Amino acid dipepetide frequency for Manacus vitellinus (golden-collared manakin)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.772AlaAla: 5.772 ± 0.045	1.287AlaCys: 1.287 ± 0.017	2.978AlaAsp: 2.978 ± 0.026	4.668AlaGlu: 4.668 ± 0.036	2.616AlaPhe: 2.616 ± 0.025	4.026AlaGly: 4.026 ± 0.037	1.4AlaHis: 1.4 ± 0.016	3.032AlaIle: 3.032 ± 0.027	3.752AlaLys: 3.752 ± 0.029	6.6AlaLeu: 6.6 ± 0.046	1.484AlaMet: 1.484 ± 0.019	2.219AlaAsn: 2.219 ± 0.021	3.035AlaPro: 3.035 ± 0.028	2.854AlaGln: 2.854 ± 0.029	3.041AlaArg: 3.041 ± 0.028	5.004AlaSer: 5.004 ± 0.033	3.282AlaThr: 3.282 ± 0.029	4.942AlaVal: 4.942 ± 0.034	0.702AlaTrp: 0.702 ± 0.012	1.607AlaTyr: 1.607 ± 0.017	0.001AlaXaa: 0.001 ± 0.0
Cys	1.216CysAla: 1.216 ± 0.016	0.683CysCys: 0.683 ± 0.015	1.062CysAsp: 1.062 ± 0.02	1.297CysGlu: 1.297 ± 0.024	0.932CysPhe: 0.932 ± 0.016	1.494CysGly: 1.494 ± 0.025	0.646CysHis: 0.646 ± 0.013	1.139CysIle: 1.139 ± 0.022	1.292CysLys: 1.292 ± 0.018	2.241CysLeu: 2.241 ± 0.029	0.443CysMet: 0.443 ± 0.01	0.899CysAsn: 0.899 ± 0.015	1.364CysPro: 1.364 ± 0.029	1.109CysGln: 1.109 ± 0.021	1.256CysArg: 1.256 ± 0.017	2.042CysSer: 2.042 ± 0.023	1.197CysThr: 1.197 ± 0.018	1.436CysVal: 1.436 ± 0.03	0.303CysTrp: 0.303 ± 0.008	0.682CysTyr: 0.682 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	2.829AspAla: 2.829 ± 0.023	1.11AspCys: 1.11 ± 0.019	2.839AspAsp: 2.839 ± 0.029	3.666AspGlu: 3.666 ± 0.033	2.305AspPhe: 2.305 ± 0.021	3.283AspGly: 3.283 ± 0.036	1.183AspHis: 1.183 ± 0.016	2.948AspIle: 2.948 ± 0.023	2.779AspLys: 2.779 ± 0.027	5.025AspLeu: 5.025 ± 0.034	1.144AspMet: 1.144 ± 0.015	1.909AspAsn: 1.909 ± 0.023	2.706AspPro: 2.706 ± 0.027	1.833AspGln: 1.833 ± 0.018	2.376AspArg: 2.376 ± 0.023	4.109AspSer: 4.109 ± 0.038	2.625AspThr: 2.625 ± 0.026	3.27AspVal: 3.27 ± 0.029	0.657AspTrp: 0.657 ± 0.012	1.656AspTyr: 1.656 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	4.688GluAla: 4.688 ± 0.037	1.332GluCys: 1.332 ± 0.026	4.492GluAsp: 4.492 ± 0.031	8.014GluGlu: 8.014 ± 0.084	2.256GluPhe: 2.256 ± 0.021	4.018GluGly: 4.018 ± 0.033	1.572GluHis: 1.572 ± 0.02	3.505GluIle: 3.505 ± 0.03	5.725GluLys: 5.725 ± 0.057	6.48GluLeu: 6.48 ± 0.052	1.792GluMet: 1.792 ± 0.018	3.433GluAsn: 3.433 ± 0.029	2.61GluPro: 2.61 ± 0.024	3.271GluGln: 3.271 ± 0.039	3.968GluArg: 3.968 ± 0.039	4.476GluSer: 4.476 ± 0.036	3.507GluThr: 3.507 ± 0.027	4.344GluVal: 4.344 ± 0.031	0.744GluTrp: 0.744 ± 0.013	1.815GluTyr: 1.815 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	2.169PheAla: 2.169 ± 0.02	1.017PheCys: 1.017 ± 0.013	1.839PheAsp: 1.839 ± 0.019	2.165PheGlu: 2.165 ± 0.022	1.891PhePhe: 1.891 ± 0.026	2.349PheGly: 2.349 ± 0.024	1.143PheHis: 1.143 ± 0.015	2.103PheIle: 2.103 ± 0.025	2.035PheLys: 2.035 ± 0.019	4.278PheLeu: 4.278 ± 0.042	0.8PheMet: 0.8 ± 0.012	1.505PheAsn: 1.505 ± 0.018	2.026PhePro: 2.026 ± 0.022	1.865PheGln: 1.865 ± 0.019	1.961PheArg: 1.961 ± 0.021	3.488PheSer: 3.488 ± 0.027	2.233PheThr: 2.233 ± 0.025	2.438PheVal: 2.438 ± 0.026	0.538PheTrp: 0.538 ± 0.011	1.357PheTyr: 1.357 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	3.615GlyAla: 3.615 ± 0.03	1.265GlyCys: 1.265 ± 0.019	3.011GlyAsp: 3.011 ± 0.034	3.794GlyGlu: 3.794 ± 0.035	2.509GlyPhe: 2.509 ± 0.028	3.96GlyGly: 3.96 ± 0.044	1.601GlyHis: 1.601 ± 0.021	3.134GlyIle: 3.134 ± 0.032	4.057GlyLys: 4.057 ± 0.035	5.246GlyLeu: 5.246 ± 0.036	1.4GlyMet: 1.4 ± 0.022	2.6GlyAsn: 2.6 ± 0.023	2.801GlyPro: 2.801 ± 0.05	2.548GlyGln: 2.548 ± 0.027	3.217GlyArg: 3.217 ± 0.037	5.088GlySer: 5.088 ± 0.043	3.48GlyThr: 3.48 ± 0.03	3.554GlyVal: 3.554 ± 0.028	0.785GlyTrp: 0.785 ± 0.012	1.883GlyTyr: 1.883 ± 0.025	0.0GlyXaa: 0.0 ± 0.0
His	1.288HisAla: 1.288 ± 0.017	0.721HisCys: 0.721 ± 0.013	0.945HisAsp: 0.945 ± 0.014	1.373HisGlu: 1.373 ± 0.016	1.116HisPhe: 1.116 ± 0.015	1.529HisGly: 1.529 ± 0.018	0.875HisHis: 0.875 ± 0.019	1.368HisIle: 1.368 ± 0.016	1.387HisLys: 1.387 ± 0.017	2.832HisLeu: 2.832 ± 0.033	0.587HisMet: 0.587 ± 0.011	0.974HisAsn: 0.974 ± 0.014	1.556HisPro: 1.556 ± 0.021	1.19HisGln: 1.19 ± 0.015	1.521HisArg: 1.521 ± 0.018	2.244HisSer: 2.244 ± 0.025	1.4HisThr: 1.4 ± 0.025	1.569HisVal: 1.569 ± 0.019	0.37HisTrp: 0.37 ± 0.009	0.855HisTyr: 0.855 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	2.952IleAla: 2.952 ± 0.025	1.218IleCys: 1.218 ± 0.019	2.284IleAsp: 2.284 ± 0.023	2.859IleGlu: 2.859 ± 0.027	2.16IlePhe: 2.16 ± 0.024	2.441IleGly: 2.441 ± 0.027	1.406IleHis: 1.406 ± 0.018	2.721IleIle: 2.721 ± 0.033	3.022IleLys: 3.022 ± 0.026	4.997IleLeu: 4.997 ± 0.038	1.068IleMet: 1.068 ± 0.018	2.12IleAsn: 2.12 ± 0.022	2.919IlePro: 2.919 ± 0.029	2.436IleGln: 2.436 ± 0.023	2.564IleArg: 2.564 ± 0.024	4.011IleSer: 4.011 ± 0.027	2.851IleThr: 2.851 ± 0.028	2.896IleVal: 2.896 ± 0.029	0.589IleTrp: 0.589 ± 0.012	1.637IleTyr: 1.637 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	4.14LysAla: 4.14 ± 0.032	1.261LysCys: 1.261 ± 0.019	3.453LysAsp: 3.453 ± 0.028	5.723LysGlu: 5.723 ± 0.058	1.955LysPhe: 1.955 ± 0.023	3.515LysGly: 3.515 ± 0.039	1.585LysHis: 1.585 ± 0.02	3.176LysIle: 3.176 ± 0.029	5.368LysLys: 5.368 ± 0.057	5.726LysLeu: 5.726 ± 0.041	1.544LysMet: 1.544 ± 0.018	2.727LysAsn: 2.727 ± 0.026	3.063LysPro: 3.063 ± 0.025	2.946LysGln: 2.946 ± 0.024	3.596LysArg: 3.596 ± 0.032	4.208LysSer: 4.208 ± 0.036	3.338LysThr: 3.338 ± 0.029	3.793LysVal: 3.793 ± 0.03	0.684LysTrp: 0.684 ± 0.013	1.867LysTyr: 1.867 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	6.309LeuAla: 6.309 ± 0.046	2.305LeuCys: 2.305 ± 0.029	4.847LeuAsp: 4.847 ± 0.033	7.088LeuGlu: 7.088 ± 0.057	3.656LeuPhe: 3.656 ± 0.033	5.345LeuGly: 5.345 ± 0.036	2.693LeuHis: 2.693 ± 0.022	4.248LeuIle: 4.248 ± 0.039	6.403LeuLys: 6.403 ± 0.042	10.149LeuLeu: 10.149 ± 0.069	2.024LeuMet: 2.024 ± 0.022	3.801LeuAsn: 3.801 ± 0.034	5.425LeuPro: 5.425 ± 0.045	5.639LeuGln: 5.639 ± 0.046	5.271LeuArg: 5.271 ± 0.035	7.861LeuSer: 7.861 ± 0.047	4.98LeuThr: 4.98 ± 0.032	5.576LeuVal: 5.576 ± 0.039	1.13LeuTrp: 1.13 ± 0.017	2.832LeuTyr: 2.832 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	1.627MetAla: 1.627 ± 0.02	0.447MetCys: 0.447 ± 0.01	1.292MetAsp: 1.292 ± 0.016	1.88MetGlu: 1.88 ± 0.02	0.84MetPhe: 0.84 ± 0.013	1.265MetGly: 1.265 ± 0.02	0.495MetHis: 0.495 ± 0.009	0.958MetIle: 0.958 ± 0.014	1.612MetLys: 1.612 ± 0.02	2.021MetLeu: 2.021 ± 0.023	0.598MetMet: 0.598 ± 0.012	0.992MetAsn: 0.992 ± 0.016	1.017MetPro: 1.017 ± 0.017	1.005MetGln: 1.005 ± 0.016	1.061MetArg: 1.061 ± 0.018	1.537MetSer: 1.537 ± 0.018	1.15MetThr: 1.15 ± 0.017	1.427MetVal: 1.427 ± 0.02	0.253MetTrp: 0.253 ± 0.007	0.649MetTyr: 0.649 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.27AsnAla: 2.27 ± 0.024	0.966AsnCys: 0.966 ± 0.015	1.688AsnAsp: 1.688 ± 0.021	2.536AsnGlu: 2.536 ± 0.024	1.644AsnPhe: 1.644 ± 0.018	2.716AsnGly: 2.716 ± 0.033	0.988AsnHis: 0.988 ± 0.014	2.448AsnIle: 2.448 ± 0.025	2.554AsnLys: 2.554 ± 0.025	4.048AsnLeu: 4.048 ± 0.031	0.994AsnMet: 0.994 ± 0.016	1.83AsnAsn: 1.83 ± 0.023	2.291AsnPro: 2.291 ± 0.026	1.717AsnGln: 1.717 ± 0.018	1.984AsnArg: 1.984 ± 0.019	3.421AsnSer: 3.421 ± 0.027	2.231AsnThr: 2.231 ± 0.023	2.434AsnVal: 2.434 ± 0.022	0.506AsnTrp: 0.506 ± 0.011	1.313AsnTyr: 1.313 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	3.807ProAla: 3.807 ± 0.039	1.153ProCys: 1.153 ± 0.024	2.625ProAsp: 2.625 ± 0.025	3.971ProGlu: 3.971 ± 0.029	1.948ProPhe: 1.948 ± 0.022	3.8ProGly: 3.8 ± 0.061	1.295ProHis: 1.295 ± 0.021	1.927ProIle: 1.927 ± 0.02	2.777ProLys: 2.777 ± 0.03	4.667ProLeu: 4.667 ± 0.036	0.928ProMet: 0.928 ± 0.014	1.887ProAsn: 1.887 ± 0.021	4.28ProPro: 4.28 ± 0.058	2.335ProGln: 2.335 ± 0.027	2.573ProArg: 2.573 ± 0.027	4.994ProSer: 4.994 ± 0.043	2.674ProThr: 2.674 ± 0.028	3.795ProVal: 3.795 ± 0.029	0.605ProTrp: 0.605 ± 0.012	1.477ProTyr: 1.477 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	3.077GlnAla: 3.077 ± 0.028	0.971GlnCys: 0.971 ± 0.018	2.278GlnAsp: 2.278 ± 0.023	3.724GlnGlu: 3.724 ± 0.034	1.483GlnPhe: 1.483 ± 0.019	2.527GlnGly: 2.527 ± 0.028	1.305GlnHis: 1.305 ± 0.018	2.214GlnIle: 2.214 ± 0.021	3.172GlnLys: 3.172 ± 0.028	4.623GlnLeu: 4.623 ± 0.041	1.09GlnMet: 1.09 ± 0.015	2.021GlnAsn: 2.021 ± 0.023	2.353GlnPro: 2.353 ± 0.035	3.014GlnGln: 3.014 ± 0.052	2.702GlnArg: 2.702 ± 0.026	3.196GlnSer: 3.196 ± 0.031	2.355GlnThr: 2.355 ± 0.025	2.82GlnVal: 2.82 ± 0.025	0.541GlnTrp: 0.541 ± 0.01	1.293GlnTyr: 1.293 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	3.261ArgAla: 3.261 ± 0.03	1.138ArgCys: 1.138 ± 0.019	2.679ArgAsp: 2.679 ± 0.028	3.841ArgGlu: 3.841 ± 0.034	1.925ArgPhe: 1.925 ± 0.022	2.966ArgGly: 2.966 ± 0.036	1.466ArgHis: 1.466 ± 0.018	2.571ArgIle: 2.571 ± 0.022	3.968ArgLys: 3.968 ± 0.035	4.925ArgLeu: 4.925 ± 0.033	1.162ArgMet: 1.162 ± 0.016	2.252ArgAsn: 2.252 ± 0.023	2.409ArgPro: 2.409 ± 0.024	2.481ArgGln: 2.481 ± 0.022	3.814ArgArg: 3.814 ± 0.04	3.989ArgSer: 3.989 ± 0.041	2.69ArgThr: 2.69 ± 0.024	3.025ArgVal: 3.025 ± 0.026	0.647ArgTrp: 0.647 ± 0.012	1.598ArgTyr: 1.598 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	5.117SerAla: 5.117 ± 0.036	1.887SerCys: 1.887 ± 0.029	4.0SerAsp: 4.0 ± 0.035	5.104SerGlu: 5.104 ± 0.038	3.138SerPhe: 3.138 ± 0.028	4.986SerGly: 4.986 ± 0.035	2.055SerHis: 2.055 ± 0.022	3.523SerIle: 3.523 ± 0.026	4.455SerLys: 4.455 ± 0.035	7.907SerLeu: 7.907 ± 0.048	1.587SerMet: 1.587 ± 0.016	2.992SerAsn: 2.992 ± 0.029	5.168SerPro: 5.168 ± 0.053	3.667SerGln: 3.667 ± 0.037	4.12SerArg: 4.12 ± 0.042	9.001SerSer: 9.001 ± 0.09	4.451SerThr: 4.451 ± 0.036	5.058SerVal: 5.058 ± 0.038	0.986SerTrp: 0.986 ± 0.014	2.236SerTyr: 2.236 ± 0.024	0.001SerXaa: 0.001 ± 0.0
Thr	3.803ThrAla: 3.803 ± 0.03	1.32ThrCys: 1.32 ± 0.022	2.701ThrAsp: 2.701 ± 0.026	3.734ThrGlu: 3.734 ± 0.029	2.222ThrPhe: 2.222 ± 0.023	3.446ThrGly: 3.446 ± 0.028	1.246ThrHis: 1.246 ± 0.023	2.588ThrIle: 2.588 ± 0.027	2.859ThrLys: 2.859 ± 0.027	5.171ThrLeu: 5.171 ± 0.036	1.107ThrMet: 1.107 ± 0.014	1.955ThrAsn: 1.955 ± 0.018	3.111ThrPro: 3.111 ± 0.033	2.126ThrGln: 2.126 ± 0.024	2.365ThrArg: 2.365 ± 0.021	4.503ThrSer: 4.503 ± 0.034	2.94ThrThr: 2.94 ± 0.032	4.094ThrVal: 4.094 ± 0.036	0.685ThrTrp: 0.685 ± 0.011	1.565ThrTyr: 1.565 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	4.119ValAla: 4.119 ± 0.031	1.608ValCys: 1.608 ± 0.029	3.082ValAsp: 3.082 ± 0.027	3.992ValGlu: 3.992 ± 0.031	2.7ValPhe: 2.7 ± 0.026	3.417ValGly: 3.417 ± 0.033	1.611ValHis: 1.611 ± 0.018	3.247ValIle: 3.247 ± 0.034	3.847ValLys: 3.847 ± 0.029	6.469ValLeu: 6.469 ± 0.039	1.381ValMet: 1.381 ± 0.016	2.518ValAsn: 2.518 ± 0.024	3.564ValPro: 3.564 ± 0.031	2.851ValGln: 2.851 ± 0.03	3.022ValArg: 3.022 ± 0.024	4.996ValSer: 4.996 ± 0.036	3.869ValThr: 3.869 ± 0.033	4.332ValVal: 4.332 ± 0.034	0.761ValTrp: 0.761 ± 0.015	1.868ValTyr: 1.868 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	0.7TrpAla: 0.7 ± 0.014	0.256TrpCys: 0.256 ± 0.008	0.687TrpAsp: 0.687 ± 0.016	0.794TrpGlu: 0.794 ± 0.014	0.476TrpPhe: 0.476 ± 0.011	0.657TrpGly: 0.657 ± 0.012	0.323TrpHis: 0.323 ± 0.008	0.649TrpIle: 0.649 ± 0.011	0.9TrpLys: 0.9 ± 0.013	1.199TrpLeu: 1.199 ± 0.016	0.318TrpMet: 0.318 ± 0.009	0.645TrpAsn: 0.645 ± 0.014	0.437TrpPro: 0.437 ± 0.009	0.548TrpGln: 0.548 ± 0.011	0.681TrpArg: 0.681 ± 0.012	0.889TrpSer: 0.889 ± 0.017	0.654TrpThr: 0.654 ± 0.012	0.689TrpVal: 0.689 ± 0.012	0.198TrpTrp: 0.198 ± 0.007	0.387TrpTyr: 0.387 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.542TyrAla: 1.542 ± 0.019	0.786TyrCys: 0.786 ± 0.014	1.473TyrAsp: 1.473 ± 0.017	1.82TyrGlu: 1.82 ± 0.021	1.426TyrPhe: 1.426 ± 0.019	1.809TyrGly: 1.809 ± 0.022	0.811TyrHis: 0.811 ± 0.011	1.653TyrIle: 1.653 ± 0.022	1.706TyrLys: 1.706 ± 0.021	2.981TyrLeu: 2.981 ± 0.027	0.672TyrMet: 0.672 ± 0.011	1.297TyrAsn: 1.297 ± 0.016	1.384TyrPro: 1.384 ± 0.018	1.324TyrGln: 1.324 ± 0.017	1.711TyrArg: 1.711 ± 0.021	2.38TyrSer: 2.38 ± 0.026	1.636TyrThr: 1.636 ± 0.021	1.761TyrVal: 1.761 ± 0.02	0.403TyrTrp: 0.403 ± 0.011	1.102TyrTyr: 1.102 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.022XaaXaa: 0.022 ± 0.004

Statistics based on 12707 proteins (5377145 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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