Amino acid dipepetide frequency for Mesorhizobium sp. MaA-C15

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.638AlaAla: 17.638 ± 0.158	0.991AlaCys: 0.991 ± 0.026	6.9AlaAsp: 6.9 ± 0.071	7.893AlaGlu: 7.893 ± 0.11	4.767AlaPhe: 4.767 ± 0.067	11.269AlaGly: 11.269 ± 0.103	2.255AlaHis: 2.255 ± 0.039	7.005AlaIle: 7.005 ± 0.069	3.702AlaLys: 3.702 ± 0.059	13.317AlaLeu: 13.317 ± 0.127	3.951AlaMet: 3.951 ± 0.053	2.87AlaAsn: 2.87 ± 0.05	5.187AlaPro: 5.187 ± 0.079	3.873AlaGln: 3.873 ± 0.057	8.992AlaArg: 8.992 ± 0.09	6.629AlaSer: 6.629 ± 0.077	6.046AlaThr: 6.046 ± 0.071	9.122AlaVal: 9.122 ± 0.089	1.472AlaTrp: 1.472 ± 0.029	2.571AlaTyr: 2.571 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.947CysAla: 0.947 ± 0.027	0.096CysCys: 0.096 ± 0.009	0.48CysAsp: 0.48 ± 0.022	0.435CysGlu: 0.435 ± 0.019	0.318CysPhe: 0.318 ± 0.015	0.871CysGly: 0.871 ± 0.026	0.234CysHis: 0.234 ± 0.013	0.395CysIle: 0.395 ± 0.018	0.161CysLys: 0.161 ± 0.01	0.724CysLeu: 0.724 ± 0.024	0.153CysMet: 0.153 ± 0.01	0.18CysAsn: 0.18 ± 0.012	0.385CysPro: 0.385 ± 0.016	0.183CysGln: 0.183 ± 0.012	0.609CysArg: 0.609 ± 0.019	0.428CysSer: 0.428 ± 0.017	0.37CysThr: 0.37 ± 0.017	0.582CysVal: 0.582 ± 0.019	0.115CysTrp: 0.115 ± 0.008	0.18CysTyr: 0.18 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.23AspAla: 7.23 ± 0.079	0.46AspCys: 0.46 ± 0.016	3.35AspAsp: 3.35 ± 0.06	4.025AspGlu: 4.025 ± 0.065	2.256AspPhe: 2.256 ± 0.04	5.222AspGly: 5.222 ± 0.063	1.237AspHis: 1.237 ± 0.03	3.156AspIle: 3.156 ± 0.047	1.539AspLys: 1.539 ± 0.035	5.413AspLeu: 5.413 ± 0.069	1.509AspMet: 1.509 ± 0.037	1.265AspAsn: 1.265 ± 0.027	3.191AspPro: 3.191 ± 0.051	1.488AspGln: 1.488 ± 0.034	4.491AspArg: 4.491 ± 0.06	1.853AspSer: 1.853 ± 0.037	2.578AspThr: 2.578 ± 0.051	4.115AspVal: 4.115 ± 0.054	0.896AspTrp: 0.896 ± 0.025	1.432AspTyr: 1.432 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	8.275GluAla: 8.275 ± 0.093	0.325GluCys: 0.325 ± 0.016	3.014GluAsp: 3.014 ± 0.047	3.699GluGlu: 3.699 ± 0.068	1.857GluPhe: 1.857 ± 0.034	4.803GluGly: 4.803 ± 0.056	1.224GluHis: 1.224 ± 0.028	3.745GluIle: 3.745 ± 0.05	2.489GluLys: 2.489 ± 0.053	5.569GluLeu: 5.569 ± 0.066	1.715GluMet: 1.715 ± 0.035	1.744GluAsn: 1.744 ± 0.034	2.943GluPro: 2.943 ± 0.053	2.122GluGln: 2.122 ± 0.048	5.435GluArg: 5.435 ± 0.067	2.298GluSer: 2.298 ± 0.038	3.801GluThr: 3.801 ± 0.045	4.021GluVal: 4.021 ± 0.054	0.773GluTrp: 0.773 ± 0.022	1.051GluTyr: 1.051 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.919PheAla: 4.919 ± 0.065	0.379PheCys: 0.379 ± 0.014	2.707PheAsp: 2.707 ± 0.037	2.305PheGlu: 2.305 ± 0.043	1.59PhePhe: 1.59 ± 0.039	3.957PheGly: 3.957 ± 0.062	0.765PheHis: 0.765 ± 0.021	1.868PheIle: 1.868 ± 0.04	0.816PheLys: 0.816 ± 0.027	3.524PheLeu: 3.524 ± 0.058	0.913PheMet: 0.913 ± 0.026	1.041PheAsn: 1.041 ± 0.026	1.613PhePro: 1.613 ± 0.033	0.993PheGln: 0.993 ± 0.027	2.458PheArg: 2.458 ± 0.04	2.341PheSer: 2.341 ± 0.041	1.904PheThr: 1.904 ± 0.045	3.057PheVal: 3.057 ± 0.048	0.578PheTrp: 0.578 ± 0.023	0.903PheTyr: 0.903 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	9.263GlyAla: 9.263 ± 0.085	0.823GlyCys: 0.823 ± 0.025	4.554GlyAsp: 4.554 ± 0.064	5.397GlyGlu: 5.397 ± 0.062	3.742GlyPhe: 3.742 ± 0.055	7.565GlyGly: 7.565 ± 0.092	1.909GlyHis: 1.909 ± 0.038	4.9GlyIle: 4.9 ± 0.063	3.137GlyLys: 3.137 ± 0.048	8.952GlyLeu: 8.952 ± 0.091	2.581GlyMet: 2.581 ± 0.044	2.192GlyAsn: 2.192 ± 0.043	3.315GlyPro: 3.315 ± 0.045	2.623GlyGln: 2.623 ± 0.05	6.372GlyArg: 6.372 ± 0.069	4.857GlySer: 4.857 ± 0.061	4.472GlyThr: 4.472 ± 0.06	6.432GlyVal: 6.432 ± 0.077	1.372GlyTrp: 1.372 ± 0.031	2.322GlyTyr: 2.322 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.406HisAla: 2.406 ± 0.042	0.224HisCys: 0.224 ± 0.013	1.243HisAsp: 1.243 ± 0.03	1.182HisGlu: 1.182 ± 0.026	0.849HisPhe: 0.849 ± 0.024	1.993HisGly: 1.993 ± 0.038	0.564HisHis: 0.564 ± 0.023	0.957HisIle: 0.957 ± 0.027	0.465HisLys: 0.465 ± 0.018	1.972HisLeu: 1.972 ± 0.037	0.527HisMet: 0.527 ± 0.019	0.451HisAsn: 0.451 ± 0.017	1.238HisPro: 1.238 ± 0.033	0.557HisGln: 0.557 ± 0.022	1.454HisArg: 1.454 ± 0.031	0.917HisSer: 0.917 ± 0.025	0.806HisThr: 0.806 ± 0.021	1.577HisVal: 1.577 ± 0.03	0.311HisTrp: 0.311 ± 0.017	0.574HisTyr: 0.574 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	7.696IleAla: 7.696 ± 0.078	0.503IleCys: 0.503 ± 0.019	3.707IleAsp: 3.707 ± 0.055	3.825IleGlu: 3.825 ± 0.062	1.868IlePhe: 1.868 ± 0.037	5.017IleGly: 5.017 ± 0.063	1.005IleHis: 1.005 ± 0.026	2.382IleIle: 2.382 ± 0.046	1.215IleLys: 1.215 ± 0.036	4.484IleLeu: 4.484 ± 0.066	1.129IleMet: 1.129 ± 0.024	1.352IleAsn: 1.352 ± 0.029	2.262IlePro: 2.262 ± 0.04	1.172IleGln: 1.172 ± 0.028	3.439IleArg: 3.439 ± 0.048	2.944IleSer: 2.944 ± 0.049	2.549IleThr: 2.549 ± 0.044	4.854IleVal: 4.854 ± 0.061	0.603IleTrp: 0.603 ± 0.021	1.163IleTyr: 1.163 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	4.206LysAla: 4.206 ± 0.06	0.132LysCys: 0.132 ± 0.009	1.534LysAsp: 1.534 ± 0.037	1.608LysGlu: 1.608 ± 0.037	0.831LysPhe: 0.831 ± 0.026	2.556LysGly: 2.556 ± 0.045	0.587LysHis: 0.587 ± 0.021	1.578LysIle: 1.578 ± 0.036	1.26LysLys: 1.26 ± 0.037	3.062LysLeu: 3.062 ± 0.049	0.74LysMet: 0.74 ± 0.024	0.801LysAsn: 0.801 ± 0.026	1.958LysPro: 1.958 ± 0.044	0.942LysGln: 0.942 ± 0.027	2.306LysArg: 2.306 ± 0.044	1.619LysSer: 1.619 ± 0.035	1.749LysThr: 1.749 ± 0.032	2.345LysVal: 2.345 ± 0.049	0.34LysTrp: 0.34 ± 0.015	0.55LysTyr: 0.55 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	13.547LeuAla: 13.547 ± 0.123	0.824LeuCys: 0.824 ± 0.021	5.902LeuAsp: 5.902 ± 0.071	5.436LeuGlu: 5.436 ± 0.065	3.744LeuPhe: 3.744 ± 0.06	8.261LeuGly: 8.261 ± 0.085	1.805LeuHis: 1.805 ± 0.041	4.855LeuIle: 4.855 ± 0.063	3.318LeuLys: 3.318 ± 0.049	9.231LeuLeu: 9.231 ± 0.109	2.492LeuMet: 2.492 ± 0.048	2.404LeuAsn: 2.404 ± 0.043	5.298LeuPro: 5.298 ± 0.079	2.448LeuGln: 2.448 ± 0.043	6.659LeuArg: 6.659 ± 0.079	6.463LeuSer: 6.463 ± 0.064	5.119LeuThr: 5.119 ± 0.055	7.789LeuVal: 7.789 ± 0.095	1.084LeuTrp: 1.084 ± 0.033	2.074LeuTyr: 2.074 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.41MetAla: 3.41 ± 0.053	0.159MetCys: 0.159 ± 0.01	1.22MetAsp: 1.22 ± 0.031	1.337MetGlu: 1.337 ± 0.032	0.777MetPhe: 0.777 ± 0.026	2.028MetGly: 2.028 ± 0.04	0.465MetHis: 0.465 ± 0.017	1.446MetIle: 1.446 ± 0.032	1.048MetLys: 1.048 ± 0.027	2.804MetLeu: 2.804 ± 0.048	0.797MetMet: 0.797 ± 0.026	0.844MetAsn: 0.844 ± 0.024	1.642MetPro: 1.642 ± 0.034	0.874MetGln: 0.874 ± 0.024	2.074MetArg: 2.074 ± 0.039	1.739MetSer: 1.739 ± 0.035	1.882MetThr: 1.882 ± 0.041	1.926MetVal: 1.926 ± 0.04	0.225MetTrp: 0.225 ± 0.013	0.324MetTyr: 0.324 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.192AsnAla: 3.192 ± 0.052	0.229AsnCys: 0.229 ± 0.014	1.397AsnAsp: 1.397 ± 0.033	1.338AsnGlu: 1.338 ± 0.034	0.908AsnPhe: 0.908 ± 0.025	2.301AsnGly: 2.301 ± 0.043	0.5AsnHis: 0.5 ± 0.018	1.362AsnIle: 1.362 ± 0.032	0.586AsnLys: 0.586 ± 0.023	2.465AsnLeu: 2.465 ± 0.043	0.631AsnMet: 0.631 ± 0.021	0.637AsnAsn: 0.637 ± 0.025	1.803AsnPro: 1.803 ± 0.037	0.742AsnGln: 0.742 ± 0.024	1.812AsnArg: 1.812 ± 0.031	1.106AsnSer: 1.106 ± 0.027	1.19AsnThr: 1.19 ± 0.029	1.998AsnVal: 1.998 ± 0.037	0.426AsnTrp: 0.426 ± 0.018	0.643AsnTyr: 0.643 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	6.143ProAla: 6.143 ± 0.076	0.293ProCys: 0.293 ± 0.013	3.421ProAsp: 3.421 ± 0.048	3.61ProGlu: 3.61 ± 0.047	2.067ProPhe: 2.067 ± 0.038	4.24ProGly: 4.24 ± 0.061	1.093ProHis: 1.093 ± 0.029	2.226ProIle: 2.226 ± 0.043	1.507ProLys: 1.507 ± 0.03	4.577ProLeu: 4.577 ± 0.063	1.186ProMet: 1.186 ± 0.028	1.227ProAsn: 1.227 ± 0.03	2.271ProPro: 2.271 ± 0.054	1.704ProGln: 1.704 ± 0.034	2.949ProArg: 2.949 ± 0.05	2.618ProSer: 2.618 ± 0.043	2.287ProThr: 2.287 ± 0.045	4.217ProVal: 4.217 ± 0.063	0.639ProTrp: 0.639 ± 0.022	1.174ProTyr: 1.174 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.835GlnAla: 3.835 ± 0.062	0.187GlnCys: 0.187 ± 0.012	1.341GlnAsp: 1.341 ± 0.032	1.632GlnGlu: 1.632 ± 0.042	1.019GlnPhe: 1.019 ± 0.026	2.252GlnGly: 2.252 ± 0.041	0.588GlnHis: 0.588 ± 0.022	1.735GlnIle: 1.735 ± 0.035	1.036GlnLys: 1.036 ± 0.03	2.74GlnLeu: 2.74 ± 0.043	0.926GlnMet: 0.926 ± 0.024	0.835GlnAsn: 0.835 ± 0.025	1.69GlnPro: 1.69 ± 0.039	1.179GlnGln: 1.179 ± 0.035	2.285GlnArg: 2.285 ± 0.048	1.609GlnSer: 1.609 ± 0.034	1.647GlnThr: 1.647 ± 0.039	2.1GlnVal: 2.1 ± 0.042	0.378GlnTrp: 0.378 ± 0.016	0.537GlnTyr: 0.537 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	7.981ArgAla: 7.981 ± 0.095	0.483ArgCys: 0.483 ± 0.02	4.219ArgAsp: 4.219 ± 0.055	4.628ArgGlu: 4.628 ± 0.078	3.136ArgPhe: 3.136 ± 0.048	4.835ArgGly: 4.835 ± 0.059	1.735ArgHis: 1.735 ± 0.033	4.186ArgIle: 4.186 ± 0.056	2.469ArgLys: 2.469 ± 0.048	7.861ArgLeu: 7.861 ± 0.084	2.058ArgMet: 2.058 ± 0.04	1.934ArgAsn: 1.934 ± 0.038	3.541ArgPro: 3.541 ± 0.055	2.548ArgGln: 2.548 ± 0.046	5.919ArgArg: 5.919 ± 0.074	3.727ArgSer: 3.727 ± 0.053	3.439ArgThr: 3.439 ± 0.055	4.778ArgVal: 4.778 ± 0.059	1.0ArgTrp: 1.0 ± 0.03	1.704ArgTyr: 1.704 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	6.133SerAla: 6.133 ± 0.068	0.421SerCys: 0.421 ± 0.018	2.878SerAsp: 2.878 ± 0.045	2.846SerGlu: 2.846 ± 0.043	2.372SerPhe: 2.372 ± 0.047	5.629SerGly: 5.629 ± 0.066	1.079SerHis: 1.079 ± 0.03	2.899SerIle: 2.899 ± 0.042	1.459SerLys: 1.459 ± 0.033	5.232SerLeu: 5.232 ± 0.067	1.466SerMet: 1.466 ± 0.03	1.308SerAsn: 1.308 ± 0.032	2.637SerPro: 2.637 ± 0.043	1.634SerGln: 1.634 ± 0.034	3.665SerArg: 3.665 ± 0.057	2.959SerSer: 2.959 ± 0.051	2.623SerThr: 2.623 ± 0.045	4.089SerVal: 4.089 ± 0.05	0.706SerTrp: 0.706 ± 0.021	1.303SerTyr: 1.303 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	6.029ThrAla: 6.029 ± 0.066	0.39ThrCys: 0.39 ± 0.016	2.678ThrAsp: 2.678 ± 0.042	2.63ThrGlu: 2.63 ± 0.042	2.064ThrPhe: 2.064 ± 0.041	5.161ThrGly: 5.161 ± 0.059	1.002ThrHis: 1.002 ± 0.028	2.988ThrIle: 2.988 ± 0.051	1.308ThrLys: 1.308 ± 0.029	5.565ThrLeu: 5.565 ± 0.06	1.32ThrMet: 1.32 ± 0.032	1.218ThrAsn: 1.218 ± 0.027	3.043ThrPro: 3.043 ± 0.049	1.39ThrGln: 1.39 ± 0.03	3.232ThrArg: 3.232 ± 0.056	2.669ThrSer: 2.669 ± 0.041	2.753ThrThr: 2.753 ± 0.05	4.355ThrVal: 4.355 ± 0.058	0.633ThrTrp: 0.633 ± 0.024	1.168ThrTyr: 1.168 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	9.85ValAla: 9.85 ± 0.087	0.6ValCys: 0.6 ± 0.019	4.088ValAsp: 4.088 ± 0.051	5.149ValGlu: 5.149 ± 0.068	2.981ValPhe: 2.981 ± 0.039	5.825ValGly: 5.825 ± 0.079	1.455ValHis: 1.455 ± 0.033	3.971ValIle: 3.971 ± 0.056	2.198ValLys: 2.198 ± 0.045	7.347ValLeu: 7.347 ± 0.086	2.059ValMet: 2.059 ± 0.033	1.99ValAsn: 1.99 ± 0.035	3.681ValPro: 3.681 ± 0.047	1.905ValGln: 1.905 ± 0.038	5.072ValArg: 5.072 ± 0.061	4.597ValSer: 4.597 ± 0.057	4.55ValThr: 4.55 ± 0.058	6.36ValVal: 6.36 ± 0.08	0.976ValTrp: 0.976 ± 0.028	1.541ValTyr: 1.541 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.222TrpAla: 1.222 ± 0.033	0.119TrpCys: 0.119 ± 0.009	0.621TrpAsp: 0.621 ± 0.022	0.587TrpGlu: 0.587 ± 0.021	0.569TrpPhe: 0.569 ± 0.019	0.849TrpGly: 0.849 ± 0.026	0.302TrpHis: 0.302 ± 0.014	0.611TrpIle: 0.611 ± 0.021	0.468TrpLys: 0.468 ± 0.02	1.715TrpLeu: 1.715 ± 0.045	0.386TrpMet: 0.386 ± 0.016	0.44TrpAsn: 0.44 ± 0.019	0.713TrpPro: 0.713 ± 0.023	0.503TrpGln: 0.503 ± 0.018	1.121TrpArg: 1.121 ± 0.031	0.822TrpSer: 0.822 ± 0.023	0.754TrpThr: 0.754 ± 0.022	0.79TrpVal: 0.79 ± 0.023	0.233TrpTrp: 0.233 ± 0.013	0.29TrpTyr: 0.29 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.531TyrAla: 2.531 ± 0.049	0.209TyrCys: 0.209 ± 0.013	1.45TyrAsp: 1.45 ± 0.036	1.339TyrGlu: 1.339 ± 0.031	0.917TyrPhe: 0.917 ± 0.026	2.148TyrGly: 2.148 ± 0.038	0.465TyrHis: 0.465 ± 0.018	0.902TyrIle: 0.902 ± 0.028	0.522TyrLys: 0.522 ± 0.019	2.198TyrLeu: 2.198 ± 0.032	0.485TyrMet: 0.485 ± 0.017	0.531TyrAsn: 0.531 ± 0.02	1.039TyrPro: 1.039 ± 0.025	0.672TyrGln: 0.672 ± 0.021	1.839TyrArg: 1.839 ± 0.033	1.142TyrSer: 1.142 ± 0.027	1.077TyrThr: 1.077 ± 0.033	1.688TyrVal: 1.688 ± 0.038	0.354TyrTrp: 0.354 ± 0.015	0.571TyrTyr: 0.571 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4601 proteins (1442372 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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