Amino acid dipepetide frequency for Leishmania braziliensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.749AlaAla: 17.749 ± 0.139	1.671AlaCys: 1.671 ± 0.02	4.918AlaAsp: 4.918 ± 0.044	7.13AlaGlu: 7.13 ± 0.1	2.876AlaPhe: 2.876 ± 0.025	6.268AlaGly: 6.268 ± 0.044	2.638AlaHis: 2.638 ± 0.031	3.037AlaIle: 3.037 ± 0.026	3.679AlaLys: 3.679 ± 0.04	10.13AlaLeu: 10.13 ± 0.071	2.538AlaMet: 2.538 ± 0.024	2.668AlaAsn: 2.668 ± 0.025	6.437AlaPro: 6.437 ± 0.091	4.278AlaGln: 4.278 ± 0.045	6.29AlaArg: 6.29 ± 0.064	9.936AlaSer: 9.936 ± 0.065	7.737AlaThr: 7.737 ± 0.056	8.503AlaVal: 8.503 ± 0.063	0.964AlaTrp: 0.964 ± 0.018	2.211AlaTyr: 2.211 ± 0.025	0.0AlaXaa: 0.0 ± 0.0
Cys	2.016CysAla: 2.016 ± 0.031	0.535CysCys: 0.535 ± 0.013	0.941CysAsp: 0.941 ± 0.016	0.954CysGlu: 0.954 ± 0.015	0.683CysPhe: 0.683 ± 0.012	1.577CysGly: 1.577 ± 0.024	0.472CysHis: 0.472 ± 0.009	0.775CysIle: 0.775 ± 0.012	0.52CysLys: 0.52 ± 0.011	1.597CysLeu: 1.597 ± 0.03	0.419CysMet: 0.419 ± 0.01	0.532CysAsn: 0.532 ± 0.01	0.929CysPro: 0.929 ± 0.016	0.518CysGln: 0.518 ± 0.01	1.325CysArg: 1.325 ± 0.023	1.632CysSer: 1.632 ± 0.019	1.3CysThr: 1.3 ± 0.025	1.627CysVal: 1.627 ± 0.019	0.211CysTrp: 0.211 ± 0.007	0.471CysTyr: 0.471 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.098AspAla: 6.098 ± 0.044	0.771AspCys: 0.771 ± 0.013	3.314AspAsp: 3.314 ± 0.038	3.478AspGlu: 3.478 ± 0.035	1.457AspPhe: 1.457 ± 0.021	3.973AspGly: 3.973 ± 0.035	0.97AspHis: 0.97 ± 0.015	1.822AspIle: 1.822 ± 0.021	1.441AspLys: 1.441 ± 0.023	3.648AspLeu: 3.648 ± 0.039	1.153AspMet: 1.153 ± 0.017	1.356AspAsn: 1.356 ± 0.019	2.329AspPro: 2.329 ± 0.034	1.165AspGln: 1.165 ± 0.019	2.643AspArg: 2.643 ± 0.03	3.612AspSer: 3.612 ± 0.031	2.946AspThr: 2.946 ± 0.031	4.233AspVal: 4.233 ± 0.031	0.494AspTrp: 0.494 ± 0.011	1.215AspTyr: 1.215 ± 0.016	0.0AspXaa: 0.0 ± 0.0
Glu	7.204GluAla: 7.204 ± 0.074	0.922GluCys: 0.922 ± 0.016	3.461GluAsp: 3.461 ± 0.041	5.959GluGlu: 5.959 ± 0.072	1.332GluPhe: 1.332 ± 0.02	3.678GluGly: 3.678 ± 0.034	1.449GluHis: 1.449 ± 0.019	1.512GluIle: 1.512 ± 0.022	2.815GluLys: 2.815 ± 0.046	5.773GluLeu: 5.773 ± 0.067	1.602GluMet: 1.602 ± 0.022	1.604GluAsn: 1.604 ± 0.022	2.042GluPro: 2.042 ± 0.023	2.678GluGln: 2.678 ± 0.036	4.655GluArg: 4.655 ± 0.06	3.874GluSer: 3.874 ± 0.029	2.874GluThr: 2.874 ± 0.042	4.727GluVal: 4.727 ± 0.037	0.779GluTrp: 0.779 ± 0.016	1.358GluTyr: 1.358 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	2.746PheAla: 2.746 ± 0.025	0.648PheCys: 0.648 ± 0.012	1.545PheAsp: 1.545 ± 0.02	1.47PheGlu: 1.47 ± 0.021	1.529PhePhe: 1.529 ± 0.054	1.879PheGly: 1.879 ± 0.022	0.874PheHis: 0.874 ± 0.014	1.183PheIle: 1.183 ± 0.019	0.846PheLys: 0.846 ± 0.016	3.103PheLeu: 3.103 ± 0.036	0.699PheMet: 0.699 ± 0.013	0.921PheAsn: 0.921 ± 0.015	1.539PhePro: 1.539 ± 0.017	1.038PheGln: 1.038 ± 0.021	1.75PheArg: 1.75 ± 0.024	2.801PheSer: 2.801 ± 0.027	1.95PheThr: 1.95 ± 0.023	2.304PheVal: 2.304 ± 0.027	0.294PheTrp: 0.294 ± 0.008	0.95PheTyr: 0.95 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	7.053GlyAla: 7.053 ± 0.057	1.257GlyCys: 1.257 ± 0.016	3.673GlyAsp: 3.673 ± 0.033	3.593GlyGlu: 3.593 ± 0.032	1.819GlyPhe: 1.819 ± 0.02	6.444GlyGly: 6.444 ± 0.061	1.492GlyHis: 1.492 ± 0.019	2.183GlyIle: 2.183 ± 0.024	2.317GlyLys: 2.317 ± 0.029	4.544GlyLeu: 4.544 ± 0.038	1.399GlyMet: 1.399 ± 0.018	2.035GlyAsn: 2.035 ± 0.02	2.373GlyPro: 2.373 ± 0.032	1.841GlyGln: 1.841 ± 0.024	3.96GlyArg: 3.96 ± 0.039	5.854GlySer: 5.854 ± 0.054	4.098GlyThr: 4.098 ± 0.034	4.919GlyVal: 4.919 ± 0.035	0.644GlyTrp: 0.644 ± 0.014	1.532GlyTyr: 1.532 ± 0.022	0.0GlyXaa: 0.0 ± 0.0
His	2.552HisAla: 2.552 ± 0.028	0.63HisCys: 0.63 ± 0.021	1.217HisAsp: 1.217 ± 0.015	1.324HisGlu: 1.324 ± 0.018	0.889HisPhe: 0.889 ± 0.014	1.766HisGly: 1.766 ± 0.021	1.202HisHis: 1.202 ± 0.022	1.004HisIle: 1.004 ± 0.014	0.757HisLys: 0.757 ± 0.013	2.622HisLeu: 2.622 ± 0.028	0.575HisMet: 0.575 ± 0.012	0.841HisAsn: 0.841 ± 0.012	1.667HisPro: 1.667 ± 0.021	1.187HisGln: 1.187 ± 0.022	2.399HisArg: 2.399 ± 0.028	2.273HisSer: 2.273 ± 0.023	1.711HisThr: 1.711 ± 0.02	1.922HisVal: 1.922 ± 0.024	0.295HisTrp: 0.295 ± 0.007	0.802HisTyr: 0.802 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	3.349IleAla: 3.349 ± 0.03	0.58IleCys: 0.58 ± 0.012	1.792IleAsp: 1.792 ± 0.022	1.844IleGlu: 1.844 ± 0.025	1.193IlePhe: 1.193 ± 0.02	1.96IleGly: 1.96 ± 0.022	0.854IleHis: 0.854 ± 0.015	1.258IleIle: 1.258 ± 0.018	1.07IleLys: 1.07 ± 0.018	2.733IleLeu: 2.733 ± 0.031	0.755IleMet: 0.755 ± 0.013	0.93IleAsn: 0.93 ± 0.014	1.947IlePro: 1.947 ± 0.021	1.2IleGln: 1.2 ± 0.022	1.999IleArg: 1.999 ± 0.022	2.628IleSer: 2.628 ± 0.025	2.071IleThr: 2.071 ± 0.024	2.371IleVal: 2.371 ± 0.027	0.243IleTrp: 0.243 ± 0.008	0.747IleTyr: 0.747 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	3.633LysAla: 3.633 ± 0.044	0.544LysCys: 0.544 ± 0.01	1.781LysAsp: 1.781 ± 0.026	2.631LysGlu: 2.631 ± 0.034	0.741LysPhe: 0.741 ± 0.014	2.137LysGly: 2.137 ± 0.023	0.885LysHis: 0.885 ± 0.018	0.949LysIle: 0.949 ± 0.017	1.982LysLys: 1.982 ± 0.029	2.983LysLeu: 2.983 ± 0.042	0.888LysMet: 0.888 ± 0.015	0.987LysAsn: 0.987 ± 0.015	1.569LysPro: 1.569 ± 0.024	1.477LysGln: 1.477 ± 0.024	2.836LysArg: 2.836 ± 0.031	2.384LysSer: 2.384 ± 0.024	1.883LysThr: 1.883 ± 0.031	2.307LysVal: 2.307 ± 0.022	0.383LysTrp: 0.383 ± 0.012	0.896LysTyr: 0.896 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	8.342LeuAla: 8.342 ± 0.064	2.167LeuCys: 2.167 ± 0.027	4.082LeuAsp: 4.082 ± 0.038	5.33LeuGlu: 5.33 ± 0.07	3.258LeuPhe: 3.258 ± 0.04	4.542LeuGly: 4.542 ± 0.036	3.15LeuHis: 3.15 ± 0.031	2.702LeuIle: 2.702 ± 0.029	3.109LeuLys: 3.109 ± 0.037	10.568LeuLeu: 10.568 ± 0.072	2.066LeuMet: 2.066 ± 0.024	2.486LeuAsn: 2.486 ± 0.024	6.051LeuPro: 6.051 ± 0.05	5.155LeuGln: 5.155 ± 0.044	8.015LeuArg: 8.015 ± 0.065	8.326LeuSer: 8.326 ± 0.052	5.281LeuThr: 5.281 ± 0.041	5.87LeuVal: 5.87 ± 0.048	1.156LeuTrp: 1.156 ± 0.016	2.542LeuTyr: 2.542 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	2.242MetAla: 2.242 ± 0.022	0.441MetCys: 0.441 ± 0.009	1.138MetAsp: 1.138 ± 0.016	1.614MetGlu: 1.614 ± 0.019	0.587MetPhe: 0.587 ± 0.012	1.226MetGly: 1.226 ± 0.017	0.655MetHis: 0.655 ± 0.014	0.652MetIle: 0.652 ± 0.012	0.913MetLys: 0.913 ± 0.015	2.119MetLeu: 2.119 ± 0.026	0.673MetMet: 0.673 ± 0.014	0.773MetAsn: 0.773 ± 0.017	1.408MetPro: 1.408 ± 0.02	1.13MetGln: 1.13 ± 0.015	1.775MetArg: 1.775 ± 0.025	1.922MetSer: 1.922 ± 0.02	1.372MetThr: 1.372 ± 0.018	1.367MetVal: 1.367 ± 0.02	0.32MetTrp: 0.32 ± 0.008	0.568MetTyr: 0.568 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.139AsnAla: 3.139 ± 0.029	0.497AsnCys: 0.497 ± 0.01	1.478AsnAsp: 1.478 ± 0.021	1.587AsnGlu: 1.587 ± 0.025	0.861AsnPhe: 0.861 ± 0.014	2.254AsnGly: 2.254 ± 0.025	0.643AsnHis: 0.643 ± 0.011	1.119AsnIle: 1.119 ± 0.018	0.947AsnLys: 0.947 ± 0.015	2.035AsnLeu: 2.035 ± 0.021	0.651AsnMet: 0.651 ± 0.012	0.977AsnAsn: 0.977 ± 0.015	1.576AsnPro: 1.576 ± 0.022	0.769AsnGln: 0.769 ± 0.013	1.655AsnArg: 1.655 ± 0.021	2.376AsnSer: 2.376 ± 0.025	1.983AsnThr: 1.983 ± 0.021	2.096AsnVal: 2.096 ± 0.02	0.266AsnTrp: 0.266 ± 0.007	0.773AsnTyr: 0.773 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	5.877ProAla: 5.877 ± 0.052	0.896ProCys: 0.896 ± 0.016	1.974ProAsp: 1.974 ± 0.02	2.616ProGlu: 2.616 ± 0.031	1.842ProPhe: 1.842 ± 0.027	2.769ProGly: 2.769 ± 0.032	1.724ProHis: 1.724 ± 0.021	1.66ProIle: 1.66 ± 0.022	1.592ProLys: 1.592 ± 0.025	6.128ProLeu: 6.128 ± 0.048	1.111ProMet: 1.111 ± 0.016	1.42ProAsn: 1.42 ± 0.017	5.492ProPro: 5.492 ± 0.068	2.441ProGln: 2.441 ± 0.029	3.577ProArg: 3.577 ± 0.045	6.479ProSer: 6.479 ± 0.087	3.907ProThr: 3.907 ± 0.038	3.713ProVal: 3.713 ± 0.033	0.59ProTrp: 0.59 ± 0.017	1.365ProTyr: 1.365 ± 0.016	0.0ProXaa: 0.0 ± 0.0
Gln	3.565GlnAla: 3.565 ± 0.049	0.81GlnCys: 0.81 ± 0.014	1.46GlnAsp: 1.46 ± 0.021	2.598GlnGlu: 2.598 ± 0.035	0.942GlnPhe: 0.942 ± 0.017	1.899GlnGly: 1.899 ± 0.022	1.593GlnHis: 1.593 ± 0.019	0.992GlnIle: 0.992 ± 0.018	1.399GlnLys: 1.399 ± 0.029	4.94GlnLeu: 4.94 ± 0.044	0.89GlnMet: 0.89 ± 0.017	0.944GlnAsn: 0.944 ± 0.014	2.252GlnPro: 2.252 ± 0.026	3.946GlnGln: 3.946 ± 0.071	4.526GlnArg: 4.526 ± 0.043	2.859GlnSer: 2.859 ± 0.029	1.837GlnThr: 1.837 ± 0.019	2.417GlnVal: 2.417 ± 0.024	0.594GlnTrp: 0.594 ± 0.013	1.076GlnTyr: 1.076 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	6.482ArgAla: 6.482 ± 0.058	1.672ArgCys: 1.672 ± 0.028	3.346ArgAsp: 3.346 ± 0.036	4.306ArgGlu: 4.306 ± 0.039	2.018ArgPhe: 2.018 ± 0.024	4.466ArgGly: 4.466 ± 0.047	2.456ArgHis: 2.456 ± 0.03	2.394ArgIle: 2.394 ± 0.028	2.543ArgLys: 2.543 ± 0.028	6.954ArgLeu: 6.954 ± 0.058	1.552ArgMet: 1.552 ± 0.018	2.002ArgAsn: 2.002 ± 0.021	3.179ArgPro: 3.179 ± 0.049	3.509ArgGln: 3.509 ± 0.034	7.044ArgArg: 7.044 ± 0.097	5.603ArgSer: 5.603 ± 0.047	3.885ArgThr: 3.885 ± 0.037	4.816ArgVal: 4.816 ± 0.036	0.971ArgTrp: 0.971 ± 0.016	1.942ArgTyr: 1.942 ± 0.021	0.0ArgXaa: 0.0 ± 0.0
Ser	10.312SerAla: 10.312 ± 0.097	1.609SerCys: 1.609 ± 0.024	3.865SerAsp: 3.865 ± 0.032	3.951SerGlu: 3.951 ± 0.035	2.738SerPhe: 2.738 ± 0.031	6.097SerGly: 6.097 ± 0.053	2.115SerHis: 2.115 ± 0.022	2.823SerIle: 2.823 ± 0.025	2.443SerLys: 2.443 ± 0.025	8.033SerLeu: 8.033 ± 0.049	1.864SerMet: 1.864 ± 0.02	2.373SerAsn: 2.373 ± 0.022	6.037SerPro: 6.037 ± 0.061	2.667SerGln: 2.667 ± 0.028	5.359SerArg: 5.359 ± 0.043	11.712SerSer: 11.712 ± 0.344	6.507SerThr: 6.507 ± 0.046	6.023SerVal: 6.023 ± 0.047	0.837SerTrp: 0.837 ± 0.026	1.732SerTyr: 1.732 ± 0.019	0.0SerXaa: 0.0 ± 0.0
Thr	8.022ThrAla: 8.022 ± 0.053	1.018ThrCys: 1.018 ± 0.018	2.642ThrAsp: 2.642 ± 0.023	3.336ThrGlu: 3.336 ± 0.03	1.784ThrPhe: 1.784 ± 0.022	3.728ThrGly: 3.728 ± 0.034	1.591ThrHis: 1.591 ± 0.017	1.992ThrIle: 1.992 ± 0.023	1.883ThrLys: 1.883 ± 0.026	5.668ThrLeu: 5.668 ± 0.04	1.329ThrMet: 1.329 ± 0.016	1.661ThrAsn: 1.661 ± 0.02	4.467ThrPro: 4.467 ± 0.048	2.173ThrGln: 2.173 ± 0.025	3.65ThrArg: 3.65 ± 0.041	6.241ThrSer: 6.241 ± 0.051	5.063ThrThr: 5.063 ± 0.066	4.625ThrVal: 4.625 ± 0.038	0.612ThrTrp: 0.612 ± 0.013	1.408ThrTyr: 1.408 ± 0.015	0.0ThrXaa: 0.0 ± 0.0
Val	7.974ValAla: 7.974 ± 0.056	1.524ValCys: 1.524 ± 0.029	3.674ValAsp: 3.674 ± 0.028	4.609ValGlu: 4.609 ± 0.037	2.297ValPhe: 2.297 ± 0.024	4.061ValGly: 4.061 ± 0.035	1.885ValHis: 1.885 ± 0.023	2.179ValIle: 2.179 ± 0.021	2.405ValLys: 2.405 ± 0.025	7.304ValLeu: 7.304 ± 0.047	1.754ValMet: 1.754 ± 0.023	1.945ValAsn: 1.945 ± 0.022	4.256ValPro: 4.256 ± 0.035	3.015ValGln: 3.015 ± 0.03	4.825ValArg: 4.825 ± 0.036	5.939ValSer: 5.939 ± 0.039	4.301ValThr: 4.301 ± 0.033	5.916ValVal: 5.916 ± 0.084	0.812ValTrp: 0.812 ± 0.015	1.83ValTyr: 1.83 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	0.947TrpAla: 0.947 ± 0.02	0.321TrpCys: 0.321 ± 0.009	0.49TrpAsp: 0.49 ± 0.009	0.58TrpGlu: 0.58 ± 0.012	0.298TrpPhe: 0.298 ± 0.009	0.651TrpGly: 0.651 ± 0.012	0.285TrpHis: 0.285 ± 0.008	0.358TrpIle: 0.358 ± 0.008	0.473TrpLys: 0.473 ± 0.012	1.033TrpLeu: 1.033 ± 0.015	0.353TrpMet: 0.353 ± 0.011	0.374TrpAsn: 0.374 ± 0.01	0.458TrpPro: 0.458 ± 0.016	0.479TrpGln: 0.479 ± 0.01	1.068TrpArg: 1.068 ± 0.021	0.898TrpSer: 0.898 ± 0.018	0.652TrpThr: 0.652 ± 0.017	0.717TrpVal: 0.717 ± 0.012	0.249TrpTrp: 0.249 ± 0.013	0.316TrpTyr: 0.316 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.355TyrAla: 2.355 ± 0.023	0.521TyrCys: 0.521 ± 0.009	1.323TyrAsp: 1.323 ± 0.019	1.39TyrGlu: 1.39 ± 0.018	0.926TyrPhe: 0.926 ± 0.016	1.655TyrGly: 1.655 ± 0.022	0.704TyrHis: 0.704 ± 0.012	0.93TyrIle: 0.93 ± 0.015	0.745TyrLys: 0.745 ± 0.015	2.281TyrLeu: 2.281 ± 0.025	0.626TyrMet: 0.626 ± 0.013	0.853TyrAsn: 0.853 ± 0.015	1.164TyrPro: 1.164 ± 0.019	0.873TyrGln: 0.873 ± 0.014	1.791TyrArg: 1.791 ± 0.026	1.748TyrSer: 1.748 ± 0.02	1.533TyrThr: 1.533 ± 0.019	2.029TyrVal: 2.029 ± 0.024	0.286TyrTrp: 0.286 ± 0.007	0.906TyrTyr: 0.906 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8084 proteins (5077572 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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