Amino acid dipepetide frequency for Sphingobacterium spiritivorum ATCC 33861

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.454AlaAla: 5.454 ± 0.091	0.556AlaCys: 0.556 ± 0.021	4.168AlaAsp: 4.168 ± 0.076	4.262AlaGlu: 4.262 ± 0.061	3.292AlaPhe: 3.292 ± 0.045	5.11AlaGly: 5.11 ± 0.066	1.151AlaHis: 1.151 ± 0.032	5.254AlaIle: 5.254 ± 0.068	4.455AlaLys: 4.455 ± 0.07	6.643AlaLeu: 6.643 ± 0.083	1.552AlaMet: 1.552 ± 0.031	3.709AlaAsn: 3.709 ± 0.072	2.099AlaPro: 2.099 ± 0.043	2.891AlaGln: 2.891 ± 0.047	2.514AlaArg: 2.514 ± 0.042	4.447AlaSer: 4.447 ± 0.054	3.917AlaThr: 3.917 ± 0.07	4.868AlaVal: 4.868 ± 0.059	0.729AlaTrp: 0.729 ± 0.022	2.982AlaTyr: 2.982 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.466CysAla: 0.466 ± 0.018	0.127CysCys: 0.127 ± 0.009	0.319CysAsp: 0.319 ± 0.016	0.357CysGlu: 0.357 ± 0.018	0.382CysPhe: 0.382 ± 0.015	0.514CysGly: 0.514 ± 0.021	0.176CysHis: 0.176 ± 0.012	0.614CysIle: 0.614 ± 0.02	0.436CysLys: 0.436 ± 0.019	0.656CysLeu: 0.656 ± 0.022	0.172CysMet: 0.172 ± 0.011	0.34CysAsn: 0.34 ± 0.015	0.283CysPro: 0.283 ± 0.014	0.264CysGln: 0.264 ± 0.015	0.274CysArg: 0.274 ± 0.014	0.509CysSer: 0.509 ± 0.02	0.4CysThr: 0.4 ± 0.016	0.393CysVal: 0.393 ± 0.016	0.064CysTrp: 0.064 ± 0.007	0.316CysTyr: 0.316 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.767AspAla: 3.767 ± 0.063	0.346AspCys: 0.346 ± 0.017	2.425AspAsp: 2.425 ± 0.047	3.317AspGlu: 3.317 ± 0.049	3.131AspPhe: 3.131 ± 0.046	3.739AspGly: 3.739 ± 0.06	1.043AspHis: 1.043 ± 0.029	4.429AspIle: 4.429 ± 0.051	4.061AspLys: 4.061 ± 0.058	5.126AspLeu: 5.126 ± 0.063	1.291AspMet: 1.291 ± 0.029	3.013AspAsn: 3.013 ± 0.051	2.145AspPro: 2.145 ± 0.042	2.249AspGln: 2.249 ± 0.037	2.361AspArg: 2.361 ± 0.044	2.961AspSer: 2.961 ± 0.051	2.546AspThr: 2.546 ± 0.041	3.34AspVal: 3.34 ± 0.051	0.782AspTrp: 0.782 ± 0.023	2.702AspTyr: 2.702 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	4.151GluAla: 4.151 ± 0.063	0.286GluCys: 0.286 ± 0.014	3.11GluAsp: 3.11 ± 0.056	4.458GluGlu: 4.458 ± 0.08	2.368GluPhe: 2.368 ± 0.039	3.591GluGly: 3.591 ± 0.048	1.105GluHis: 1.105 ± 0.028	4.731GluIle: 4.731 ± 0.065	4.981GluLys: 4.981 ± 0.069	5.758GluLeu: 5.758 ± 0.073	1.444GluMet: 1.444 ± 0.034	3.64GluAsn: 3.64 ± 0.05	1.489GluPro: 1.489 ± 0.032	2.775GluGln: 2.775 ± 0.045	2.631GluArg: 2.631 ± 0.046	3.185GluSer: 3.185 ± 0.046	3.015GluThr: 3.015 ± 0.046	3.905GluVal: 3.905 ± 0.055	0.696GluTrp: 0.696 ± 0.024	2.27GluTyr: 2.27 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.234PheAla: 3.234 ± 0.051	0.396PheCys: 0.396 ± 0.016	2.954PheAsp: 2.954 ± 0.047	2.916PheGlu: 2.916 ± 0.05	2.46PhePhe: 2.46 ± 0.044	3.444PheGly: 3.444 ± 0.049	0.834PheHis: 0.834 ± 0.023	3.398PheIle: 3.398 ± 0.059	3.025PheLys: 3.025 ± 0.051	4.195PheLeu: 4.195 ± 0.062	1.178PheMet: 1.178 ± 0.027	2.884PheAsn: 2.884 ± 0.044	1.727PhePro: 1.727 ± 0.035	1.617PheGln: 1.617 ± 0.036	2.033PheArg: 2.033 ± 0.04	3.688PheSer: 3.688 ± 0.055	2.876PheThr: 2.876 ± 0.045	2.908PheVal: 2.908 ± 0.04	0.559PheTrp: 0.559 ± 0.019	2.122PheTyr: 2.122 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	4.509GlyAla: 4.509 ± 0.084	0.521GlyCys: 0.521 ± 0.022	3.265GlyAsp: 3.265 ± 0.057	3.461GlyGlu: 3.461 ± 0.053	3.417GlyPhe: 3.417 ± 0.053	4.616GlyGly: 4.616 ± 0.071	1.153GlyHis: 1.153 ± 0.028	5.391GlyIle: 5.391 ± 0.063	5.147GlyLys: 5.147 ± 0.072	6.004GlyLeu: 6.004 ± 0.068	1.716GlyMet: 1.716 ± 0.038	3.849GlyAsn: 3.849 ± 0.069	1.373GlyPro: 1.373 ± 0.026	2.39GlyGln: 2.39 ± 0.039	2.631GlyArg: 2.631 ± 0.051	4.373GlySer: 4.373 ± 0.072	4.306GlyThr: 4.306 ± 0.084	4.323GlyVal: 4.323 ± 0.073	0.89GlyTrp: 0.89 ± 0.03	3.268GlyTyr: 3.268 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	1.151HisAla: 1.151 ± 0.03	0.17HisCys: 0.17 ± 0.011	0.845HisAsp: 0.845 ± 0.026	0.965HisGlu: 0.965 ± 0.027	1.04HisPhe: 1.04 ± 0.027	0.97HisGly: 0.97 ± 0.028	0.487HisHis: 0.487 ± 0.024	1.616HisIle: 1.616 ± 0.035	1.062HisLys: 1.062 ± 0.024	1.865HisLeu: 1.865 ± 0.045	0.421HisMet: 0.421 ± 0.016	0.961HisAsn: 0.961 ± 0.023	0.916HisPro: 0.916 ± 0.027	0.731HisGln: 0.731 ± 0.023	0.733HisArg: 0.733 ± 0.023	1.032HisSer: 1.032 ± 0.028	1.058HisThr: 1.058 ± 0.027	0.988HisVal: 0.988 ± 0.029	0.237HisTrp: 0.237 ± 0.013	0.883HisTyr: 0.883 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.622IleAla: 5.622 ± 0.068	0.722IleCys: 0.722 ± 0.026	4.308IleAsp: 4.308 ± 0.059	4.363IleGlu: 4.363 ± 0.062	3.268IlePhe: 3.268 ± 0.053	4.899IleGly: 4.899 ± 0.065	1.446IleHis: 1.446 ± 0.035	5.168IleIle: 5.168 ± 0.082	4.904IleLys: 4.904 ± 0.058	6.865IleLeu: 6.865 ± 0.078	1.469IleMet: 1.469 ± 0.034	4.192IleAsn: 4.192 ± 0.057	3.32IlePro: 3.32 ± 0.049	2.783IleGln: 2.783 ± 0.044	3.53IleArg: 3.53 ± 0.048	5.385IleSer: 5.385 ± 0.06	4.224IleThr: 4.224 ± 0.07	4.46IleVal: 4.46 ± 0.068	0.763IleTrp: 0.763 ± 0.024	2.791IleTyr: 2.791 ± 0.05	0.0IleXaa: 0.0 ± 0.0
Lys	4.871LysAla: 4.871 ± 0.062	0.29LysCys: 0.29 ± 0.013	4.426LysAsp: 4.426 ± 0.057	5.173LysGlu: 5.173 ± 0.068	2.652LysPhe: 2.652 ± 0.042	4.571LysGly: 4.571 ± 0.057	1.155LysHis: 1.155 ± 0.029	5.128LysIle: 5.128 ± 0.06	5.264LysLys: 5.264 ± 0.069	5.894LysLeu: 5.894 ± 0.061	1.867LysMet: 1.867 ± 0.034	4.32LysAsn: 4.32 ± 0.058	2.393LysPro: 2.393 ± 0.041	2.758LysGln: 2.758 ± 0.046	2.784LysArg: 2.784 ± 0.05	4.363LysSer: 4.363 ± 0.054	4.067LysThr: 4.067 ± 0.058	4.285LysVal: 4.285 ± 0.057	0.851LysTrp: 0.851 ± 0.026	2.92LysTyr: 2.92 ± 0.045	0.0LysXaa: 0.0 ± 0.0
Leu	6.322LeuAla: 6.322 ± 0.068	0.737LeuCys: 0.737 ± 0.023	4.922LeuAsp: 4.922 ± 0.061	5.203LeuGlu: 5.203 ± 0.082	4.665LeuPhe: 4.665 ± 0.064	5.666LeuGly: 5.666 ± 0.059	1.705LeuHis: 1.705 ± 0.035	6.817LeuIle: 6.817 ± 0.086	6.839LeuLys: 6.839 ± 0.078	9.22LeuLeu: 9.22 ± 0.114	2.195LeuMet: 2.195 ± 0.038	5.3LeuAsn: 5.3 ± 0.064	3.904LeuPro: 3.904 ± 0.06	3.739LeuGln: 3.739 ± 0.057	3.823LeuArg: 3.823 ± 0.052	7.311LeuSer: 7.311 ± 0.072	5.538LeuThr: 5.538 ± 0.066	4.991LeuVal: 4.991 ± 0.062	0.894LeuTrp: 0.894 ± 0.026	3.745LeuTyr: 3.745 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	1.634MetAla: 1.634 ± 0.032	0.126MetCys: 0.126 ± 0.009	1.265MetAsp: 1.265 ± 0.029	1.381MetGlu: 1.381 ± 0.031	0.861MetPhe: 0.861 ± 0.028	1.504MetGly: 1.504 ± 0.032	0.387MetHis: 0.387 ± 0.015	1.604MetIle: 1.604 ± 0.034	2.117MetLys: 2.117 ± 0.033	2.158MetLeu: 2.158 ± 0.034	0.639MetMet: 0.639 ± 0.023	1.386MetAsn: 1.386 ± 0.027	0.963MetPro: 0.963 ± 0.027	0.934MetGln: 0.934 ± 0.027	0.909MetArg: 0.909 ± 0.025	1.468MetSer: 1.468 ± 0.032	1.284MetThr: 1.284 ± 0.032	1.289MetVal: 1.289 ± 0.031	0.214MetTrp: 0.214 ± 0.011	0.79MetTyr: 0.79 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.748AsnAla: 3.748 ± 0.058	0.346AsnCys: 0.346 ± 0.016	2.749AsnAsp: 2.749 ± 0.051	2.982AsnGlu: 2.982 ± 0.042	2.657AsnPhe: 2.657 ± 0.043	4.098AsnGly: 4.098 ± 0.069	0.916AsnHis: 0.916 ± 0.024	4.528AsnIle: 4.528 ± 0.071	4.041AsnLys: 4.041 ± 0.056	4.979AsnLeu: 4.979 ± 0.054	1.291AsnMet: 1.291 ± 0.031	3.524AsnAsn: 3.524 ± 0.068	2.767AsnPro: 2.767 ± 0.044	2.197AsnGln: 2.197 ± 0.037	2.445AsnArg: 2.445 ± 0.043	3.617AsnSer: 3.617 ± 0.063	3.559AsnThr: 3.559 ± 0.058	3.257AsnVal: 3.257 ± 0.061	0.752AsnTrp: 0.752 ± 0.023	2.671AsnTyr: 2.671 ± 0.055	0.0AsnXaa: 0.0 ± 0.0
Pro	2.787ProAla: 2.787 ± 0.05	0.18ProCys: 0.18 ± 0.01	2.444ProAsp: 2.444 ± 0.039	2.782ProGlu: 2.782 ± 0.051	1.842ProPhe: 1.842 ± 0.033	2.341ProGly: 2.341 ± 0.044	0.627ProHis: 0.627 ± 0.022	2.19ProIle: 2.19 ± 0.039	2.156ProLys: 2.156 ± 0.043	3.196ProLeu: 3.196 ± 0.05	0.732ProMet: 0.732 ± 0.023	1.891ProAsn: 1.891 ± 0.04	0.834ProPro: 0.834 ± 0.026	1.41ProGln: 1.41 ± 0.034	1.135ProArg: 1.135 ± 0.031	2.317ProSer: 2.317 ± 0.042	1.906ProThr: 1.906 ± 0.042	3.175ProVal: 3.175 ± 0.048	0.387ProTrp: 0.387 ± 0.017	1.617ProTyr: 1.617 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	2.551GlnAla: 2.551 ± 0.044	0.181GlnCys: 0.181 ± 0.011	2.017GlnAsp: 2.017 ± 0.035	2.521GlnGlu: 2.521 ± 0.046	1.681GlnPhe: 1.681 ± 0.036	2.104GlnGly: 2.104 ± 0.049	0.976GlnHis: 0.976 ± 0.029	2.899GlnIle: 2.899 ± 0.046	2.829GlnLys: 2.829 ± 0.046	4.117GlnLeu: 4.117 ± 0.053	0.881GlnMet: 0.881 ± 0.023	2.173GlnAsn: 2.173 ± 0.043	1.243GlnPro: 1.243 ± 0.032	2.37GlnGln: 2.37 ± 0.044	1.587GlnArg: 1.587 ± 0.034	2.38GlnSer: 2.38 ± 0.04	2.21GlnThr: 2.21 ± 0.038	2.288GlnVal: 2.288 ± 0.038	0.442GlnTrp: 0.442 ± 0.019	1.838GlnTyr: 1.838 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	2.479ArgAla: 2.479 ± 0.046	0.195ArgCys: 0.195 ± 0.011	2.022ArgAsp: 2.022 ± 0.038	2.423ArgGlu: 2.423 ± 0.05	2.091ArgPhe: 2.091 ± 0.039	2.173ArgGly: 2.173 ± 0.047	0.732ArgHis: 0.732 ± 0.024	3.449ArgIle: 3.449 ± 0.05	3.114ArgLys: 3.114 ± 0.048	3.992ArgLeu: 3.992 ± 0.058	1.086ArgMet: 1.086 ± 0.024	2.449ArgAsn: 2.449 ± 0.039	1.359ArgPro: 1.359 ± 0.032	1.664ArgGln: 1.664 ± 0.034	1.591ArgArg: 1.591 ± 0.035	2.471ArgSer: 2.471 ± 0.047	2.304ArgThr: 2.304 ± 0.04	2.429ArgVal: 2.429 ± 0.037	0.553ArgTrp: 0.553 ± 0.021	2.072ArgTyr: 2.072 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	4.706SerAla: 4.706 ± 0.064	0.633SerCys: 0.633 ± 0.019	3.385SerAsp: 3.385 ± 0.054	3.406SerGlu: 3.406 ± 0.045	3.681SerPhe: 3.681 ± 0.055	5.213SerGly: 5.213 ± 0.073	1.058SerHis: 1.058 ± 0.023	4.717SerIle: 4.717 ± 0.062	4.328SerLys: 4.328 ± 0.062	6.263SerLeu: 6.263 ± 0.068	1.336SerMet: 1.336 ± 0.031	3.47SerAsn: 3.47 ± 0.058	2.417SerPro: 2.417 ± 0.043	2.14SerGln: 2.14 ± 0.035	2.709SerArg: 2.709 ± 0.046	4.486SerSer: 4.486 ± 0.071	3.775SerThr: 3.775 ± 0.046	4.373SerVal: 4.373 ± 0.051	0.792SerTrp: 0.792 ± 0.025	3.168SerTyr: 3.168 ± 0.056	0.0SerXaa: 0.0 ± 0.0
Thr	4.58ThrAla: 4.58 ± 0.065	0.342ThrCys: 0.342 ± 0.017	3.455ThrAsp: 3.455 ± 0.051	3.123ThrGlu: 3.123 ± 0.048	2.896ThrPhe: 2.896 ± 0.047	4.515ThrGly: 4.515 ± 0.08	0.996ThrHis: 0.996 ± 0.027	4.294ThrIle: 4.294 ± 0.054	3.332ThrLys: 3.332 ± 0.051	5.564ThrLeu: 5.564 ± 0.076	0.957ThrMet: 0.957 ± 0.025	2.972ThrAsn: 2.972 ± 0.054	2.358ThrPro: 2.358 ± 0.04	1.879ThrGln: 1.879 ± 0.032	1.902ThrArg: 1.902 ± 0.036	3.675ThrSer: 3.675 ± 0.058	3.355ThrThr: 3.355 ± 0.066	4.012ThrVal: 4.012 ± 0.066	0.557ThrTrp: 0.557 ± 0.018	2.59ThrTyr: 2.59 ± 0.066	0.0ThrXaa: 0.0 ± 0.0
Val	4.39ValAla: 4.39 ± 0.068	0.51ValCys: 0.51 ± 0.021	3.486ValAsp: 3.486 ± 0.054	3.515ValGlu: 3.515 ± 0.059	3.04ValPhe: 3.04 ± 0.045	3.758ValGly: 3.758 ± 0.063	1.053ValHis: 1.053 ± 0.029	4.56ValIle: 4.56 ± 0.06	4.189ValLys: 4.189 ± 0.05	5.98ValLeu: 5.98 ± 0.074	1.384ValMet: 1.384 ± 0.034	3.58ValAsn: 3.58 ± 0.056	2.304ValPro: 2.304 ± 0.043	2.227ValGln: 2.227 ± 0.037	2.644ValArg: 2.644 ± 0.036	4.711ValSer: 4.711 ± 0.063	3.614ValThr: 3.614 ± 0.065	4.147ValVal: 4.147 ± 0.061	0.728ValTrp: 0.728 ± 0.023	2.571ValTyr: 2.571 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	0.69TrpAla: 0.69 ± 0.022	0.1TrpCys: 0.1 ± 0.009	0.622TrpAsp: 0.622 ± 0.021	0.678TrpGlu: 0.678 ± 0.022	0.54TrpPhe: 0.54 ± 0.02	0.827TrpGly: 0.827 ± 0.025	0.24TrpHis: 0.24 ± 0.013	0.836TrpIle: 0.836 ± 0.024	0.941TrpLys: 0.941 ± 0.026	1.046TrpLeu: 1.046 ± 0.026	0.338TrpMet: 0.338 ± 0.015	0.762TrpAsn: 0.762 ± 0.026	0.303TrpPro: 0.303 ± 0.016	0.461TrpGln: 0.461 ± 0.017	0.475TrpArg: 0.475 ± 0.019	0.732TrpSer: 0.732 ± 0.027	0.696TrpThr: 0.696 ± 0.02	0.64TrpVal: 0.64 ± 0.022	0.175TrpTrp: 0.175 ± 0.011	0.495TrpTyr: 0.495 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.943TyrAla: 2.943 ± 0.045	0.301TyrCys: 0.301 ± 0.016	2.587TyrAsp: 2.587 ± 0.046	2.301TyrGlu: 2.301 ± 0.038	2.483TyrPhe: 2.483 ± 0.047	2.95TyrGly: 2.95 ± 0.053	0.89TyrHis: 0.89 ± 0.027	2.859TyrIle: 2.859 ± 0.046	2.81TyrLys: 2.81 ± 0.045	4.017TyrLeu: 4.017 ± 0.051	0.961TyrMet: 0.961 ± 0.026	2.707TyrAsn: 2.707 ± 0.054	1.753TyrPro: 1.753 ± 0.036	1.807TyrGln: 1.807 ± 0.039	1.937TyrArg: 1.937 ± 0.042	2.945TyrSer: 2.945 ± 0.047	2.704TyrThr: 2.704 ± 0.059	2.321TyrVal: 2.321 ± 0.044	0.531TyrTrp: 0.531 ± 0.019	2.148TyrTyr: 2.148 ± 0.049	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4471 proteins (1536412 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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