Amino acid dipepetide frequency for Methylobacterium haplocladii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.576AlaAla: 19.576 ± 0.198	1.219AlaCys: 1.219 ± 0.035	7.254AlaAsp: 7.254 ± 0.092	8.283AlaGlu: 8.283 ± 0.103	4.694AlaPhe: 4.694 ± 0.061	12.013AlaGly: 12.013 ± 0.131	2.292AlaHis: 2.292 ± 0.045	6.4AlaIle: 6.4 ± 0.072	4.166AlaLys: 4.166 ± 0.069	14.886AlaLeu: 14.886 ± 0.129	3.452AlaMet: 3.452 ± 0.055	2.715AlaAsn: 2.715 ± 0.053	6.544AlaPro: 6.544 ± 0.095	3.87AlaGln: 3.87 ± 0.058	10.31AlaArg: 10.31 ± 0.124	6.903AlaSer: 6.903 ± 0.092	6.747AlaThr: 6.747 ± 0.087	9.742AlaVal: 9.742 ± 0.102	1.633AlaTrp: 1.633 ± 0.038	2.731AlaTyr: 2.731 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.969CysAla: 0.969 ± 0.032	0.11CysCys: 0.11 ± 0.012	0.506CysAsp: 0.506 ± 0.018	0.47CysGlu: 0.47 ± 0.018	0.285CysPhe: 0.285 ± 0.016	0.897CysGly: 0.897 ± 0.031	0.177CysHis: 0.177 ± 0.012	0.322CysIle: 0.322 ± 0.016	0.166CysLys: 0.166 ± 0.012	0.917CysLeu: 0.917 ± 0.027	0.142CysMet: 0.142 ± 0.011	0.182CysAsn: 0.182 ± 0.012	0.462CysPro: 0.462 ± 0.021	0.182CysGln: 0.182 ± 0.012	0.726CysArg: 0.726 ± 0.026	0.432CysSer: 0.432 ± 0.018	0.42CysThr: 0.42 ± 0.019	0.607CysVal: 0.607 ± 0.023	0.1CysTrp: 0.1 ± 0.008	0.159CysTyr: 0.159 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.818AspAla: 7.818 ± 0.08	0.425AspCys: 0.425 ± 0.019	3.326AspAsp: 3.326 ± 0.057	3.36AspGlu: 3.36 ± 0.052	1.913AspPhe: 1.913 ± 0.042	5.76AspGly: 5.76 ± 0.078	1.139AspHis: 1.139 ± 0.031	2.448AspIle: 2.448 ± 0.042	1.448AspLys: 1.448 ± 0.041	6.402AspLeu: 6.402 ± 0.077	0.974AspMet: 0.974 ± 0.029	1.014AspAsn: 1.014 ± 0.03	4.003AspPro: 4.003 ± 0.061	1.381AspGln: 1.381 ± 0.035	4.926AspArg: 4.926 ± 0.073	1.993AspSer: 1.993 ± 0.042	2.723AspThr: 2.723 ± 0.046	4.253AspVal: 4.253 ± 0.056	0.862AspTrp: 0.862 ± 0.025	1.273AspTyr: 1.273 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	8.713GluAla: 8.713 ± 0.112	0.341GluCys: 0.341 ± 0.018	2.637GluAsp: 2.637 ± 0.051	2.645GluGlu: 2.645 ± 0.056	1.458GluPhe: 1.458 ± 0.037	4.526GluGly: 4.526 ± 0.068	1.173GluHis: 1.173 ± 0.034	3.205GluIle: 3.205 ± 0.058	1.865GluLys: 1.865 ± 0.043	4.346GluLeu: 4.346 ± 0.069	1.266GluMet: 1.266 ± 0.032	1.272GluAsn: 1.272 ± 0.033	3.231GluPro: 3.231 ± 0.058	1.7GluGln: 1.7 ± 0.04	5.713GluArg: 5.713 ± 0.1	2.451GluSer: 2.451 ± 0.044	3.93GluThr: 3.93 ± 0.061	3.499GluVal: 3.499 ± 0.058	0.566GluTrp: 0.566 ± 0.021	0.826GluTyr: 0.826 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.649PheAla: 4.649 ± 0.058	0.368PheCys: 0.368 ± 0.016	2.46PheAsp: 2.46 ± 0.045	2.047PheGlu: 2.047 ± 0.043	1.256PhePhe: 1.256 ± 0.035	3.61PheGly: 3.61 ± 0.063	0.627PheHis: 0.627 ± 0.026	1.235PheIle: 1.235 ± 0.031	0.92PheLys: 0.92 ± 0.031	3.213PheLeu: 3.213 ± 0.052	0.587PheMet: 0.587 ± 0.022	0.777PheAsn: 0.777 ± 0.027	1.497PhePro: 1.497 ± 0.034	0.826PheGln: 0.826 ± 0.025	2.398PheArg: 2.398 ± 0.039	2.153PheSer: 2.153 ± 0.044	1.852PheThr: 1.852 ± 0.039	2.871PheVal: 2.871 ± 0.044	0.479PheTrp: 0.479 ± 0.021	0.804PheTyr: 0.804 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	10.294GlyAla: 10.294 ± 0.113	0.875GlyCys: 0.875 ± 0.028	4.585GlyAsp: 4.585 ± 0.071	4.741GlyGlu: 4.741 ± 0.068	3.771GlyPhe: 3.771 ± 0.052	8.218GlyGly: 8.218 ± 0.16	1.911GlyHis: 1.911 ± 0.045	4.557GlyIle: 4.557 ± 0.068	2.745GlyLys: 2.745 ± 0.048	10.001GlyLeu: 10.001 ± 0.107	1.969GlyMet: 1.969 ± 0.045	1.946GlyAsn: 1.946 ± 0.059	4.152GlyPro: 4.152 ± 0.057	2.75GlyGln: 2.75 ± 0.061	7.626GlyArg: 7.626 ± 0.095	5.152GlySer: 5.152 ± 0.078	5.257GlyThr: 5.257 ± 0.135	6.108GlyVal: 6.108 ± 0.079	1.346GlyTrp: 1.346 ± 0.032	2.314GlyTyr: 2.314 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.517HisAla: 2.517 ± 0.048	0.187HisCys: 0.187 ± 0.012	1.221HisAsp: 1.221 ± 0.032	0.96HisGlu: 0.96 ± 0.027	0.712HisPhe: 0.712 ± 0.025	1.997HisGly: 1.997 ± 0.045	0.573HisHis: 0.573 ± 0.025	0.71HisIle: 0.71 ± 0.026	0.375HisLys: 0.375 ± 0.017	2.038HisLeu: 2.038 ± 0.04	0.355HisMet: 0.355 ± 0.018	0.365HisAsn: 0.365 ± 0.018	1.347HisPro: 1.347 ± 0.034	0.432HisGln: 0.432 ± 0.018	1.561HisArg: 1.561 ± 0.036	0.759HisSer: 0.759 ± 0.025	0.74HisThr: 0.74 ± 0.024	1.5HisVal: 1.5 ± 0.037	0.312HisTrp: 0.312 ± 0.014	0.481HisTyr: 0.481 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.124IleAla: 7.124 ± 0.085	0.43IleCys: 0.43 ± 0.019	3.352IleAsp: 3.352 ± 0.055	3.506IleGlu: 3.506 ± 0.054	1.292IlePhe: 1.292 ± 0.038	4.798IleGly: 4.798 ± 0.075	0.813IleHis: 0.813 ± 0.026	1.475IleIle: 1.475 ± 0.039	1.193IleLys: 1.193 ± 0.031	4.141IleLeu: 4.141 ± 0.066	0.677IleMet: 0.677 ± 0.024	1.052IleAsn: 1.052 ± 0.039	2.224IlePro: 2.224 ± 0.041	1.161IleGln: 1.161 ± 0.032	3.301IleArg: 3.301 ± 0.047	2.229IleSer: 2.229 ± 0.044	2.351IleThr: 2.351 ± 0.045	4.213IleVal: 4.213 ± 0.061	0.46IleTrp: 0.46 ± 0.019	0.861IleTyr: 0.861 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	4.215LysAla: 4.215 ± 0.069	0.129LysCys: 0.129 ± 0.009	1.548LysAsp: 1.548 ± 0.039	1.297LysGlu: 1.297 ± 0.038	0.699LysPhe: 0.699 ± 0.026	2.506LysGly: 2.506 ± 0.046	0.463LysHis: 0.463 ± 0.02	1.427LysIle: 1.427 ± 0.039	1.061LysLys: 1.061 ± 0.034	2.734LysLeu: 2.734 ± 0.045	0.577LysMet: 0.577 ± 0.021	0.785LysAsn: 0.785 ± 0.027	2.227LysPro: 2.227 ± 0.048	0.835LysGln: 0.835 ± 0.024	2.369LysArg: 2.369 ± 0.05	1.61LysSer: 1.61 ± 0.039	1.754LysThr: 1.754 ± 0.042	2.117LysVal: 2.117 ± 0.046	0.24LysTrp: 0.24 ± 0.014	0.487LysTyr: 0.487 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	15.079LeuAla: 15.079 ± 0.136	0.914LeuCys: 0.914 ± 0.029	6.598LeuAsp: 6.598 ± 0.088	4.563LeuGlu: 4.563 ± 0.075	3.405LeuPhe: 3.405 ± 0.059	8.798LeuGly: 8.798 ± 0.085	1.895LeuHis: 1.895 ± 0.041	4.566LeuIle: 4.566 ± 0.078	3.368LeuLys: 3.368 ± 0.055	8.969LeuLeu: 8.969 ± 0.128	2.025LeuMet: 2.025 ± 0.04	2.171LeuAsn: 2.171 ± 0.043	5.931LeuPro: 5.931 ± 0.07	2.526LeuGln: 2.526 ± 0.049	7.528LeuArg: 7.528 ± 0.087	6.183LeuSer: 6.183 ± 0.078	5.885LeuThr: 5.885 ± 0.088	8.05LeuVal: 8.05 ± 0.09	1.061LeuTrp: 1.061 ± 0.027	1.966LeuTyr: 1.966 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	2.659MetAla: 2.659 ± 0.05	0.117MetCys: 0.117 ± 0.009	0.824MetAsp: 0.824 ± 0.023	0.891MetGlu: 0.891 ± 0.026	0.523MetPhe: 0.523 ± 0.021	1.479MetGly: 1.479 ± 0.037	0.357MetHis: 0.357 ± 0.018	1.098MetIle: 1.098 ± 0.031	0.766MetLys: 0.766 ± 0.026	2.205MetLeu: 2.205 ± 0.045	0.548MetMet: 0.548 ± 0.023	0.602MetAsn: 0.602 ± 0.022	1.576MetPro: 1.576 ± 0.035	0.678MetGln: 0.678 ± 0.024	1.864MetArg: 1.864 ± 0.038	1.529MetSer: 1.529 ± 0.032	1.586MetThr: 1.586 ± 0.031	1.323MetVal: 1.323 ± 0.035	0.136MetTrp: 0.136 ± 0.012	0.2MetTyr: 0.2 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.076AsnAla: 3.076 ± 0.064	0.187AsnCys: 0.187 ± 0.012	1.228AsnAsp: 1.228 ± 0.038	1.008AsnGlu: 1.008 ± 0.03	0.746AsnPhe: 0.746 ± 0.026	2.154AsnGly: 2.154 ± 0.064	0.429AsnHis: 0.429 ± 0.021	0.972AsnIle: 0.972 ± 0.035	0.549AsnLys: 0.549 ± 0.021	2.343AsnLeu: 2.343 ± 0.047	0.393AsnMet: 0.393 ± 0.017	0.536AsnAsn: 0.536 ± 0.024	1.657AsnPro: 1.657 ± 0.037	0.606AsnGln: 0.606 ± 0.024	1.774AsnArg: 1.774 ± 0.042	0.941AsnSer: 0.941 ± 0.036	1.122AsnThr: 1.122 ± 0.04	1.617AsnVal: 1.617 ± 0.04	0.304AsnTrp: 0.304 ± 0.014	0.489AsnTyr: 0.489 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	7.46ProAla: 7.46 ± 0.11	0.377ProCys: 0.377 ± 0.019	4.102ProAsp: 4.102 ± 0.067	3.9ProGlu: 3.9 ± 0.063	2.063ProPhe: 2.063 ± 0.044	5.154ProGly: 5.154 ± 0.074	1.033ProHis: 1.033 ± 0.024	2.352ProIle: 2.352 ± 0.044	1.743ProLys: 1.743 ± 0.037	4.848ProLeu: 4.848 ± 0.064	1.175ProMet: 1.175 ± 0.036	1.347ProAsn: 1.347 ± 0.033	3.281ProPro: 3.281 ± 0.066	1.589ProGln: 1.589 ± 0.039	3.619ProArg: 3.619 ± 0.062	3.17ProSer: 3.17 ± 0.06	2.797ProThr: 2.797 ± 0.054	4.595ProVal: 4.595 ± 0.067	0.706ProTrp: 0.706 ± 0.025	1.102ProTyr: 1.102 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	4.264GlnAla: 4.264 ± 0.067	0.152GlnCys: 0.152 ± 0.01	1.409GlnAsp: 1.409 ± 0.039	1.22GlnGlu: 1.22 ± 0.032	0.839GlnPhe: 0.839 ± 0.029	2.486GlnGly: 2.486 ± 0.048	0.526GlnHis: 0.526 ± 0.019	1.528GlnIle: 1.528 ± 0.034	0.876GlnLys: 0.876 ± 0.028	2.278GlnLeu: 2.278 ± 0.05	0.592GlnMet: 0.592 ± 0.02	0.675GlnAsn: 0.675 ± 0.027	1.73GlnPro: 1.73 ± 0.04	0.945GlnGln: 0.945 ± 0.041	2.228GlnArg: 2.228 ± 0.044	1.545GlnSer: 1.545 ± 0.044	1.653GlnThr: 1.653 ± 0.035	2.095GlnVal: 2.095 ± 0.042	0.275GlnTrp: 0.275 ± 0.016	0.505GlnTyr: 0.505 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	9.286ArgAla: 9.286 ± 0.096	0.567ArgCys: 0.567 ± 0.02	4.526ArgAsp: 4.526 ± 0.069	4.529ArgGlu: 4.529 ± 0.078	3.194ArgPhe: 3.194 ± 0.048	5.706ArgGly: 5.706 ± 0.073	1.816ArgHis: 1.816 ± 0.046	4.371ArgIle: 4.371 ± 0.057	2.103ArgLys: 2.103 ± 0.052	9.029ArgLeu: 9.029 ± 0.108	1.837ArgMet: 1.837 ± 0.036	1.73ArgAsn: 1.73 ± 0.036	4.454ArgPro: 4.454 ± 0.071	2.367ArgGln: 2.367 ± 0.05	6.996ArgArg: 6.996 ± 0.088	4.457ArgSer: 4.457 ± 0.062	4.007ArgThr: 4.007 ± 0.062	5.417ArgVal: 5.417 ± 0.069	0.997ArgTrp: 0.997 ± 0.03	1.748ArgTyr: 1.748 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.668SerAla: 6.668 ± 0.083	0.415SerCys: 0.415 ± 0.019	2.999SerAsp: 2.999 ± 0.051	3.0SerGlu: 3.0 ± 0.05	2.01SerPhe: 2.01 ± 0.037	5.706SerGly: 5.706 ± 0.098	0.977SerHis: 0.977 ± 0.025	2.3SerIle: 2.3 ± 0.046	1.446SerLys: 1.446 ± 0.032	5.607SerLeu: 5.607 ± 0.067	1.062SerMet: 1.062 ± 0.027	1.221SerAsn: 1.221 ± 0.033	2.928SerPro: 2.928 ± 0.056	1.479SerGln: 1.479 ± 0.036	3.985SerArg: 3.985 ± 0.059	2.768SerSer: 2.768 ± 0.051	2.642SerThr: 2.642 ± 0.053	3.926SerVal: 3.926 ± 0.07	0.651SerTrp: 0.651 ± 0.025	1.198SerTyr: 1.198 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	6.921ThrAla: 6.921 ± 0.087	0.444ThrCys: 0.444 ± 0.019	2.861ThrAsp: 2.861 ± 0.052	2.672ThrGlu: 2.672 ± 0.053	1.847ThrPhe: 1.847 ± 0.041	5.513ThrGly: 5.513 ± 0.117	0.977ThrHis: 0.977 ± 0.028	2.814ThrIle: 2.814 ± 0.055	1.417ThrLys: 1.417 ± 0.035	6.243ThrLeu: 6.243 ± 0.088	1.084ThrMet: 1.084 ± 0.031	1.221ThrAsn: 1.221 ± 0.043	3.384ThrPro: 3.384 ± 0.06	1.457ThrGln: 1.457 ± 0.036	3.698ThrArg: 3.698 ± 0.056	2.652ThrSer: 2.652 ± 0.058	2.948ThrThr: 2.948 ± 0.073	4.847ThrVal: 4.847 ± 0.085	0.691ThrTrp: 0.691 ± 0.023	1.128ThrTyr: 1.128 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	10.356ValAla: 10.356 ± 0.104	0.622ValCys: 0.622 ± 0.02	4.042ValAsp: 4.042 ± 0.05	4.64ValGlu: 4.64 ± 0.067	2.67ValPhe: 2.67 ± 0.047	5.976ValGly: 5.976 ± 0.074	1.305ValHis: 1.305 ± 0.033	3.627ValIle: 3.627 ± 0.056	2.035ValLys: 2.035 ± 0.048	7.637ValLeu: 7.637 ± 0.091	1.615ValMet: 1.615 ± 0.04	1.691ValAsn: 1.691 ± 0.055	4.215ValPro: 4.215 ± 0.06	2.0ValGln: 2.0 ± 0.039	5.395ValArg: 5.395 ± 0.062	4.358ValSer: 4.358 ± 0.064	4.625ValThr: 4.625 ± 0.077	6.321ValVal: 6.321 ± 0.074	0.848ValTrp: 0.848 ± 0.026	1.391ValTyr: 1.391 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.118TrpAla: 1.118 ± 0.03	0.143TrpCys: 0.143 ± 0.01	0.57TrpAsp: 0.57 ± 0.023	0.469TrpGlu: 0.469 ± 0.02	0.488TrpPhe: 0.488 ± 0.019	0.769TrpGly: 0.769 ± 0.026	0.287TrpHis: 0.287 ± 0.015	0.597TrpIle: 0.597 ± 0.021	0.35TrpLys: 0.35 ± 0.017	1.567TrpLeu: 1.567 ± 0.034	0.31TrpMet: 0.31 ± 0.016	0.352TrpAsn: 0.352 ± 0.017	0.638TrpPro: 0.638 ± 0.022	0.48TrpGln: 0.48 ± 0.018	1.223TrpArg: 1.223 ± 0.035	0.792TrpSer: 0.792 ± 0.026	0.801TrpThr: 0.801 ± 0.025	0.724TrpVal: 0.724 ± 0.024	0.211TrpTrp: 0.211 ± 0.014	0.269TrpTyr: 0.269 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.671TyrAla: 2.671 ± 0.054	0.211TyrCys: 0.211 ± 0.012	1.395TyrAsp: 1.395 ± 0.042	1.162TyrGlu: 1.162 ± 0.038	0.761TyrPhe: 0.761 ± 0.03	2.252TyrGly: 2.252 ± 0.043	0.374TyrHis: 0.374 ± 0.016	0.647TyrIle: 0.647 ± 0.022	0.486TyrLys: 0.486 ± 0.023	2.077TyrLeu: 2.077 ± 0.04	0.321TyrMet: 0.321 ± 0.015	0.474TyrAsn: 0.474 ± 0.023	0.933TyrPro: 0.933 ± 0.027	0.556TyrGln: 0.556 ± 0.021	1.898TyrArg: 1.898 ± 0.039	0.911TyrSer: 0.911 ± 0.032	0.978TyrThr: 0.978 ± 0.031	1.545TyrVal: 1.545 ± 0.035	0.279TyrTrp: 0.279 ± 0.014	0.505TyrTyr: 0.505 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4347 proteins (1297323 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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