Amino acid dipepetide frequency for Rheinheimera sp. SA_1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.261AlaAla: 12.261 ± 0.134	0.998AlaCys: 0.998 ± 0.028	6.113AlaAsp: 6.113 ± 0.058	6.395AlaGlu: 6.395 ± 0.075	3.494AlaPhe: 3.494 ± 0.047	7.609AlaGly: 7.609 ± 0.077	1.651AlaHis: 1.651 ± 0.035	5.497AlaIle: 5.497 ± 0.063	4.688AlaLys: 4.688 ± 0.067	11.978AlaLeu: 11.978 ± 0.113	2.578AlaMet: 2.578 ± 0.042	3.521AlaAsn: 3.521 ± 0.049	3.71AlaPro: 3.71 ± 0.052	5.158AlaGln: 5.158 ± 0.072	4.343AlaArg: 4.343 ± 0.064	5.787AlaSer: 5.787 ± 0.063	5.525AlaThr: 5.525 ± 0.081	7.582AlaVal: 7.582 ± 0.081	1.107AlaTrp: 1.107 ± 0.026	2.44AlaTyr: 2.44 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	0.852CysAla: 0.852 ± 0.028	0.214CysCys: 0.214 ± 0.012	0.512CysAsp: 0.512 ± 0.018	0.45CysGlu: 0.45 ± 0.019	0.461CysPhe: 0.461 ± 0.022	0.802CysGly: 0.802 ± 0.021	0.297CysHis: 0.297 ± 0.015	0.451CysIle: 0.451 ± 0.018	0.311CysLys: 0.311 ± 0.017	1.064CysLeu: 1.064 ± 0.032	0.182CysMet: 0.182 ± 0.011	0.327CysAsn: 0.327 ± 0.016	0.437CysPro: 0.437 ± 0.018	0.699CysGln: 0.699 ± 0.024	0.553CysArg: 0.553 ± 0.021	0.736CysSer: 0.736 ± 0.024	0.453CysThr: 0.453 ± 0.02	0.529CysVal: 0.529 ± 0.02	0.203CysTrp: 0.203 ± 0.012	0.411CysTyr: 0.411 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	4.769AspAla: 4.769 ± 0.063	0.508AspCys: 0.508 ± 0.019	2.667AspAsp: 2.667 ± 0.048	2.901AspGlu: 2.901 ± 0.049	2.43AspPhe: 2.43 ± 0.036	3.716AspGly: 3.716 ± 0.058	1.084AspHis: 1.084 ± 0.025	3.168AspIle: 3.168 ± 0.046	2.396AspLys: 2.396 ± 0.046	5.716AspLeu: 5.716 ± 0.07	1.051AspMet: 1.051 ± 0.027	1.979AspAsn: 1.979 ± 0.035	2.28AspPro: 2.28 ± 0.042	2.594AspGln: 2.594 ± 0.044	2.205AspArg: 2.205 ± 0.039	3.046AspSer: 3.046 ± 0.045	2.311AspThr: 2.311 ± 0.046	3.516AspVal: 3.516 ± 0.053	0.965AspTrp: 0.965 ± 0.027	1.871AspTyr: 1.871 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	4.513GluAla: 4.513 ± 0.061	0.314GluCys: 0.314 ± 0.015	1.945GluAsp: 1.945 ± 0.04	2.004GluGlu: 2.004 ± 0.051	2.195GluPhe: 2.195 ± 0.038	2.535GluGly: 2.535 ± 0.042	1.413GluHis: 1.413 ± 0.032	2.942GluIle: 2.942 ± 0.047	2.458GluLys: 2.458 ± 0.048	7.304GluLeu: 7.304 ± 0.077	1.302GluMet: 1.302 ± 0.034	1.719GluAsn: 1.719 ± 0.036	2.093GluPro: 2.093 ± 0.035	4.529GluGln: 4.529 ± 0.071	2.854GluArg: 2.854 ± 0.054	2.366GluSer: 2.366 ± 0.045	2.461GluThr: 2.461 ± 0.041	3.434GluVal: 3.434 ± 0.054	0.574GluTrp: 0.574 ± 0.021	1.338GluTyr: 1.338 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.324PheAla: 4.324 ± 0.052	0.526PheCys: 0.526 ± 0.019	2.591PheAsp: 2.591 ± 0.042	2.145PheGlu: 2.145 ± 0.039	1.637PhePhe: 1.637 ± 0.042	3.207PheGly: 3.207 ± 0.049	0.823PheHis: 0.823 ± 0.025	2.285PheIle: 2.285 ± 0.045	1.583PheLys: 1.583 ± 0.036	3.319PheLeu: 3.319 ± 0.05	0.887PheMet: 0.887 ± 0.024	1.82PheAsn: 1.82 ± 0.037	1.378PhePro: 1.378 ± 0.035	1.614PheGln: 1.614 ± 0.035	1.809PheArg: 1.809 ± 0.037	3.412PheSer: 3.412 ± 0.05	2.152PheThr: 2.152 ± 0.042	2.831PheVal: 2.831 ± 0.048	0.618PheTrp: 0.618 ± 0.023	1.432PheTyr: 1.432 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	5.653GlyAla: 5.653 ± 0.082	0.826GlyCys: 0.826 ± 0.026	3.378GlyAsp: 3.378 ± 0.056	3.556GlyGlu: 3.556 ± 0.057	3.268GlyPhe: 3.268 ± 0.055	4.59GlyGly: 4.59 ± 0.078	1.52GlyHis: 1.52 ± 0.034	3.905GlyIle: 3.905 ± 0.049	3.43GlyLys: 3.43 ± 0.062	7.345GlyLeu: 7.345 ± 0.08	1.794GlyMet: 1.794 ± 0.038	2.396GlyAsn: 2.396 ± 0.047	1.833GlyPro: 1.833 ± 0.032	3.581GlyGln: 3.581 ± 0.045	3.296GlyArg: 3.296 ± 0.055	4.267GlySer: 4.267 ± 0.057	3.375GlyThr: 3.375 ± 0.053	4.865GlyVal: 4.865 ± 0.057	1.155GlyTrp: 1.155 ± 0.031	2.502GlyTyr: 2.502 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	1.8HisAla: 1.8 ± 0.038	0.335HisCys: 0.335 ± 0.013	0.964HisAsp: 0.964 ± 0.023	0.953HisGlu: 0.953 ± 0.023	1.078HisPhe: 1.078 ± 0.029	1.629HisGly: 1.629 ± 0.037	0.71HisHis: 0.71 ± 0.025	1.137HisIle: 1.137 ± 0.03	0.85HisLys: 0.85 ± 0.025	2.458HisLeu: 2.458 ± 0.038	0.392HisMet: 0.392 ± 0.017	0.804HisAsn: 0.804 ± 0.025	1.23HisPro: 1.23 ± 0.031	1.816HisGln: 1.816 ± 0.043	1.128HisArg: 1.128 ± 0.024	1.476HisSer: 1.476 ± 0.035	0.911HisThr: 0.911 ± 0.024	1.094HisVal: 1.094 ± 0.029	0.506HisTrp: 0.506 ± 0.018	0.865HisTyr: 0.865 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.965IleAla: 5.965 ± 0.062	0.656IleCys: 0.656 ± 0.021	3.282IleAsp: 3.282 ± 0.052	3.4IleGlu: 3.4 ± 0.057	1.798IlePhe: 1.798 ± 0.04	4.022IleGly: 4.022 ± 0.058	1.041IleHis: 1.041 ± 0.024	2.293IleIle: 2.293 ± 0.046	2.362IleLys: 2.362 ± 0.046	4.385IleLeu: 4.385 ± 0.063	0.837IleMet: 0.837 ± 0.026	2.331IleAsn: 2.331 ± 0.04	2.237IlePro: 2.237 ± 0.039	2.183IleGln: 2.183 ± 0.042	2.734IleArg: 2.734 ± 0.042	4.025IleSer: 4.025 ± 0.059	2.759IleThr: 2.759 ± 0.051	3.304IleVal: 3.304 ± 0.053	0.685IleTrp: 0.685 ± 0.021	1.448IleTyr: 1.448 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	4.564LysAla: 4.564 ± 0.068	0.205LysCys: 0.205 ± 0.012	2.024LysAsp: 2.024 ± 0.042	1.848LysGlu: 1.848 ± 0.044	1.511LysPhe: 1.511 ± 0.035	2.397LysGly: 2.397 ± 0.046	0.905LysHis: 0.905 ± 0.025	2.403LysIle: 2.403 ± 0.05	2.032LysLys: 2.032 ± 0.055	5.146LysLeu: 5.146 ± 0.063	1.039LysMet: 1.039 ± 0.028	1.635LysAsn: 1.635 ± 0.034	2.304LysPro: 2.304 ± 0.043	2.614LysGln: 2.614 ± 0.051	1.975LysArg: 1.975 ± 0.042	2.331LysSer: 2.331 ± 0.041	2.72LysThr: 2.72 ± 0.05	3.288LysVal: 3.288 ± 0.051	0.41LysTrp: 0.41 ± 0.017	1.078LysTyr: 1.078 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	13.318LeuAla: 13.318 ± 0.124	1.322LeuCys: 1.322 ± 0.04	5.74LeuAsp: 5.74 ± 0.078	5.396LeuGlu: 5.396 ± 0.063	4.42LeuPhe: 4.42 ± 0.069	6.858LeuGly: 6.858 ± 0.077	2.467LeuHis: 2.467 ± 0.045	5.586LeuIle: 5.586 ± 0.074	5.092LeuLys: 5.092 ± 0.063	15.257LeuLeu: 15.257 ± 0.198	2.653LeuMet: 2.653 ± 0.048	4.279LeuAsn: 4.279 ± 0.058	6.42LeuPro: 6.42 ± 0.095	8.252LeuGln: 8.252 ± 0.118	5.197LeuArg: 5.197 ± 0.059	8.055LeuSer: 8.055 ± 0.082	7.12LeuThr: 7.12 ± 0.076	7.846LeuVal: 7.846 ± 0.084	1.671LeuTrp: 1.671 ± 0.044	3.007LeuTyr: 3.007 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.468MetAla: 2.468 ± 0.042	0.147MetCys: 0.147 ± 0.01	0.945MetAsp: 0.945 ± 0.024	0.875MetGlu: 0.875 ± 0.029	0.854MetPhe: 0.854 ± 0.028	1.169MetGly: 1.169 ± 0.034	0.442MetHis: 0.442 ± 0.018	1.007MetIle: 1.007 ± 0.029	1.015MetLys: 1.015 ± 0.028	3.175MetLeu: 3.175 ± 0.051	0.574MetMet: 0.574 ± 0.024	0.779MetAsn: 0.779 ± 0.024	1.245MetPro: 1.245 ± 0.03	1.514MetGln: 1.514 ± 0.034	0.988MetArg: 0.988 ± 0.029	1.548MetSer: 1.548 ± 0.032	1.422MetThr: 1.422 ± 0.028	1.55MetVal: 1.55 ± 0.031	0.206MetTrp: 0.206 ± 0.012	0.498MetTyr: 0.498 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.268AsnAla: 3.268 ± 0.057	0.38AsnCys: 0.38 ± 0.015	1.78AsnAsp: 1.78 ± 0.039	1.692AsnGlu: 1.692 ± 0.033	1.57AsnPhe: 1.57 ± 0.04	2.633AsnGly: 2.633 ± 0.051	0.811AsnHis: 0.811 ± 0.023	2.04AsnIle: 2.04 ± 0.037	1.519AsnLys: 1.519 ± 0.034	3.687AsnLeu: 3.687 ± 0.051	0.759AsnMet: 0.759 ± 0.02	1.584AsnAsn: 1.584 ± 0.036	2.015AsnPro: 2.015 ± 0.038	2.187AsnGln: 2.187 ± 0.036	1.829AsnArg: 1.829 ± 0.032	2.438AsnSer: 2.438 ± 0.045	1.934AsnThr: 1.934 ± 0.039	2.086AsnVal: 2.086 ± 0.039	0.632AsnTrp: 0.632 ± 0.021	1.179AsnTyr: 1.179 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	5.38ProAla: 5.38 ± 0.077	0.322ProCys: 0.322 ± 0.016	2.845ProAsp: 2.845 ± 0.043	3.006ProGlu: 3.006 ± 0.041	1.754ProPhe: 1.754 ± 0.037	2.972ProGly: 2.972 ± 0.053	0.868ProHis: 0.868 ± 0.021	1.856ProIle: 1.856 ± 0.036	1.892ProLys: 1.892 ± 0.032	5.386ProLeu: 5.386 ± 0.083	1.017ProMet: 1.017 ± 0.027	1.434ProAsn: 1.434 ± 0.031	1.493ProPro: 1.493 ± 0.036	2.455ProGln: 2.455 ± 0.051	1.479ProArg: 1.479 ± 0.035	2.234ProSer: 2.234 ± 0.038	2.362ProThr: 2.362 ± 0.039	3.735ProVal: 3.735 ± 0.06	0.618ProTrp: 0.618 ± 0.022	1.214ProTyr: 1.214 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	6.133GlnAla: 6.133 ± 0.083	0.464GlnCys: 0.464 ± 0.02	2.238GlnAsp: 2.238 ± 0.042	1.934GlnGlu: 1.934 ± 0.042	2.333GlnPhe: 2.333 ± 0.042	3.512GlnGly: 3.512 ± 0.057	2.063GlnHis: 2.063 ± 0.04	3.164GlnIle: 3.164 ± 0.047	2.149GlnLys: 2.149 ± 0.042	10.11GlnLeu: 10.11 ± 0.151	1.295GlnMet: 1.295 ± 0.029	1.852GlnAsn: 1.852 ± 0.038	3.178GlnPro: 3.178 ± 0.054	8.555GlnGln: 8.555 ± 0.167	3.333GlnArg: 3.333 ± 0.059	3.681GlnSer: 3.681 ± 0.056	2.885GlnThr: 2.885 ± 0.048	3.8GlnVal: 3.8 ± 0.057	1.033GlnTrp: 1.033 ± 0.028	1.671GlnTyr: 1.671 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	3.749ArgAla: 3.749 ± 0.055	0.469ArgCys: 0.469 ± 0.022	2.411ArgAsp: 2.411 ± 0.036	2.434ArgGlu: 2.434 ± 0.043	2.33ArgPhe: 2.33 ± 0.039	2.629ArgGly: 2.629 ± 0.043	1.279ArgHis: 1.279 ± 0.035	2.635ArgIle: 2.635 ± 0.04	1.838ArgLys: 1.838 ± 0.037	6.068ArgLeu: 6.068 ± 0.087	1.086ArgMet: 1.086 ± 0.024	1.641ArgAsn: 1.641 ± 0.031	1.882ArgPro: 1.882 ± 0.041	3.709ArgGln: 3.709 ± 0.058	2.495ArgArg: 2.495 ± 0.048	2.832ArgSer: 2.832 ± 0.045	2.162ArgThr: 2.162 ± 0.037	2.854ArgVal: 2.854 ± 0.048	0.839ArgTrp: 0.839 ± 0.021	1.846ArgTyr: 1.846 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	6.528SerAla: 6.528 ± 0.07	0.665SerCys: 0.665 ± 0.022	3.196SerAsp: 3.196 ± 0.048	3.064SerGlu: 3.064 ± 0.052	2.781SerPhe: 2.781 ± 0.045	5.087SerGly: 5.087 ± 0.068	1.444SerHis: 1.444 ± 0.033	3.066SerIle: 3.066 ± 0.054	2.656SerLys: 2.656 ± 0.046	6.892SerLeu: 6.892 ± 0.065	1.455SerMet: 1.455 ± 0.026	2.304SerAsn: 2.304 ± 0.052	2.506SerPro: 2.506 ± 0.046	3.398SerGln: 3.398 ± 0.06	3.119SerArg: 3.119 ± 0.045	4.258SerSer: 4.258 ± 0.067	3.291SerThr: 3.291 ± 0.052	4.164SerVal: 4.164 ± 0.051	1.07SerTrp: 1.07 ± 0.024	2.184SerTyr: 2.184 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	6.257ThrAla: 6.257 ± 0.074	0.376ThrCys: 0.376 ± 0.018	3.005ThrAsp: 3.005 ± 0.054	3.214ThrGlu: 3.214 ± 0.046	1.841ThrPhe: 1.841 ± 0.041	4.152ThrGly: 4.152 ± 0.065	0.929ThrHis: 0.929 ± 0.024	2.696ThrIle: 2.696 ± 0.049	1.89ThrLys: 1.89 ± 0.037	6.268ThrLeu: 6.268 ± 0.071	1.033ThrMet: 1.033 ± 0.027	1.691ThrAsn: 1.691 ± 0.038	2.922ThrPro: 2.922 ± 0.048	2.453ThrGln: 2.453 ± 0.037	1.959ThrArg: 1.959 ± 0.037	3.25ThrSer: 3.25 ± 0.056	2.977ThrThr: 2.977 ± 0.053	3.987ThrVal: 3.987 ± 0.06	0.422ThrTrp: 0.422 ± 0.018	1.249ThrTyr: 1.249 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	7.268ValAla: 7.268 ± 0.075	0.662ValCys: 0.662 ± 0.023	3.558ValAsp: 3.558 ± 0.056	3.551ValGlu: 3.551 ± 0.044	2.64ValPhe: 2.64 ± 0.044	4.296ValGly: 4.296 ± 0.055	1.247ValHis: 1.247 ± 0.028	3.783ValIle: 3.783 ± 0.051	2.987ValLys: 2.987 ± 0.05	8.198ValLeu: 8.198 ± 0.084	1.704ValMet: 1.704 ± 0.037	2.556ValAsn: 2.556 ± 0.042	2.965ValPro: 2.965 ± 0.051	3.349ValGln: 3.349 ± 0.046	3.122ValArg: 3.122 ± 0.049	4.639ValSer: 4.639 ± 0.064	3.927ValThr: 3.927 ± 0.063	5.214ValVal: 5.214 ± 0.067	0.824ValTrp: 0.824 ± 0.026	1.746ValTyr: 1.746 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	0.915TrpAla: 0.915 ± 0.029	0.167TrpCys: 0.167 ± 0.012	0.546TrpAsp: 0.546 ± 0.02	0.384TrpGlu: 0.384 ± 0.016	0.73TrpPhe: 0.73 ± 0.024	0.701TrpGly: 0.701 ± 0.023	0.428TrpHis: 0.428 ± 0.018	0.585TrpIle: 0.585 ± 0.024	0.312TrpLys: 0.312 ± 0.014	2.486TrpLeu: 2.486 ± 0.057	0.284TrpMet: 0.284 ± 0.014	0.397TrpAsn: 0.397 ± 0.015	0.711TrpPro: 0.711 ± 0.021	1.831TrpGln: 1.831 ± 0.039	0.933TrpArg: 0.933 ± 0.023	0.853TrpSer: 0.853 ± 0.026	0.555TrpThr: 0.555 ± 0.023	0.815TrpVal: 0.815 ± 0.025	0.301TrpTrp: 0.301 ± 0.015	0.412TrpTyr: 0.412 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.45TyrAla: 2.45 ± 0.042	0.386TyrCys: 0.386 ± 0.019	1.43TyrAsp: 1.43 ± 0.036	1.089TyrGlu: 1.089 ± 0.027	1.267TyrPhe: 1.267 ± 0.031	2.02TyrGly: 2.02 ± 0.037	0.717TyrHis: 0.717 ± 0.023	1.245TyrIle: 1.245 ± 0.03	0.972TyrLys: 0.972 ± 0.03	3.719TyrLeu: 3.719 ± 0.058	0.5TyrMet: 0.5 ± 0.021	0.972TyrAsn: 0.972 ± 0.025	1.483TyrPro: 1.483 ± 0.031	2.895TyrGln: 2.895 ± 0.053	1.838TyrArg: 1.838 ± 0.033	1.892TyrSer: 1.892 ± 0.039	1.267TyrThr: 1.267 ± 0.033	1.742TyrVal: 1.742 ± 0.034	0.507TyrTrp: 0.507 ± 0.018	0.947TyrTyr: 0.947 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4186 proteins (1508662 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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