.465TrpLys: 0.465 ± 0.191
2.419TrpLeu: 2.419 ± 0.494
0.279TrpMet: 0.279 ± 0.166
0.372TrpAsn: 0.372 ± 0.16
0.651TrpPro: 0.651 ± 0.267
0.651TrpGln: 0.651 ± 0.228
1.489TrpArg: 1.489 ± 0.397
1.116TrpSer: 1.116 ± 0.314
1.023TrpThr: 1.023 ± 0.26
0.651TrpVal: 0.651 ± 0.237
0.186TrpTrp: 0.186 ± 0.117
0.186TrpTyr: 0.186 ± 0.186
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.07TyrAla: 3.07 ± 0.441
0.186TyrCys: 0.186 ± 0.138
1.582TyrAsp: 1.582 ± 0.388
1.395TyrGlu: 1.395 ± 0.399
1.395TyrPhe: 1.395 ± 0.502
1.302TyrGly: 1.302 ± 0.321
1.116TyrHis: 1.116 ± 0.264
0.93TyrIle: 0.93 ± 0.264
0.558TyrLys: 0.558 ± 0.223
2.512TyrLeu: 2.512 ± 0.583
0.465TyrMet: 0.465 ± 0.191
0.558TyrAsn: 0.558 ± 0.193
0.558TyrPro: 0.558 ± 0.185
1.302TyrGln: 1.302 ± 0.276
2.512TyrArg: 2.512 ± 0.478
0.651TyrSer: 0.651 ± 0.229
1.209TyrThr: 1.209 ± 0.384
2.512TyrVal: 2.512 ± 0.457
0.465TyrTrp: 0.465 ± 0.159
0.465TyrTyr: 0.465 ± 0.189
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 48 proteins (10750 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski